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Extensive calcific myonecrosis of the lower leg treated with free tissue transfer

  • Kim, Tae Gon;Sakong, Yong;Kim, Il Kug
    • Archives of Plastic Surgery
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    • v.48 no.3
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    • pp.329-332
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    • 2021
  • Calcific myonecrosis is a rare condition in which hypoperfusion due to compartment syndrome causes soft tissue and muscle to become calcified. As calcific myonecrosis gradually deteriorates, secretions steadily accumulate inside the affected area, forming a cavity that is vulnerable to infection. Most such cases progress to chronic wounds that are unlikely to heal spontaneously. After removing the calcified tissue, the wound can be treated by primary closure, flap coverage, or a skin graft. In this case, a 72-year-old man had extensive calcific myonecrosis on his left lower leg, and experienced swelling and increasing tenderness. After removing the muscle calcification, we combined two anterolateral thigh free flaps, which were harvested from the patient's right and left thigh, respectively, to reconstruct the wound with a dead-space filler and skin-defect cover at the same time. The patient recovered without revision surgery or major complications.

Tour of Truffles: Aromas, Aphrodisiacs, Adaptogens, and More

  • Allen, Kirsten;Bennett, Joan W.
    • Mycobiology
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    • v.49 no.3
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    • pp.201-212
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    • 2021
  • Truffles are the fruiting bodies of ascomycete fungi that form underground. Truffles are globally valued, culturally celebrated as aphrodisiacs, and highly sought-after delicacies in the culinary world. For centuries, naturalists have speculated about their mode of formation, and in cultures surrounding the Mediterranean Sea, many species have been prized as a delectable food source. Truffle fruiting bodies form underground and emit a variety of volatile organic compounds (VOCs). Truffle volatiles are believed to have evolved to attract animals that disperse their spores. The main VOCs identified from truffles include sulfur compounds, such as dimethyl sulfide (DMS) and dimethyl disulfide (DMDS); in addition, 1-octen-3-ol and 2-methyl-1-propanol have been found in most truffle species. Humans use pigs and dogs trained to detect truffle VOCs in order to find these prized subterranean macrofungi. Truffles have pharmacological potential, but until more reliable cultivation methods become available their high price means they are unlikely to see widespread use as medicinals.

Treatment-Resistant Schizophrenia: Terminology and Clinical Features (치료저항성 조현병: 정의와 임상양상)

  • Lee, Kounseok
    • Korean Journal of Schizophrenia Research
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    • v.23 no.2
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    • pp.45-50
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    • 2020
  • Schizophrenia is one of serious mental illnesses and is often described as a heterogeneous disorder. Approximately one-third of schizophrenia cases are treatment-resistant schizophrenia (TRS). The aim of this study was to review the definitions and clinical features of TRS. Though it was found that the criteria for TRS were considerably diverse, the Treatment Response and Resistance in Psychosis (TRRIP) consensus criteria were recently introduced. According to the TRRIP criteria, TRS should be suspected if symptoms persist alongside psychotic symptoms despite sufficient treatment for ≥12 weeks, or two or more symptoms persist significantly for ≥6 weeks. The clinical characteristics of TRS includes an earlier age of onset, more severe and familial form, possibly more rural residence, unlikely association with male sex, and an increase in cognitive deficits.

A case report of "minor" trauma leading to a major disability: whiplash-associated dysphagia, dysphonia, and dysgeusia

  • Schattner, Ami;Glick, Yair
    • Journal of Trauma and Injury
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    • v.35 no.2
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    • pp.115-117
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    • 2022
  • "Whiplash"-type injuries are commonly encountered and often cause neck pain, neck stiffness, and headaches. However, these injuries can have rare and poorly recognized complications, such as the development of a prevertebral hematoma leading to acute respiratory failure in the emergency department, followed by severe, life-threatening dysphagia and recurrent aspirations. In the patient described herein, a whiplash injury was accompanied by vocal cord paralysis and dysphonia (vagus nerve), dysgeusia (glossopharyngeal nerve, vagus nerve), and upper esophageal spasm (cricopharyngeal muscle, vagus nerve). It is unlikely that this was a complication of cervical fusion surgery. Instead, a combined stretch-induced lower cranial nerve injury, possibly on the exit of these nerves through the jugular foramen, seems to be a likely, but underappreciated mechanism occurring in rare instances of whiplash injuries.

Titius-Bode's Relation in Exoplanetary Systems

  • Heon-Young Chang
    • Journal of Astronomy and Space Sciences
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    • v.40 no.2
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    • pp.67-77
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    • 2023
  • The Titius-Bode's relation has been historically successful in predicting the location of Ceres in the solar system, while its physical basis remains hidden. In this study, we attempt to answer the question of whether the Titius-Bode's relation is universally valid for exoplanetary systems with plural exoplanets. For this purpose, we statistically study the distribution of the ratio of the orbiting periods of two planets in 32 exoplanetary systems hosted by a single star. We only consider the period ratios derived from exoplanets orbiting a single star since celestial objects under investigation are kept as simple as possible and free from uncertainties such as the mass of the host star. We find that the distribution of period ratios of two exoplanets appears inconsistent with that derived from the Titius-Bode's relation using the χ2 test. We also found that the distance distribution in exoplanetary systems unlikely follows the uniform distribution or the Poisson's distribution. It is noted, however, that more rigorous statistical tests should be carried out to reach a more certain conclusion.

DEVELOPMENT OF FEASIBILITY ANALYSIS MODEL FOR DEVELOPER-REQUESTED HOUSING PROJECTS

  • Young-Ki Huh;Bon-Gang Hwang;Joong-Seok Lee
    • International conference on construction engineering and project management
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    • 2009.05a
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    • pp.847-855
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    • 2009
  • While many studies on feasibility analysis for housing projects have been released, the main focus was on economic feasibility and factors related to developers were not clearly identified enough to be used in practice. In order to establish a feasibility analysis model for apartment development projects requested by developers in Korea, 31 driving factors behind projects' success were identified under seven different categories. Criterions of the each factor were also developed, and weight of each factor was assigned by applying the Analytical Hierarchy Process(AHP). Finally, based on the Monte Carlo simulation, the feasibility analysis model was established, providing probability distribution of project's grade. The model was applied to 12 housing projects to verify its reliability, and found that the model properly filtered projects that are unlikely to be profitable, indicating reasonable reliability of the model. The model can be a useful tool for contractors, especially with less experience in analyzing project development feasibility.

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Myogenic Autoregulation of Coronary Vessels and Heterometric Autoregulation of the Myocardium

  • Doring, H.J.;Schlicht, I.;Hiller, V.;Jiang, X.R.
    • The Korean Journal of Physiology
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    • v.23 no.2
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    • pp.225-236
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    • 1989
  • 1) At the isolated perfused guinea-pig and rat heart heterometric autoregulation of the myocardium and myogenic autoregulation of the coronary vessels were induced by means of stepwise increases of perfusion pressure. 2) According to this loading test Frank-Starling function curves of the left ventricle and pressure-flow curves of the coronary vessels can be drawn. This graphic evaluation gives more information about the condition of the heart and the coronary vessels than simple evaluation under hemodynamic equilibrium. 3) There are significant differences in both curves between animal species and between different perfusate Mg concentration. 4) Myogenic autoregulation is not affected by the cyclooxygenase inhibitors indometacin and me- clofenamate. Thus it appears unlikely that prostanoides are involved in myogenic autoregulation. 5) Ca antagonists (Gallopamil, prenylamine) depress myogenic autoregulation dose-dependently. Enhanced myogenic autoregulation, induced by low extracellular magnesium, can be reduced effectively by Gallopamil. 6) Ginsenosides from Panax ginseng as well as the ginsenoside 'Rg' are effective inhibitors of myogenic autoregulation without major negative inotropic effects.

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2008 Republican Nomination Struggle and Choice of the Republican Party (2008년 공화당 예비선거: 공화당의 선택과 매케인)

  • Yoo, Sung-jin
    • American Studies
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    • v.32 no.1
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    • pp.169-198
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    • 2009
  • Unlike the Democratic nomination, Republican nomination struggle has ended with an easy victory of Senator John McCain. This paper claims that the easy victory of McCain should not be interpreted as Republican's return to the median voter, because it masks religious schism and ideological discord among the Republicans. Christian rights were still reluctant to support McCain mostly due to his liberal position on social issues. In addition, the conservatives who request stricter immigration policy presented the mixed feeling toward the Republican candidate. Even though McCain chose the harmony inside the Republican party, rather than sticked to his liberal attitude toward social issues during the campaign for 2008 general election, McCain's defeat is unlikely to result in a rapid change in the Republican party.

Still Aquamarine: China Factor and the 2020 Election Revisited

  • Kai-Ping Huang
    • Asian Journal for Public Opinion Research
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    • v.11 no.2
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    • pp.77-106
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    • 2023
  • The DPP's victory over the KMT in Taiwan's 2020 elections has been interpreted as a triumph for anti-China sentiment. However, the rise of political outsiders and their influence on voting behavior in this election were overlooked and underestimated. In this article, we examined different sources of data and found that supporters of these political outsiders mentioned sovereignty and cross-Strait issues less than the incumbent Tsai Ing-wen. However, when faced with the choice between Tsai and challenger Han Kuo-yu, voters who were concerned about governance chose Tsai, contributing to her winning a record number of votes. This article suggests that economic and governance issues had a considerable role in the election's result and will probably be the main focus of the 2024 presidential election. With the potential for a conflict in the Taiwan Strait increasing, anti-China sentiment is unlikely to be the deciding factor this time around.

Agreement of Label Information of Antihistamine, Anti-allergy Medications in Pregnancy among Korea, the USA, the UK, and Japan (임신부에서 항히스타민제와 알레르기용약의 국가별 안전정보 일치도 분석 : 한국, 미국, 영국, 일본 허가사항을 중심으로)

  • Park, Mi-Ju;Shin, Ju-Young;Kim, Hong-Ah;Park, Hyo-Ju;Kim, Mi-Hee;Shin, Sun-Mi;Park, Byung-Joo
    • Korean Journal of Clinical Pharmacy
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    • v.23 no.4
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    • pp.327-333
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    • 2013
  • Background: Antihistamine and anti-allergy medications are widely used during pregnancy. Reading label information is one of the easiest ways to get safety information. But there are content gaps among countries. Objective: To compare the risk level and the recommendation level of antihistamine/anti-allergy drug's label information in pregnant women among Korea, the USA, the UK, and Japan. Method: Study drugs of antihistamine/anti-allergy medications were selected according to Korea drug classification codes. Based on the label information of selected product, risk level was classified into 5 categories as follows: 'Definite', 'Probable', 'Possible', and 'Unlikely', 'Unclassified' according to the level of evidence. Recommendation level was classified into 4 categories as follows: 'Contraindicated', 'Cautious', 'Compatible', and 'Unclassified'. Frequency and proportion were presented according to the each category. To estimate agreement of each category among 4 countries, percent agreement and kappa (k) coefficient were calculated. Results: Total 13 drug ingredients were selected for antihistamine/anti-allergy medications. In risk level, Korea (46%) and Japan (69%) were mostly classified in the category of 'Unclassified', but 'Unlikely' category was more frequent in the UK (62%) and the USA (46%). In recommendation level, the proportion of 'Contraindicated' was highest in Korea (46%) compared to other countries. In contrast, the category of 'Cautious' was 77%-85% in the USA, the UK, and Japan. The percent agreement for risk level was highest in the USA-UK (54%). The recommendation level of Korea-USA showed lowest agreement for percent agreement (46%) and kappa coefficient (k=0.02). Conclusion: We confirmed the differences among safety information provided by four different countries. 'Contraindicated' was more likely in Korea compared with other countries.