• Archives of Pharmacal Research
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• v.18 no.5
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• pp.301-307
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• 1995

In the particulate fraction obtained from PKC-down regulated K562 cells by treatment for 24 h with 200nM TPA, phosphorylation of two proteins with molecular weight, 100 kDa and 23 kDa (designated p100 and p23, respectvely) was depleted and addition of exogenous purified PKC to this fraction failed to testore their phosphorylation. However, in the soluble fraction, all of phosphoproteins abolished by long-term treatment with TPA were restored by exogenously added PKC. Phosphorylation of two proteins was increased by short-term tretment (20 min), and diminished with the persistant exposure to TPA as well as at a concentration as low as 1nM. When K562 cells were treated with 1 nM and 200 nM TPA for 24 h, phosphorylation of p100 was restored with or without exogenous PKC on 2-3day and 6day after removal of treated TPA, respectively. Two-dimensional electrophoresis of phosphoproteins revealed that phosphorylated p100 (pl=5.9) and p66 species were completely absent from the particulate fraction of K562 cells treated with 200nM TPA for 24 h. These results suggest that the interaction of sensitive endogenous substrates, p100 and p23 with the plasma membrane might be regulated by PKC-down regulation without displacement to the cytosol and the interaction of p100 with the membrane might be reveersible.

• Proceedings of the Korea Water Resources Association Conference
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• 2016.05a
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• pp.386-390
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• 2016

Water aeration is an effective water treatment process, which involves the injection of air or air-water mixture into water treatment reservoir commonly through pipes. The main purpose of water aeration is to maintain healthy levels of dissolved oxygen (DO), which is the most important water quality factor. The pipes' operating conditions are important for controlling the efficiency and effectiveness of aeration process. Many studies have been conducted on two-phase flows in pipes, however, there are a few studies to deal with small s ale in millimeter. The main objective of this study is to perform 2-dimensional two-phase simulations inside various straight pipes using the computational fluid dynamic (CFD) OpenFOAM (Open source Field Operation And Manipulation) tools to examine the influence of flow patterns on bubble size, which is closely related to DO concentration in a water body. The both flow regimes, laminar and turbulence, have been considered in this study. For turbulence, Reynolds-averaged Navier-Stokes (RANS) has been applied. The coalescence and breakage of bubbles caused by random collisions and turbulent eddies, respectively, are considered in this research. Sauter mean bubble diameter and water velocity are compared against experimental data. The simulation results are in good agreement with the experimental measurements.

• Transactions of the Korean Society of Mechanical Engineers
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• v.9 no.5
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• pp.555-563
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• 1985

Two-dimensional turbulent wake flow behind a circular cylinder is investigated experimentally by suing linearized constant temperature hot wire anemometer. Turbulent fluctuations and mean velocity defects are measured in the rage of 5 dia.- 500 dia. downstream from the cylinder and for the Reynolds numbers of 2000-4000. Results with statistical treatment and digital data processing techniques are as follows: (1) The transition region from near wake to far wake is 30 dia. - 50 dia. downstream from the cylinder. (2) In the near wake, it is found that strong periodic ( f=845Hz) coherent structure exists. (3) It shows that the inertial subrange is 180Hz-2000Hz in self preservation region.

• Journal of Chest Surgery
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• v.19 no.3
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• pp.506-514
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• 1986

Coarctation of aorta is rather common congenital cardiovascular defect in the western countries, but it is known to be rare in Korea. And no coarctation of Aorta has been reported and operated upon during early infancy in Korea. During 4 months period from May 1984 to September 1984, four small infants of coarctation of aorta were seen and treated surgically by subclavian flap aortoplasty in Guro Hospital, Korea University. All infants were male, ranging from 7 days to 54 days old [mean 29 days], weighing between 3.2 Kg and 5.0 Kg [mean 4.1 Kg], and all were in congestive heart failure. Examination of the femoral artery pulse gave in all cases clues to the diagnosis. By Two dimensional echocardiogram, detail anatomical features as well as the diagnosis were revealed and associated anomalies, for example, ventricular septal defect could be seen. Besides one case of isolated coarctation of aorta, other three infants had associated VSD. The 3 patients with VSD were treated by pulmonary artery banding in addition to aortoplasty. The postoperative course were smooth in all patients. In conclusion, coarctation of aorta may not be so rare in Korea as we thought previously. The importance of femoral pulse examination can not be overemphasized for the diagnosis. As we experienced, two-dimensional echocardiography in most cases can substitute those invasive examinations such as angiography and catheterization which carry difficulty and risk in infants.

• Bulletin of the Korean Chemical Society
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• v.35 no.4
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• pp.1067-1072
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• 2014

In this study, we report a new approach for $Mn_3O_4$-graphene nanocomposite by ex situ method. This nanocomposite shows two-dimensional aggregation of nanoparticle, and doping effect by decorated manganese oxide ($Mn_3O_4$), as well. The graphene film was made through micromechanical cleavage of graphite on the $SiO_2/Si$ wafer. Manganese oxide ($Mn_3O_4$) nanoparticle with uniform cubic shape and size (about $5.47{\pm}0.61$ nm sized) was synthesized through the thermal decomposition of manganese(II) acetate, in the presence of oleic acid and oleylamine. The nanocomposite was obtained by self-assembly of nanoparticles on graphene film, using hydrophobic interaction. After heat treatment, the decorated nanoparticles have island structure, with one-layer thickness by two-dimensional aggregations of particles, to minimize the surface potential of each particle. The doping effect of $Mn_3O_4$ nanoparticle was investigated with Raman spectra. Given the upshift in positions of G and 2D in raman peaks, we suggest that $Mn_3O_4$ nanoparticles induce p-doping of graphene film.

• Journal of Korea Water Resources Association
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• v.35 no.3
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• pp.261-274
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• 2002

The purpose of this study was to develop two dimensional contaminant transport numerical model by finite element method. The developed model system was tested for water quality analysis when contaminants from tributaries and sewage treatment Plants flow into the main river. In this study, the model was to perform calibration for reasonable parameter production and verification for reliability and accuracy. And, the proposed model was applied on the downstream of Han river using calibrated parameters. These results represented real con taminant distribution profile along the channel, and produced the good agreement in comparing calculated vague with measured value.

• International Journal of Fluid Machinery and Systems
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• v.3 no.4
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• pp.379-385
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• 2010

We developed a high-efficiency, wide-operating-range centrifugal blower stage to meet the demand for reduced total energy-consumption in sewage treatment plants. We improved the efficiency of the two-dimensional impeller using a shape optimization tool and one-dimensional performance prediction tool. A limit of the throat deceleration ratio was set to maintain the stall-margin of the impeller. The low solidity vaned diffuser and return channel were designed using a sensitivity analysis with orthogonal arrays and three-dimensional steady flow simulations. The low solidity diffuser was designed in order to improve the performance in the low-flow-rate region. The return channel was designed so that the total pressure loss in the return channel was minimized. Model tests of both the conventional and optimized blower stages were carried out, and the efficiency and operating range of both stages were compared. The optimized blower stage improved in stage efficiency by 3% and in operating range by 5% compared with the conventional blower stage.

• Proceedings of the Korean Society of Machine Tool Engineers Conference
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• 1998.03a
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• pp.154-160
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• 1998

This study describes a theoretical and experimental investigation of gas wave propagation in the pipe system. Most calculations of compressible flows in the pipe have been based on the method of characteristics. This technique has propensity to truncate waves and is difficult to apply to non-perfect gas. A method that describes the application of a two-step Lax-Wendroff acheme to solution of the unsteady one-dimentional flow in the pipe was developed. Theoretical calculations using both the method of characteristics and the two-step Lax-Wendroff method are presented including a realistic model for heat transfer and friction processes. In the present work, account is taken of the nonlinear behavior. For sections of parallel pipe, an one dimensional unsteady homentropic analysis is employed, and a numerical solution is obtained with the aid of a digital computer, using the method of characteristics and two-step Lax-Wendroff method. This analysis is then combined with boundary models, based on a quasi-steady flow approach, to give a complete treatment of the flow behavior in the pipe system.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.6
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• pp.4098-4107
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• 2015

The purpose of this study was to investigate the effects of 8-week schroth 3-dimensional exercise and ball-sling complex exercise treatment on cobb's angle, abdominal muscle endurance, flexibility and balance in adolescents with idiopathic scoliosis. Thirty subjects with scoliosis were random assignment into one of two experimental groups, either schroth treatment(n=15) or ball-sling complex exercise treatment(n=15). Exercise program was to perform for 8-week and 90min and 3 times per week. The results of this study were as follows; First, cobb's angle was significantly decreased after 8-weeks in schroth treatment(p<.001). And also abdominal muscle endurance(p<.05), flexibility(p<.001) and balance(p<.001) were significantly improve in pre vs. post treatment. Second, the ratio of cobb's angle change was significantly higher in schroth treatment compared to ball-sling complex exercise treatment following 8-weeks(p<.05). These results suggest that although both the schroth treatment and bal-sling complex exercise treatment in adolescents with idiopathic scoliosis can improve on cobb's angle, abdominal muscle endurance, flexibility and balance, but schroth treatment was better than ball-sling complex exercise treatment improving effect of cobb's angle. Therefore, we consider that schroth treatment has more effect of prevention and therapy in idiopathic scoliosis in adolescents.

• Korean Institute of Interior Design Journal
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• v.14 no.5 s.52
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• pp.185-192
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• 2005

The purpose of this study was to clarify spatial composition of the staffs at nursing homes for the elderly with dementia. For this, the data was taken from the staffs in 2 nursing homes in Tokyo by the questionnaire from December4 to 28 in 2004. Replicated MDS (Multi-dimensional Scaling) was employed for data analysis. The results of the study were following. Staffs perceived nursing home by four spatial compositions; facility spaces as like sanitation room, laundry, bathroom, washroom, washbowl, social interaction spaces as like training room, inner court/balcony, living room, staff related spaces as like room for staff, treatment room, fundamental living spaces as like bedroom, dining room. According to two-dimensional perceptual map, sanitation room was wanted near by laundry, treatment room was wanted near by room for staff, bedroom was wanted near by dining room, and training room, living room were wanted near by inner court/balcony. On the other hand, washbowl and washroom were desired somewhere near by every spaces. Therefore, simple shaped washbowls are desired to install in dining room, living room, hallways. And sanitation room and laundry were desired somewhere remote by dining room, bedroom, and living room. Responding upper results, it is recommended planning for visual and sense of smell isolation in case of having difficulty in floor structure and circulation.