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http://dx.doi.org/10.15207/JKCS.2022.13.01.119

Convergence research on cytological diagnosis of gynecological diseases and genital HPV : Based on data from the Obstetrics and Gynecology Department of a general hospital located in Suwon-si  

Joung, You Hyun (Department of Medical Laser, Graduate School of Medicine, Dankook University)
Lee, Jun Min (Department of Biomedical Laboratory Science, College of Health Sciences, Dankook University)
Kim, Jong-Wan (Department of Laboratory Medicine, College of Medicine, Dankook University)
Kim, Jae Kyung (Department of Biomedical Laboratory Science, College of Health Sciences, Dankook University)
Publication Information
Journal of the Korea Convergence Society / v.13, no.1, 2022 , pp. 119-129 More about this Journal
Abstract
Cervical cytology has been widely used as a screening tool for cervical cancer. However, Human papillomavirus (HPV) detection and subtype testing are suggested to overcome the high false-negative rate associated with cytology. We aimed to investigate the clinical usefulness and infection rate in the HPV polymerase chain reaction (PCR) test performed in hospitals. HPV PCR data from 217 patients were analyzed. Analysis of variance revealed a significant difference in the infection rate among different age groups (P=0.015). The biopsy results showed that epithelial cell abnormalities and high HPV-positivity rate was observed in 1 (100%) subject aged <29 years, in 4 out of 5 (80%) patients in their 30s, and in 3 out of 4 (75%) patients aged ≥70 years. The prevalence of HPV infection was very high (46.1%). The highest prevalence (87.5%) was observed among patients in their <29, followed by those in their 30s (67.7%) and those in their 40s (31.9%).A high rate of epithelial cell abnormalities (≥ cervical intraepithelial neoplasia type 1, mild dysplasia) was observed in HPV-infected women aged<30 years. Therefore, extensive research and prevention activities are needed in this age group. HPV PCR testing is recommended to complement cervical cytology
Keywords
HPV; HPV genotype; Cervical cancer; Cervical intraepithelial neoplasia; PAP; Cytology; PCR;
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