• Childhood Kidney Diseases
• /
• v.28 no.1
• /
• pp.8-15
• /
• 2024

With the rapid evolution of diagnostic tools, particularly next-generation sequencing, the identification of genetic diseases, predominantly those with pediatric-onset, has significantly advanced. However, this progress presents challenges that span from selecting appropriate tests to the final interpretation of results. This review examines various genetic testing methodologies, each with specific indications and characteristics, emphasizing the importance of selecting the appropriate genetic test in clinical practice, taking into account factors like detection range, cost, turnaround time, and specificity of the clinical diagnosis. Interpretation of variants has become more challenging, often requiring further validation and significant resource allocation. Laboratories primarily classify variants based on the American College of Medical Genetics and Genomics and the Association for Clinical Genomic Science guidelines, however, this process has limitations. This review underscores the critical role of clinicians in matching patient phenotypes with reported genes/variants and considering additional factors such as variable expressivity, disease pleiotropy, and incomplete penetrance. These considerations should be aligned with specific gene-disease characteristics and segregation results based on an extended pedigree. In conclusion, this review aims to enhance understanding of the complexities of clinical genetic testing, advocating for a multidisciplinary approach to ensure accurate diagnosis and effective management of rare genetic diseases.

• Korean Chemical Engineering Research
• /
• v.54 no.3
• /
• pp.340-349
• /
• 2016

Electro oxidation system was designed in this study for the reduction of COD (Chemical Oxygen Demand) from high-strength wastewater, produced during refinery turnaround period. First, BDD (Boron Doped Diamond) electrode was synthesized and electro oxidation system of actual industrial wastewater was developed by adopting the synthesized BDD electrode. The experiments were carried out under various operating conditions under certain range of current density, pH, electrolyte concentration and reaction time. Secondly, reaction kinetics were identified based on the experimental results, and the kinetics were embedded into a genetic mathematical model of the electro oxidation system. Lastly, design and operating parameters of the process were optimized to maximize the efficiency of the pretreatment system. The coefficient of determination ($R^2$) of the model was found to be 0.982, and it proved high accuracy of the model compared with experimental results.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
• /
• 2003.05a
• /
• pp.226-230
• /
• 2003

In this thesis I analyzed that V5.2 protocol function is effective to fulfill all of the services that are provided at the existing local exchange. I analyzed this in five methods that refer to ETSI inside patronage. I experimented turnaround time by Start-up method and verified V5.2 protocol function when Start-up. Also I confirmed stability of system by the reconstruction-ability experiment related E1 switch over. I verified V5.2 protocol function through PSTN call process that uses a special service test and local call simulator. As a result of experiment, I confirmed the best method when simultaneous Start-up. V5.2 protocol function was excellent and It becomes switch over at 1/1000 seconds when E1 is out of service. V5.2 protocol function was effective to fulfill all of the special services that are provided at local exchange and its long call process ability was superior to KT standard with 4 fails in 20000 calls. Through the experiment, it was proved that V5.2 interface will become a significant element of communication network when after LE side expanse of v5 interface ID with TDX-100 exchanger and the AN occurrences OOS by message transmission limit and call disconnect when E1 switch over are improved.

• Journal of the Korean Magnetics Society
• /
• v.15 no.2
• /
• pp.61-66
• /
• 2005

In order to make submicron cell for spin-injection device, lift-off method using Pt stencil and wet etching was chosen. This approach allows batch fabrication of stencil substrate with electron-beam lithography. It simplifies the process between magnetic film stack deposition and final device testing, thus enabling rapid turnaround in sample fabrication. Submicron junctions with size of $200nm{\times}300nm$ and $500nm{\times}500nm$ 500 nm and pseudo spin valve structure of $CoFe(30{\AA})/Cu(100{\AA})/CoFe(120{\AA}$) was deposited into the nanojunctions. MR ratio was 0.8 and $1.1{\%}$, respectively and spin transfer effect was confirmed with critical current of $7.65{\times}10^7A/cm^2$.

• Journal of Korea Society of Industrial Information Systems
• /
• v.29 no.1
• /
• pp.63-76
• /
• 2024

In this study, we analyzed queue length and sojourn time of discrete-time BMAP/G/1 queues under the workload control. Group customers (packets) with correlations arrive at the system following a discrete-time Markovian arrival process. The server starts busy period when the total service time of the arrived customers exceeds a predetermined workload threshold D and serves customers until the system is empty. From the analysis of workload and waiting time, distributions of queue length at the departure epoch and arbitrary time epoch and system sojourn time are derived. We also derived the mean value as a performance measure. Through numerical examples, we confirmed that we can obtain results represented by complex forms of equations, and we verified the validity of the theoretical values by comparing them with simulation results. From the results, we can obtain key performance measures of complex systems that operate similarly in various industrial fields and to analyze various optimization problems.

• Journal of computational fluids engineering
• /
• v.20 no.2
• /
• pp.7-15
• /
• 2015

This paper attempts to evaluate the accuracy and efficiency of a design optimization procedure by combining wavelets-based multi resolution analysis method and proper orthogonal decomposition (POD) technique. Aerodynamic design procedure calls for high fidelity computational fluid dynamic (CFD) simulations and the consideration of large number of flow conditions and design constraints. Thus, even with significant computing power advancement, current level of integrated design process requires substantial computing time and resources. POD reduces the degree of freedom of full system by conducting singular value decomposition for various field simulations. In this research, POD combined Design Optimization model is proposed and its efficiency and accuracy are to be evaluated. For additional efficiency improvement of the procedure, multi resolution analysis method is also being employed during snapshot constructions (POD training period). The proposed design procedure was applied to the optimization of wing aerodynamic performance. Throughout the research, it was confirmed that the POD/MRA design procedure could significantly reduce the total design turnaround time and also capture all detailed complex flow features as in full order analysis.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
• /
• 2023.05a
• /
• pp.61-62
• /
• 2023

There have been cases where the number of port workers has temporarily decreased due to COVID-19. To prevent the spread of COVID-19, a number of workers were quarantined, resulting in bottlenecks and waiting throughout the port operation process, increasing the congestion of terminals. As a result, problems such as a decrease in terminal operation efficiency occurred. However, it is understood that congestion centered on unloading equipment inside the terminal is not clearly calculated. Terminal congestion is thought to be a key factor directly related to the operational efficiency of the terminal. The congestion calculation method generally used in various fields measures congestion based on image-based data. Due to the nature of the loading and unloading equipment that moves according to the quantitative loading plan, it is unreasonable to apply the existing congestion calculation method. Therefore, this study presented a method of calculating terminal congestion using equipment waiting time and turnaround time, and verified the statistical significance of the congestion calculated using data from Terminal A of Busan Port.

• Proceedings of the Korean Society of Near Infrared Spectroscopy Conference
• /
• 2001.06a
• /
• pp.1523-1523
• /
• 2001

The wine industry requires practical methods for objectively measuring the composition of both red wine grapes on the vine to determine optimal harvest time; and of freshly harvested grapes for efficient allocation to vinery process streams for particular red wine products, and to determine payment of contract grapegrowers. To be practical for industry application these methods must be rapid, inexpensive and accurate. In most cases this restricts the analyses available to measurement of TSS (total soluble solids, predominantly sugars) by refractometry and pH by electropotentiometry. These two parameters, however, do not provide a comprehensive compositional characterization for the purpose of winemaking. The concentration of anthocyanin pigment in red wine grapes is an accepted indicator of potential wine quality and price. However, routine analysis for total anthocyanins is not considered as a practical option by the wider wine industry because of the high cost and slow turnaround time of this multi-step wet chemical laboratory analysis. Recent work by this ${group}^{l,2}$ has established the capability of near infrared (NIR) spectroscopy to provide rapid, accurate and simultaneous measurement of total anthocyanins, TSS and pH in red wine grapes. The analyses may be carried out equally well using either research grade scanning spectrometers or much simpler reduced spectral range portable diode-array based instrumentation. We have recently expanded on this work by collecting thousands of red wine grape samples in Australia. The sample set spans two vintages (1999 and 2000), five distinct geographical winegrowing regions and three main red wine grape varieties used in Australia (Cabernet Sauvignon, Shiraz and Merlot). Homogenized grape samples were scanned in diffuse reflectance mode on a FOSE NIR Systems6500 spectrometer and subject to laboratory analysis by the traditional methods for total anthocyanins, TSS and pH. We report here an analysis of the correlations between the NIR spectra and the laboratory data using standard chemometric algorithms within The Unscrambler software package. In particular, various subsets of the total data set are considered in turn to elucidate the effects of vintage, geographical area and grape variety on the measurement of grape composition by NIR spectroscopy. The relative ability of discrete calibrations to predict within and across these differences is considered. The results are then used to propose an optimal calibration strategy for red wine grape analysis.

• The Journal of the Korea institute of electronic communication sciences
• /
• v.6 no.4
• /
• pp.533-537
• /
• 2011

The revision of the criminal procedure act in 2008 marked a great turnaround in the criminal trial system in our country, and the criminal trial system has been based on the trial priority principle from then on. People in general have been entitled to participate in criminal trials, which can be called the jury system, and their awareness of the law has consequently been taken to another level. And the principle of trial by evidence that requires fair process, explanation and scientific evidence is realized in a manner to be appropriate at people(jury)'s level. The prosecution was introduced a video recording system to ensure the efficiency of scientific criminal investigation and assisted every prosecutor's office across the nation to hire computer-added stenographers to back up the documentation of statements during video recording. The purpose of this study was to examine the Korean and foreign computer-added stenography systems and the prospect of computer-added stenography of the video recording system that has been utilized to make a scientific investigation. The effort by this study to look into the roles and prospect of computer-added stenography in the video recording system that has been introduced to improve the efficiency of scientific investigation, which the prosecution pursues, is expected to expedite the advancement of criminal investigation, to guarantee the protection of human rights and to shed new light on the importance and status of computer-added stenography in the trial priority principle.

• Journal of KIISE:Computing Practices and Letters
• /
• v.14 no.7
• /
• pp.625-635
• /
• 2008

Portable multimedia players have some different properties compared to general multimedia file server. Some of those properties are single user ownership, relatively low hardware performance, I/O burst by user special functions, and short software development cycles. Though suitable for processing multiple user requests at a time, the general multimedia file systems are not efficient for special user functions such as fast forwards/backwards. Soml' methods has been proposed to improve the performance and functionality, which the application programs give prediction hints to the file system. Unfortunately, they require the modification of all applications and recompilation. In this paper, we present a file system that efficiently supports user special functions in embedded multimedia systems using file block allocation, buffer-cache, and prefetch. A prefetch algorithm, SPRA (SPeed-based PRefetch Algorithm) predicts the next block using I/O patterns instead of hints from applications and it is resident in the file system, so doesn't affect application development process. From the experimental file system implementation and comparison with Linux readahead-based algorithms, the proposed system shows $4.29%{\sim}52.63%$ turnaround time and 1.01 to 3,09 times throughput in average.