• Clinical and Experimental Reproductive Medicine
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• 제43권1호
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• pp.51-53
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• 2016

Uterine fibroids are benign tumors of the myometrium with a diverse range of manifestations. Fibroids can dramatically increase in size during pregnancy due to the increase in estrogen levels. After delivery, the fibroids usually shrink back to their pre-pregnancy size. Uterine myomas may have many complications, including abnormal uterine bleeding, infertility, pressure on nearby organs, degeneration, and malignant transformation. No previous reports have indicated that a fistula may develop between a uterine fibroid and the bowel loops, although previous studies have documented the occurrence of fistulas from the uterus to the bowel following myomectomy or uterine artery embolization performed to treat a myoma. In our case report, we document the rare complication of a fistula occurring between a degenerated myoma in the posterior wall and the ileum 1 week postoperatively in a patient who underwent a Caesarean section but did not have a history of uterine artery embolization.

• Journal of Yeungnam Medical Science
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• 제25권2호
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• pp.124-127
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• 2008

Leiomyomas are common in the myometrial layer of the uterus, though they are rarely found in other reproductive organs. Leiomyomas are benign, hormone-sensitive smooth muscle tumors. They develop during the reproductive years and regress after menopause. Preoperative diagnosis is difficult to make. We present a case of a 54-year-old woman with a vaginal wall tumor. The management in this case included surgical excision. Histologic examination definitively confirmed the diagnosis of a vaginal leiomyoma. We report the details of this case along with a brief review of the literature.

• Reproductive and Developmental Biology
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• 제38권2호
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• pp.63-70
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• 2014

Plasminogen activators (PAs) are serine proteases that convert plasminogen to plasmin. Two type of PAs are urokinase-type PA (uPA) and tissue-type PA (tPA). Plasminogen is present in most extracellular fluids. PAs play in various reproductive processes including implantation, ovulation and fertilization. In the spermatozoa, PAs and PAIs play a role in sperm motility and fertilization. PAs in the sertoli cell are stimulated spermatozoa maturation and sperm activation through the phospholipase A2. The oocyte maturation is the process for fertilization and implantation. PAs in cumulus-oocyte complexes (COCs) are related to oocyte maturation by protein kinase A and C. In the ovulatory process, PAs activity are changed and it are related to reducing the tensile strength of ovarian follicle wall. The uterine environment is important for reproduction and the uterus undergo tissue remodeling. In the uterus and oviduct of mammals, expression and activity of PAs are changed during estrous cycle. Thus, expression and activity of PAs are concerned to many reproductive functions. Therefore, PAs seem to important factor of regulator in reproductive events.

• 한국임상수의학회지
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• 제14권1호
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• pp.112-117
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• 1997

12-month-old Buldig and 3-year-old German Shepherd, treated with corticosteroids duringthe late pregnancy, were referred to the Veterinary Teaching Hospital, Chonnam National University, with chief complaints of vaginal discharge. Radiographic, ultrasonographic and surgical findings that obtained from each cases were as follows; case I: Radiographic findings were identified 2 fetuses that were normal skeleton, however, fetal viability could not be determined. Ultrasonographic findings were identified absence of fetal heartbeat and fetal movement, abnormal echogenicity of the abdominal visera, and echogenic materials remaining within the fetal fluid. After hysterotomy, macroscopic findings of uterus were liquefied materials remaining within the uterine lumen. Fetuses were excessively autolysis (falling off the hair, depression of the eye, and necrosis of the abdormal visera and skin). case II: Radiographic findings were identified irregular fetal structures and fetal movement, loss of recognizable fetal anatomy, dislocation of fetal veterbrae and echogenic materials remaining within the uterine lumen. After ovariohysterectomy, macroscopic finding of uterus and fetus were thickened uterine wall, yellowish-brown colored administration of corticosteroids during gestation should be contraindicated because fetal death is inducced. Ultrasonography has an advantage over radiography in that it permits evaluation of fetal viability.

• 한국동물위생학회지
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• 제35권1호
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• pp.63-67
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• 2012

An 8-months-old young Maltese bitch was presented for investigation of anorexia and occasional vomiting. The body weight was 2 kg. Abdominal sonography demonstrated abnormal enlargement of uterus. The dog had been clinically and pathologically examined. Also, ovariohystectomy was performed. Staphylococcus aureus was identified in the pus-like materials of the uterine lumen. This case was confirmed as pyometra induced by Staphylococcus aureus. Gross examination of the dissected uterus revealed enlarged uterine horn, which had yellowish or brownish pus-like materials in the lumen. Also, there was several segments formation between the enlarged areas of left and right uterine horns. Histopathologically, endometritis and necrosis were present in uterine wall. The bitch made a complete recovery following an ovariohystectomy. This case was spontaneous pyometra induced by Staphylococcus species. On our knowledge, this is a very rare report of pyometra occurrence in young dog and Staphylococcus species-induced pyometra. This study may provide a valuable data on the study of canine pyometra.

• 한국임상수의학회지
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• 제18권2호
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• pp.139-145
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• 2001

This study was undertaken to determine the normal serial ultrasonographic appearance of the postpartum uterine involution in small pet dogs (Yorkshire terrier and Maltese). Postpartum changes in uterine shape, architecture, echogenicity and diameter were monitored by ultrasonography in 12 small pet dogs. Serial ultrasonographic examinations were done daily during the first week, 3 days interval from 8 to 30 days, and weekly from 31 to 100 days postpartum. The excretory period of vaginal discharge in 12 normal bitches of uterine involution was finished completely within 3 weeks postpartum. The short axis shape of the uterus was initially often flaccid-appearing. It varied from circular to polygonal. This lasted until 15.75$\pm$3.84 days postpartum, during which time the short axis uterine shape gradually changed to circular. Also, the long axis shape of the uterus was a beaded appearance until 30.89$\pm$4.25 days postpartum. After 30 days, it was appeared as tubular shape between placental and interplacental sites. The ultrasonographic image of the postpartum uterus consisted of four echogenicity distinct layers. Uterine wall was represented as very hyperechoic serosa, hypoechoic myometrium, hyperechoic endometrium and anechoic structures of fluid in the uterine cavity until 7 days postpartum. The individual uterine layers were most prominent during the first week postpartum, and they became progressively less distinct throughout the course of uterine involution. The thickness of myometrium was decreased rapidly in the placental sites from 4.47$\pm$1.42 mm at 1 day to 1.92$\pm$0.26 mm at 16 day, and in the interplacental sites from 3.19$\pm$0.61 mm at 1 day to 1.39$\pm$0.61 mm at 16 day. And it was decreased slowly until 94 day and was been minimum thickness at 94 day. The thickness of endometrium was also decreased like that of myometrium. The uterine diameter in the placental sites was decreased from 22.28$\pm$3.01 mm at 1 day to 16.11$\pm$1.46 mm at 7 day, and in the interplacental sites was decreased from 13.65$\pm$2.34 mm at 1 day to 9.41$\pm$1.59 mm at 7 day postpartum. From 7 day to 93 day, the change of diameter was more and more slow. At 94 days postpartum, the uterine diameter was 5~6 mm both placental and interplacental sites, and the uterine horns were uniform hypoechoic, tubular structures without enlargement. Therefore, complete involution of the uterus occurred at 94 days. It was concluded that normal post partum uterine involution in small pet dogs appeared to be completed 94 days postpartum by gross findings such as vaginal discharges, and by ultrasonographic findings, uterine shape and echogenicity.

• 한국수정란이식학회지
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• 제32권4호
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• pp.325-329
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• 2017

A 2-year-old female Maltese dog was admitted with a history of pyometra and resulting peritonitis and septicemia. Uterine specimen sampled by ovariohysterectomy was processed routinely for histopathological observation. Grossly, the uterine mucosa was covered with necrotic debris and on the cut surface, lesion extended into the uterine wall. Microscopically, severe necrosis was observed throughout thickened mucosa, submucosa, and wall of uterus. Tumorous lesions composed of anaplastic cells with bizarre nuclei or tubular structures of cuboidal to short columnar cells were infrequently observed around the necrotic lesions and muscular layer far from necrotic areas. Immunohistochemically, central necrotic area with ambiguous cell and tissue structures, peri-necrotic tumor lesions, and muscular layer were strongly positive for cytokeratin. Since huge necrosis of adenocarcinoma lesions in this case made it difficult to diagnose, immunohistochemical results enable to diagnose as a severe necrotizing adenocarcinoma. Thus, histopathological and immunohistochemical findings in this case may serve as an important knowledge to diagnose uterine adenocarcinoma with huge necrosis in the veterinary field.

• 한국가축번식학회지
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• 제21권1호
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• pp.31-37
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• 1997

Ultrasonographic diagnosis of genital disease and early pregnancy diagnosis was performed in Korean native cattle. The size of ovarian follicle in preovulation, luteal stage and follicular cyst was 18.9, 9.2 and 27.6 mm, respectively, and the thickness of follicular wall was 2.3, 1.8 and 2.8 mm, respectively. The size of corpus luteums in formation stage, activity stage, regression stage, cystic corpora lutea and luteal cyst was 6.2, 11.3, 8.6, 26.7 and 25.9 mm, respectively. The thickness of luteal wall in cystic corpora lutea and luteal cyst was 8.4 and 4.9 mm, respectively. The size of embryo or fetus on day 25, 27, 30, 35, 40, 45 and 50 was 0.8, 0.9, 1.3, 1.5, 2.2, 2.8 and 3.8 cm, respectively. The size of amniotic vesicle on day 25, 27 and 30 was 1.2, 2.1 and 3,0 cm, respectively. The diameter of pregnant uterus on day 25 and 27 was 7.0 and 7.8 cm, respectively. It was concluded that the ultrasonographci values determined in this study can be used as references for the treatment of genital disease and early pregnancy diagnosis in Korean native cattle.

• 대한수의학회지
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• 제60권3호
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• pp.179-182
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• 2020

A 16-year-old cat presented with a 2-week history of anorexia and lethargy. Radiography revealed a soft-tissue opacity, heart-shaped mass between the descending colon and urinary bladder. Ultrasonography showed a large uterine body with a heterogeneously hypoechoic, thickened wall and hypoechoic intraluminal fluid. Computed tomography revealed a large, fluid-filled uterine mass with contrast enhancement, without evidence of regional lymph node or pulmonary metastasis. Ovariohysterectomy was performed and leiomyosarcoma was confirmed by histology. No notable abnormalities were observed during the 1-year postoperative follow-up periods. This report describes the diagnostic imaging and treatment of a rare case of feline uterine leiomyosarcoma.

• 한국수정란이식학회지
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• 제29권4호
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• pp.393-395
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• 2014

A 6-year old, Greyhound bitch was presented with vaginal hemorrhage and dystocia. Physical examination revealed severe vaginal hemorrhage, abdominal pain, pale mucous membranes and the presence of solid structures to abdominal palpation. A hematological test revealed a marked hemorrhagic anemia, and abdominal radiography and ultrasonographic examination showed two dead fetuses in the uterus. Median laparotomy revealed a rupture of the left uterine horn adjacent to the bifurcation, region of weakened uterine wall in the right uterine horn, blood clots and uterine fluids in abdominal cavity without septic peritonitis. The bitch underwent ovariohysterectomy and recovered without complication.