• Proceedings of the Korean Biophysical Society Conference
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• 2003.06a
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• pp.60-60
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• 2003

GSH-dependent glutaredoxinl (Grxl) was characterized in Dictyostelium discoideum. After starvation, the mRNA levels of grx1 gene increased during aggregation, thereafter decreased up to tip formation and increased again during culmination. To investigate the function of Grxl, the protein was overexpressed in D. discoideum using actinl5 promoter, The phenotype analysis on Grxl-overexpressed cells showed the maintenance of slug stage for a long period and delayed culmination under dark condition. To corroborate these phenotype by the enzyme, the two mutant forms of Grxl (C21S and C24S) were overexpressed in D. discoideum. The phenotype of two mutant cells represented no slug formation and the early culmination on dark condition. These results indicate that Grxl might regulate the transition from slug to culminant in darkness.

• Journal of Environmental Science International
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• v.16 no.7
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• pp.839-845
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• 2007

It is necessary to draw up many plans to solve problems in the management of groundwater resources in Jeju Island while systematically develop and utilize water resources at an optimal level. It also seems to an evitable option to establish Groundwater Management Areas in Jeju Island. The excess use of groundwater could be discouraged by imposing charges on those licenses. Such policy as allowance trading system do not appear to be because of transaction costs, but could be applied if only were accompanied by complementary method. The methods of using and conserving the limited resources of groundwater should be founded through socially agreeable and appropriate ways. The policy complemented allowance trading system by Pigouian tax could be effective to regulate licenses. This is cutting the numbers of licenses at a constant rate, imposing charges on those who want to continue using licenses, and reimbursing in cash to those who return the licenses.

• Journal of The Korea Institute of Healthcare Architecture
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• v.13 no.2
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• pp.37-44
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• 2007

Rehabilitation medicine is an area which tries to help people who have physical inconvenience in everyday activities to live like healthy people as much as possible by training programs. As society gets more advanced and as the standard of living continuously rises, the need of the "Rehabilitation medicine" is also increasing. Also as we are entering into the aging society, especially geriatric rehabilitation medicine is getting more and more attention as a method to maintain the healthy lives of the elders. However, the standards related to medical care space for rehabilitation medicine is not thoroughly prepared. Although requirement for geriatric hospital is increasing, the standard of geriatric hospital is not following up to regulate them properly. Therefore, in this study, I will propose a 'suitable planning' needed in geriatric rehabilitation by analyzing the rehabilitation sections of 5 general hospitals and 1 geriatric hospital.

• Journal of the Korean housing association
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• v.15 no.3
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• pp.53-62
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• 2004

Recently the landscape of housing has been emphasized. This trend seems to reflect the negative aspects of housing landscape in urban area. Throughout the analysis on the various visual density index, the following findings were obtained; 1) Elevation blockage ratio(EBR) was permitted differently according to the types of housing blocks, and the preference of block layout was different to the location of site. 2) EBR regulation level was acceptable. But 40m level of general area should be stepped up to the 35m level. 3) The correlation between the floor area ratio(FAR) and the EBR was not high. Therefore it is reasonable to regulate the EBR to the location. 4) Elevation coverage ratio(ECR) was highly correlated with the FAR. It means that FAR can substitute for the ECR, and ECR should be regulated to the level of FAR.

• Journal of Electrical Engineering and Technology
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• v.7 no.6
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• pp.869-875
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• 2012

Because of the nature of wind, the output power of wind turbines fluctuates according to wind speed variation. Therefore, many countries have set up wind-turbine interconnection standards usually named as Grid-Code to regulate the output power of wind farms to improve power system reliability and power quality. This paper proposes three operation modes of wind farms such as maximum power point tracking (MPPT) mode, single wind turbine control mode and wind farm control mode to control the output power of wind turbines as well as overall wind farms. This paper also proposes an operation scheme of wind farm to alleviate power fluctuation of wind farm by choosing the appropriate control mode and coordinating multiple wind turbines in consideration of grid conditions. The performance of the proposed scheme is verified via simulation studies in PSCAD/EMTDC with doubly-fed induction generator (DFIG) based wind turbine models.

• Journal of Korea Multimedia Society
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• v.25 no.9
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• pp.1338-1347
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• 2022

In recent years, the number of Chinese college students in unhealthy or sub-healthy state in terms of mental health accounts for about 30% and has been going up. As we know, college students are in the middle of youth, an important stage of physical and psychological development. In this case, how to regulate mental health will become an important research direction. Based on emotion regulation theory, this thesis discussed the impact that 'healing animation' had on college students' psychological capital, and how emotion regulation had done its work in the process. According to documents research and empirical study, 'healing animation' is positively affecting the psychological capital of college students through the medium -- emotion regulation. Finally, this thesis provided a practical layout to accumulate college students' psychological capital, and theoretical reference for 'healing animation' as well.

• Clinical and Experimental Vaccine Research
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• v.12 no.2
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• pp.176-178
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• 2023

We report the case of a toddler, with a history of mild atopic dermatitis (AD) since early infancy, presented to the Giannina Gaslini, a pediatric polyclinic hospital, 14 days after measles-mumps-rubella (MMR) vaccination, for the occurrence of a disseminated vesico-pustular rash, accompanied by general malaise, fever, restlessness, and anorexia. Eczema herpeticum (EH) was diagnosed clinically and confirmed by laboratory examinations. The exact pathogenesis of EH in AD is still debated and possibly involves an inter-play between altered cell-mediated and humoral immunity, failure to up-regulate antiviral proteins, and exposure of viral binding sites through the dermatitis and an epidermal barrier failure. We hypothesize that in this particular case, MMR vaccination might have played an additional important role in the alteration of innate immune response, facilitating the manifestation of herpes simplex virus type 1 in the form of EH.

• Proceedings of the Korean Society of Crop Science Conference
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• 2017.06a
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• pp.35-35
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• 2017

How do plants take up water from soils especially when water is scarce in soils? Plants have a strategy to respond to water deficit to manage water necessary for their survival and growth. Plants regulate water transport inside them. Water flows inside the plant via (i) apoplastic pathway including xylem vessel and cell wall and (ii) cell-to-cell pathway including water channels sitting in cell membrane (aquaporins). Water transport across the root and leaf is explained by a composite transport model including those pathways. Modification of the components in those pathways to change their hydraulic conductivity can regulate water uptake and management. Apoplastic barrier is modified by producing Casparian band and suberin lamellae. These structures contain suberin known to be hydrophobic. Barley roots with more suberin content from the apoplast showed lower root hydraulic conductivity. Root hydraulic conductivity was measured by a root pressure probe. Plant root builds apoplastic barrier to prevent water loss into dry soil. Water transport in plant is also regulated in the cell-to-cell pathway via aquaporin, which has received a great attention after its discovery in early 1990s. Aquaporins in plants are known to open or close to regulate water transport in response to biotic and/or abiotic stresses including water deficit. Aquaporins in a corn leaf were opened by illumination in the beginning, however, closed in response to the following leaf water potential decrease. The evidence was provided by cell hydraulic conductivity measurement using a cell pressure probe. Changing the hydraulic conductivity of plant organ such as root and leaf has an impact not only on the speed of water transport across the plant but also on the water potential inside the plant, which means plant water uptake pattern from soil could be differentiated. This was demonstrated by a computer simulation with 3-D root structure having root hydraulic conductivity information and soil. The model study indicated that the root hydraulic conductivity plays an important role to determine the water uptake from soil with suboptimal water, although soil hydraulic conductivity also interplayed.

• International Journal of Stem Cells
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• v.15 no.2
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• pp.155-163
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• 2022

Background and Objectives: Mesenchymal stem cells (MSCs) have immunomodulatory function and participate in the pathogenesis of many immunoregulation-related diseases, including psoriasis. Previously, we found that MSCs from psoriatic lesions overexpress the proinflammatory microRNA, miR-155 and exhibit a decreased immunosuppressive capacity. But the origin of these aberrant characteristics is still not clear. To investigate whether inflammatory cytokines in serum and peripheral blood mononuclear cells (PBMCs) from psoriatic patients can regulate the expression patterns of immunoregulation-related cytokines and the immunoregulation function of MSCs. Methods and Results: Normal dermal mesenchymal stem cells (nDMSCs) were treated with serum or PBMCs derived from patients with psoriasis or healthy donors. Expression of miR-155 and immunoregulation-related genes in each MSCs were measured using real-time PCR or western-blot. Meanwhile, the immunosuppressive capacity of DMSCs was evaluated by its inhibitory ability on proliferation of activated PBMCs. Compared to control serum, psoriatic serum significantly increased the expression levels of miR-155 (27.19±2.40 vs. 3.51±1.19, p<0.001), while decreased TAB₂ expression (0.28±0.04 vs. 0.72±0.20, p<0.01) in DMSCs. Expression levels of immunoregulation-related genes such as PGE₂, IL-10, and TLR4 were also markedly down-regulated following the psoriatic serum treatment. Those DMSCs treated with healthy serum could inhibit PBMC proliferation, while those psoriatic serum-treated DMSCs could not inhibit PBMC proliferation effectively. Conclusions: Psoriatic serum up-regulate the expression of miR-155, down-regulate the expression of immunoregulation-related genes (PGE₂, IL-10, and TLR4) in DMSCs, and along with the inhibition of the immunosuppressive function of MSCs.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.4
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• pp.1183-1186
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• 2012

Objective: To observe the effect of insulin-like growth factor-1 (IGF-1) on bone morphogenetic protein (BMP)-2 expression in hepatocellular carcinoma SMMC7721 cells. Methods: Cells were divided into blank control, IGF-1, IGF-1 + SB203580, and SB203580 groups. SB203580 was used to block the p38 MAPK signaling pathway. Changes in the expression of BMP-2, p38 MAPK, and phosphorylated p38, MERK, ERK and JNK were determined using reverse transcription polymerase chain reactions (RT-PCR) and Western blot analysis. Results: Protein expression of phosphorylated BMP-2, MERK, ERK, and JNK was significantly up-regulated by IGF-1 compared with the control group ($1.138{\pm}0.065$ vs. $0.606{\pm}0.013$, $0.292{\pm}0.005$ vs. $0.150{\pm}0.081$, $0.378{\pm}0.006$ vs. $0.606{\pm}0.013$, and $0.299{\pm}0.015$ vs. $0.196{\pm}0.017$, respectively; P<0.05). Levels of BMP-2 and phosphorylated MERK and JNK were significantly reduced after blocking of the p38MAPK signaling pathway ($0.494{\pm}0.052$ vs. $0.165{\pm}0.017$, $0.073{\pm}0.07$ vs. $0.150{\pm}0.081$, and $0.018{\pm}0.008$ vs. $0.196{\pm}0.017$, respectively; P<0.05), but such a significant difference was not observed for phosphorylated ERK protein expression ($0.173{\pm}0.07$ vs. $0.150{\pm}0.081$, P>0.05). Conclusion: IGF-1 can up-regulate BMP-2 expression, and p38 MAPK signaling pathway blockage can noticeably reduce the up-regulated expression. We can conclude that the up-regulatory effect of IGF-1 on BMP-2 expression is realized through the p38 MAPK signaling pathway.