• Asian Pacific Journal of Cancer Prevention
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• 제16권11호
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• pp.4691-4698
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• 2015

Background: The tumor suppressor phosphatase and tensin homolog (PTEN) is an important negative regulator of cell-survival signaling. However, available results for the prognostic value of PTEN expression in patients with cancer remain controversial. Therefore, a meta-analysis of published studies investigating this issue was performed. Materials and Methods: A literature search via PubMed and EMBASE databases was conducted. Statistical analysis was performed by using the STATA 12.0 (STATA Corp., College, TX). Data from eligible studies were extracted and included into the meta-analysis using a random effects model. Results: A total of 3,810 patients from 27 studies were included in the meta-analysis, 22 investigating the relationship between PTEN expression and overall survival (OS) using univariate analysis, and nine with multivariate analysis. The pooled hazard ratio (HR) for OS was 1.64 (95% confidence interval (CI): 1.32-2.05) by univariate analysis and 1.56 (95% CI: 1.20-2.03) by multivariate analysis. In addition, eight papers including two disease-free-survival analyses (DFSs), four relapse-free-survival analyses (RFSs), three progression-free-survival analyses (PFSs) and one metastasis-free-survival analysis (MFS) reported the effect of PTEN on survival. The results showed that loss of PTEN expression was significant correlated with poor prognosis, with a combined HR of 1.74 (95% CI: 1.24-2.44). Furthermore, in the stratified analysis by the year of publication, ethnicity, cancer type, method, cut-off value, median follow-up time and neoadjuvant therapy in which the study was conducted, we found that the ethnicity, cancer type, method, median follow-up time and neoadjuvant therapy are associated with prognosis. Conclusions: Our study shows that negative or loss of expression of PTEN is associated with worse prognosis in patients with cancer. However, adequately designed prospective studies need to be performed for confirmation.

• 한국지능시스템학회논문지
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• 제21권2호
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• pp.268-275
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• 2011

본 논문에서는 uDEAS(Univariate Dynamic Encoding Algorithm for Searches)를 이용하여 두 가지의 이동 로봇 최적 전역 경로 계획을 제안한다. 이동 로봇의 자율 주행을 위해서는 빠른 시간 내에 작업 공간에서의 최적 경로를 생성해야 한다. 따라서 본 논문에서는 이동 로봇의 실시간 최적 경로 계획을 위해 전역 경로 계획을 도입하여 장애물 지역과 비장애물 지역을 확인하고, 지도상의 노드점과 노트점을 이용하여 출발 지점과 도착 지점 사이의 기본 경로를 생성한다. 그리고 기본 경로를 사용하여 두 가지의 방법으로 경로를 생성하게 된다. 첫 번째 방법은 기본 경로에서 세 개의 노드점을 이용하여 대각선 경로를 생성하는 방법이다. 두 번째는 혼합 다항식의 파라미터를 uDEAS를 이용하여 탐색하고, 곡선 궤적을 생성하는 방법이다. 시뮬레이션을 통해 두개의 방법에 대해 비교 분석하였다.

• Journal of Chest Surgery
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• 제49권1호
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• pp.22-28
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• 2016

Background: Carotid endarterectomy (CEA) with selective shunting is the surgical method currently used to treat patients with carotid artery disease. We evaluated the incidence of major postoperative complications in patients who underwent CEA with selective shunting under transcranial Doppler (TCD) at our institution. Methods: The records of 45 patients who underwent CEA with TCD-based selective shunting under general anesthesia from November 2009 to June 2015 were reviewed. The risk factors for postoperative complications were analyzed using univariate and multivariate analysis. Results: Preoperative atrial fibrillation was observed in three patients. Plaque ulceration was detected in 10 patients (22.2%) by preoperative computed tomography imaging. High-level stenosis was observed in 16 patients (35.5%), and 18 patients had contralateral stenosis. Twenty patients (44.4%) required shunt placement due to reduced TCD flow or a poor temporal window. The 30-day mortality rate was 2.2%. No cases of major stroke were observed in the 30 days after surgery, but four cases of minor stroke were noted. Univariate analysis showed that preoperative atrial fibrillation (odds ratio [OR], 40; p=0.018) and ex-smoker status (OR, 17.5; p=0.021) were statistically significant risk factors for a minor stroke in the 30-day postoperative period. Analogously, multivariate analysis also found that atrial fibrillation (p<0.001) and ex-smoker status (p=0.002) were significant risk factors for a minor stroke in the 30-day postoperative period. No variables were identified as risk factors for 30-day major stroke or death. No wound complications were found, although one (2.2%) of the patients suffered from a hypoglossal nerve injury. Conclusion: TCD-based CEA is a safe and reliable method to treat patients with carotid artery disease. Preoperative atrial fibrillation and ex-smoker status were found to increase the postoperative risk of a small embolism leading to a minor neurologic deficit.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2000년도 추계학술대회논문집A
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• pp.541-547
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• 2000

This paper presents the closed-form forward kinematics of the 6-6 Stewart platform of planar base and moving platform. Based on algebraic elimination method and with one extra linear sensor, it first derives an 8th-degree univariate equation and then finds tentative solution sets out of which the actual solution is to be selected. In order to provide more exact solution despite the error between measured sensor value and the theoretical one, a correction method is also used. The overall procedure requires so little computation time that it can be efficiently used for realtime applications. In addition, unlike the iterative schemes e.g. Newton-Raphson, the algorithm does not require initial estimates of solution and is free of the problems that it does not converge to actual solution within limited time. The presented method has been implemented in C language and a numerical example is given to confirm the effectiveness and accuracy of the developed algorithm.

• 대한토목학회논문집
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• 제34권1호
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• pp.17-27
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• 2014

유한요소 해석 기술의 발달에 따라 수치해석은 실구조물의 상태파악 및 유지관리에 중요한 요소가 되었다. 이러한 유한요소 해석모델을 이용하여 실 구조물의 상태 파악하고 수치 실험을 행하기 위해서는 계측 응답을 바탕으로 수치해석 모델의 개선이 반드시 이루어져야 한다. 본 연구에서는 새롭게 개발된 단변분 탐색법을 기반으로 반복적 개선을 수행하면서도 미분함수를 작성하지 않아도 되는 새로운 수치해석모델 개선기법을 소개하고, 동적안정성 분석을 통하여 고속철도교량에서의 적용성을 검토하였다. 정확한 동특성 분석을 위하여 무선계측시스템과 계측점 이동법을 이용한 세밀한 계측을 실시하고, 상관성 검토 및 모드분해기법을 활용하여 고유진동수와 모드형상을 추정하였다. 설계자료를 바탕으로 구축된 수치해석 초기 모델을 추정된 동특성과 개발된 수치해석 모델 개선 기법을 이용하여 모델 개선을 수행하였으며, 개선된 모델을 이용한 수치 실험 결과와 실 교량에서의 응답과 비교하여 수치해석 모델 개선 기법의 적용성을 검토하였다. 또한, 개선된 모델의 유용성을 검토하기 위하여 고속철도교량의 동적안정성 분석을 실시하여 성공적으로 수행할 수 있었다. 개발된 수치해석 모델 개선기법의 적용성을 추가적으로 검증된다면, 다양한 구조물 및 교량에서 개발된 수치해석 모델 개선기법을 사용할 수 있을 것이다.

• 한국지진공학회논문집
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• 제11권3호
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• pp.1-10
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• 2007

현수교 행어케이블의 장력은 현수교의 상태점검에 있어 중요한 요소이다. 현재 케이블의 장력 추정에는 여러 이론식에 의한 간접적인 방법들이 사용되고 있으며, 케이블의 가속도신호로부터 고유진동수를 측정한 후 고유진동수와 장력과의 관계로부터 케이블의 장력을 추정하는 진동법이 대표적이다. 하지만 운동방정식을 기반으로 하는 진동법은 휨강성의 영향이 큰 짧은 케이블의 장력추정에는 적합하지 않다. 본 논문에서는 10m 미만의 짧은 케이블에 대해서도 전기 가능한 새로운 장력 추정 방법으로 단변분탐색법과, 최적화 기법을 이용한 역해석 기법을 제시하였다. 이론에 대한 검증을 위해 국내에 사용 중인 광안대교 행어케이블을 대상으로, 역해석과 진동법에 의한 추정장력들과 설계장력을 상호 비교하였고, 이를 통해 역해석기법이 길이에 상관없이 장력추정에 유용하다는 결론을 얻었다.

• Genomics & Informatics
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• 제20권1호
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• pp.8.1-8.14
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• 2022

Despite the success of recent genome-wide association studies investigating longitudinal traits, a large fraction of overall heritability remains unexplained. This suggests that some of the missing heritability may be accounted for by gene-gene and gene-time/environment interactions. In this paper, we develop a Bayesian variable selection method for longitudinal genetic data based on mixed models. The method jointly models the main effects and interactions of all candidate genetic variants and non-genetic factors and has higher statistical power than previous approaches. To account for the within-subject dependence structure, we propose a grid-based approach that models only one fixed-dimensional covariance matrix, which is thus applicable to data where subjects have different numbers of time points. We provide the theoretical basis of our Bayesian method and then illustrate its performance using data from the 1000 Genome Project with various simulation settings. Several simulation studies show that our multivariate method increases the statistical power compared to the corresponding univariate method and can detect gene-time/ environment interactions well. We further evaluate our method with different numbers of individuals, variants, and causal variants, as well as different trait-heritability, and conclude that our method performs reasonably well with various simulation settings.

• Geomechanics and Engineering
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• 제32권5호
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• pp.503-512
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• 2023

In tunneling projects, a significant part of the costs is spent on segment production. By more economically producing, the cost of tunnel construction can be greatly reduced, especially in long and large-diameter tunnels. In the present study, the effect of using the Carousel method in the improvement of the production system performance compared to the conventional Static system has been studied. To carry out the research, a quantitative comparison of cost and production time was carried out for two production methods using the available documentation. The opinions of experts have been obtained using questionnaires and qualitative comparison of cost, time and production quality was done by implementation of statistical analysis. The SPSS software and the univariate t-test were used to analyze the questionnaires. According to the results of statistical analysis with SPSS, the use of the Carousel method will reduce production time and costs along with increasing manufacturing quality. According to the documentation analysis, the Carousel method reduces the cost of production by almost 30% and leads to a reduction of the production time to approximately 40% of the Static moulds system. The Carousel method has a higher production rate, efficiency, and better performance. Research into quantifying the benefits of Carousel method in the production system performance is very limited. This comparison is based on real information from the under construction Tabriz Metro project. This article can be very helpful in choosing the best production method.

• 대한산업공학회지
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• 제10권1호
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• pp.17-25
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• 1984

The use of Box-Jenkins technique is still very limited due to the high level of knowledge required in comprehending the technique and the cumbersome iterative procedure which requires a large amount of cost and time. This paper proposes a method of automating the univariate Box-Jekins modelling to overcome the limitations of subjective identification in iterative procedure by using Variate Difference method, D-statistic and Pattern Recognition algorithm combined with Akaike's Information Criterion. The results of the application to real data show that the average performance of automatic modelling procedure is better or not worse, at least, than those of the existing models which have been manually set up and reported in the literature.

• 대한가정학회지
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• 제30권3호
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• pp.325-345
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• 1992

The purpose of this study was to investigated the imfluences of family life cycle stages and perception of housework's value on perceived time pressure and role conflict in housewife-teachers. The subjects of this study were 329 married women teachers that teach in junior or senior high schools in Taegu. A questionaire was used as the survey method and for the method of data analysis, factor analysis, MANOVA, and Scheff test as a post-hoc analysis. The major findings were as follows: 1) There were significant interaction effects of family life cycle stages and perception of housework's value on perceived time pressure and role conflict. 2) The main effect for family life cycle stages was significant. 3) Followup univariate F-tests revealed significant mean differences for marital, parental and homemaker's role conflict.