• The Korean Journal of Physiology and Pharmacology
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• v.24 no.3
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• pp.193-201
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• 2020

Chromosomal region maintenance 1 (CRM1) is associated with an adverse prognosis in glioma. We previously reported that CRM1 inhibition suppressed glioma cell proliferation both in vitro and in vivo. In this study, we investigated the role of CRM1 in the migration and invasion of glioma cells. S109, a novel reversible selective inhibitor of CRM1, was used to treat Human glioma U87 and U251 cells. Cell migration and invasion were evaluated by wound-healing and transwell invasion assays. The results showed that S109 significantly inhibited the migration and invasion of U87 and U251 cells. However, mutation of Cys528 in CRM1 abolished the inhibitory activity of S109 in glioma cells. Furthermore, we found that S109 treatment decreased the expression level and activity of MMP2 and reduced the level of phosphorylated STAT3 but not total STAT3. Therefore, the inhibition of migration and invasion induced by S109 may be associated with the downregulation of MMP2 activity and expression, and inactivation of the STAT3 signaling pathway. These results support our previous conclusion that inhibition of CRM1 is an attractive strategy for the treatment of glioma.

• Proceedings of the KSRS Conference
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• 1999.11a
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• pp.281-284
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• 1999

Ground truth measurement system using RC helicopter is very useful to measure BRDF. The helicopter is operated human operator but it can keep its position by GPS aided hovering system. We developed the measurement system and have done ground truth in Mongolia in the summer of 1999 and have made sure the system can measure BRDF expectedly.

• Proceedings of the Korean Society of Medical Physics Conference
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• 1999.11a
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• pp.222-223
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• 1999

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2003.10a
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• pp.457-459
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• 2003

This paper considers the application of Fuzzy Logic to Smart Decision process of Smart Sensor system that interprets and response to the change of environmental parameters. The considered system consists of three sensors: temperature sensor, humidity sensor and pressure sensor. The smartness of system is constituted by the applying of Fuzzy Logic. The paper discusses the technical details of the application of Fuzzy Logic for making the system to be smarter.

• Proceedings of the SAREK Conference
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• 2007.06a
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• pp.85-85
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• 2007

• Proceedings of the KIEE Conference
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• 1995.07b
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• pp.584-587
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• 1995

Recent development in the digital relay technology has introduced the adaptive relaying system which adopts the relays to the current operating states. This paper proposes the hierarchical digital protection system whose design has been based on 154 kV S/S. Applying the newest communication networking, the system provides the new protection capabilities improving the system reliability and speed.

• Proceedings of the Korean Society of Dyers and Finishers Conference
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• 2010.03a
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• pp.133-133
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• 2010

• Proceedings of the Korean Society of Sericultural Science Conference
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• 2002.10a
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• pp.83-83
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• 2002

No Abstract, See Full Text

• 제어로봇시스템학회:학술대회논문집
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• 1996.10a
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• pp.372-375
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• 1996

In this paper, a designing method of model following control system for linear descriptor system with disturbances is proposed. The features of this method are:1) both the physical structure of the system and the physical system variables properties can be preserved because there is no necessary to make transformation of this system. 2) boundedness of internal states are proved by means of coprime factorization of descriptor system.

• 한국태양에너지학회:학술대회논문집
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• 2012.03a
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• pp.427-432
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• 2012

This paper proposes efficient operation method of PV system consisted of multi-central which is suitable for large scale system. The multi-central system used switch at a DC-link and applied proposed algorithm can improve the efficiency and the reliability on the existing system. This algorithm, with advantage of Multi-Central system can minimize the effect of different characteristic of each PV array due to a shadow or damaged PV cell. Each system is analysed and maximum power point tracking control, DC-link voltage control and output current control is used commonly. The validity is verified after comparing of the existing system and proposed system by simulation.