• 약학회지
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• 제45권2호
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• pp.140-146
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• 2001

The synthesis of new 6-exomethylene penams with triazole ring for $\beta$-lactamase inhibitor was described. The 6,6-dibromopenam 6 was treated with $CH_3$MgBr and carbaldehyde 5 to afford the 6-bromo-6-(1-hydroxy-1-methyl)penicillanate 7, which was reacted with acetic anhydride to give acetoxy compound 8. The deacetoxybromination of 8 with zinc and acetic acid gave 6-exomethylenepenams, Z-isomer 9 and E-isomer 10, which were oxidized to sulfones 11 and 12 by m-CPBA. The p-methoxybenzyl compounds 9~12 were deprotected by AIC1$_3$and neutralized to give the sodium salts 13~16.

• Archives of Pharmacal Research
• /
• 제12권2호
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• pp.103-107
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• 1989

Several new 1,2,4-triazolo[5,1-a]pyrimidine derivatives were synthesized via the reactions of 3-amino-1,2,4-triazole with active methylene nitrites and thier ylidene derivatives. The structures assigned for the reaction products were based on elemental analyses and spectral data.

• Bulletin of the Korean Chemical Society
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• 제32권spc8호
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• pp.3101-3104
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• 2011

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
• /
• pp.249.2-250
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• 2003

3D-QSAR analyses by CoMFA and CoMSIA were conducted on a series of thiazole and triazole analogues with respect to their antifungal activities against Microsporum gypseum. A total of twenty analogues were used for the derivation of the 3D-QSAR models (training set). Thesuperposition of the compounds was performed by applying the FlexS with shape-based screening method. (omitted)

• Bulletin of the Korean Chemical Society
• /
• 제32권9호
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• pp.3306-3310
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• 2011

A series of novel linear aromatic ether ketone polymers containing triazole units were synthesized by click chemistry and their structures and properties were characterized by FT-IR, $^1H$ NMR, GPC, TGA, DSC and WAXD. The results showed that these polymers exhibited relatively small molecular weights distributions, good thermal stability and solvent-repelling which could have potential applications as engineering thermoplastic.

• Bulletin of the Korean Chemical Society
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• 제35권12호
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• pp.3675-3678
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• 2014

• Bulletin of the Korean Chemical Society
• /
• 제29권11호
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• pp.2195-2201
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• 2008

• Archives of Pharmacal Research
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• 제25권1호
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• pp.28-38
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• 2002

A series of Schiff's benzimidazole bases, thiosemicarbazides were synthesized, azole ring systems as 1,3,4-triazole, 1,3,4-oxadiazole were prepared. 1-Methylbenzimidazole incorporated to substituted dithio-carbamate, thiophenol, diethylamine via acetamido group were synthesized. A series of pyrimidinobenzimidazoles, triazinobenz-imidazoles, and 2-(acetonylamino)-1-methyl-benzimidazole were prepared. The antimicrobial and molluscicidal activities of some newly prepared compounds were carried out.

• 약학회지
• /
• 제47권5호
• /
• pp.288-292
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• 2003

The synthesis of new 6-exomethylene penams with substituted triazole ring was described. The 6,6-dibromopenam 5 was reacted with $CH_3$MgBr and substituted triazole 4 to afford the 6-bromo penicillanate 6, which was treated with acetic anhydride to give acetoxy compound 7. The deacetobromination of acetoxy compound 7 with zinc and acetic acid gave 6-exomethylene penams 8, which was oxidized to sulfones 9 by m-CPBA. The p-methoxybenzyl compounds 6∼9 were deprotected by AlCl$_3$ and neutralized to give the sodium salts 10∼13.

• 약학회지
• /
• 제44권2호
• /
• pp.128-134
• /
• 2000

The synthesis of new 6-exomethylene penams with triazole ring was described. The 6,6-dibromopenam 5 was treated with $CH_3$MgBr and carbaldehyde 4 to afford the 6-bromo-6-(1-hydroxy-1-methyl)penicillanate 6, which was reacted with acetic anhydride to give acetoxy compound 7. The deacetobromination of 7 with zinc and acetic acid gave 6-exomethylenpenams, Z-isomer 8 and E-isomer 9, which were oxidized to sulfones 10 and 11 by m-CPBA. The p-methoxybenzyl compounds 6~11 were deprotected by AlCl$_3$ and neutralized to give the sodium salts 12~17.