• 한국콘텐츠학회논문지
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• 제19권4호
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• pp.381-393
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• 2019

본 연구는 남북 여성 건강 격차 완화에 기여하기 위해 북한이탈여성을 위한 자궁경부암 예방 교육을 개발하여 시행하고 그 효과를 검증한 비동등성 대조군 전후 설계를 이용한 유사 실험 연구이다. 남한에 거주하고 있는 20대 북한이탈여성 42명을 대상으로 연구를 진행하였다. 인유두종 바이러스 연계 자궁경부암 예방 교육을 받은 실험군은 대조군에 비해 자궁경부암 지식(U=40.00, p<.001), 인유두종 바이러스 지식(U=4.50, p<.001), 인유두종 바이러스 백신접종에 대한 태도(U=128.00, p=.013) 점수가 유의하게 증가하였다. 본 연구에서 개발한 북한이탈여성을 위한 자궁경부암 예방이 대상자들의 자궁경부암 지식, 인유두종 바이러스 지식, 인유두종 바이러스 백신접종에 대한 태도를 향상시키는 효과적인 간호 중재인 것으로 나타났다. 통일에 대비하여 남북 여성 건강 격차를 완화하기 위해서는 자궁경부암 예방 교육을 집단교육에 지속적으로 적용할 수 있도록 하는 등의 정책 지원이 필요하다.

• 여성건강간호학회지
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• 제27권4호
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• pp.368-378
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• 2021

Purpose: The purpose of this study was to explore the association between breastfeeding and the prevalence of breast, thyroid, and cervical cancer among Korean adult women. Methods: The study was a secondary analysis of data from the Korea Genome and Epidemiology Study. The final samples were 113,944 Korean women among 173,205 urban-based cohort participants collected between 2004 and 2013 for adults aged forty and over. To determine the association between female cancers and breastfeeding experience, the number of childbirth, and total breastfeeding duration, logistic regression analysis was done. The demographic characteristics, health behavior, and female history were adjusted. Results: The prevalence of breast cancer was 1.37 times higher in the non-breastfeeding group than in the breastfeeding group. Compared to having breastfed for more than 36 months, the prevalence of thyroid cancer was 1.68 times higher at breastfeeding for 13 to 36 months, 1.67 times higher at breastfeeding for 6 to 12 months, and 2.06 times higher at breastfeeding less than 6 months. Also, the prevalence of cervical cancer was 1.54 times higher at breastfeeding for 13 to 36 months, compared to breastfeeding for more than 36 months. Conclusion: The study found that breastfeeding experience and a longer breastfeeding duration are associated with reduced risk of breast, thyroid, and cervical cancer in Korean women. It can be used as a basis for encouraging breastfeeding, and suggests further research on modifiable factors that reduce cancer risks.

• 여성건강간호학회지
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• 제29권4호
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• pp.317-327
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• 2023

Purpose: This study investigated the influence of cervical cancer knowledge, human papillomavirus (HPV) knowledge, self-efficacy, and uncertainty on the intention to engage in cervical cancer preventive behavior in HPV-infected women. Methods: This descriptive correlational study was conducted among 129 adult women aged 20 to 65 years who received positive HPV results at a general hospital in Changwon, Korea. The dataset was analyzed using descriptive statistics, the independent t-test, analysis of variance, the Pearson correlation coefficient, and multiple regression. Results: The mean score for the intention to engage in cervical cancer preventive behavior was high (4.43±0.65). This intention was significantly different according to age at first sexual intercourse (F=7.38, p=.001), HPV type (F=4.79, p=.010), vaccination (t=3.19, p=.002), and condom use (t=3.03, p=.003). The intention to engage in cervical cancer preventive behavior showed significant, weak-to-moderate positive correlations with HPV knowledge (r=.22, p=.012) and self-efficacy (r=.42, p<.001). Self-efficacy (β=.46, p<.001), first sexual intercourse at <20 years (β=.45, p<.001), first sexual intercourse at 20-24 years (β=.29, p=. 018), HPV high- and low-risk group infection (β=.26, p=.019), HPV high-risk group infection (β=.26, p=.026), and vaccination (β=.21, p=.007) significantly influenced the intention to engage in cervical cancer preventive behavior. These variables explained 34.6% of variance in intention. Conclusion: Study findings support the need to develop a program that effectively conveys accurate information about cervical cancer prevention to HPV-infected women and helps them enhance self-efficacy to boost the intention to engage in cervical cancer preventive behavior.

• Asian Pacific Journal of Cancer Prevention
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• 제15권10호
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• pp.4203-4206
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• 2014

Purpose: The objective of this study was to assess the predictive role of the neutrophil/lymphocyte ratio (NLR) for invasion of gestational trophoblastic disease (GTD). Materials and Methods: A retrospective analysis was conducted on 127 women who were managed at our clinic for GTD. Of all patients, 8 showed invasion according to histological examination. The clinical parameters of patients with invasive GTD (Group 1; n=8) were compared with patients who showed no invasion (Group 2; n=119). All underwent a prior uterine evacuation and followed up by regular assessment of ${\beta}$-hCG titers. Results: Demographic and obstetric history and pre-evacuation hCG levels of the patients showed no statistically significantly difference between the groups (p>0.05). The mean gestational weeks (GW), size of the GTD and NLR levels were statistically significantly higher in the invasive GTD group (p<0.05). Correlations between invasion and gestational weeks, size of GTD, post-evacuation chemotherapy and NLR were evident. ROC curve analysis demonstrated that GW, size of GTD and NLR may be discriminative parameters in predicting invasion of GTD. Conclusions: To the best of our knowledge, this is the first study evaluating the predictive role of NLR in invasion of GTD. In conclusion, we think that pretreatment NLR can be used as a biomarker of invasion in GTD.

• 디지털융복합연구
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• 제19권5호
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• pp.263-268
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• 2021

본 연구에서는 병원에서 실질적인 태아분만 시스템에 관리를 위한 태아건강분류모델을 설계하는 것을 목적으로 한다. 출산 중 사망자 수는 2017년을 기준으로 295,000명인 산모 사망률과 유사하다. 이러한 사망의 94%는 환경에 의해 발생하므로 대부분 예방할 수 있다. 따라서 본 논문에서는 랜덤 포레스트(Random Forest)를 이용하여 Cardiotocograms(CTG) 검사에서 추출한 2개의 데이터(태아의 심박수, 태아의 움직임, 자궁 수축 등)로 태아의 건강을 예측하는 모델을 제안하였다. 본 연구에서 제안된 모델은 태아분만 보건운영 시스템을 안정적으로 관리하기 위해 태아분만에 대한 데이터의 분포가 불균형한 이상 데이터를 갖는 항목을 찾아 표준편차의 상한 및 하한의 임계값을 설정하여 이상값을 제거하여 정확도를 높혔다. 또한 태아의 건강상태를 나타내는 클래스의 비율이 불규칙함으로, 데이터 리샘플링을 이용하여 소수의 클래스를 복제하여 클래스의 균형을 맞추었다. 그 결과 정확도가 4~5% 향상되어 97.75%로 나타났다. 이에 예측 모델을 통해 발생 할 수 있는 태아의 사망과 병을 사전에 정확히 예측하여 우선적으로 관리함으로써 효율적인 태아 보건운영과 태아 사망 및 병 예방에 기여할 수 있을 것이라고 기대한다.

• Anatomy and Cell Biology
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• 제51권4호
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• pp.274-283
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• 2018

Hyper-O-GlcNAcylation is a general feature of cancer which contributes to various cancer phenotypes, including cell proliferation and cell growth. Quercetin, a naturally occurring dietary flavonoid, has been reported to reduce the proliferation and growth of cancer. Several reports of the anticancer effect of quercetin have been published, but there is no study regarding its effect on O-GlcNAcylation. The aim of this study was to investigate the anticancer effect of quercetin on HeLa cells and compare this with its effect on HaCaT cells. Cell viability and cell death were determined by MTT and terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labelling assays. O-GlcNAcylation of AMP-activated protein kinase (AMPK) was examined by succinylated wheat germ agglutinin pulldown and immunoprecipitation. Immunofluorescence staining was used to detect the immunoreactivitiy of O-linked N-acetylglucosamine transferase (OGT) and sterol regulatory element binding protein 1 (SREBP-1). Quercetin decreased cell proliferation and induced cell death, but its effect on HaCaT cells was lower than that on HeLa cells. O-GlcNAcylation level was higher in HeLa cells than in HaCaT cells. Quercetin decreased the expression of global O-GlcNAcylation and increased AMPK activation by reducing the O-GlcNAcylation of AMPK. AMPK activation due to reduced O-GlcNAcylation of AMPK was confirmed by treatment with 6-diazo-5-oxo-L-norleucine. Our results also demonstrated that quercetin regulated SREBP-1 and its transcriptional targets. Furthermore, immunofluorescence staining showed that quercetin treatment decreased the immunoreactivities of OGT and SREBP-1 in HeLa cells. Our findings demonstrate that quercetin exhibited its anticancer effect by decreasing the O-GlcNAcylation of AMPK. Further studies are needed to explore how quercetin regulates O-GlcNAcylation in cancer.

• 농촌의학ㆍ지역보건
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• 제20권1호
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• pp.39-49
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• 1995

현재 우리나라 피임시술방법의 대부분을 차지하고 있는 정관불임수술, 난관불임수술 및 자궁내 피임장치시술(Copper T삽입) 수용자의 피임실천상태, 피임실천의 결정요인과 피임시술후의 부작용 및 피임시술 동기 등을 알아보기 위하여 구미시에 거주하는 피임시술을 받은 대상자 중 1990-1992년 사이에 난관불임수술을 받은 남성 105명, 1992년도에 정관불임수술을 받은 남성 109명, 자궁내 피임장치시술을 받은 여성 214명, 총 428명을 대상으로 피임시술확인서와 설문지를 조사분석한 결과는 다음과 같다. 대상자의 연령은 정관불임수술 수용자는 30-34세가 56.0%, 그리고 난관불임수술 수용자의 자궁내 피임장치시술 수용자는 25-29세 사이가 가장 높았다. 직업은 정관불임수술 수용자는 회사원이 가장 많았고, 난관불임수술 수용자와 자궁내 피임장치시술 수용자의 대부분은 직업이 없었다. 전체의 81.2%가 교육정도가 고졸이상이었고, 결혼기간은 9년이내가 대부분이었고, 최종자녀 출산에서 피임시술시까지 기간이 6개월 미만이 34.8%, 3.5년 사이가 25.0%였다. 두자 이하를 얻은 뒤 피임시술을 받은 사람의 정관불임수술 남성의 90.8%, 남관불임수술을 여성의 80.1% 및 자궁내 피임장치시술 수용자중 93.9%이었다. 대부분의 사람들이 다른 사람의 권유보다 자기 스스로 필요성을 느껴서 피임시술을 받았고, 피임시술을 받음 중요한 이유는 원하는 자녀 수를 획득한 것과 양육비 및 교육비부담을 줄이기 위한 것이었다. 정관불임수술 수용자의 11.0%가 부작용을 호소했으며, 가장 흔한 증상은 상처부위염증 및 성욕저하였다. 난관불임수술 수용자의 46.7%가 월경량 증가, 요통, 무기력이었으며, 자궁내 피임장치시술 수용자도 난관불임수술 수용자와 유사하였다. 피임시술실천을 후회하고 있다고 응답한 비율은 난관불임수술과 자궁내 피임장치시술 수용자가 정관불임수술 수용자보다 높았으며, 후회하는 가장 큰 이유는 난관불임수술과 자궁내 피임장치시술 수용자는 부작용 때문이었고, 정관불임수술 수요자는 자식을 낳을 수 없는 불안감, 성욕저하가 가장 큰 이유이었다. 남편대신 부인이 난관불임수술이나 자궁내 피임장치시술 시술을 실천하게 된 가장 큰 이유는 원치 않는 임신으로 인공유산 시키게 될 것 같아서 이었다. 피임시술실천자의 83.2%가 시술비를 정부에서 지원해 주기를 바랐으나, 시술비를 본인 부담 시에도 대부분(86.9%)이 시술을 받았을 것이다라고 응답하여 시술비 부담이 피임시술 실천의지에 크게 영향을 미치지 않았다.

• 여성건강간호학회지
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• 제17권3호
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• pp.225-242
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• 2011

Purpose: The purpose of this study was to identify students' experiences of performance and their satisfaction with clinical nursing practice in Women's health nursing. Methods: Data was collected using questionnaire consisting of 104; 89,; and 82 nursing activities with 12; 10; and 7 domains for delivery floor, obstetric, and gynecologic wards retrospectively. Five hundred ninety nursing students from 10 four year and one three year colleges, were recruited and selected for data collection. Results: Site specific core nursing activities among top 15 items of performed experience were: interpreting fetal monitoring; massage for pain reduction; breathing technique; perineal pad change; non stress test; manual check for uterine contraction; and position change for the delivery floor. Experiences of clinical nursing practice for the obstetric ward and the gynecologic ward were identified and ranked as well. Observation of delivery, measurement & test during labor and observation of anesthesia and operation were the highest ranked activity domains of satisfaction for delivery floor, obstetric and gynecologic wards retrospectively. Conclusion: Discussions are needed to standardize curriculum for clinical practice in women's health nursing initiated at the level of Korean Society of Womens' Health Nursing by reflecting this result. Strategic approaches are emphasized in order to enhance a collaboration between clinical fields and colleges.

• Journal of Preventive Medicine and Public Health
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• 제38권1호
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• pp.82-92
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• 2005

Objective : To evaluate the relationships among sociodemographic characteristics, health behaviors, levels of pros and cons and stages of change in Pap testing for uterine cervical cancer. Methods : A questionnaire survey was performed on 560 randomly sampled people who were assigned to participate in a Pap testing program by the National Cancer Screening Project in 2003' between 25 September and 10 October in Gyeonggi, Korea. Data about the behaviors and intentions of Pap testing, sociodemographic characteristics, health behaviors, and levels of acknowledged benefit (pros) and barrier (cons) for Pap testing was collected. The stages of change were grouped according to behaviors and intentions of Pap testing as passive, active, and relapse. Results : Logistic analysis between the passive and active groups showed that city dwellers, 'high' and 'middle' groups in terms of the individual s health belief, those who had undergone a health examination within the past 2 years, and those who had undergone hormone replacement therapy had a higher odds ratios to be in the active group. As the 'benefit' scores increased and the 'Unnecessity' scores decreased, the probabilities to be in the active group increased. According to the logistic analysis results between the active and relapse groups, those who were 60 years or older, members of the National Heath Insurance, and those who had not undergone a health examination within the past 2 years had a higher odds ratio to be in the relapse group. The 'Benefit' scores were not significant in this relationship. The probabilities of being in the relapse group increased as the Unnecessity and 'Shamefulness' scores increased. Conclusions : In conclusion, health planners should inform women in the passive group of the benefits and necessity of Pap testing. It would be better to reduce the barriers to the active group of undergoing Pap smear. This study might be a useful guide for future planning of Pap testing program.

• Journal of Preventive Medicine and Public Health
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• 제40권6호
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• pp.505-511
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• 2007

Objectives : While cervical cancer is one of the leading cancers among women worldwide, there are a number of effective early detection tests available. However, the participation rates in cervical cancer screening among Korean women remain low. After the nationwide efforts in 1988 and thereafter to encourage participation in cervical cancer screening, few studies have investigated the effects of socioeconomic inequality on participation in cervical cancer screening. The purpose of this study was to investigate 1) the level of socioeconomic disparities in receiving cervical cancer screening by age group and 2) if there was an improvement in reducing these disparities between 1995 and 2001. Methods : Using data from the Korean National Health Status, Health Behavior and Belief Survey in 1995, the Korean National Health and Nutrition Examination Surveys from 1998 and 2001 (sample sizes of 2,297, 3,738, and 3,283), age-standardized participation rates were calculated according to education level, equivalized household income, and job status. Odds ratios and the relative inequality index (RII) were also calculated after controlling for age. Results : Women with lower education levels were less likely to attend the screening test, and the disparities by education level were most pronounced among women aged 60 years and older. The RIIs among women 60 years and older were 3.64, 4.46, and 8.64 in 1995, 1998, and 2001, respectively. Higher rates of participation were reported among those in the highest income category, which was more notable among the middle aged women (40s and 50s). An inconsistent trend in the rate of participation in cervical cancer screening by occupational level was found. Conclusions : Indicators of socioeconomic position seem to have varying impacts on the inequalities in the rates of participation in cervical cancer screening according to age group. These results demonstrate the need for more aggressive and age-based interventions and policy programs to eliminate the remaining inequalities.