DOI QR코드

DOI QR Code

Unusual Necrotizing Uterine Adenocarcinoma in a Dog

  • Kim, Tae-Jung (College of Veterinary Medicine, Chonnam National University) ;
  • Shin, Sung-Shik (College of Veterinary Medicine, Chonnam National University) ;
  • Park, Sang-Ik (College of Veterinary Medicine, Chonnam National University)
  • Received : 2017.11.15
  • Accepted : 2017.12.15
  • Published : 2017.12.30

Abstract

A 2-year-old female Maltese dog was admitted with a history of pyometra and resulting peritonitis and septicemia. Uterine specimen sampled by ovariohysterectomy was processed routinely for histopathological observation. Grossly, the uterine mucosa was covered with necrotic debris and on the cut surface, lesion extended into the uterine wall. Microscopically, severe necrosis was observed throughout thickened mucosa, submucosa, and wall of uterus. Tumorous lesions composed of anaplastic cells with bizarre nuclei or tubular structures of cuboidal to short columnar cells were infrequently observed around the necrotic lesions and muscular layer far from necrotic areas. Immunohistochemically, central necrotic area with ambiguous cell and tissue structures, peri-necrotic tumor lesions, and muscular layer were strongly positive for cytokeratin. Since huge necrosis of adenocarcinoma lesions in this case made it difficult to diagnose, immunohistochemical results enable to diagnose as a severe necrotizing adenocarcinoma. Thus, histopathological and immunohistochemical findings in this case may serve as an important knowledge to diagnose uterine adenocarcinoma with huge necrosis in the veterinary field.

Keywords

References

  1. Baldwin CJ, Roszel JF, Clark TP. 1992. Uterine adenocarcinoma in dogs. Compend Contin Educ. 14: 731-737.
  2. Cave TA, Hine R, Howie F, Thompson H, Argyle DJ. 2002. Uterine carcinoma in a 10-month-old golden retriever. J Small Anim Pract. 43: 133-135. https://doi.org/10.1111/j.1748-5827.2002.tb00044.x
  3. Caruso RA, Branca G, Fedele F, Irato E, Finocchiaro G, Parisi A, Ieni A. 2014. Mechanism of coagulative necrosis in malignant epithelial tumors. Onco Lett. 8: 1397-1402. https://doi.org/10.3892/ol.2014.2345
  4. Kennedy PC, Miller RB. 1993. The female genital tract. In: Jubb KVF, Kennedy PC, Palmer N. (Eds), Pathology of Domestic Animals, 3rd volume. Academic Press, San Diego. pp. 349-470.
  5. McEntee K, Nelsen SW. Tumours of the female genital tract. Bull. World Org. 1976.53: 217-226.
  6. Meuten D. 2016. Tumors in Domestic Animals 5th ed. Wiley Blackwell. pp. 701-705.
  7. Murphy ST, Kruger JM and Watson GL. 1994. Uterine adenocarcinoma in the dog: a case report and review. Journal of the American Animal Hospital Association. 30: 440-444.
  8. O'Keefe DA. 1995. Tumours of the genital system and mammary glands. In: Etinger, Felman (Eds.), Veterinary Internal Medicine, Vol. 2, W.B. Saunders Company, Philadelphia. pp. 1699-1704.
  9. Payne-Johnson CE, Kelley DE and Davies PT. 1986. Endometrial carcinoma in a young dog. Journal of Comparative Pathology. 96: 463-467. https://doi.org/10.1016/0021-9975(86)90042-3
  10. Pires MA, Seixas F, Palmeira C and Payan-Carreira R. 2010. Histopathologic and immunohistochemical exam in one case of canine endometrial adenocarcinoma. Reproduction in Domestic Animals. 45: 545-549.