• Journal of fish pathology
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• v.9 no.1
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• pp.53-63
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• 1996

The present study was undertaken to investigate the physiological characteristics of the cholinergic responses in the tilapia dorsal aorta. In vessels under resting tension or precontracted with norepinephrine, acetylcholine caused only concentration-dependent vasoconstrictions. Contractile response to acetylcholine was not affected by the removal of endothelium or the application of methylene blue. Atropine, gallamine or pirenzepine shifted concentration-response curve to the right. However pirenzepine showed a similar effect on the curve only at high concentration ($1{\times}10^{-5}$M). Acetylcholine-induced vasoconstriction was not markedly influenced by indomethacin, or verapamil, but was almost abolished in the calcium-free physiological buffer solution. These results suggest that acetylcholine produces only an endothelium-independent vasoconstriction in tilapia dorsal aorta and that the contractile effect of acetylcholine is mainly mediated by the activation of $M_2$ subtype receptor, which might be associated with the extracellular calcium influx through receptor-linked calcium channel.

• Journal of the Korea Concrete Institute
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• v.22 no.6
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• pp.777-786
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• 2010

This paper examines the flexural behavior of full-scale prestressed concrete girders that were constructed of steel fiber reinforced ultra high performance concrete (UHPC). This study is designed to provide more information about the bending characteristics of UHPC girders in order to establish a reasonable prediction model for flexural resistance and deflection for future structural design codes. Short steel fibers have been introduced into prestressed concrete T-girders in order to study their effects under flexural loads. Round straight high strength steel fibers were used at volume fraction of 2%. The girders were cast using 150~190 MPa steel fiber reinforced UHPC and were designed to assess the ability of steel fiber reinforced UHPC to carry flexural loads in prestressed girders. The experimental results show that steel fiber reinforced UHPC enhances the cracking behavior and ductility of beams. Moreover, when ultimate failure did occur, the failure of girders composed of steel fiber reinforced UHPC was observed to be precipitated by the pullout of steel fibers that were bridging tension cracks in the concrete. Flexural failure of girders occurred when the UHPC at a particular cross section began to lose tensile capacity due to steel fiber pullout. In addition, it was determined that the level of prestressing force influenced the ultimate load capacity.

• Journal of the Korean Home Economics Association
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• v.18 no.2
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• pp.1-13
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• 1980

When we design a dress, we should not only consider the esthetic sense and the relationship between movements of the body and the type of dress, but also the combination between the qualities and proper uses of textiles. recently the sale of ready-made clothes has been booming but I wonder whether they have been made in accordance with research concerning body movements and dresses. I would like to make the following observations on dresses, because I have personally suffered the inconvenience of restricted arm movements when wearing ready-made clothes. I have made four types types of foundations with muslin and Jersey, with these foundations I measured the degree of tension or how much the waist-line was drawn up then the arm was moved in increments of 45 degree angles and there by covering the entire span of vertical and horizontal movements. I have intended to experiment with sleeves of differing height in several ways. Concerning the movement factor, I have determined that with excessive activity vertical movements are twice as uncomfortable as horizontal movements. Concerning the faburic, I have found that because jersey has more elastic qualities than muslin, it has proven to be more responsive to body movements. concerning dresses, I have fund that the higher the height of the sleeves, the more uncomfortable it is to move the arms and the greater the degree to which the waist-line is drawn up. As a result this experiment I have made the following observations. Firstly, the vertical movement of the arms to a 180 degree angle has the most extreme influence on the breadth of movement of the waist-line. Secondly, because jersey permits freer body movements than muslin, it should be the preferred material for use in making sportswear. Thirdly, the formula A·H/4+3 of the sleev's cap height is suitable for making street dresses and formal wear. The formula A·H/5 and A·H/6 are properly used when making working clothes and sportswear, and the formula A·H/8 is proper for a sleeping garment and clothes for patients. Fourthly when deciding to any garments, it is important to consider the amount of arm movement anticipated and the relationship between the material and the degree to which the waistline is drawn up. In nder-blouse, when we raise our arms to the most extreme position, we should at that point still have 20∼25 cm of material remaining under the waist-line which includes the maximum of 14.1cm plus part of the blouse and breath of skirt's belt. In the case of the over blouse it is proper for us to have the length of 17∼20 cm remaining below the waist-line.

• Journal of The Korean Dental Society of Anesthesiology
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• v.14 no.3
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• pp.157-165
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• 2014

Background: Incisional site of surgical operation become transient ischemic state and then occur reoxygenation due to vasodilatation by inflammatory reaction, the productive reactive oxygen species (ROS) give rise to many physiologic results. Apoptosis have major role on elimination of inflammatory cell and formation of granulation tissue in normal wound healing process. Remifentanil can prevent the inflammatory response and can suppress inducible nitric oxide synthase expression in a septic mouse model. After cardiopulmonary bypass for coronary artery surgery, remifentanil can also inhibit the release of biomarkers of myocardial damage. Here we investigated whether remifentanil pretreatment has cellular protective effect against hypoxia-reoxygenation in HaCaT human keratinocytes, if so, the role of apoptosis and autophagy on this phenomenon. Methods: The HaCaT human keratinocytes were exposed to various concentrations of remifentanil (0.01, 0.05, 0.1, 0.5 and 1 ng/ml) for 2 h before hypoxia (RPC/HR group). These cells were cultured under 1% oxygen tension for 24h at $37^{\circ}C$. After hypoxia, to simulate reoxygenation and recovery, the cells were reoxygenated for 12 h at $37^{\circ}C$. 3-MA/RPC/HR group was treated 3-methyladenine (3-MA), autophagy inhibitor for 1h before remifentanil treatment. Cell viability was measured using a quantitative colorimetric assay with thiazolyl blue tetrazoliumbromide (MTT, amresco), showing the mitochondrial activity of living cells. To investigate whether the occurrence of autophagy and apoptosis, we used fluorescence microscopy and Western blot analysis. Results: The viability against hypoxia-reoxygenation injury in remifentanil preconditioning keratinocytes were increased, and these cells were showed stimulated expression of autophagy 3-MA suppressed the induction of autophagy effectively and the protective effects on apoptosis. Atg5, Beclin-1, LC3-II and p62 were elevated in RPC/HR group. But they were decreased when autophagy was suppressed by 3-MA. Conclusions: Remifentanil preconditioning showed the protective effect in human keratinocytes, and we concluded that autophagy may take the major role in the recovery of wound from hypoxia-reoxygenation injury. We suggest that further research is needed about the cell protective effects of autophagy.

• Journal of the Korea Concrete Institute
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• v.27 no.3
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• pp.253-263
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• 2015

Ultra-high strength concrete which have 100 MPa compressive strength or higher can be developed applying RPC(Reactive Powder Concrete). Preventing brittle failure under compression and tension, ultra-high strength concrete usually use the steel fibers as reinforcements. For the effective use of steel fiber reinforced ultra-high strength concrete, estimation of tensile strength is very important. However, there are insufficient research results are available with no relation between them. Therefore, in this study, correlation between compressive strength and tensile strength of ultra-high strength concrete was investigated by test and statistical analysis. According to test results, increasing tendency of tensile strength was also shown in the range of ultra-high strength. Evaluation of test results of this study and collected test results were carried out. Using 284 splitting test specimens and 265 flexural test specimens, equations suggested by previous researchers cannot be applied to ultra-high strength concrete. Therefore, using database and test results, regression analysis was carried out and we suggested new equation for splitting and flexural tensile strength of steel fiber reinforced ultra-high strength concrete.

• Composites Research
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• v.29 no.4
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• pp.209-215
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• 2016

The failure of composite sandwich structures with thickness and material variation was studied. The main body of the structure is sandwich plate made of the carbon composite face and Aluminum honeycomb core. It is connected with composite laminated flange without core through transition region of tapered sandwich panel with foam core. Tension and compression tests were conducted for the total of 6 panels, 3 for each. Test results showed that the panels under compression are vulnerable to the face failure along the material discontinuity line between two different cores. However the failure load of which panel does not show such failure can carry 16% more load and fails in honeycomb core and face debonding. For the tensile load, the extensive delamination failure was observed at the corner radius which connects the panel and the flange. The average failure load for compression is about 7 times the tensile failure load. Accordingly, these sandwich structures should be applied to the components that endure the compressive loadings.

• Journal of Bio-Environment Control
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• v.18 no.3
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• pp.273-279
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• 2009

This study was conducted to identify optimal concentrations of N (nitrogen) and K (Potassium) fertilizers on growth, yield and quality of melon (Cucumis melo. L) when they were grown with a fertigation culture in a greenhouse. Three strength (S) levels of fertilizers, including 1 S, 1/2S, and 1/4S were supplied N and K nutrients as using a trickle irrigation system. When the strength level of fertilizers was increased from 1/4S to 1 S, the level of EC (electronic conductivity) in soil was increased. Soil-water tension was ranged between -15 and -20kPa until fruit setting stage, whereas it was ranged between -45 and -50kPa in the later growth stages. In results, N fertilizer had effects on fruit yield and quality. A higher fruit yield was observed when plants were supplied with 1 S and 1/2S level of N fertilizer. The highest yield of marketable fruit, about 5,086kg/10a, was also observed when plants were supplied with 1/2S N fertilizer. A higher net index and sugar content of fruit was observed in the treatments of 1/2S and 1/4S level of N fertilizer compared to 1 S level. In contrast, there was no statistic difference in the yield and quality with three levels of K fertilizer. Results indicate that the 1/2S level for N and 1/4S level for K fertilizer are effective and optimal for the melon plants grown under the fertigation culture in terms of increasing fruit yield and quality and reducing the cost of fertilizers.

• Journal of Convergence for Information Technology
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• v.10 no.5
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• pp.224-231
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• 2020

The purpose of this study was to analyze the change in phytoncide intake in mood state and health-related quality of life menopausal women through an 8-week experiment. For the study, 41 subjects under 2 years after menopause in D and N districts in Seoul were targeted. consisting of three study points: pre-measurement (0week), intermediate (4week), and post-measurement (8week). Was used As a dependent variable of this study, mood status and health-related quality of life were set, and data were collected through three questionnaires: pre-measurement, intermediate measurement, and post-measurement. As for the analysis method, one-way ANOVA and post verification were performed. Derived result First, the phytoncide inhalation group of postmenopausal women showed statistically significant effects of reducing tension, depression, fatigue, chaos, and increasing vitality among the sub-factors of mood status compared to the control group. Second, the phytoncide inhalation group of postmenopausal women showed statistically significant increase in competence, mental well-being, stability, and vitality among the sub-factors of health-related quality of life compared to the control group.

• The Journal of Internal Korean Medicine
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• v.19 no.1
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• pp.385-408
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• 1998

Pyeongpaesan (平肺散) has been used in Korea for many centuries as a treatment for respiratory disease. The effect of Pyeongpaesan (平肺散) on tracheal smooth muscle is not known. The purpose of the present study is to determine the effect of Pyeongpaesan (平肺散) on histamine and acetylcholine induced tracheal smooth muscle contraction in rats and guinea pigs. Guinea pig (500 g, male) and Sprague Dawley rats (200 g, male) were killed by $CO_2$ exposure and a segment (8-10 mm) of the thoracic trachea from each rat and guinea pig was cut into equal segments and mounted 'in pairs' in a tissue bath. Contractile force was measured with force displacement transducers under 0.5 g loading tension. The dose of histamine (His) and acetylcholine (Ach) which evoked 50% of maximal response ($ED_{50}$) was obtained from cumulative dose response curves for histamine and acetylcholine $(10^{-7}{\sim}10^{-4}M)$. Contractions evoked by His $(ED_{50})$ and Ach $(ED_{50})$ were inhibited significantly by Pyeongpaesan (平肺散). In guinea pig tracheal smooth muscle, the mean percent inhibition of acetylcholine induced contraction was 13.5% (p<0.05) after $10{\mu}l/ml$ Pyeongpaesan (平肺散), $64.6\(p<0.01)\;after\;30{\mu}l/ml$ Pyeongpaesan (平肺散), and $92.8\(p<0.01)\;after\;100{\mu}l/ml$ Pyeongpaesan (平肺散). In rat tracheal smooth muscle, the mean percent inhibition of acetylcholine induced contraction was $60.9\(p<0.01)\;after\;30{\mu}l/ml$ Pyeongpaesan (平肺散), and $91.2\(p<0.01)\;after\;100{\mu}l/ml$ Pyeongpaesan (平肺散). Also, in guinea pig tracheal smooth muscle, the mean percent inhibition of histamine induced contraction was $104.8\(p<0.01)\;after\;30{\mu}l/ml$ Pyeongpaesan (平肺散) and $142.3\(p<0.01)\;after\;100{\mu}l/ml$ Pyeongpaesan (平肺散). In rat tracheal smooth muscle, the mean percent inhibition of histamine induced contraction was $63.7\(p<0.01)\;after\;30{\mu}l/ml$ Pyeongpaesan (平肺散), and $107.5\(p<0.01)\;after\;100{\mu}l/ml$ Pyeongpaesan (平肺散). Propranolol $(10^{-7}M)$ slightly but significantly attenuated the inhibitory effects of Pyeongpaesan (平肺散). Following treatment with propranolol, the mean percent inhibition caused by $100{\mu}l/ml$ Pyeongpaesan (平肺散) fell to 15.7% (p<0.05) in guinea pig induced by acetylcholine contraction and the mean percent inhibition caused by $100{\mu}l/ml$ Pyeongpaesan (平肺散) fell to 22.3% (p<0.05) in guinea pig induced by histamine contraction and by $100{\mu}l/ml$ Pyeongpaesan (平肺散) fell to 28.7% (p<0.01) in rat induced by histamine contraction. Indomethacin and methylene blue $(10^{-7}\;M)$ did not significantly alter the inhibitory effect of Pyeongpaesan (平肺散). Also, I could find the effects of Pyeongpaesan (平肺散) and Pyeongpaesanga (平肺散加) morphine on the tracheal smooth muscle in guinea pig and rat did not change significantly. These results indicate that Pyeongpaesan. (平肺散) can relax histamine and acetylcholine-induced contraction of guinea pig and rat tracheal smooth muscle, and that this inhibition involves sympathetic effects and the release of cyclooxygenase products.

• Journal of Korean Society of Steel Construction
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• v.9 no.3 s.32
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• pp.363-375
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• 1997

This study encompasses the performance of static and fatigue test for the 8 large scale test specimens to clarify the fatigue behavior of coped stringer and the effect of the repair and strengthening on the damaged stringer of the floor system in steel railway bridges. For the purpose of the research, the actual stress wave for the existing bridge was measured, the basic stress range frequency histogram was made and the equivalent stress range was calculated. Using the result from the equivalent stress range made by adjusting the stress range, the static and fatigue test was carried out by identifying the previous rehabilitation and after. As the result of the static tests, it was revealed that the level of local stress under the S1 specimen test of the real equivalent stress range was similar to tensile strength of the test material, and it was consistent with the requirement of the initiation condition of the fatigue crack. Through the various rehabilitation methods to the damaged specimens, the effects of the repair and reinforcement were analyzed. According to the results of the repair of effect, bolting the high tension bolt over the stop hole was confirmed to be more adequate method than drilling only stop hole to delay the fatigue crack growth. Futhermore, in case of the stringer subjected by bending moment, the reinforcement over the upper flange side was determined to be a useful strengthening method, and the reinforcement to the web of the stringer was not appropriate to accomodate as a adequate strengthening method. Also it was confirmed that the category of the fatigue design for the coped stringer met with the category E specified on the fatigue design criteria of the Highway Standard Specification in Korea.