• Korean Journal of Veterinary Research
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• v.61 no.1
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• pp.10.1-10.11
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• 2021

The purpose of this retrospective study was to provide additional data on the use of toceranib in a wide variety of tumor types in small breed dogs, especially < 8 kg (except 5 dogs). This was a retrospective study of 31 dogs with malignant tumors treated with a 2.5 mg/kg median dose of toceranib (Palladia; Zoetis, USA) on a Monday-Wednesday-Friday schedule. Clinical benefit was observed in 13 of 15 dogs (86.7%, 3 with complete response, 4 with partial response, 6 with stable disease) with gross disease. Distant metastasis, response to treatment, and treatment setting were significantly associated with survival time. Negative prognostic factors were multiple chemotherapy and distant metastasis (affecting progression-free survival [PFS]), surgery, regional enlarged lymph nodes, underlying disease, and toxicity (affecting median survival time [MST]). Positive prognostic factors were epithelial and round cell tumor (affecting PFS), epithelial tumor, microscopic disease, no evidence of disease response, and stable disease (MST). In conclusion, a clinical benefit from toceranib treatment was noted in most of the dogs with gross disease in our study. This study suggested that the toceranib is probably selective treatment to various tumor types in small breed dogs.

• Journal of The Geomorphological Association of Korea
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• v.26 no.1
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• pp.1-14
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• 2019

Large landslide is a type of mass movement that causes drastic landform changesin a short period, and it causes huge human and property damage over a large area. The purpose of this study is to categorize the types and characteristics of large landslides around the Kokomeren River basin, Kyrgyzstan and to discuss the geomorphic development after the large landslides. The topographic analysis about a total of 20 landslides documented collapsed volumes of 0.01 to 1.10 km³, height drops of 180 to 1,770 m, and runout distances of 1,200 to 5,400 m. Rock avalanche and rockslide are identified as major types of large-scale landslides in the study area. Rock avalanches can be divided into P-type, J-type, and S-type based on the features of slope failure and kinematic characteristics of rock debris. Landslide synchronistic landforms such as trimlines, transverse ridges, longitudinal ridges, levees, and hummocks are well developed in the rock avalanche. The pieces of evidence of landslide dam, landslide-dammed lake, and remnant outburst flood deposits are observed in the upstream and downstream where the rockslides occurred. The Ak-Kiol landslide dam is the best example of a geomorphic development due to lake spillover and the large landslides were likely to be triggered by huge paleo-seismic events.

• East Asian Economic Review
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• v.18 no.1
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• pp.29-54
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• 2014

The purpose of this research is to identify the relation between OFDI (Outward Foreign Direct Investment) and wage inequality. In order to analyze various effects of OFDI on wages depending on the types of workers, the research classified laborers into four categories: permanent/skilled worker, permanent/unskilled worker, temporary/skilled worker, and temporary/unskilled worker. With controlling wage-determining factors such as education, labor union, individual fixed-effect, and industry-level effect, this paper examines whether OFDI attributes to the wage inequality among each type of workers. Moreover, this study also analyzes possible effects on wages that could vary according to the different characteristics of investments by classifying OFDI into two groups: OECD and non-OECD. The results reveal that OFDI makes certain differences according to skill-intensity and contract type in terms of influences on wages. It also shows that the effect of OFDI on wages is more subject to contract type than to skill-intensity. The classification of OFDI into OECD and non-OECD proves that effects on wages can vary by characteristics of the subject of investment.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.17 no.4
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• pp.508-519
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• 2010

Purpose: This study was done to identify the types of pain identification made by nurses caring for patients with dementia in nursing homes. Method: To collect the Q-population, 12 nurses working in nursing homes were interviewed. From the collected data, 69 statements were derived and eight patterns of pain identification were categorized. Thirty statements were derived as the Q-sample. Thirty nurses were sampled as the P-sample. The 30 Q-cards with Q-statements were Q-sorted by the P-sample. The results of the Q-sorting were coded and analyzed using the PC QUANL program. Results: Five types of pain identification were identified by nurses for patients with dementia living in nursing homes; Type 1 was named "estimating based on verbal expressions". Type 2 was named "reasoning through physical symptoms". Type 3 was named "confirming pain based on nonverbal expressions being consistent with conditions of physical function". Type 4 was named "empathizing with vocal expressions". Type 5 was named "confirming by comparison with objective pain indicators one by one". Conclusions: The results of this study indicate that comprehensive understanding of pain identification by nurses could help improve the assessment of pain in patients with dementia.

• Journal of the Korean Society of School Health
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• v.20 no.1
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• pp.11-24
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• 2007

Purpose : Health Risk behaviors are a leading cause of preventable morbidity and mortality. Adolescents is a critical transitional period for establishing health behavior for healthy life. The purpose of this study was to describe the types and frequency of the health risk behaviors being performed by middle school students, examine the gender and grade differences of health risk behaviors, and identify the relationship among health risk behaviors. Methods : A total of 1952 early adolescents recruited from 7 middle schools in a district of urban setting completed questionnaires. Youth Risk Behavior Survey-Middle school questionnaires was used to identify the types of health risk behaviors among early adolescents. Data were analyzed by descriptive statistics and Chi-Square test using SAS program . Results : The results showed the frequency for most health risk behaviors and increased with advancing grade level. Males were more likely than females to behaviors related to smoking and violence, whereas females were more likely than males to have suicidal thoughts, be physical inactive and attempt to lose weight. Among health risk behaviors, the relationship of alcohol experience, smoking, and suicide was high. Conclusion : The findings identify a high risk target group among middle school adolescents and suggest that preventive intervention strategies should take into consideration the types with gender and grade, and provided the evidence that one of health risk behaviors may induce the other health risk behaviors.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.42 no.6
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• pp.327-336
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• 2016

Cervical cancer is the second most prevalent cancer among women, and it arises from cells that originate in the cervix uteri. Among several causes of cervical malignancies, infection with some types of human papilloma virus (HPV) is well known to be the greatest cervical cancer risk factor. Over 150 subtypes of HPV have been identified; more than 40 types of HPVs are typically transmitted through sexual contact and infect the anogenital region and oral cavity. The recently introduced vaccine for HPV infection is effective against certain subtypes of HPV that are associated with cervical cancer, genital warts, and some less common cancers, including oropharyngeal cancer. Two HPV vaccines, quadrivalent and bivalent types that use virus-like particles (VLPs), are currently used in the medical commercial market. While the value of HPV vaccination for oral cancer prevention is still controversial, some evidence supports the possibility that HPV vaccination may be effective in reducing the incidence of oral cancer. This paper reviews HPV-related pathogenesis in cancer, covering HPV structure and classification, trends in worldwide applications of HPV vaccines, effectiveness and complications of HPV vaccination, and the relationship of HPV with oral cancer prevalence.

• ALGAE
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• v.19 no.3
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• pp.175-190
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• 2004

The morphological and molecular characteristics of Pachydictyon coriaceum (Holmes) Okamura (1899) are described. Plants are collected from Korea all year round and have maximum height from August to September. The monthly variability of thallus growth is in the way with that of the seawater temperature. Two types of thallus structures, thick cortical layer tallus type and thin cortical cell layer type, are distinguished according to growing seasons. The habit of Korean plants is also classified into two thallus types, slender type and wide type, based on the length and the width of internodes, but this distinction between two types is not supported by either anatomical or molecular characteristics. P. coriaceum shares typical morphology in branching pattern and morphogenetic processes with the other species of Dictyota: 1) multi-cellular cortical and medullar layer in the partial of thallus, 2) same development of thallus from apical meristem cell, and 3) sub-lineage within Dictyota species lineage in rbcL, psaA and psbA gene sequences analyses. These characteristics lead to propose the new combination of Dictyota coriacea (Homes) I.K. Hwang, H.S. Kim et W.J. Lee, comb. nov.

• The Korean Journal of Cytopathology
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• v.18 no.1
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• pp.1-12
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• 2007

Approximately 70% of cervical cancers are caused by HPV types 16/18 and thus the implementation of vaccination programmes with vaccines against HPV types 16/18 will have a major impact on the incidence of cervical cancer worldwide. However, this reduction will not be seen until several decades after full implementation of such vaccination programmes since the vaccines must be given to young adolescents before exposure to the virus and women who are already sexually active are not likely to be protected. Both GSK and Merck insist that even vaccinated women must continue to participate in regular cervical screening by the most sensitive method available since the vaccine can only give protection against up to 70% of cervical cancers. It is unlikely that the current vaccines will be modified to include additional high risk HPV types in the foreseeable future. While HPV testing is highly sensitive, it is not recommended for women under 30 years of age nor for vaccinated women. Additionally, HPV testing has poor specificity. The Digene Hybrid Capture 2 test is licensed for use only in conjunction with a cytology test, not as a stand-alone test, and the high risk panel has recognised cross reactivity with low risk HPV types. None of the other HPV test methods currently commercially available are FDA approved and all must be internally validated before use. This makes comparison of test results between laboratories difficult. The most sensitive and specific screening test currently available for women of all ages is the Cytyc ThinPrep System consisting of the ThinPrep Pap Test (TPPT) and the ThinPrep Imaging System (Imager). The TPPT was the first LBC system approved by the US FDA in 1996 and there are about 4,000 processors in use worldwide. The Imager was FDA approved in 2003 and over 350 systems are in routine use, mainly in the US. 40% of TPPT in the US are processed on Imager. There is clear evidence in peer reviewed literature that the Imager increases laboratory productivity by 100% and growing evidence that Imager detects more high grade SIL than the conventional smear or manual evaluation of TPPT. This aspect is particularly important since the number of cytological abnormalities will decrease as vaccination programmes are implemented. Cytotechnologists will see fewer and fewer abnormal smears and their skills will be put at risk. By doubling throughput, Imager will allow cytotechnologists to maintain their skills.

• Asian-Australasian Journal of Animal Sciences
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• v.31 no.9
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• pp.1525-1534
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• 2018

Objective: The aim of this study was to examine the use of outcome-based observations within Assured Dairy Farm scheme (ADF), Soil Association Organic Standards (SA), and cross compliance (CC) farm assessment reports. Methods: A total of 449 ADF reports, 37 SA reports and 26 CC reports were analyzed and their objective comments categorized as either resource-based or outcome-based. Results: A mean of 61.0% of ADF questions were responded to with comments, in comparison to 25.0% of SA and, 21.0% of CC report questions. The SA and CC reports had significantly more outcome-based comments than the ADF (p<0.001). The assessors' tendency of choosing resource-based approach was revealed in the questionnaire results. Conclusion: Generally, the comments were comprehensive and contained professional judgements. Large numbers of comments provided in the ADF reports were mostly compliant and resource-based evidence, which serves as proof of assessment rather than aiding the certifying process. The inclusion of specific welfare outcome measures in the SA inspection likely increased the use of outcome-based comments in the reports, irrespective of whether the farm achieved compliance with a given standards. The CC scheme, on the other hand, focused on providing outcome-based evidence to justify noncompliant decisions.

• Journal of Ginseng Research
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• v.39 no.4
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• pp.299-303
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• 2015

Panax ginseng is a well-known economic medical plant that is widely used in Chinese traditional medicine. This species contains a unique class of natural products-ginsenosides. Recent clinical and experimental studies have presented numerous lines of evidence on the promising role of ginsenosides on different diseases including neurodegenerative diseases, cardiovascular diseases, and certain types of cancer. Nowadays, most of the attention has focused on ginsenoside Rd as a neuroprotective agent to attenuate ischemic stroke damages. Some of the evidence showed that ginsenoside Rd ameliorates ischemic stroke-induced damages through the suppression of oxidative stress and inflammation. Ginsenoside Rd can prolong neural cells' survival through the upregulation of the endogenous antioxidant system, phosphoinositide-3-kinase/AKT and extracellular signal-regulated protein kinase 1/2 pathways, preservation of mitochondrial membrane potential, suppression of the nuclear factor-kappa B, transient receptor potential melastatin, acid sensing ion channels 1a, poly(ADP-ribose) polymerase-1, protein tyrosine kinase activation, as well as reduction of cytochrome c-releasing and apoptosis-inducing factor. In the current work, we review the available reports on the promising role of ginsenoside Rd on ischemic stroke. We also discuss its chemistry, source, and the molecular mechanism underlying this effect.