Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
권호 표지
DOI QR코드

DOI QR Code

Predictive Role of the Neutrophil Lymphocyte Ratio for Invasion with Gestational Trophoblastic Disease

  • Guzel, Ali Irfan (Department of Obstetrics and Gynecology, Division of Infertility and Gynecological Endocrinology, Women's Health Research and Education Hospital) ;
  • Kokanali, Mahmut Kuntay (Department of Obstetrics and Gynecology, Division of Infertility and Gynecological Endocrinology, Women's Health Research and Education Hospital) ;
  • Erkilinc, Selcuk (Department of Obstetrics and Gynecology, Division of Infertility and Gynecological Endocrinology, Women's Health Research and Education Hospital) ;
  • Topcu, Hasan Onur (Department of Obstetrics and Gynecology, Division of Infertility and Gynecological Endocrinology, Women's Health Research and Education Hospital) ;
  • Oz, Murat (Department of Obstetrics and Gynecology, Division of Infertility and Gynecological Endocrinology, Women's Health Research and Education Hospital) ;
  • Ozgu, Emre (Department of Obstetrics and Gynecology, Division of Infertility and Gynecological Endocrinology, Women's Health Research and Education Hospital) ;
  • Erkaya, Salim (Department of Obstetrics and Gynecology, Division of Infertility and Gynecological Endocrinology, Women's Health Research and Education Hospital) ;
  • Gungor, Tayfun (Department of Obstetrics and Gynecology, Division of Infertility and Gynecological Endocrinology, Women's Health Research and Education Hospital)
  • Published : 2014.05.30
Download PDF
⟨ Previous Next ⟩

Abstract

Purpose: The objective of this study was to assess the predictive role of the neutrophil/lymphocyte ratio (NLR) for invasion of gestational trophoblastic disease (GTD). Materials and Methods: A retrospective analysis was conducted on 127 women who were managed at our clinic for GTD. Of all patients, 8 showed invasion according to histological examination. The clinical parameters of patients with invasive GTD (Group 1; n=8) were compared with patients who showed no invasion (Group 2; n=119). All underwent a prior uterine evacuation and followed up by regular assessment of ${\beta}$-hCG titers. Results: Demographic and obstetric history and pre-evacuation hCG levels of the patients showed no statistically significantly difference between the groups (p>0.05). The mean gestational weeks (GW), size of the GTD and NLR levels were statistically significantly higher in the invasive GTD group (p<0.05). Correlations between invasion and gestational weeks, size of GTD, post-evacuation chemotherapy and NLR were evident. ROC curve analysis demonstrated that GW, size of GTD and NLR may be discriminative parameters in predicting invasion of GTD. Conclusions: To the best of our knowledge, this is the first study evaluating the predictive role of NLR in invasion of GTD. In conclusion, we think that pretreatment NLR can be used as a biomarker of invasion in GTD.

Keywords

References

  1. Acmaz G, Aksoy H, Unal D, et al (2014). Are neutrophil/lymphocyte and platelet /lymphocyte ratios associated with endometrialprecancerous and cancerous lesions in patients with abnormal uterine bleeding? Asian Pac J Cancer Prev, 15, 1689-92. https://doi.org/10.7314/APJCP.2014.15.4.1689
  2. Dirican A, Kucukzeybek Y, Erten C, et al (2013). Prognostic and predictive value of hematologic parameters in patients with metastatic renal cell carcinoma: second line sunitinib treatment following IFN-alpha. Asian Pac J Cancer Prev, 14, 2101-5. https://doi.org/10.7314/APJCP.2013.14.3.2101
  3. Duffy BK, Gurm HS, Rajagopal V, et al (2006). Usefulness of an elevated neutrophil to lymphocyte ratio in predicting longterm mortality after percutaneous coronary intervention. Am J Cardiol, 97, 993-6. https://doi.org/10.1016/j.amjcard.2005.10.034
  4. Gabrilovich DI, Nagaraj S (2009). Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol, 9, 162-74. https://doi.org/10.1038/nri2506
  5. Goldstein DP, Berkowitz RS (2012. Current management of gestational trophoblastic neoplasia. Hematol Oncol Clin North Am, 26, 111-31. https://doi.org/10.1016/j.hoc.2011.10.007
  6. Halazun KJ, Hardy MA, Rana AA, et al (2009) Negative impact of neutrophil-lymphocyte ratio on outcome after liver transplantation for hepatocellular carcinoma. Ann Surg, 250, 141-51. https://doi.org/10.1097/SLA.0b013e3181a77e59
  7. Hotchkiss RS, Karl IE. (2003) The pathophysiology and treatment of sepsis. N Engl J Med, 348, 138-50. https://doi.org/10.1056/NEJMra021333
  8. Karaman H, Karaman A, Erden A, et al (2013). Relationship between colonic polyp type and the neutrophil/ lymphocyte ratio as a biomarker. Asian Pac J Cancer Prev, 14, 3159-61. https://doi.org/10.7314/APJCP.2013.14.5.3159
  9. Koh YW, Kang HJ, Park C, et al (2012). Prognostic significance of the ratio of absolute neutrophil count to absolute lymphocyte count inclassic Hodgkin lymphoma. Am J Clin Pathol, 138, 846-54. https://doi.org/10.1309/AJCPO46GFKGNXCBR
  10. Kuang DM, Zhao Q, Wu Y, et al (2011). Peritumoral neutrophils link inflammatory response to disease progression by fostering angiogenesis in hepatocellular carcinoma. J Hepatol, 54, 948-55. https://doi.org/10.1016/j.jhep.2010.08.041
  11. Manopunya M, Suprasert P (2012). Resistant gestational trophoblastic neoplasia patients treated with 5-fluouracil plus actinomycin D. Asian Pac J Cancer Prev, 13, 387-90 https://doi.org/10.7314/APJCP.2012.13.1.387
  12. Movahedi K, Guilliams M, Van den Bossche J, et al (2008). Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cellsuppressive activity. Blood, 111, 4233-44. https://doi.org/10.1182/blood-2007-07-099226
  13. Oranratanaphan S, Lertkhachonsuk R (2014). Treatment of extremely high risk and resistant gestational trophoblastic neoplasia patients in King Chulalongkorn memorial hospital. Asian Pac J Cancer Prev, 15, 925-8 https://doi.org/10.7314/APJCP.2014.15.2.925
  14. Prabha B, Molykutty J, Swapna A, et al (2001). Increased expression of interleukin-1 beta is associated with persistence of the disease and invasion in complete hydatidiform moles. Eur J Gynaecol Oncol, 22, 50-6.
  15. Scapini P, Morini M, Tecchio C, et al (2004). CXCL1/macrophage inflammatory protein-2-induced angiogenesis in vivo is mediated by neutrophil-derived vascular endothelial growth factor-A. J Immunol, 172, 5034-40. https://doi.org/10.4049/jimmunol.172.8.5034
  16. Shanbhogue AK, Lalwani N, Menias CO (2013). Gestational trophoblastic disease. Radiol Clin North Am, 51, 1023-34. https://doi.org/10.1016/j.rcl.2013.07.011
  17. Shi ZH, Zhao C, Wu H, et al (2011). CLIC1 protein: a candidate prognostic biomarker for malignant-transformed hydatidiform moles. Int J Gynecol Cancer, 21,153-60. https://doi.org/10.1097/IGC.0b013e3182022997
  18. Shu H, Chen H, Yang B, et al (2013). Aberrant expression of E-cadherin and integrin $\beta$-1 in trophoblasts is associated with malignant gestational trophoblastic diseases. Int J Gynecol Cancer, 23, 749-54. https://doi.org/10.1097/IGC.0b013e31827da23f
  19. Unal D, Eroglu C, Kurtul N, Oguz A, Tasdemir A (2013). Are neutrophil/lymphocyte and platelet/lymphocyte rates in patients with non-small cell lung cancer associated with treatment response and prognosis? Asian Pac J Cancer Prev, 14, 5237-42. https://doi.org/10.7314/APJCP.2013.14.9.5237
  20. Wu Y, Zhao Q, Peng C, et al (2011). Neutrophils promote motility of cancer cells via a hyaluronan-mediated TLR4/PI3K activation loop. J Pathol, 225, 438-47. https://doi.org/10.1002/path.2947
  21. Yoon NB, Son C, Um SJ (2013). Role of the neutrophillymphocyte count ratio in the differential diagnosis between pulmonary tuberculosis and bacterial community-acquired pneumonia. Ann Lab Med, 33, 105-10. https://doi.org/10.3343/alm.2013.33.2.105
  22. Yucel B, Babacan NA, Kacan T, et al (2013). Survival analysis and prognostic factors for neuroendocrine tumors in Turkey. Asian Pac J Cancer Prev, 14, 6687-92. https://doi.org/10.7314/APJCP.2013.14.11.6687
  23. Zhang Z, Xu Q, Shi C, et al (2012). Interleukin-12 inhibits cell invasion in choriocarcinoma. Int J Mol Med, 30, 57-62.

Cited by

  1. Roles of Neutrophil/Lymphocyte and Platelet/Lymphocyte Ratios in the Early Diagnosis of Malignant Ovarian Masses vol.15, pp.16, 2014, https://doi.org/10.7314/APJCP.2014.15.16.6881
  2. Malignancy Risk Scoring of Hydatidiform Moles vol.16, pp.6, 2015, https://doi.org/10.7314/APJCP.2015.16.6.2441
  3. May the Neutrophil/Lymphocyte Ratio Be a Predictor in the Differentiation of Different Thyroid Disorders? vol.16, pp.9, 2015, https://doi.org/10.7314/APJCP.2015.16.9.3875
  4. Can Plateletcrit be a Marker for Recurrent Pregnancy Loss? vol.22, pp.5, 2016, https://doi.org/10.1177/1076029614565882
  5. Predictive value of some hematological parameters for non-invasive and invasive mole pregnancies vol.31, pp.3, 2018, https://doi.org/10.1080/14767058.2017.1281906