• Journal of Genetic Medicine
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• 제10권1호
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• pp.38-42
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• 2013

Purpose: The purpose of this study was to assess the characteristics of achondroplasia (ACH) diagnosed in fetuses or neonates and to evaluate the usefulness of a molecular genetic testing to confirm ACH. Materials and Methods: The medical and ultrasonographic records of 16 pregnant women, who had molecular genetic testing for ACH performed on their fetus or neonate at the Cheil General Hospital between February 1999 and April 2013, were retrospectively analyzed. Detection of G1138A and G1138C mutations of the fibroblast growth factor receptor 3 (FGFR3) gene was accomplished by polymerase chain reaction - restriction fragment length polymorphism analysis. Results: Of the eight fetuses and two neonates who were suspected of having ACH during pregnancy, four fetuses and one neonate was confirmed to have ACH and they all carried the heterozygous G1138A mutation. Out of 6 cases which had a history of ACH in prior pregnancies, three had genetic information for the previous fetuses while the other three did not. All six fetuses had no mutations at G380R. However, the one fetus of pregnant woman with non-confirmed ACH showed shortened long bone on ultrasound thereafter and the fetus was identified as having oto-spondylo-megaepiphyseal dysplasia after birth. Conclusion: Korean patients with achondroplasia have the heterozygous G1138A mutation that is most commonly defined in other countries. Molecular genetic evaluations of ACH are helpful not only for establishing diagnosis but for appropriate counseling with subsequent pregnancies.

• 비파괴검사학회지
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• 제26권2호
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• pp.77-83
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• 2006

초음파 비선형성은 적층 구조물 내부의 미세크랙이나 계면 들뜸을 검출하기 위한 수단으로 주목받고 있다. 비선형 초음파의 특징적인 현상은 전파 과정중에 고조파가 발생되는 것이다. 그러므로 비선형성의 정량화를 위해서는 수신된 초음파 신호에 포함된 고조파 성분의 검출이 중요하며, 일반적으로 2차 조화 성분과 기본 주파수 성분의 진폭비가 비선형 파라미터로 이용되고 있다. 그러나 이 비선형 파라미터를 정확하게 추정할 수 있는 방법이 확립되어 있지 않기 때문에 현재까지는 현장적용에 어려움을 겪고 있다. 본 연구에서는 초음파 비선형 파라미터의 정밀 추정을 위한 신호 처리 기술을 제안하고자 한다 이 기술은 파워 스펙트럼과 바이스펙트럼 분석에 기초하며, 특히 본 연구에서는 초음파 현미경(SAM, scanning acoustic microscope)에 사용되는 펄스형 신호로부터 고조파를 검출하는데 주목하였다. 제안된 기법의 유효성은 틈새의 크기가 접촉 중심에서 반경 방향으로 일정하게 증가하는 뉴턴링(Newton-ring)과 칩의 윗면에 국부적인 들뜸을 가진 반도체 샘플에 대한 실험을 통해 검증되었다. 결과적으로 제안된 신호처리기법에 의해 획득된 비선형 파라미터는 계면 들뜸과 좋은 상관성을 보였다.

• 한국방사선학회논문지
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• 제13권5호
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• pp.683-689
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• 2019

소아의 선천적 심장질환 진단을 위해 High Pitch Mode를 사용하여 획득한 소아 심장 CT 영상과 Wide Coverage Volume Axial Mode를 사용하여 획득한 소아 심장 CT 영상으로부터 환자의 피폭선량과 각 영상의 화질을 비교 및 분석하여 Wide Coverage Volume Axial Mode의 유용성을 평가해보고자 한다. 소아 심장 CT 검사 시 High Pitch Mode와 Wide Coverage Volume Axial Mode를 각각 50명 총 100명의 환자를 대상으로 시행하였으며, 각 프로토콜로부터 얻은 영상을 이용하여 환자의 피폭선량을 비교하였다. 각 영상에 ROI를 설정해 SNR과 CNR을 산출하여 영상의 화질을 비교하였다. High Pitch Mode에 비해 Wide Coverage Volume Axial Mode를 사용하여 검사하였을 때 환자의 피폭선량이 13.07% 감소하였고, SNR과 CNR이 향상되었다. Wide Coverage Volume Axial Mode는 고속 회전 스캐너를 이용하여 조사시간을 줄이고, 저선량 기술인 ASi R-V를 통해 High Pitch Mode를 사용했을 때보다 환자의 피폭선량이 감소하고 영상의 화질 또한 향상되는 유용한 검사라 할 수 있다.

• 한국융합학회논문지
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• 제13권1호
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• pp.119-129
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• 2022

자궁경부세포검사는 자궁경부암 선별검사로 널리 사용되어 왔다. 그러나, 위음성 비율이 높아 인유두종바이러스 중합효소연쇄반응 (HPV PCR) 검사로 보완이 제안되고 있다. HPV PCR 검사의 임상적 유용성을 확인하여, 자궁경부암을 예방하는 선별검사의 효과를 알아보고자 한다. 217명의 환자의 데이터를 분석하였고, 높은 HPV 감염률(46.1%)과 분산분석결과 연령 집단간 HPV 감염률에 유의한 차이가 보였다(P=0.015). 특히, 연구기간 중 CIN3 3건 상피세포암 1건이 관찰되었는데, 고위험군 HPV(16, 33)감염이 모두 관찰되었고, 20대와 30대 상피세포 이형성증 진단 환자에서 높은 고위험군 HPV감염이 관찰되었다. 따라서 이 연령대에 대한 광범위한 연구 및 예방 활동이 필요하며, 자궁암 예방을 위한 선별검사로써 세포학적 검사와 함께 HPV PCR 검사가 유용할 것으로 판단된다.

• 한국경영과학회:학술대회논문집
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• 한국경영과학회/대한산업공학회 2005년도 춘계공동학술대회 발표논문
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• pp.854-861
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• 2005

The functional behavior of a portable consumer electronic (PCE) product is nearly all expressed with human-machine interaction (HMI) tasks. Although physical prototyping and computer aided design (CAD) software can show the appearance of the product, they cannot properly reflect its functional behavior. In this paper, we propose a virtual prototyping (VP) system that incorporates virtual reality and HMI functional simulation in order to enables users to capture not only the realistic look of a PCE product but also its functional behavior. We obtain geometric part models of the product and their assembly and kinematics information with the help of CAD and reverse engineering tools, and visualize them with various display tools. We adopt state transition methodology to capture the HMI functional behavior of the product into a state transition chart, which is later used to construct a finite state machine (FSM) for the functional simulation of the product. The FSM plays an important role to control the transition between states of the product. The proposed VP system receives input events such as mouse clicks on buttons and switches of the virtual prototype model, and it reacts to the events based on the FSM by activating associated activities. The VP system provides the realistic visualization of the product and the vivid simulation of its functional behavior. It can easily allow users to perform functional evaluation and usability testing. Moreover, it can greatly reduce communication errors occurring in a typical product development process. A case study about VP of an MP3 player is given to show the usefulness of the proposed VP system.

• 대한의용생체공학회:의공학회지
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• 제38권1호
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• pp.25-31
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• 2017

Testing TB in chest X-ray images is a typical method to diagnose presence and magnitude of PTB lesion. However, the method has limitation due to inter-reader variability. Therefore, it is essential to overcome this drawback with automatic interpretation. In this study, we propose a novel method for detection of PTB using SegNet, which is a deep learning architecture for semantic pixel wise image labelling. SegNet is composed of a stack of encoders followed by a corresponding decoder stack which feeds into a soft-max classification layer. We modified parameters of SegNet to change the number of classes from 12 to 2 (TB or none-TB) and applied the architecture to automatically interpret chest radiographs. 552 chest X-ray images, provided by The Korean Institute of Tuberculosis, used for training and test and we constructed a receiver operating characteristic (ROC) curve. As a consequence, the area under the curve (AUC) was 90.4% (95% CI:[85.1, 95.7]) with a classification accuracy of 84.3%. A sensitivity was 85.7% and specificity was 82.8% on 431 training images (TB 172, none-TB 259) and 121 test images (TB 63, none-TB 58). This results show that detecting PTB using SegNet is comparable to other PTB detection methods.

• 한국콘텐츠학회논문지
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• 제8권1호
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• pp.27-38
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• 2008

정보 기술의 급격한 발달로 인해 다양한 상품과 서비스가 출시되고 있다. 하지만 지속적으로 사용을 계속하는 상품이나 서비스는 많지 않은 것이 현실이다. 새로운 사용자를 유치하는 것보다 기존 사용자를 지속시키는 것은 기업의 효율적인 측면에서 매우 중요하다. 하지만, 기존의 정보 기술과 관련한 연구들은 새로운 사용자를 유치하는데 초점이 맞추어져 왔다. 따라서 기존 사용자를 지속적으로 유지하기 위한 연구는 매우 미미한 실정이다. 본 연구에서는 모바일 웹 사용자를 대상으로 모바일 웹의 지속적 사용을 위한 지속 사용 모델을 개발하였고, 이러한 지속 사용 행동이 실제 사용량에 어떠한 영향을 끼쳤는지 파악하고자 하였다. 이를 위해 모바일 웹의 지속적 사용에 중요한 영향을 끼치는 요인을 발굴하였고, 이를 실증적으로 검증하고자 하였다. 연구 결과, 사후 기대인 사후 유용성, 사후 사용 편의성, 사후 즐거움, 사후 지각된 가치가 사용자의 만족, 사용 지속의도에 유의하게 영향을 끼쳤으며, 사용자의 사용지속의도 역시 모바일 웹의 실 사용량에 유의하게 영향을 끼쳤다. 본 연구 결과와 더불어, 만족과 사용 지속의도에 중요하게 끼치는 영향은 서로 다르게 나타나 만족과 사용 지속의도를 높이는 전략이 서로 다르게 해야 함을 시사하고 있다. 마지막으로 본 연구는 연구의 한계점과 실증적 시사점에 대하여 제시하고 있다.

• 대한수의학회지
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• 제43권1호
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• pp.25-29
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• 2003

This study was carried out to investigate a usefulness of the microsatellite DNA markers for parentage verification of Thoroughbred (TB) horses. 9 TB horses samples were genotyped for nine international minimum standard markers (AHT4, 5, ASB2, HMS3, 6, 7, HTG4, 10, and VHL20), and the additional panel of four markers, ASB17, CA425, LEX33, and TKY321. This methods consisted of multiplexing PCR procedures, and it showed reasonable amplification of all PCR products. Genotyping was performed with an ABI 310 genetic analyzer. Foal I was excluded according to principles of Mendelian genetics in AHT4 (H/K), ASB2 (Q/Q), HMS3 (I/P), HTG4 (M/O), HTG1O (K/R), VHL20 (M/P), ASB17 (F/N), LEX33 (M/O), and TKY321 (G/I) markets. Foal II was excluded with markers AHT5 (K/M), ASB2 (M/N), HMS7 (N/N), HTG1O (K/K), VHL20 (I/I), ASB17 (F/F) and TKY321 (G/I). Foal III was excluded with markers AHT4 (O/O), AHT5 (K/K), ASB2 (M/R), HMS6 (M/P), HMS7 (O/O), HTG10 (R/S), VHL20 (L/M), and ASB17 (N/O). These results suggest that the present DNA typing is so useful for parentage verification of TB horses.

• 한국정보시스템학회지:정보시스템연구
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• 제13권2호
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• pp.22-48
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• 2004

Information systems that are not used cannot be useful. In order to increase user acceptance, it is necessary to understand why people accept or reject information systems. Technology Acceptance Model(TAM) is one of the most influential research models for studying determinants how users accept information systems. Recently, Knowledge Management Systems(KMS) have become important components of corporate systems as the foundation of industrialized economics has shifted from natural resources to knowledge assets. This paper applies TAM to investigate users' acceptance of KMS in public administration institutions. It sampled 182 users who had experience in using KMS. Many empirical researches have suggested that TAM can be integrated with other organizational theories to improve its predictive and explanatory ower. We extended the basic TAM by the integration of appraisal and reward satisfaction theory. There are many external variables that influence the perception and the belief of system users. We introduced two external variables(job characteristics, IT self-efficacy) and one additional perception variable, perceived appraisal and reward(PAR) in the basic TAM model. The LISREL model analysis is used for finding out the causality among variables and testing the model fitness. As result, The IT self-efficacy influences to the perceived ease of use(PEOU) and the PAR, and the PEOU influences directly to the perceived usefulness(PU), the PAR, and the attitude toward KMS. The KMS participation intention(PI) was influenced by the PAR and the attitude directly,andbythePEOUindirectly. Finally, this paper suggests some guidelines for the adoption of KMS in public sectors on the basis of the study results.

• 기본간호학회지
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• 제5권2호
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• pp.269-279
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• 1998

In nursing research that the data is collected through clinical observation, analysis of clinical recording or coding of interpersonal interaction in clinical areas, testing and reporting interrater reliability is very important to assure reliable results. Procedures for interrater reliability in these studies should follow two steps. The first step is to determine unitizing reliability, which is defined as consistency in the identification of same data elements in the record by two or more raters reviewing the same record. Unitizing reliability have been rarely reported in previous studies. Unitizing reliability should be tested before progressing to the next step as precondition. Next step is to determine interpretive reliability. Cohen's kappa is a preferable method of calculating the extent of agreement between observer or judges because it provides beyond-chance agreement. Despite its usefulness, kappa can sometimes present paradoxical conclusions and can be difficult to interpret. These difficulties result from the feature of kappa which is affected in complex ways by the presence of bias between observers and by true prevalence of certain categories. Therefore, percentage agreement should be reported with kappa for adequate interpretation of kappa. The presence of bias should be assessed using the bias index and the effect of prevalence should be assessed using the prevalence index. Researchers have been reported only global reliability reflecting the extent to which coders can consistently use the whole coding system across all categories. Category-by-category reliability also need to be reported to inform the possibility that some categories are harder to use than others.