• 한국융합학회논문지
• /
• 제9권1호
• /
• pp.433-440
• /
• 2018

FDG PET 영상에서 MTV는 종양의 전체 대사정도를 반영하여 종양의 체적을 나타낸다. 하지만 MTV는 영상재구성의 영향을 받게 된다. 본 연구의 목적은 팬텀실험을 통하여 영상재구성에 따라 SUVmax의 역치 값을 달리하여 실제 체적과 MTV의 상관관계를 평가해보고자 하였다. NEMA IEC Body 팬텀에 $^{18}F-FDG$를 구와 배후 방사능의 비율(4:1, 8:1, 10:1, 20:1)이 되도록 주입 후 영상을 획득하였다. 획득한 영상에 4가지 방법(OSEM3D, OSEM3D+PSF, OSEM3D+TOF, OSEM3D+TOF+PSF)으로 영상을 재구성한 후 다양한 SUVmax 역치 값을 적용하여 MTV의 변화를 비교해 보았다. 전반적으로 SUVmax 역치 값이 증가 할수록 MTV가 감소하였으며, 구와 배후방사능 비율이 증가할수록 동일한 SUVmax 역치 값에서 MTV가 감소하였다. PSF와 TOF+PSF재구성영상에서 40% 역치 값, OSEM3D와 TOF 재구성 영상에서는 45% 역치 값을 적용하였을 때 팬텀의 실제체적과 MTV의 높은 상관관계를 보였다. 이번 연구결과를 통하여 영상재구성에 따라 MTV 측정에 기초적인 자료로 제공되어 질 것으로 사료된다.

• 한국융합학회논문지
• /
• 제9권6호
• /
• pp.299-310
• /
• 2018

연구목적은 만성 경부통증 환자의 건강관련 삶의 질 영향요인을 파악하고, 이를 기반으로 향후 효과적인 프로그램 개발을 위한 전략을 제시하고자 시도된 융합연구이다. 연구대상자는 일 지역의 만성경부통증 환자 92명을 편의표집 하였으며, 자가보고식 설문지를 이용하여 자료수집하였다. 자료분석은 PASW 18.0 프로그램을 이용하여 t-test, ANOVA, 상관분석과 단계적 회귀분석을 시행하였다. 연구결과, 만성경부통증 환자의 건강관련 삶의 질에 미치는 영향요인은 기능장애(${\beta}=-.403$, p<.001), 우울(${\beta}=-.313$, p<.001), 연령(${\beta}=-.194$, p=.008), 근력 이상(${\beta}=-.176$, p=.009), 교육수준(${\beta}=-.151$, p=.043)으로 이들의 설명력은 67.1%였다(F=38.118, p<.001). 이를 토대로 만성경부통증 환자의 건강관련 삶의 질 향상을 위해 개인특성을 고려한 신체적 기능향상과 심리적 지지가 중요함을 확인하였다. 따라서 이와 같은 건강관련 삶의 질에 미치는 영향요인들을 기반으로 건강증진 프로그램 개발 및 적용효과를 분석하는 연구가 필요하다.

• 한국융합학회논문지
• /
• 제9권6호
• /
• pp.77-88
• /
• 2018

신종 감염병에 직면하고 있는 의료종사자들을 보호하고, 모든 의료 환경에서 전염병 전파를 막기 위한 표준주의는 미래의 간호사가 될 간호대학생들에게 감염병 전파를 예방하기 위해 중요하다. 이에 간호대학생들의 표준주의에 대한 태도에 미치는 영향을 조사하였다. 연구시기는 2016년 5월부터 6월까지이며, 연구대상자는 D시에 소재한 대학의 간호대학생 291명이다. 연구결과는 간호대학생의 건강신념 하위요인 중 지각된 이익(4.26)이 가장 높게 나타났고, 표준주의 지식점수는 정답률 78.9%이었고, 태도 수준(4점 척도)은 평균 3.63점 이었다. 지각된 민감성, 지각된 이익, 지각된 장애, 자기효능감, 표준주의에 대한 지식이 표준주의에 대한 태도와 유의한 상관관계를 보였다. 건강신념의 하위요인 중 지각된 민감성(${\beta}=.152$, p<.05)과 지각된 장애(${\beta}=-.125$, p<.05)가 간호대학생의 표준주의에 대한 태도(F= 5.680, p<.001)에 영향을 주는 것으로 나타났다. 이에 따라 간호대학생의 표준주의에 대한 태도 수준을 높이기 위해 간호대학생에게 건강신념을 향상 시킬 수 있는 융합적 교육프로그램이 필요하다.

• 대한족부족관절학회지
• /
• 제17권2호
• /
• pp.130-135
• /
• 2013

Purpose: Preshaped Locking compression plate(LCP) has holes with fixed angle between screw and plate and have advantage firm fixation because it has stability of angular and axial deformity. We evaluated usefulness of LCP after open reduction and internal fixation in distal fibular fracture. Materials and Methods: Between December 2011 and May 2012, 23 patients with fracture of distal fibula were followed up at least 12 months underwent open reduction and internal fixation with LCP. There were 15 males and 8 females with a mean age 39.8(20~69) years. According to Danis-Weber classification, there were 20 cases of type B and 3 cases of type C. There were 13 cases of isolated lateral malleolus fractures, 1 case of bimalleolar fracture, 6 cases of trimalleolar fractures and 3 cases of distal tibia fractures with proximal fibula fracture. Intraoperatively, we assessed whether preshaped LCP fit lateral margin of distal fibula or not and evaluated quality of reduction and postoperative complications. The cases were analyzed by radiological bone union time and clinical results according to the criteria of Meyer Results: Of all cases, complete bone union was achieved and average radiological bone union time was 7.3(6~12) weeks. The clinical results were excellent in 18 cases(78%), good in 5 cases(22%). There were 5 cases of plate with 3 holes, 13 cases of plate with 4 holes, 2 cases of plate with 5 holes, 1 case of plate with 6 holes and 2 cases of plate with 7 holes. The average number of screws at proximal fragement was 2.5 and at distal fragment was 3.5. In 14 cases (60.8 %), we needed re-bending of plate because the distance between plate and lateral cortical margin of distal fibula was more than 5 mm at anteroposterior X-ray after reduction. All cases have anatomical reduction and there were no complications of wound infections. There were no complaint about hardware irritation. Conclusion: At fractures of distal fibula,preshaped LCP had a excellent stability although far cortex was not fixed with screw and bending of plate. And there are less complications of hardware irritation and wound problems. But, Some complement would be needed because there were no complete fitting between precontour of LCP and lateral cortical margin of distal fibula.

• 한국전자통신학회논문지
• /
• 제12권1호
• /
• pp.219-228
• /
• 2017

본 연구는 테블릿 pc 어플리케이션을 사용한 인지훈련이 인지 손상이 있는 아급성 뇌졸중 환자의 인지기능, 일상생활 및 만족감에 미치는 영향을 알고자 하였다. 인천에 소재한 I병원에 입원 중인 14명의 아급성 뇌졸중 환자들이 본 연구에 참여하였다. 14명의 대상자들은 실험군과 대조군으로 7명씩 무작위 배정되었다. 두 그룹의 대상자들은 모두 전통적인 인지치료를 4주간 주 5회, 1일 30분의 중재를 받았으며, 실험군은 테블릿 pc 어플리케이션을 사용한 인지훈련을 30분씩 추가적으로 실시하였다. 평가는 중재 전과 후에 한국판 간이 정신상태 검사, 한국판 몬트리올 인지평가, 수정된 바델 지수, 시각 상사 척도를 사용하여 인지기능, 일상생활, 만족감을 측정하였다. 연구 결과, 두 그룹은 중재 전과 후로 몬트리올 인지평가와 수정된 바델 지수에서 유의한 향상을 보였다(p<.05). 두 그룹 간 변화량 비교에서 실험군은 대조군보다 몬트리올 인지평가에서 유의한 향상을 보였다(p<.05). 두 그룹 간 만족감 비교에서 실험군과 대조군은 유의한 차이가 없었다(p>.05). 본 연구의 결과를 통하여 테블릿 pc 어플리케이션을 사용한 인지훈련은 아급성 뇌졸중 환자의 인지기능 향상에 긍정적인 효과를 기대할 수 있는 중재법으로 사료된다.

• BMB Reports
• /
• 제41권4호
• /
• pp.287-293
• /
• 2008

In a yeast two-hybrid screen, we identified the microtubule-destabilizing protein SCG10 as a potential effector protein of $BRI_3$. The association was verified using GST pull-down, Co-IP, and their perinuclear co-localization. The analysis of in vitro microtubule polymerization/depolymerization showed that the binding of $BRI_3$ to SCG10 effectively blocked the ability of SCG10 to induce microtubule disassembly, as determined by turbidimetric assays. In intact PC12 cells, $BRI_3$ exhibited the ability to stabilize the microtubule network and attenuate the microtubule-destabilizing activity of SCG10. Furthermore, co-expression of $BRI_3$ with SCG10 attenuated SCG10-mediated PC12 cell neurite outgrowth induced by NGF. These results identify a novel connection between a neuron-specific BRI protein and the cytoskeletal network, suggesting possible roles of BRI3 in the process of neuronal differentiation.

• 근관절건강학회지
• /
• 제1권1호
• /
• pp.31-47
• /
• 1994

The purposes of this research are to examine the effects of muscle relaxation to the rheumatoid arthritis patients' physiological, psychological, and social adaptation, and to verify that the technique Is an effective tool for improving the patients' adaptation. This research utilized a qusi-experimental design that compares the pre-experiment measures and the post-experiment measures. The subjects of this study were 37 out-patients who were diagnosed for rheumatoid arthritis in P university hospital and K clinic between September 12, 1993 and November 30, 1993. The experimental group consisted of patients treated on Monday, Wednesday and Friday. The control group consisted of patients treated on Tuesday, Thursday and Saturday The pre-experimental survey utilized the following tools. The physiological adaptation was measured by a graphic rating scale for pain and activity of daily living. The psychological adaptation was measured by Zung's depression scale and Rosenberg's self-esteem scale : and the social adaptation was measured by Derogatis' psychosocial adjustment scale. The experimental group received muscle relaxation treatment for 15 minutes per day for the period of 2 weeks, the control group received no treatment and had quiet time. The post-experiment measurement was carried out similar to the pre-experiment survey, SPSS $PC^+$ is used to analyze the collected data. The reliabilities of the measurement tools were examined by Cronbach's ${\alpha}$ coefficients. The homogeneities between the experimental and control groups were tested by t-test and chi-square test, hypotheses were tested by t-test. This research found that the general characteristics between the groups were statistically homogenious. The physiological, psychological, and social adaptation between the groups in the pre-experimental survey were also statistically homogenious. The results of this research can be summarized as follows : 1. Concerning the Physiological adaptation, the experimental group showed a statistically lower pain score than the control group. Thus, muscle relaxation was effective to relieve the pain of rheumatoid arthritis patients (t=-2.95, p=.006). 2. Concerning the psychological adaptation, the experimental group showed a statistically lower depression score than the control group. Thus, muscle relaxation was effective to reduce the patient's depression(t=-4.00, p=.001). 3. Concerning social adaptation, the experimental group showed a statistically higher score for the health maintenance and disease control than the control groups. Thus, muscle relaxation was effective for the health maintenance and disease control (t=2.09, p=.004). This research showed that the muscle relaxation is a nursing intervention that can promote the physiological, psychological and social adaptation of the rheumatoid arthritis patients in terms of short-term and cognitive changes. However, more fundomental changes in behavior and long-term physiology could not be found through such a short-term relaxation treatment.

• 근관절건강학회지
• /
• 제7권1호
• /
• pp.102-130
• /
• 2000

The aims of this study were to understand and to predict the determinant factors affecting the exercise behaviors and physical fitness by testing the Ponder's health promotion model, and to help the patients with rheumatoid arthritis and osteoarthritis perform the continuous exercise program, and to help them maximize the physical effect such as muscle strength. endurance, and fuctional status and mental effects including self efficacy and quality of life, and improve the physical and mental wellbeing, and to provide a basis for the nursing intervention strategies. We analyzed the clinical records of 208 patients with rheumatoid arthritis and degenerative arthritis who visited the outpatient clinics at H university hospital in Seoul between October 5, 1999 and October 24, 1999. Data were composed of self reported questionnaire and good of fitness score which were obtained by pedalling the ergometer of bicycle for 9 minutes. SPSS Win 8.0 and Window LISREL 8.12a were used for statistical analysis. 24 Of 54 hypothetical paths were supported in modified model, which was considered as a proper model with improved fit index. The physical fitness was directly influenced by exercise participation behavior and education level, and indirectly by physical fitness, while fatigue, physical disability, pastexercise behavior, life-style, self-efficacy, which explained 20% of physical fitness. The exercise participation were directly influenced by perceived benefits and self-efficacy, and indirectly influenced by life-style, fatigue and physical disability, and directly and indirectly by past exercise behavior, which explained 53% of exercise participation. Exercise score were directly affected by perceived health status, perceived benefits, self efficacy, and past exercise behavior, and were indirectly affected by fatigue, physical disability, and life-style, which explained 50%. Perceived health status were directly influeced by level of education, depression, sleep disorder, and physical disability, which explained 34% of perceived health status. Perceived benefit was directly influenced by fatigue, sleep disorder, physical disability, and life-style, which explained 45%. Perceived barriers was directly influenced by fatigue, sleep disorder, and lifestyle, which explained 9%. Self- efficacy was directly influenced by fatigue, physical disability, past exercise behavior, and level of education, which explained 61%. In conclusion, important variables for physical fitness were exercise participation and level of education, and variables affecting exercise participation were perceived self-efficacy, benefits, and past exercise behavior. Perceived self-efficacy of exercise was a significant predictor of exercise participation. Life-style, fatigue, and physical disability showed direct effects on perceived benefit, perceived barriers, and self-efficacy, and indirect effects on exercise behavior. Therefore, disease related factor should be minimized for physical performance and well being in nursing intervention for patients with rheumatoid arthritis, and plans to promote and continue exercise should be soaked to reduce disability. In addition, Exercise program should be planned and performed by the exact evaluation of exercise according to the ability of the patients and the contents to improve the importance of exercise and self efficacy in self control program, dedicated educational program should be involved.

• 의료법학
• /
• 제13권2호
• /
• pp.79-113
• /
• 2012

This study focuses on the protection of trial subjects, who participate in clinical trials for new drug. It takes long time to develop new drugs and the clinical trials are required. Usually, pharmaceutical company, which develop new drug, request a research institution(usually, hospital) to investigate the examination of security and side effects of new drug. The institution recruit trial subject to participate in the trials. The contract for clinical research of investigational new drug is concluded between the pharmaceutical company and the institution. This thesis studies the legal regulations for protection of participants of clinical research for new drug. In this respect the first matter of this study is to seek which relation between pharmaceutical firm and participants of clinical trials. Especially, there is a question which the trial subject is entitled to demand the pharmaceutical company which requested clinical trials the institution to supply the investigational new drug, after the contract for clinical trials had terminated or cancelled. This study take into account the liability of the pharmaceutical company to trial subject. Secondly, it is researched the roles and authority of Institutional Review Board(IRB). IRB is Research Ethics Committee of the institution, in which clinical trials for new drug are conducted. According to the rule of Korea good clinical practice(KGCP), IRB is the mandatory organization which is authorized to approve, secure approval or disapprove the clinical trials for investigational new drug in the institution. The important roles are the review of ethical perspective of trial research and the protection of trial subject. Thirdly, this paper focuses if the participants are to be paid for the participation for clinical research. This is ethical aspect of clinical trials. It is resonable that the participant is reimbursed for expenditure such as travels, and other expenses incurred in participation in trials. It is not allowed that the benefit of clinical trials is paid to trial subject. The payment should not function as financial inducements for participations of trials. Finally, the voluntary consent of the trial subject is required. The institution ought to inform the subject, who would like to participate in trials, and it ought to received informed consent in writing for subject. In this regard, it is matter that trial subject has ability of consent. It is principle that the subject as severely psychogeriatric patient has not ability of consent. However, it is required that not only healthy people but also patients are allowed to take part in clinical trials of new drug, in order to confirm which the investigation new drug is secure. Therefore there are cases, in which the legal representative of subject consent the participation of the trials. In addition, it is very important that the regulations concerning clinical trials of new drug is to be systematically well-modified. The approach of legal and political approach is needed to achieve this purpose.

• 의료법학
• /
• 제10권2호
• /
• pp.455-492
• /
• 2009

(Background) Recent biotechnological breakthroughs are shedding new lights on various ethical and legal issues about human biological material. Since Rudolph Virchow, a German pathologist, had founded the medical discipline of cellular pathology, issues centering around human biological materials began to draw attention. The issues involving human biological materials were revisited with more attention along with series concerns when the human genome map was finally completed. Recently, with researches on human genes and bioengineering reaping enormous commercial values in the form of material patent, such changes require a society to reassess the present and future status of human tissue within the legal system. This in turn gave rise to a heated debate over how to protect the rights of material donors: property rule vs. no property rule. (Debate and Cases) Property rule recognizes the donors' property rights on human biological materials. Thus, donors can claim real action if there were any bleach of informed consent or a donation contract. Donors can also claim damages to the responsible party when there is an infringement of property rights. Some even uphold the concept of material patents overtaking. From the viewpoint of no property rule, human biological materials are objects separated from donors. Thus, a recipient or a third party will be held liable if there were any infringement of donor's human rights. Human biological materials should not be commercially traded and a patent based on a human biological materials research does not belong to the donor of the tissues used during the course of research. In the US, two courts, Moore v. Regents of the University of California, and Greenberg v. Miami Children's Hospital Research Institute, Inc., have already decided that research participants retain no ownership of the biological specimens they contribute to medical research. Significantly, both Moore and Greenberg cases found that the researcher had parted with all ownership rights in the tissue samples when they donated them to the institutions, even though there was no provision in the informed consent forms stating either that the participants donated their tissue or waived their rights to ownership of the tissue. These rulings were led to huge controversy over property rights on human tissues. This research supports no property rule on the ground that it can protect the human dignity and prevent humans from objectification and commercialization. Human biological materials are already parted from human bodies and should be treated differently from the engineering and researches of those materials. Donors do not retain any ownership. (Suggestions) No property rule requires a legal breakthrough in the US in terms of donors' rights protection due to the absence of punitive damages provisions. The Donor rights issue on human biological material can be addressed through prospective legislation or tax policies, price control over patent products, and wider coverage of medical insurance. (Conclusions) Amid growing awareness over commercial values of human biological materials, no property rule should be adopted in order to protect human dignity but not without revamping legal provisions. The donors' rights issue in material patents requires prospective legislation based on current uncertainties. Also should be sought are solutions in the social context and all these discussions should be based on sound medical ethics of both medical staffs and researchers.