• 대한암한의학회지
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• 제14권1호
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• pp.29-35
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• 2009

Approximately 10 percent of advanced stomach cancer patients have internal bleeding in their stomach. It is crucial to treat internal bleeding since it severely deteriorates patient's condition, and disturbs process of chemotherapy. There are hemostatic agents and dressing, radiotherapy, endoscopic ligation and coagulation, surgical methods to treat bleeding. However, these methods cannot be executed in some cases in which patient is in terminal stage or not in desirable condition to take these treatments. We are going to introduce a case of advanced gastric cancer patient having stomach bleeding who made a choice to take oriental medical treatments. The patient was on third stage of stomach cancer, had 3200cc of blood transfusion for five times. After diagnosed as not being able to have resection, he started to oriental medical treatments to stop bleeding. From March 28, 2009 to April 16, 2009, we administer 120cc Bojungikgi-tang gamibang to the patient in 90minutes after each meal. During 19days of having Bojungikgi-tang gamibang, we observed that the patient needed significantly lower amount blood transfusion, to 640cc. The patient improves in performance, and was able to eat more. Despite of short period of observation, this case indicates that Bojungikgi-tang gamibang treatment to the patient could work as hemostat, further improved quality of patient's life.

• 대한암한의학회지
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• 제14권1호
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• pp.13-20
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• 2009

Lung cancer remains the leading cause of cancer-related death throughout the world. Non-small cell lung cancer(NSCLC) is the most deadly form of lung cancer. Patients with non-small cell lung cancer are often found to be unavailable for operation at primary diagnosis. They are typically given conventional chemotherapy. When the tumor progresses during chemotherapy, a change in regimen is considered. The average period of administration differs with the regimen. In this case report, the authors introduce two cases of non-small cell lung cancer patients treated with allergen removed Rhus verniciflua stokes based herbal medicine along with pemetrexed($Alimta^{(R)}$) and erlotinib($Tarceva^{(R)}$). The authors report this case because these molecular-targeted agents were used for longer periods than expected, while improving the performance and other symptoms. Further studies illuminating the synergistic effects through conjunctive treatment with both conventional and Eastern medicine in lung cancer treatment should be performed in the future.

• Journal of Chest Surgery
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• 제49권5호
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• pp.383-386
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• 2016

Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) is an extremely rare, potentially fatal, congenital anomaly with a high mortality rate in the first year of life. It occurs rarely in adulthood and may appear with malignant ventricular arrhythmia or sudden death. We report a case of a 49-year-old woman with ALCAPA who presented with dyspnea on exertion. Management was coronary artery bypass grafting to the left anterior descending artery and obtuse marginal arteries, closure of the left main coronary artery ostium, and reestablishment of the dual coronary artery system.

• 한국해양공학회:학술대회논문집
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• 한국해양공학회 2002년도 춘계학술대회 논문집
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• pp.80-85
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• 2002

The progressive die for U-bending production part is a very specific division. This study reveals the Sheet metal forming process with multi-forming die by Center Carrier type feeding system. Through the FEM simulation by DEFORM it was accepted to u-bending process as the first performance to design in strip process layout design. The next process of die development was studied according to sequence of die development.

• 한국산학기술학회논문지
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• 제11권2호
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• pp.576-583
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• 2010

u-City에는 다양한 정보화 기기들이 존재하며, 정보화 기기 사이를 연결하는 다양한 네트워크 기술이 존재한다. u-City의 핵심 요소인 통합관리센터는 u-City 내의 모든 서비스를 처리하도록 설계되었으며, 도시를 통제하는 중요한 기능을 수행한다. 따라서 사용자의 인증 및 보안을 처리하기 위한 기술이 요구되며 이러한 기술은 통합관리센터에 필수적으로 구현되어야 한다. 본 논문에서는 기존의 인증 기술에 대해 설명하고, u-City 네트워크 환경에 적합한 인증방법과 절차를 제안한다. 제안된 u-City 인증 모델은 u-City에 존재하는 정보화 단말기와 사용자를 인증하여 정당한 사용자에게만 IP를 할당하고, 할당된 사용자에 대해 정책에 따라 차별화된 권한을 부여함으로써, 통합관리센터의 보안에 중요한 역할을 한다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권3호
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• pp.1553-1564
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• 2016

Identification of novel therapeutics in glioblastoma remains crucial due to the devastating and infiltrative capacity of this malignancy. The current study was aimed to appraise effect of arsenic trioxide (ATO) in U87MG cells. The results demonstrated that ATO induced apoptosis and impeded proliferation of U87MG cells in a dose-dependent manner and also inhibited classical NF-${\kappa}B$ signaling pathway. ATO further upregulated expression of Bax as an important proapoptotic target of NF-${\kappa}B$ and also inhibited mRNA expression of survivin, c-Myc and hTERT and suppressed telomerase activity. Moreover, ATO significantly increased adhesion of U87MG cells and also diminished transcription of NF-${\kappa}B$ down-stream targets involved in cell migration and invasion, including cathepsin B, uPA, MMP-2, MMP-9 and MMP-14 and suppressed proteolytic activity of cathepsin B, MMP-2 and MMP-9, demonstrating a possible mechanism of ATO effect on a well-known signaling in glioblastoma dissemination. Taken together, here we suggest that ATO inhibits survival and invasion of U87MG cells possibly through NF-${\kappa}B$-mediated inhibition of survivin and telomerase activity and NF-${\kappa}B$-dependent suppression of cathepsin B, MMP-2 and MMP-9.

• Spatial Information Research
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• 제17권4호
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• pp.417-430
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• 2009

본 연구에서는 유시티의 U-서비스와 도시경쟁력 평가지표의 상호 연관성을 찾고 있다. 연구결과 U-서비스가 빈도에 차이를 보이지만 6개의 도시유형별로 도시경쟁력 강화 수단으로 활용되고 있다. 특히 안전 건강, 활력(경제)도시형에서 적절한 U-서비스 활용은 도시경쟁력 강화에 기여할 수 있는 빈도가 높다. 다음으로 도시경쟁력 평가항목 중 공동항목과 문화도시형에서는 U-서비스가 도시경쟁력 강화에 상대적 기여도가 낮다. 이는 도시의 정책을 평가하는 항목으로 구성되어 있는 공동항목이 도시의 물리적 시설 지능화를 통해 U-서비스를 구현하는 유시티 성격에 부합되지 않는 것이다. 반면 문화도시형과 관련된 U-서비스는 상대적으로 서비스개발이 미약하기 때문이다. 본 연구를 통해 U-서비스는 도시 경쟁력 강화에 활용될 수 있음을 확인할 수 있었다.

• BMB Reports
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• 제47권10호
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• pp.575-580
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• 2014

In this study, we investigate whether arsenite-induced DNA damage leads to p53-dependent premature senescence using human glioblastoma cells with p53-wild type (U87MG-neo) and p53 deficient (U87MG-E6). A dose dependent relationship between arsenite and reduced cell growth is demonstrated, as well as induced ${\gamma}H2AX$ foci formation in both U87MG-neo and U87MG-E6 cells at low concentrations of arsenite. Senescence was induced by arsenite with senescence-associated ${\beta}$-galactosidase staining. Dimethyl- and trimethyl-lysine 9 of histone H3 (H3DMK9 and H3TMK9) foci formation was accompanied by p21 accumulation only in U87MG-neo but not in U87MG-E6 cells. This suggests that arsenite induces premature senescence as a result of DNA damage with heterochromatin forming through a p53/p21 dependent pathway. p21 and p53 siRNA consistently decreased H3TMK9 foci formation in U87M G-neo but not in U87MG-E6 cells after arsenite treatment. Taken together, arsenite reduces cell growth independently of p53 and induces premature senescence via p53/p21-dependent pathway following DNA damage.

• Journal of Genetic Medicine
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• 제14권1호
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• pp.1-7
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• 2017

Purpose: The aim of this study was to assess the diagnostic efficacy of noninvasive prenatal screening for trisomy 18 by assessing the levels of unmethylated-maspin (U-maspin) and fetal nuchal translucency (NT) thickness during the first trimester of pregnancy. Materials and Methods: A nested case-control study was conducted using maternal plasma samples collected from 65 pregnant women carrying 11 fetuses with trisomy 18 and 54 normal fetuses. We compared the U-maspin levels, NT thicknesses, or a combination of both in the first trimester between the case and control groups. Results: U-maspin levels and NT thickness were significantly elevated in the first trimester in pregnant women carrying fetuses with trisomy 18 when compared to those carrying normal fetuses (27.2 vs. 6.6 copies/mL, P<0.001 for U-maspin; 5.9 vs. 2.0 mm, P<0.001 for NT). The sensitivities of the U-maspin levels and NT thickness in prenatal screening for fetal trisomy 18 were 90.9% and 90.9%, respectively, with a specificity of 98.1%. The combined U-maspin levels and NT thickness had a sensitivity of 100% in prenatal screening for fetal trisomy 18, with a specificity of 98.1%. Conclusion: A combination of U-maspin levels and NT thickness is highly efficacious for noninvasive prenatal screening of fetal trisomy 18 in the first trimester of pregnancy.

• Spatial Information Research
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• 제17권1호
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• pp.15-23
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• 2009

u-City의 계획, 건설 및 운영 관리를 지원하기 위한 "유비쿼터스도시의건설등에관한법률(이하 'u-City법'이라고 함)"이 제정 공포되었다(2008.3.28). u-City 통합운영센터(이하 '운영센터'라고 함)는 u-City의 의미와 상징성에 있어서 그 역할이 매우 크며, 그 제도적 정착이 u-City 실현에 가장 중요한 요소라고 하겠다. 운영센터의 설치는 u-City가 일반도시와 구별되는 가장 상징적 의미를 가질 뿐만 아니라, 일반도시가 u-City화 되기 위한 필수 구현요소에 해당한다. 또한 도시내 다양한 시설, 서비스 및 이를 지원하기 위한 관련 정보시스템과 인프라기반 등의 융복합화를 총괄적으로 관할하는 핵심시설로서 그 의미와 중요성이 매우 크다. 이러한 핵심역할과 상징성에도 불구하고 운영센터의 기초 개념정의, 구조 및 운영방안 등 전반적 사항에 대한 재정리와 이를 적극적으로 표준화하여 제도적으로 정착시키는 방안마련이 매우 미진한 것이 현실이다. 본 연구의 목적은 운영센터의 성공적 구현을 위한 법적 기반 조성의 일환으로 이제까지 거론된 운영센터의 제반 현안들을 정의와 위상을 중심으로 정리하고, 성공적 운영센터구현을 향한 제도적 정착방안 마련을 위한 기본방향과 추진전략을 제시하는데 있다.