• 대한의생명과학회지
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• 제17권1호
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• pp.79-84
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• 2011

Photodynamic therapy consists of a photosensitizer, suitable light source and oxygen. The excitation of the photosensitizer at a cancer mass results in oxidation which would ultimately reduce the mass via apoptosis. Millimeter wave (MMW) therapy has also been known to be effective on cancer cell mass reduction, human cell regeneration and immunity enhancement among the Russian clinicians and scientists. In the present study, the two modalities were combined to achieve synergistic effects while reducing the administration dosage of the photosensitizer, photogem, thus minimizing the side effects. The CT-26 adenocarcinoma cell mass was implanted on mice and the tumors were exposed to a simple MMW irradiation or a combined treatment of MMW and PDT. The treatments continued for 4 weeks and the size of the tumor was measured continuously. The significant therapeutic result of MMW was not found during 4 weeks, preferably more cancer recurrence possibility after MMW irradiation was observed. The results of this study suggest that the combination of MMW irradiation and photodynamic treatment should not be recommended. The result of the MMW treatment alone, however, displayed suppressive effect on cancer cell proliferation for both in vitro and in vivo. The results of the present study suggest that the millimeter wave therapy deserves a further study.

• 대한두경부종양학회지
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• 제39권2호
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• pp.41-44
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• 2023

Follicular dendritic cell sarcoma (FDCS) is rare lymphoid sarcoma occurs anywhere in body, mostly in lymph nodes. Sixty-two-year-old man presented left submandibular gland region mass for 5 months. Mass excision with submandibular gland resection was performed. Histopathology showed proliferation of spindle and ovoid cells with storiform arrangement which were positive for CD21, CD23, Vimentin, Ki-67, suggested FDCS in submandibular gland region lymph node. Tumor size was 3cm with no involvement of resection margin, nor cellular atypia and necrosis, so regular follow up was performed. After 4 years, new enhancing mass in left submandibular area was found. Wide excision of mass with neck dissection on left level I-III was performed. Histopathology confirmed recurrence of FDCS. The patient underwent radiation therapy from left mandible to hyoid area. After 2 years, new nodule was found in left lung upper lobe, and wedge resection confirmed metastasis of FDCS. The patient is on adjuvant chemotherapy.

• 한국임상수의학회지
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• 제18권1호
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• pp.82-84
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• 2001

An 11 kg, 7-year-old male pug dog with lameness and tumor of the 2-3rd interdigital portion of the right forelimb was referred to the Veterinary Medical Center of the Tokyo University. On the clinical examination findings, the tumor size was $3{\times}3 cm but alopecia and necrosis were not found. On the radiological findings, a bone lysis was found in the phalanges of digit II of the right forelimb but pulmonary metastasis was not found. The mass was removed with metacarpal bone. Histopathological examination of the mass revealed highly differentiated hemangiopericytoma. Two weeks after the operation, the dog was irradiated by orthovoltage radiation. The source of irradiation was 300 kV, 4mA, 4Gy and a focal spot to skin distance of 40 cm using 1.0 Cu, 1.0Al filter. The radiation therapy was performed twice a week for 5 weeks. The dog showed no recurrence and no metastasis. It was thought that the surgery and radiation therapy treatment was quite a useful method to treat a canine heman-giopericytoma.

• Journal of Chest Surgery
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• 제22권6호
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• pp.1061-1069
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• 1989

A case of liposarcoma was reported in 52 year-old female. She had the operation history due to mediastinal lipoma at other Hospital before 26 months ago. Chest X-ray revealed a huge soft tissue mass- density at the entire right lung field, and left middle and lower lung field at admission. At the lateral film, the mass was located in the anterior and middle mediastinum. Transsternal bilateral thoracotomy was performed, followed by extirpation of liposarcoma, wedge resection of superior vena cava, angioplasty of superior vena cava, and then partial pericardiectomy. The post-operative treatment was 5500 rad irradiation. Post-operative course was uneventful, that was noticed by OPD follow-up for 10 months. Primary liposarcoma of the mediastinum is very rare tumor. This tumor grows to an enormous size, and symptoms are referable to compression of the contiguous intrathoracic structures. The treatment of choice is surgery in all cases. Such an approach serves to establish a tissue diagnosis, to relieve the patients* symptoms, and may results in a cure sometimes. Radiotherapy or/and chemotherapy seems to be ineffective, but should be further studied.

• Journal of Gastric Cancer
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• 제15권1호
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• pp.64-67
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• 2015

Inflammatory myofibroblastic tumors (IMTs) of the stomach are extremely rare in adults, and their oncologic prognosis is not well understood. We present a 28-year-old man with a proximal gastric IMT. The patient visited the emergency department of Yeouido St. Mary's Hospital with syncope and hematemesis. Hemoglobin levels were <5.5 g/dl. Gastric fibroscopy showed a protruding mass $4{\times}4cm$ in size, with central ulceration on the posterior wall of the fundus and diffuse wall thickening throughout the cardia and anterior wall of the upper body. Endoscopic biopsy revealed indeterminate spindle cells, along with inflammation. Given the risk of rebleeding, an operation was performed despite the uncertain diagnosis. Because the mass was circumferential, laparoscopic proximal gastrectomy and double-tract anastomosis were performed to ensure a safe resection margin. The pathological diagnosis was consistent with an IMT originating from the stomach, although the tumor was negative for anaplastic lymphoma kinase gene mutation.

• 대한수의학회지
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• 제48권3호
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• pp.305-310
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• 2008

A 10-year-old female Yorkshire terrier with the clinical signs of nasal swelling, epistaxis and nasal discharge was presented to the Veterinary Teaching Hospital in the Cheju National University. Abnormal nasal mass was detected in physical examination and radiographic findings. After surgical excision, the sample of nasal mass was referred to Pathology Department of Veterinary Medicine. Grossly, the mass was soft, friable, and $2.5{\times}4cm$ cm in size. Histopathologically, the mass was composed of mediumsized non-keratinizing columnar to polyhedral cells arranged in anastomosing ribbon and large nest. It has complex in-folding of thick epithelial layers separated by fibrovascular septa. Tumor cells showed characteristic palisading arrangement of columnar cells, and perpendicularly distributed to the basement membrane. The cells had pale basophilic cytoplasm, oval nucleus and one or more nucleoli, and indistinct cellular border. Many tumor cell emboli were presented in lymphatics. Immunohistochemistry revealed that tumor cells were cytokeratin (CK) 19 and CK clone MNF116 positive and but CK7 and CK high molecular weight negative. Based on the gross, histopathologic, and immunohistochemical findings, the mass was diagnosed as transitional carcinoma in nasal cavity. In our best knowledge, this is the first report of transitional carcinoma originated from transitional zone of canine nasal cavity in Korea.

• 한국임상수의학회지
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• 제19권2호
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• pp.236-238
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• 2002

A 10-year-old mixed male dog, weighed 4.2 kg, was referred to an animal hospital in Pusan. Clinical signs were generalized alopecia, cough, cardiac murmur, dehydration, and right side cryptorchidism. Testis was surgically removed, fixed in formalin and submitted to Diagnostic Laboratory, Chonbuk National University. Grossly, right testis was enlarged. A bulging tumor mass of right testis was homogeneous and grayish white in cut surface, but left testis was normal. Microscopically, no border lines of tubules were formed and the cells grew diffusely, forming sheets with scant supporting stroma. Tumor cells were flirty uniform in size and round or polyhedral, and had discrete cellular lines. The nuclei were large and of variable size, and ovoid, round, vesicular but the cell cytoplasm was scanty. Mitotic figures were common. And giant cells and vacuolated histiocytes were scattered, which is called starry sky appearance. This is the case of seminoma with diffuse type in a mixed dog.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제21권4호
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• pp.414-417
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• 1999

The congenital epulis of newborn is a rare benign tumor that occurs on the gingiva of the anterior alveolar ridge of the jaws, also known as a congenital granular cell tumor. Females are affected 8 - 10 times more often than males. The typical location is the alveolar ridge of the maxilla near the canine but the mandibular region can also be involved. The lesion may be sessile or pedunculated with red or normal color. The size of tumor varies from several millimeters to a few centimeters in diameter. Surgical excision is generally indicated and no recurrences have been noticed. Spontaneous regression is rare. It is histologically similar to the granular cell tumor, although pseudoepitheliomatous hyperplasia does not occur in the former lesion. Thus sheets of large, closely packed cells showing fine, granular, eosinophilic cytoplasm comprise the tumor mass. This is a case report of congenital epulis in the fetus. The lesion was detected in ultrasonogram, its size is 3cm in diameter. The infant showed nursing disturbance and respiratory obstruction after birth, so the tumor was surgically excised under local anesthesia.

• Journal of Korean Neurosurgical Society
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• 제49권1호
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• pp.68-70
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• 2011

Neuroblastoma is a common tumor of children. We report a patient with extensive calvarial metastases of a neuroblastoma as an initial presentation. A 2-year-old girl presented with a history of gradually increasing head size and fever. A brain CT showed a multilobulated, large, extra-axial tumor involving both frontotemporoparietal areas with a sunray-spiculated hyperostosis of the skull and marked contrast enhancement. A brain MRI demonstrated extensive calvarial lesions with simultaneous involvement of the orbits. A biopsy was performed and a ganglioneuroblastoma was diagnosed. On systemic evaluation, an enlarged abdominal mass was detected. After neo-adjuvant chemotherapy, most of the tumors disappeared except for a tumor in the left parietal area; there was a corresponding decrease in the circumference of the head. We performed surgery for the remnant mass. Intensive chemotherapy was administered and a bone marrow transplantation was performed. Adequate neo-adjuvant chemotherapy followed by surgery to the neuroblatoma with extensive metastases to the skull and orbit may be helpful.

• Journal of Chest Surgery
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• 제31권7호
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• pp.735-738
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• 1998

심장내의 혈관종은 매우 드문 질환으로써 부검 예가 아닌 경우로는 전세계적으로 37예만이 보고되어있다. 증상은 종양의 위치에 따라 우심실 유출로 폐쇄에 따른 증상이나 상공정맥 혹은 하공정맥을 막아서 생기는 등의 다양한 증상이 나타날 수 있으며 때로는 증상이 없이 발견되기도 한다. 치료는 수술 적인 절제를 원칙으로 하나 보고된 예가 적은 관계로 예후에 대해서는 잘 알려져 있지 않다. 그러나 조직학적으로는 양성에 속한다. 연세대학교 심장혈관센터에서는, 흉부 둔상을 주소로 내원한 40세 남자 환자에서 심장 초음파 검사결과 우연히 심장내의 종괴를 발견하였다. 종괴는 수술을 시행하여 절제하였으며 조직학적 검사상 양성 혈관종으로 판명되었다. 환자는 수술후 합병증이 없이 퇴원하였으며 수술후 1년간 관찰 추적중인데, 현재까지 재발없이 양호한 상태를 보이고 있다.