• Title/Summary/Keyword: usefulness testing

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Invirto alternatives to photosensitization Test (광감작성 시험에서의 동물대체 시험법)

  • Lee, Ho;Nam, Ki-Taek;Koh, Jae-Sook;Park, Won-Jae
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.22 no.1
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    • pp.84-101
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    • 1996
  • To minimize the use of animals in toxicity testing, and to reduce the cost in vivo test, more rational test method was described which determines, in the same animal, photoxic and photoallergic potential of a substance, and is daptable to routine testing. The other purpose of this study was to investigate the usefulness of in vivo alternatives ; photostability and spectrophotometric carbonyl assay. In this modified photosensitization model, animal numbers and resting periods, the number and method of topical application were simplified. Two positive photoreactive agents, Benzocaine and 6-methyl coumarine, showed a similar photoallergic potential to that of Ichikawa's method. Two sunscreens, Octyl methoxy cinnamate, Butyl methoxyl dibenzoyl methane, hardly showed photoallergic potentials. The photostability test could be used in the step of prescreening of photosensitization potential because most of the photoreactive agents represented the reduction of more than 20% in the absorbance. And photoreactive agents have a high potential of photosensitization in the sddessment of spectrophotometric carbonyl level although two sunscreens have a low possibility of photosensitization. Therefore this method was assumed as a valuable in vivo alternatives in the respect even in the very low concentrations which phototoxicity test using almonella showed no phototoxic potential.

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Application of Bispectral Analysis to Estimate Nonlinear Acoustic Parameter (음향 비선형 파라미터의 추정을 위한 바이스펙트럼 해석법의 적용)

  • Kim, K.C.;Jhang, K.Y.
    • Journal of the Korean Society for Nondestructive Testing
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    • v.19 no.2
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    • pp.85-92
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    • 1999
  • The fact that material degradation can be evaluated by measuring nonlinear acoustic effect has been proposed by previous studies. The most conventional method to measure nonlinear acoustic effect is to measure the absolute magnitude of fundamental and $2^{nd}$ order harmonic frequency component in the propagated ultrasonic wave. For this aim, power spectral analysis technique has been used widely. However, the power spectral analysis has fatal disadvantage that the gaussian additive noise superimposed in the wave signal remains in the power spectrum domain. Moreover, the magnitude of $2^{nd}$ order harmonic frequency component generated by nonlinear effect is so small that it may be suppressed by the noise remained in the power spectrum. In order to overcome this problem, this paper proposes an alternative method using bispectrum analysis, which can reduce the effect of addictive gaussian noise and. the nonlinear parameter can be obtained more stably. Simulations showed that the proposed method can obtain the value of nonlinear parameter near to the true value in the case of low SNR signal. Also, in order to confirm the usefulness of our method in actual case, we compared the nonlinear parameter obtained by using both of power spectral and bispectral analysis for several specimen intentionally degraded by fatigue load.

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Non-Contact Guided Wave Technique with Enhanced Mode-Selectivity (모드 선택성을 강화한 비접촉식 유도초음파 기술)

  • Kim, Hyun-Mook;Lee, Tae-Hun;Jhang, Kyung-Young
    • Journal of the Korean Society for Nondestructive Testing
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    • v.24 no.6
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    • pp.597-602
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    • 2004
  • In practical applications of guided wave techniques, it is very important but also difficult to identify the propagating modes, and it is preferred to generate and detect a single or less dispersive mode. Also the noncontact method is required in the automated field application. So this paper considers a non-contact guided wave technique with enhanced mode-selectivity, where a laser beam illuminated through arrayed line slits is used as the transmitter and the air-coupled transducer is used as the receiver. The line arrayed laser illumination is a wavelength matching technique that ran generate only a few modes. The air-coupled transducer detects the leaky wave of the propagated guided wave, and by tuning its detection angle we ran detect the selected single mode. Experimental results for a 1mm thick aluminum plate proved the usefulness of the proposed method, and especially it was shown that this method was powerful in the generation and detection of the $a_0$ mode.

A Study on Production and Its Usefulness of AAPM TG18 Guiding Instrument for Diagnostic Monitor QC (영상의학 검사 판독용 모니터 정도관리 Guiding Instrument 제작과 유용성 고찰)

  • Son, Gi-Gyeong;Sung, Dong-Wook;Jeong, Jae-Ho;Kang, Hui-Doo;Ryu, Kyung-Nam
    • Korean Journal of Digital Imaging in Medicine
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    • v.10 no.1
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    • pp.21-28
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    • 2008
  • Diagnostic display monitor QA according to AAPM TG18 is usually performed by PACS administrator, product manager and reading doctor, and for acceptance testing and periodic quality control evaluation, a combination of visual and quantitative tests can be used, as outlined in sections 5 and 6 of 'assessment of display performance for medical imaging systems'. Although many display tests can be performed visually, a more objective and quantitative evaluation of display performance requires special test tools. The required instruments vary in their complexity and cost, depending on the context of the evaluation(research, acceptance testing, or quality control) and how thorough the evaluation needs to be. Objective and reliable assessment of many display characteristics can be performed with relatively inexpensive equipment, So, we made 'AAPM TG18 guiding instrument' to ues variable purpose of the evaluation of 'geometrical distortions(quantitative"', 'veiling glare(visual)' and 'sensor calibration'. The spatial measurements for the quantitative evaluation of geometric distortions, and the measurement of the veling-glare ring response function which provides information regarding the spatial extent of the luminance spread, can be performed using the TG18 guiding instrument can be used to sensor calibration to standardize the basic rate of 0% luminance when periodic calibration.

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A Practical Method of Acoustic Emission Source Location in Anisotropic Composite Laminates (이방성 적층복합재 구조에서 AE 발생원 위치표정을 위한 실용적인 방법)

  • Kim, Jeong-Kon;Kang, Yong-Kyu;Kwon, Oh-Yang
    • Journal of the Korean Society for Nondestructive Testing
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    • v.23 no.3
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    • pp.237-245
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    • 2003
  • Since the velocity is dependent on the fiber orientation in anisotropic composites, the application of traditional acoustic emission (AE) source location techniques based on the constant velocity to composite structures has been practically impossible. The anisotropy makes the source location procedure complicated and deteriorates the accuracy of the location. In this study, we have divided the region of interest(ROI) into a set of finite elements, taken each element as a virtual source, and calculated the arrival time differences between sensors by using the velocities at every degree from 0 to 90. The calculated and the experimentally measured values of the arrival time difference aye then compared to minimize the location error. The results from two different materials, namely AA6061-T6 and CFRP(uni-directional; UD, $[0]_{32}4$) laminate confirmed the practical usefulness of the proposed method.

Detection of Rifampicin- and Isoniazid-Resistant Mycobacterium tuberculosis Using the Quantamatrix Multiplexed Assay Platform System

  • Wang, Hye-young;Uh, Young;Kim, Seoyong;Cho, Eunjin;Lee, Jong Seok;Lee, Hyeyoung
    • Annals of Laboratory Medicine
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    • v.38 no.6
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    • pp.569-577
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    • 2018
  • Background: The increasing prevalence of drug-resistant tuberculosis (TB) infection represents a global public health emergency. We evaluated the usefulness of a newly developed multiplexed, bead-based bioassay (Quantamatrix Multiplexed Assay Platform [QMAP], QuantaMatrix, Seoul, Korea) to rapidly identify the Mycobacterium tuberculosis complex (MTBC) and detect rifampicin (RIF) and isoniazid (INH) resistance-associated mutations. Methods: A total of 200 clinical isolates from respiratory samples were used. Phenotypic anti-TB drug susceptibility testing (DST) results were compared with those of the QMAP system, reverse blot hybridization (REBA) MTB-MDR assay, and gene sequencing analysis. Results: Compared with the phenotypic DST results, the sensitivity and specificity of the QMAP system were 96.4% (106/110; 95% confidence interval [CI] 0.9072-0.9888) and 80.0% (72/90; 95% CI 0.7052-0.8705), respectively, for RIF resistance and 75.0% (108/144; 95% CI 0.6731-0.8139) and 96.4% (54/56; 95% CI 0.8718-0.9972), respectively, for INH resistance. The agreement rates between the QMAP system and REBA MTB-MDR assay for RIF and INH resistance detection were 97.6% (121/124; 95% CI 0.9282-0.9949) and 99.1% (109/110; 95% CI 0.9453-1.0000), respectively. Comparison between the QMAP system and gene sequencing analysis showed an overall agreement of 100% for RIF resistance (110/110; 95% CI 0.9711-1.0000) and INH resistance (124/124; 95% CI 0.9743-1.0000). Conclusions: The QMAP system may serve as a useful screening method for identifying and accurately discriminating MTBC from non-tuberculous mycobacteria, as well as determining RIF- and INH-resistant MTB strains.

A Development of Automatic Extraction System for Welding Inspection Information based on Shipbuilding and Maritime CAD (조선해양 CAD 기반 용접검사 정보 자동 추출 시스템 개발)

  • Kim, Bae-Sung;Hwang, Hun-Gyu;Song, Chang-Sub;Lee, Ki-Taek
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.24 no.1
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    • pp.28-36
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    • 2020
  • In shipbuilding industry, there is conducting most of works by welding at the shipyard, and the volume of welding is increasing with international trends of green ships. Welding joint is guaranteed quality through non-destructive testing (NDT). The manual welding inspection report is produced by identifying the drawings designed, which results in losses the many workforce and occurs human errors. To solve these problems, this paper covers a system that reports on inspection information is automatically generation by input data based on shipbuilding-specific CAD. The developed system analyzes the shape data from drawings of modeling. Also, the system determines welding joints through expansion of the part boundary and generates tag numbers. In addition, it provides the function to automatically extract the information needed for inspection such as weld length, thickness and etc. We conducted test to verify the usefulness of the developed system and confirmed that the welding inspection information extracted through system matches the information shown in drawings of modeling.

Determination of True Resistance from Load Transfer Test Performed on a PHC Pile (PHC 말뚝의 하중전이실험을 통한 참 지지력의 산정)

  • Kim, Sung-Ryul;Chung, Sung-Gyo;Dzung, N.T.
    • Journal of the Korean Geotechnical Society
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    • v.22 no.11
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    • pp.113-122
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    • 2006
  • Although a number of static pile load tests have been performed in this country, re-consideration on the interpretation and loading method is needed, because of their less usefulness in practice. For this study, a static loading testing was performed for a long instrumented PHC pile, which was installed in sand layer overlying thick soft clay. The shaft resistance of the pile had been monitored for a long time after installation, and then the static load testing was performed by the quick load test, unlike the recent Korean practice. Using the measured data, the elastic modulus of pile, residual stress and true resistance on the pile were determined. In the event, it was found that the residual stress on the pile, which remained prior to the static loading, significantly affects the shaft and toe resistances. Also, it was realized that the setup effect for the long pile is significant.

A Study on Consumer Acceptance toward the Commercialized Smart Clothing (상용화된 스마트 의류제품에 대한 소비자의 수용도)

  • Chae, Jin-Mie;Cho, Hyun-Seung;Lee, Joo-Hyeon
    • Science of Emotion and Sensibility
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    • v.12 no.2
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    • pp.181-192
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    • 2009
  • The purpose of this study was to explain the attitudes and acceptance toward the smart clothing adopted by the TAM(Technology Acceptance Model). A theoretical model on consumer acceptance of the commercialized smart clothing was constructed on the basis of previous studies and a review of literature and tested the path analysis. For the data analysis, statistical methods of confirmatory factor analysis, correlation, and covariance structural analysis using AMOS 5.0 package were employed. The results from a web-based survey of 557 online consumers indicate that the TAM by Davis(1989) adopted by perceived value according to market price was able to explain consumer acceptance of smart clothing substantially well. Using structural equation modeling, eight of the six hypotheses investigated in this study were supported. The results of the testing of the hypothesis were as fellows: First, perceived ease of use had a side effect on attitude through perceived usefulness. In addition, the attitude was found to affect consumer acceptance. Second, perceived usefulness was found to affect consumer attitude on perceived value, however, had not significant effect on consumer acceptance toward smart clothing. Third, perceived value was found to affect both consumer acceptance and attitude toward smart clothing. Finally, the attitude toward smart clothing had a direct effect on the consumer acceptance.

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Evaluation of Usefulness and Fabrication of Femur Phantom on Quality Control of Bone Mineral Density Using 3D Printing Technology (3D 프린팅기술을 이용한 골밀도 정도관리 대퇴골 팬텀 제작 및 유용성 평가)

  • Da-Yeong, Hong;Jeong, Lee;Jun-Ho, Lee;Jae-Won, Mun;Han-Saem, Oh;Yu-Won, Jeong;Seong-Hyun, Jin;Jong-Min, Hong;In-Ja, Lee
    • Journal of radiological science and technology
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    • v.46 no.1
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    • pp.1-8
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    • 2023
  • As the demand for bone mineral density testing increases in Korea, which is close to an aging society, it is necessary to evaluate the repeatability of equipment such as femur phantom other than l-spine for more accurate diagnosis. However, in clinical practice, it is often not possible to proceed such evaluation due to insufficient quality control conditions. Therefore, this study is to evaluate the usefulness of the femur phantom after fabricating the same using 3D printing technology. The femur phantom was output using GlowFill filament and FDM 3D printing type. Each phantom was repeatedly scaned 20 times to compare whether the existing l-spine phantom and the fabricated femur phantom were suitable as a phantom for quality control. Each time the seven researchers took three times, the location of the femur phantom was readjusted, and then scanned to confirm the error between the researchers. As a result of conducting repeatability evaluation using femur phantom, the coefficient of variation rate was 2%, which was within the minimum precision tolerance of 2.5%. The reproducibility between the researcher was also found to be suitable as the average coefficient of variation was 0.031 and the coefficient of variation rate was 3.1%, which was within the minimum precision error range of 5%. In conclusion, it is considered that the prospective attitude and usefulness of the femur phantom fabricated by 3D printing in clinical practice will be sufficient.