• Parasites, Hosts and Diseases
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• v.60 no.4
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• pp.295-299
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• 2022

Malaria elimination and control require prompt and accurate diagnosis for treatment plan. Since microscopy and rapid diagnostic test (RDT) are not sensitive particularly for diagnosing low parasitemia, highly sensitive diagnostic tools are required for accurate treatment. Molecular diagnosis of malaria is commonly carried out by nested polymerase chain reaction (PCR) targeting 18S rRNA gene, while this technique involves long turnaround time and multiple steps leading to false positive results. To overcome these drawbacks, we compared highly sensitive cytochrome oxidase gene-based single-step multiplex reaction with 18S rRNA nested PCR. Cytochrome oxidase (cox) genes of P. falciparum (cox-III) and P. vivax (cox-I) were compared with 18S rRNA gene nested PCR and microscopy. Cox gene multiplex PCR was found to be highly specific and sensitive, enhancing the detection limit of mixed infections. Cox gene multiplex PCR showed a sensitivity of 100% and a specificity of 97%. This approach can be used as an alternative diagnostic method as it offers higher diagnostic performance and is amenable to high throughput scaling up for a larger sample size at low cost.

• Korean Journal of Radiology
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• v.24 no.8
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• pp.752-760
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• 2023

Radiologists and trauma surgeons should monitor for early killers among patients with thoracic trauma, such as tension pneumothorax, tracheobronchial injuries, flail chest, aortic injury, mediastinal hematomas, and severe pulmonary parenchymal injury. With the advent of cutting-edge technology, rapid volumetric computed tomography of the chest has become the most definitive diagnostic tool for establishing or excluding thoracic trauma. With the notion of "time is life" at emergency settings, radiologists must find ways to shorten the turnaround time of reports. One way to interpret chest findings is to use a systemic approach, as advocated in this study. Our interpretation of chest findings for thoracic trauma follows the acronym "ABC-Please" in which "A" stands for abnormal air, "B" stands for abnormal bones, "C" stands for abnormal cardiovascular system, and "P" in "Please" stands for abnormal pulmonary parenchyma and vessels. In the future, utilizing an artificial intelligence software can be an alternative, which can highlight significant findings as "warm zones" on the heatmap and can re-prioritize important examinations at the top of the reading list for radiologists to expedite the final reports.

• Childhood Kidney Diseases
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• v.28 no.1
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• pp.8-15
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• 2024

With the rapid evolution of diagnostic tools, particularly next-generation sequencing, the identification of genetic diseases, predominantly those with pediatric-onset, has significantly advanced. However, this progress presents challenges that span from selecting appropriate tests to the final interpretation of results. This review examines various genetic testing methodologies, each with specific indications and characteristics, emphasizing the importance of selecting the appropriate genetic test in clinical practice, taking into account factors like detection range, cost, turnaround time, and specificity of the clinical diagnosis. Interpretation of variants has become more challenging, often requiring further validation and significant resource allocation. Laboratories primarily classify variants based on the American College of Medical Genetics and Genomics and the Association for Clinical Genomic Science guidelines, however, this process has limitations. This review underscores the critical role of clinicians in matching patient phenotypes with reported genes/variants and considering additional factors such as variable expressivity, disease pleiotropy, and incomplete penetrance. These considerations should be aligned with specific gene-disease characteristics and segregation results based on an extended pedigree. In conclusion, this review aims to enhance understanding of the complexities of clinical genetic testing, advocating for a multidisciplinary approach to ensure accurate diagnosis and effective management of rare genetic diseases.

• Nuclear Engineering and Technology
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• v.18 no.3
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• pp.175-182
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• 1986

The KNUI (Korea Nuclear Unit 1) loss of offsite power transient as a design-base accident has been simulated using the RELAP5/MOD1/NSC computer code. The analysis is carried out using the best-estimate methodology, but the sequence and its assumptions are based on the evaluation methodology th at emphasizes conservatism. Important thermal-hydraulic parameters such as average temperature, steam generator level and pressurizer water volume are compared with the results in the KNU1 Final Safety Analysis Report (FSAR). The present analysis gives much lower RCS average temperature and pressurizer water volume, and much higher S/G water volume at the turnaround point, which may be considered to be additional improved safety margins. This is expected since the present analysis deals with the best-estimate thermal-hydraulic models as well as the initial conditions on a best-estimate basis. These additional safety margins may contribute to further validate the safety of the KNU1 in this type of accidents(Decrease in Heat Removal by the Secondary System).

• Journal of computational fluids engineering
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• v.20 no.2
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• pp.7-15
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• 2015

This paper attempts to evaluate the accuracy and efficiency of a design optimization procedure by combining wavelets-based multi resolution analysis method and proper orthogonal decomposition (POD) technique. Aerodynamic design procedure calls for high fidelity computational fluid dynamic (CFD) simulations and the consideration of large number of flow conditions and design constraints. Thus, even with significant computing power advancement, current level of integrated design process requires substantial computing time and resources. POD reduces the degree of freedom of full system by conducting singular value decomposition for various field simulations. In this research, POD combined Design Optimization model is proposed and its efficiency and accuracy are to be evaluated. For additional efficiency improvement of the procedure, multi resolution analysis method is also being employed during snapshot constructions (POD training period). The proposed design procedure was applied to the optimization of wing aerodynamic performance. Throughout the research, it was confirmed that the POD/MRA design procedure could significantly reduce the total design turnaround time and also capture all detailed complex flow features as in full order analysis.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.4
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• pp.2443-2449
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• 2014

The recent increase in the number of network RTK users has led to a longer wait time for connecting to the existing VRS service, and consequently caused inconvenience such as a longer turnaround time for surveys. To resolve such issue, the NGII has developed the FKP service that involves a one-way communication. However, it is not spreading across the market as fast as anticipated, due to accuracy problems in the field. This study uses eight unified control points for a reliability assessment to compare and analyze the survey results obtained through the VRS and FKP services in various ways. The analysis reveals that the standard deviation of the FKP service is ${\pm}0.02m$, which is two times larger than that of the VRS, whilst its standard errors are X:-0.025m and Y:0.011m, proving that it is reliable to be used in the field. Therefore, we expect that the FKP service is going to be more broadly utilized for field surveys in the future.

• The Journal of Korean Association of Computer Education
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• v.11 no.1
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• pp.97-107
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• 2008

The result verification that determines correctness for the work results calculated in each PC is one of the most important issues in PC grid environments. In this literature, voting-based and trust-based schemes have been mainly used to guarantee the correctness of work results. However, these schemes suffer from both waste of resource utilization and high computation delay because they can not effectively cope with dynamic computational environments. To overcome these shortcomings, we introduce the distribution information of PC resources based on credibility and availability into result verification phase. Using this information, we propose a new result verification scheme, which can determine the correctness of work results by each PC resources' credibility and cope with the dynamic changing environments by each PC resources' availability. To demonstrate the efficiency of our result verification scheme, we evaluate the performance of our scheme from the viewpoints of turnaround time and resource utilization, utilizing resource distribution information in the Korea@Home that is a representative PC grid system in domestic. We also compare the performance of our scheme with that of other ones.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2003.05a
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• pp.226-230
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• 2003

In this thesis I analyzed that V5.2 protocol function is effective to fulfill all of the services that are provided at the existing local exchange. I analyzed this in five methods that refer to ETSI inside patronage. I experimented turnaround time by Start-up method and verified V5.2 protocol function when Start-up. Also I confirmed stability of system by the reconstruction-ability experiment related E1 switch over. I verified V5.2 protocol function through PSTN call process that uses a special service test and local call simulator. As a result of experiment, I confirmed the best method when simultaneous Start-up. V5.2 protocol function was excellent and It becomes switch over at 1/1000 seconds when E1 is out of service. V5.2 protocol function was effective to fulfill all of the special services that are provided at local exchange and its long call process ability was superior to KT standard with 4 fails in 20000 calls. Through the experiment, it was proved that V5.2 interface will become a significant element of communication network when after LE side expanse of v5 interface ID with TDX-100 exchanger and the AN occurrences OOS by message transmission limit and call disconnect when E1 switch over are improved.

• Clinical and Experimental Pediatrics
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• v.56 no.6
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• pp.235-241
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• 2013

Repair of tetralogy of Fallot (TOF) has shown excellent outcomes. However it leaves varying degrees of residual hemodynamic impairment, with severe pulmonary stenosis (PS) and free pulmonary regurgitation (PR) at both ends of the spectrum. Since the 1980s, studies evaluating late outcomes after TOF repair revealed the adverse impacts of residual chronic PR on RV volume and function; thus, a turnaround of operational strategies has occurred from aggressive RV outflow tract (RVOT) reconstruction for complete relief of RVOT obstruction to conservative RVOT reconstruction for limiting PR. This transformation has raised the question of how much residual PS after conservative RVOT reconstruction is acceptable. Besides, as pulmonary valve replacement (PVR) increases in patients with RV deterioration from residual PR, there is concern regarding when it should be performed. Regarding residual PS, several studies revealed that PS in addition to PR was associated with less PR and a small RV volume. This suggests that PS combined with PR makes RV diastolic property to protect against dilatation through RV hypertrophy and supports conservative RVOT enlargement despite residual PS. Also, several studies have revealed the pre-PVR threshold of RV parameters for the normalization of RV volume and function after PVR, and based on these results, the indications for PVR have been revised. Although there is no established strategy, better understanding of RV mechanics, development of new surgical and interventional techniques, and evidence for the effect of PVR on RV reverse remodeling and its late outcome will aid us to optimize the management of TOF.

• Journal of KIISE:Computing Practices and Letters
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• v.16 no.5
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• pp.513-518
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• 2010

The advancement of information technology along with the proliferation of communication and multimedia has increased the demand of digital contents. Video data of digital contents such as VOD, NOD, Digital Library, IPTV, and UCC are getting more permeated in various application fields. Video data have sequential characteristic besides providing the spatial and temporal information in its 3D format, making searching or browsing ineffective due to long turnaround time. In this paper, we suggest ATVC(Authoring Tool for Video Contents) for solving this issue. ATVC is a video editing tool that detects key frames using visual rhythm and insert metadata such as keywords into key frames via XML tagging. Visual rhythm is applied to map 3D spatial and temporal information to 2D information. Its processing speed is fast because it can get pixel information without IDCT, and it can classify edit-effects such as cut, wipe, and dissolve. Since XML data save key frame information via XML tag and keyword information, it can furnish efficient browsing.