• The Bulletin of The Korean Astronomical Society
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• v.40 no.2
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• pp.32.1-32.1
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• 2015

The gradual infall of small dark matter halos onto larger ones has become a relatively straightforward aspect of the standard hierarchical formation paradigm. What happens to the baryons they contain, however, is less well understood. Of special relevance are the processes that regulate and ultimately suppress star formation in galaxies in the early universe. The z=1.5-2.5 epoch is then particularly interesting as a transition period when global star-formation in the universe starts peaking but also where the first ostensibly collapsed and virialized galaxy clusters appear, along with segregated galaxy populations. From a theoretical point of view, the mode of gas accretion in massive halos is also expected to change around this time, switching from a cold to a hot phase and affecting the build-up and evolution of the galaxies they host. A lot of effort has thus been devoted to the search for high-redshift structures, in particular galaxy clusters, through a variety of methods. However, as the limited area for which deep datasets are available remains relatively limited, only few massive z>1.5 structures have been found so far. Here I will instead discuss the regulation of star-formation in lower-mass, X-ray detected halos at z~2 and its implication for galaxy quenching at high redshift. As these smaller, group-size halos are vastly more abundant and structurally simpler than massive clusters, they allow for true statistical studies and offer a novel way to probe environmental effects in this transitional epoch.

• BMB Reports
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• v.45 no.8
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• pp.464-469
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• 2012

Endothelial cells (ECs) apoptosis induced by oxidized low-density lipoprotein (ox-LDL) is thought to play a critical role in atherosclerosis. MicroRNAs (miRNAs) are a class of noncoding RNAs that posttranscriptionally regulate the expression of genes involved in diverse cell functions, including differentiation, growth, proliferation, and apoptosis. MiRNA let-7 family is known to be involved in the regulation of cell apoptosis. However, the function of let-7 in ox-LDL induced ECs apoptosis and atherosclerosis is still unknown. Here, we show that let-7c expression was markedly up-regulated in ox-LDL induced apoptotic human umbilical cord vein endothelial cells (HUVECs). Let-7c over-expression enhanced apoptosis in ECs whereas inhibition of let-7c could partly alleviate apoptotic cell death mediated by ox-LDL. Searching for how let-7c affected apoptosis, we discovered that antiapoptotic protein Bcl-xl was a direct target of let-7c in ECs. Our data suggest that let-7c contributes to endothelial apoptosis through suppression of Bcl-xl.

• Korean Journal of Acupuncture
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• v.28 no.3
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• pp.127-140
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• 2011

Objectives : The aim of this study is to regulate the medical meaning about Kwan [self-denial] which is used by Jeongkyeok [reinforcing the weak body part] and Seungkyeok [consolidating the weak body part while inducing cathartic action of comparatively stronger body part] of Saam Acupuncture in common. Methods : This study generalized the method of understanding 'The Five Viscera Interaction' in Oriental Medicine from the perspective of literature and considering human organs in the medical context. Results and Conclusions : 1. There existed 'The Five Viscera Interaction' theory regulating the correlation between the five viscera headed by "Nankyeong" in the traditional Oriental medicine. The five viscera interaction theory was used as the standard of judging the symptom and the prognosis of a disease in the history of Oriental medicine and further used even as the method of preventing and treating diseases. 2. The treatment included in "Biyebaekyobang", a medical book in the period of Goryeo, can be rated as the most developmental form of medical theory which applied 'the five viscera interaction theory' to clinical treatment. The author of "Biyebaekyobang" managed to break away from the schematism of the five viscera interaction through the method of treating two internal organs using one organ treatment and applying the individually different relations between organs. "Biyebaekyobang" shows close similarities to Saam Acupuncture. 3. The organs handled in Saam Acupuncture has a significance in that it put forward the part which had not been aggressively dealt with in medical history up until then.

• Environmental Mutagens and Carcinogens
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• v.23 no.1
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• pp.35-40
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• 2003

Polycyclic aromatic hydrocarbons (PAH) are frequently detected in food, water, soil, and sediment and are widespread environmental pollutants formed by the incomplete combustion of fossil fuels, woods and other organic matter. PAHs are considered to be probable human carcinogens. The mechanism of action of PAHs has been studied extensively, however it is not clear how PAHs turn on CYP1A1 in human breast cancer. Our laboratory have been studied the effect of PAHs in the human breast cancer cell MCF7. In this study, we examined the ZR-75-1 human breast cancer cells as a new system to evaluate bioactivity of PAHs. ZR-75-1 human breast cancer cell line responses to estrogen and progesteron. We have been able to estbilish long term culture system of this cells then used for the study to observe the effect of PAHs. We demonstrate that PAHs induced the CYP1A1 promoter and 7-ethoxyresolufin O-deethylase (EROD) activity in a concentration-dependant manner. RT-PCR analysis indicated that PAHs significantly up-regulate the level of CYP1A1 mRNA. Some of PAHs showed stronger stimulatory effect on CYP1 gene expression than TCDD. Apparently, ZR-75-1 cells have Aryl hydrocarbon receptors, therefore it would be good experimental tool to study the cross-talk between PAHs and steroid actions.

• Journal of Power Electronics
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• v.14 no.2
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• pp.226-236
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• 2014

A new active LED driver with high power factor (PF) and low total harmonic distortion (THD) compatible with a rapid-start ballast is proposed. An LC input filter is attached to the ballast to increase PF and reduce THD. A boost converter is then installed to regulate the LED current, where an unstable operating region has been newly identified. The unstable region is successfully stabilized by feedback control with two zeroes. The extremely high overall system of the 10th order is completely analyzed by the newly introduced phasor transformed circuits in static and dynamic analyses. Although a small DC capacitor is utilized, the flicker percentage of the LED is drastically mitigated to 1% by the fast controller. The proposed LED driver that employs a simple controller with a start-up circuit is verified by extensive experiments whose results are in good agreement with the design.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.33 no.8B
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• pp.630-635
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• 2008

Recently, in order to improve the energy efficiency of WSN(Wireless Sensor Network), widely research have teen carried on. But, up to the present, Majority of methods are based on direct communication between CH(cluster head) and sink node, and based on the assumption that node can regulate signal energy actively according to the distance between nodes. So it's hard to implement those methods. Based on the theory that node has fixed radio wave radius, this paper present a multi leveling routing protocol. According to the simulation of the presented protocol, we have proved the energy saving efficiency and the implementation in real WSN.

• Journal of Korean Society of Water and Wastewater
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• v.9 no.3
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• pp.88-98
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• 1995

Several kinds of coagulants such as aluminum sulfate, PAC, PASS are being used to treat drinking water resulting in residual aluminum ions in the water. Recently, it has been reported that high intake of aluminum ion may cause neurological dieseases such as Alzheimer's diesease and presenile dementia. Because of the possible adverse effect, WHO and EEC recommand to regulate residual aluminum. The autorities in Korea also has plan of regulating residual alunimum from 1995. But there is not enough information about the range of residual aluminum ion concentration when the aluminum sulfate, PAC or PASS has been used as a coagulant. Therefore the study has been conducted to find out the range of residual aluminum ion concentration after using aluminum sulfate, PAC, and PASS. Furthermore the effect of turbidity and alkalinity have been investigated. The experimental results are summarized as; 1. Most of the residual aluminum ion concentrations were within $10^{-6}$ and $10^{-5}mole/l$. Three coagulants have not showed any considerable difference in the residual aluminum concentration up to 50 NTU. However PAC has showed the least residual aluminum in high turbidity water over 100 NTU. 2. The low alkalinity water having 25mg/l as $CaCO_3$ has showed less residual aluminum than the water having 50mg/l alkalinity. However, the difference was not significcant. 3. Even the lowest residual aluminum concentration was over 0.05mg/l. Therefore the process to reduce residual aluminum would be necessary in water treatment plants.

• IMMUNE NETWORK
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• v.10 no.4
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• pp.126-134
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• 2010

Background: $CD8^+$ T cells contribute to the clearance of Hepatitis B virus (HBV) infection and an insufficient $CD8^+$ T cell response may be one of the major factors leading to chronic HBV infection. Since the HBx antigen of HBV can up-regulate cellular expression of several immunomodulatory molecules, we hypothesized that HBx expression in hepatocytes might affect $CD8^+$ T cell activity. Methods: We analyzed the activation and apoptosis of $CD8^+$ T cells co-cultured with primary hepatocytes rendered capable of expressing HBx by recombinant baculovirus infection. Results: Expression of HBx in hepatocytes induced low production of $interferon-{\gamma}$ and apoptosis of CD8+ T cells, with no effect on CD8 T cell proliferation. However, transcriptional levels of H-2K, ICAM-1 and PD-1 ligand did not correlate with HBx expression in hepatocytes. Conclusion: Our results suggest that HBx may inhibit $CD8^+$ T cell response by regulation of $interferon-{\gamma}$ production and apoptosis.

• Genomics & Informatics
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• v.3 no.1
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• pp.8-14
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• 2005

Although much is known about the molecular biology of platelets, the megakaryocytes' (MKs) molecular biology was not understood so well because of their rareness. By the cloning and characterization of thrombopoietin (TPO), which is the principal regulator of the growth and development of the MKs, researches on the MKs have been growing rapidly. To understand megakaryocytopoiesis, we investigated the gene expression profile of the MKs using oligonucleotide microarray where 10,108 unique genes were spotted. Comparing the fluorescence intensities of which ratio is $\ge$ ${\mid}2{\mid}$, 372 genes were up-regulated and 541 genes were down-regulated in MKs. For confirmatory expression, RNase protection assay (RPA) establishing abundant apoptotic gene expression was carried out. In MKs, many of the known genes, including several platelet related genes, GATA binding protein were highly expressed. Particularly, TGF beta, clusterin (complement lysis inhibitor), and thymosin beta 4 (actin-sequestering molecules) were expressed highly in MKs. As MKs specific expressed genes may regulate normal and pathologic platelet (and/or MK) functions, the transcript profiling using microarray was useful on molecular understanding of MKs,

• BMB Reports
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• v.39 no.5
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• pp.607-617
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• 2006

A novel calcium-dependent protein kinase gene (designated as IiCPK2) was cloned from tetraploid Isatis indigotica. The full-length cDNA of IiCPK2 was 2585 bp long with an open reading frame (ORF) of 1878 bp encoding a polypeptide of 625 amino acid residues. The predicted IiCPK2 polypeptide included three domains: a kinase domain, a junction domain (or autoinhibitory region), and a C-terminal calmodulin-like domain (or calcium-binding domain), which presented a typical structure of plant CDPKs. Further analysis of IiCPK2 genomic DNA revealed that it contained 7 exons, 6 introns and the length of most exons was highly conserved. Semi-quantitative RT-PCR revealed that the expression of IiCPK2 in root, stem and leaf were much higher in tetraploid sample than that in diploid progenitor. Further expression analysis revealed that gibberellin ($GA_3$), NaCl and cold treatments could up-regulate the IiCPK2 transcription. All our findings suggest that IiCPK2 might participate in the cold, high salinity and GA3 responsive pathways.