• Journal of The Korea Institute of Healthcare Architecture
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• 제29권1호
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• pp.53-62
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• 2023

Purpose: Recently, the number of severely mentally ill patients has been increasing rapidly in Korea, but there are no design guidelines for spatial planning of Korea's acute psychiatric wards. The study aims to clarify the areas and required rooms in Korea's acute psychiatric wards which are important in establishing the design guidelines for Korea's acute psychiatric wards. Methods: This study proposed a structural framework based on the results of investigating and analyzing the acute psychiatric ward guidelines in the UK, Australia, and the U.S. and the areas and the required rooms of the wards stipulated in the basic data for establishing acute psychiatric ward design guidelines in Korea. The design guidelines for overseas acute psychiatric wards are 'Adult Acute Mental Health' in the UK, 'Adult Acute Mental Health Inpatient Unit' in the Australia, and 'Specific Requirements for Mental Health Hospitals' in the United States. Results: As a result of investigating and analyzing the design guidelines for overseas acute psychiatric wards, the areas of wards applicable to acute wards in domestic psychiatric wards were access, patient, treatment, support, and employee areas. In addition, the required rooms for each area were defined around major considerations such as visibility, convenience, comfort, security, safety, patient observation, barrier-free design, and privacy protection. Implications: The results of the study will be presented as a structural framework and basic data for establishing design guidelines for Korea's acute psychiatric wards, which is still absent.

• BMB Reports
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• 제55권12호
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• pp.615-620
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• 2022

The murine leukemia virus-based semi-retroviral replicating vectors (MuLV-based sRRV) had been developed to improve safety and transgene capacity for cancer gene therapy. However, despite the apparent advantages of the sRRV, improvements in the in vivo transduction efficiency are still required to deliver therapeutic genes efficiently for clinical use. In this study, we established a gibbon ape leukemia virus (GaLV) envelope-pseudotyped semi-replication-competent retrovirus vector system (spRRV) which is composed of two transcomplementing replication-defective retroviral vectors termed MuLV-Gag-Pol and GaLV-Env. We found that the spRRV shows considerable improvement in efficiencies of gene transfer and spreading in both human glioblastoma cells and pre-established human glioblastoma mouse model compared with an sRRV system. When treated with ganciclovir after intratumoral injection of each vector system into pre-established U-87 MG glioblastomas, the group of mice injected with spRRV expressing the herpes simplex virus type 1-thymidine kinase (HSV1-tk) gene showed a survival rate of 100% for more than 150 days, but all control groups of mice (HSV1-tk/PBS-treated and GFP/GCV-treated groups) died within 45 days after tumor injection. In conclusion, these findings sug-gest that intratumoral delivery of the HSV1-tk gene by the spRRV system is worthy of development in clinical trials for the treatment of malignant solid tumors.

• Journal of Korean Port Research
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• 제12권1호
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• pp.55-64
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• 1998

Directed graphic algorithm was applied to an empirical analysis of traffic occupant fatalities based on a model by Crandall. In this paper, Crandall's data on U.S. traffic fatalities for the period 1947-1981 are focused and extended to include 1982-1993. Based on the 1947-1981 annual data, the directed graph algorithms reveal that occupant traffic deaths are directly caused by income, vehicle miles, and safety devices. Vehicle mileage is caused by income and rural driving. The estimation is conducted using three stage least squares regression. Those results show a difference between the traditional regression methodology and causal graphical analysis. It is also found that forecasts from the directed graph based model outperform forecasts from the regression-based models, in terms of mean squared forecasts error. Furthermore, it is demonstrates that there exists some latent variables between all explanatory variables and occupant deaths.

• Korean Journal of Hazardous Materials
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• 제2권1호
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• pp.12-17
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• 2014

With a rapid growth of domestic industry in korea, now about 25,000 kinds of chemicals are being distributed, and it has been known that just about 15% of them has toxic substances. Recently, South Koreans have an anxiety about the stability and accidents of chemicals because chemical accidents like Gumi hydrofluoric acid accident have occurred. The U.S. has adopted the systems like EPCRA (Emergency Planning and Community Right-to-Know Act), TRI (Toxic Release Inventory) and TSCA (Toxic Substances Control Act), and is also managing the hazardous chemicals by providing the information about them to its people and site workers. Japan's Ministry of Health, Labor and Welfare also has adopted J-CHECK system and is implementing it to let Japanese people know the information of safety of chemicals about REACH. However, the Korean government has a difficult situation to mediate the different idea with the Korean industry to make lower statute of Pre-legislation registration & evaluation of chemicals that will be implemented and Chemical Material Control Association that is being implemented. Especially city and country areas located in the industrial areas need political improvement focusing on vulnerable area through the check about current situation of hazardous chemicals of jurisdiction and management method, but the information about the management situation of small scale work places is insufficient. Therefore this study set up the urgent management area in Ansan Smart Hub through NFPA code according to the types of accident and dander characteristics of each chemical being used in the companies that have less than 50 workers and deal with chemicals located in Ansan Smart Hub in Gyeonggi-do.

• Journal of Korean Society of Industrial and Systems Engineering
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• 제46권4호
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• pp.246-262
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• 2023

The purpose of this study is to identify the major peacekeeping activities that the Korean armed forces has performed from the past to the present. To do this, we collected 692 press releases from the National Defense Daily over the past 20 years and performed topic modeling and social network analysis. As a result of topic modeling analysis, 112 major keywords and 8 topics were derived, and as a result of examining the Korean armed forces's peacekeeping activities based on the topics, 6 major activities and 2 related matters were identified. The six major activities were 'Northeast Asian defense cooperation', 'multinational force activities', 'civil operations', 'defense diplomacy', 'ceasefire monitoring group', and 'pro-Korean activities', and 'general troop deployment' related to troop deployment in general. Next, social network analysis was performed to examine the relationship between keywords and major keywords related to topic decision, and the keywords 'overseas', 'dispatch', and 'high level' were derived as key words in the network. This study is meaningful in that it first examined the topic of the Korean armed forces's peacekeeping activities over the past 20 years by applying big data techniques based on the National Defense Daily, an unstructured document. In addition, it is expected that the derived topics can be used as a basis for exploring the direction of development of Korea's peacekeeping activities in the future.

• Proceedings of the Korean Society of Disaster Information Conference
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• 한국재난정보학회 2022년 정기학술대회 논문집
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• pp.361-362
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• 2022

그동안 재난안전 연구개발은 2008년 제1차 재난안전 연구개발 종합계획 수립 이후, 지난 15년간('08~'22년) 21개 부처가 총 10조 7.372억원을 상회하는 R&D 투자성장을 이루어왔다. 연평균으로 보면 매년 25.3%의 성장세다. 과학·기술적 성과로 최근 4년간('18~'21) 연평균 논문 3,030건, 특허 1,745건으로 지난, 제2차 종합계획 기간대비('13~'17) 1.74배 증가를 하며, 양적·질적 성장에도 꾸준히 우상향하는 추세다. 더불어, 최근 4년간('18~'21) 연평균 기술료는 3,729백만원으로 제2차('13~'17) 종합계획 기간 대비 1.54배 증가하였으며, 사회적 성과는 전반적으로 매년 평균치를 유지하고 있다. 한편, 이러한 지속적인 정부투자 R&D 증가에도 불구하고 연구성과 및 실효성에 대해서는 상대적으로 미미하다는 시각이다. 본 연구에서는 행정안전부 출연금 연구개발사업을 대상으로 재난안전 연구개발의 투자현황 및 효과에 대해서 분석하였다. 또한, 연구개발사업 종료과제를 대상으로 한 추적조사 결과를 바탕으로 연구성과의 미흡한 원인을 일차적으로 분석하고, 실효적인 성과창출 전략에 대해 고찰하였다. 특히, 재난안전 연구개발 사업에 대한 지속가능한 성과이음과 사장(死藏)되는 핵심기술에 대한 성과 재발견을 통해 실용화까지 이어질 수 있는 전략적 추진방안에 대해 제언하고자 하였다.

• Journal of Biomedical Engineering Research
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• 제44권6호
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• pp.414-427
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• 2023

Implantable bioabsorbable combination products undergo inherent degradation and systemic absorption within the physiological environment, thereby streamlining the therapeutic regimen and obviating the imperative for invasive extraction procedures. This inherent property not only enhances patient convenience and therapeutic efficacy but also underpins a paradigm of support characterized by heightened safety parameters. Within the regulatory landscapes of Korea, the United States, and Europe, implantable bioabsorbable combination products are meticulously classified into distinct categories, either as pharmaceutical implants or as implantable medical devices, depending on their primary mode of action. This scholarly investigation systematically examines the regulatory frameworks governing implantable bioabsorbable combination products in South Korea, the United States, and Europe. Notable discrepancies across national jurisdictions emerge concerning regulatory specifics, including terminology, product classification, and product name associated with these products. The conspicuous absence of standardized approval regulations presents a formidable barrier to the commercialization of these advanced medical devices. This academic discourse passionately emphasizes the critical need for formulating and implementing a sophisticated regulatory framework capable of streamlining the product approval process, thereby paving the way for a seamless path to commercializing implantable bioabsorbable combination products.

• Animal Bioscience
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• 제37권4_spc호
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• pp.775-785
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• 2024

Pork production is a significant agricultural enterprise in the United States and Canada. The United States is the third-largest global producer of pork and Canada ranks seventh in pork production. The North American Free Trade Agreement and its successor, the U.S.-Mexico-Canada Agreement, have facilitated trade and integration between the two countries. The majority of production systems are modern and intensive, characterized by large vertically integrated farms using advanced technologies. Both nations benefit from their status as major producers of feed grains, with the United States leading in corn and soybeans, while Canada excels in canola and barley production. The regulatory frameworks for food safety, animal welfare, and environmental stewardship differ slightly, with the FDA and USDA overseeing these aspects in the United States, and Health Canada and the Canada Food Inspection Agency in Canada. The United States and Canada also have well-established distribution networks for pork products, relying on both domestic and international markets. Export markets play a crucial role, with the United States being a major importer of Canadian pigs, and both countries exploring opportunities in Asia. Despite a rise in global demand, domestic pork consumption trends differ, with per capita consumption remaining stable in the USA and declining in Canada. Changing consumer preferences, including a demand for ethically raised and locally sourced pork, may influence production practices. Future trends in pig production include a focus on consumer concerns, sustainability, disease prevention, reduction of antimicrobial use, and advancements in technology. The industry is adapting to challenges such as disease outbreaks and changing regulations, with a strong emphasis on animal welfare. Labor and workforce considerations, along with advancements in technology and automation, are expected to shape the efficiency of pork production in the future.

• Journal of Cerebrovascular and Endovascular Neurosurgery
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• 제25권2호
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• pp.175-181
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• 2023

Objective: Endovascular treatment of cerebrovascular diseases is often challenging due to small caliber, tortuous distal vessels. Several devices and techniques have evolved to overcome these challenges. Recently, a low profile dual lumen microballoon catheter, specifically designed for distal navigation is employed for neurovascular procedures. Due to its recent advent, scarce data is available on clinical utility and safety of Scepter Mini. The aim of this case series is to report our initial experience with Scepter Mini in the management of various cerebrovascular diseases. Methods: All interventional neurovascular cases performed using Scepter Mini between January 2020 till April 2021 were included. Data regarding patient demographics, procedural details and complications was retrospectively collected from patient's electronic medical record and procedure reports. Results: Total twelve embolization procedures were performed in eleven patients, including six brain arteriovenous malformation, two dural arteriovenous fistula, one vein of Galen malformation and three hyper-vascular glomus tumor embolizations. All procedures were successfully performed with adequate penetration of the embolic agent. Complete embolization was performed in six procedures, while intended partial embolization was performed in the rest of procedures. Scepter Mini was solely used in ten procedures, however in the other two embolization procedures it was used as an additional conjunct tool to complete the intended embolization. No balloon related complication was observed in any procedure. Conclusions: Scepter Mini dual lumen microballoon catheter is safe and feasible for delivery of liquid embolic agents for cerebrovascular embolization procedures.

• Journal of the Society of Disaster Information
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• 제17권3호
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• pp.442-453
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• 2021

Purpose: The objective of this study is to suggest desirable direction of Korean accident investigation organization by analyzing the operation status and way of overseas developed countries' investigation agency. Method: To accomplish the objective of this study, we were examined four main characteristics of accident investigation agencies of the U.S., Japan, and Sweden, focusing on (1); the background of the establishment, (2);organizational structure, (3);major tasks and functions, (4); accident investigation procedures. Result: First, the purpose of its establishment and task is to prevent recurrence of disasters and accidents, at the same time, administrating and researching duties such as legal system, policy, recommending improvement and conducting scientific disaster-cause analysis to contribute safety for the government. Second, it is operated as an independent organization under the president, not belonging to the ministry, in order to enable fair investigation in an impartial position. Third, it has the authority to be recognized for its expertise in the results of investigation. In other words, it is operated as a permanent organization with professional personnel, and secures authority through the accident research with indepth investigation and high-quality recommendations. Conclusion: The overseas investigation agencies rapidly manage and coordinate their operational practices in order to resolve national requirements and social conflicts with fairness, accuracy and expertise in accident investigations. In order to prevent the recurrence of similar events, Korea needs to efficiently reconstruct its investigative functions distributed by each government department. In addition, institutional improvement is needed to make general adjustments at the national level, organize and operate control tower for when the accident has happened.