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Synthesis, Antinicrobial and Molluscicidal Activities of New Benzimidazole Derivatives  

Nofal, Z.M. (Therapeutical Chemistry Dept. National Research Centre Dokki, Cairo, Egypt)
Fanmy, H.H. (Therapeutical Chemistry Dept. National Research Centre Dokki, Cairo, Egypt)
Mohamed, H.S. (Therapeutical Chemistry Dept. National Research Centre Dokki, Cairo, Egypt)
Publication Information
Archives of Pharmacal Research / v.25, no.1, 2002 , pp. 28-38 More about this Journal
Abstract
A series of Schiff's benzimidazole bases, thiosemicarbazides were synthesized, azole ring systems as 1,3,4-triazole, 1,3,4-oxadiazole were prepared. 1-Methylbenzimidazole incorporated to substituted dithio-carbamate, thiophenol, diethylamine via acetamido group were synthesized. A series of pyrimidinobenzimidazoles, triazinobenz-imidazoles, and 2-(acetonylamino)-1-methyl-benzimidazole were prepared. The antimicrobial and molluscicidal activities of some newly prepared compounds were carried out.
Keywords
Schiffs bases; Thiosemicarbazides 1,3,4-triazole; 1,3,4-oxadiazole; pyrimidino-benzimidazoles; Triazinobenzimidazoles;
Citations & Related Records

Times Cited By Web Of Science : 15  (Related Records In Web of Science)
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1 EI-Masry, A. H., Fahmy, H. H. and Abdelwahed, S. H. A., Synthesis and antimicrobial activity of some new benzimidazole derivatives. Molecules, 5, 1429-1438 (2000)   DOI
2 Fahmy, H. H., El-Masry, A. and Abdelwahed, S. H. A., Synthesis and preliminary antimicrobial screening of new benzimidazole heterocycles. Arch. Pharm. Res., 24(1), 27-34 (2001)   DOI   ScienceOn
3 Ishi, T. and Ito, T., Japan Pat. 7034, 804 (CI. CO 7C, Aolm) 1970, Fungicidal S-(benzyl)-N,N-dialkyldithiocarbamates. Chem. Abst., 74, 87665v (1971)
4 Joshi, S., Matkar, S., Khosla, N. and Bhandari, V., synthesis and biological screening of $N^4$-phthallmldomethyl sulphonamides. J. lndian Chem. Soc., 74, 156-157 (1997)
5 Kamel, M. M., Nofal, Z. M., Fahmy, H. H. Refai, M. and Haiba, M. E., New quinolines and thiazolo quinolines with possible antitumor activity, Proc. Pakistan Acad. Sci., 37(1), 41-55 (2000)
6 Kenji, K., Nagashima, H., Ninoi, N. and Handa, T., (Gifu Coll Pharm.). Synthesis and antibacterial activity of 2-salicylidene hydrazono-4-thiazolidone and its related compounds. J. Pharm. Soc. Japan, 75, 438-441 (1955)   DOI
7 Wolly, D. W., Some biological effects produced by benzimidazole and their reversal by purines. J. Biol. Chem., 152, 225 (1944)
8 Kamel, M. M., Fahmy, H. H. and Abdou, W. A. M., Synthesis of some substituted tetralins of possible molluscicidal activity. Egypt. J. Chem. 39(6), 573-580 (1996)
9 Abbas, S. E., Abou-Yossef, H. E., EI-Taliaw, G. M., and Hassan, A. B., Synthesis of certain 1,2,4-triazoles derived from diclofenac as potential antiinflammatory agents. Egypt. J. Pharm. Sci., 32, 503-514 (1991)
10 Dewani, M. B., Pathak, V. S. and Amine, U. M., Synthesis of some 1-acyl-4-substituted thiosemicarbazides. Indian J. Chem., 11, 1078-1079 (1973)
11 Kandeel, E. M., Hammouda, M. and Metwally, M. A., Aminoazoles in heterocyclic synthesis. Synthesis of new pyrimidobenzimidazoles and pyrazolonopyridines as well as riazolo-, tetrazolo- and pyrazolo-pyrimidines of pharmaceutical interest. Boll. Chim. Farm., 135(4), 232-235 (1996)   PUBMED
12 Sindelar, K., Metysova, J. and Protiva, M., 2-amino-substituted derivatives of benzimidazoles from 2-isothiocyanato carboxylates. Collect. Czech. Chem. Commun., 54(1), 229-234 (1989)   DOI
13 Zaki, M. E. A. and Fathalla, O. A., Studies on ketene S,S, Acetal Part 1. Synthesis of new pyrazolo[1,5-a]pyrimidines and pyrazolo[1,5-a] triazines utilizing ketene S,S Acetals. Egypt. J. Pharm. Sci., 38(4-6), 363-376 (1997)
14 Aboul Wafa, O. M. and Berto, F. A, G., Benzo[b]thiophenes Part I: Synthesis and antimicrobial activity of benzo[b]thionyl 1,3,4-oxadiazole, 1,2,4-triazoline, and thiazoline derivatives. Arch. Pharm., 325,123-127 (1992)   DOI   ScienceOn
15 Miyazaki, Y.; Uchiyama, Y. and Noguchi, T., Dithiocarbamate derivatives. Japan Pat. 7111, 172, (CI CO 7C, Aolr) 1979; Chem. Abst., 75, 5535m (1979)
16 Zayed, A, Metri, J. and El-Hawary, S., Reactions on 6,7-benzindazole- 3-carboxylic acid hydrazide, Synthesis of some heterocycles of potential biological activity. Egypt. J. Chem., 24(5), 389-396 (1981)
17 Omar, M. T., Fahmy, H. H. and Mohamed, H. S., Synthesis of some novel benzimidazole derivatives as antimicrobial agents. Egypt. J. Pharm. Sci., 37, 609-620 (1996)
18 Bielak, E. and Bilinski, S., Reactions of 1-(x-benzoyl)-4-Rthiosemi- carbazide with chloroacetone and omega-bromoacetophenone. III-4-phenyl- and 4-(p-tolyl)thiosemicarbazide of O-nitrobenzoic acid. Ann. Univ. Mariae Curie Sklodowska, 45, 131-139 (1990)
19 Coleman, D. L., Wood, N. L., and Darling, W. M., Martindale the Extra-pharmacopoei Edited by James E. F. Reynolds Published by Direction of the Council of Royal Pharmaceutical Society of Great Britain 13th edition, 37-55 (1993)
20 Sengupta, A. K. and Avasthi, K. J., Studies on potential pesticides: Part IV. Synthesis of several new dithiocarbamates. J. Indian Chem. Soc., 433 (1975)
21 Dose, E. A. and White, E. R., U.S. Patent, 3, 725, 406 (1973), Fungicidal benzimidazole derivatives. Chem. Abst., 79, 62595 (1973)
22 Nawwar, G. A. M., Salicylamides containing amino acid or pyran moieties with molluscicidal activity. Arch. Pharm. (Weinheim), 327, 201-205 (1994)   DOI   PUBMED   ScienceOn
23 Wikel, J. H., Paget, C. J., Delong, D. C., Nelson, D., Wu, C. Y. E., Paschal, J. W, Dinner, A., Templeton, R. J., Chaney, M. O., Jones, N. D. and Chamberlin, J. W, Synthesis of Syn and Anti isomers of 6-{[(Hydroxyimino)phenyl]methyl}-1-[(1methylethyl) sulfonyl]-1 H-benzimidazole-2-amine Inhibitors of Rhinovirus Multiplication. J. Med. Chem., 23, 268-272 (1980)
24 Kaslow, C. E. and Stayner, R. D., Ozonolysis of styryl derivatives of nitrogen heterocycles. J. Amer Chem. Soc., 67, 1716-1717 (1945)   DOI
25 Memoranda, That took place on 17-21 November 1964 in Geneva, Switzerland, Molluscicide Screening and evaluation, Bull WHO, 33, 567 (1965)
26 Mohamed, H. S., Ph. D. (Science). Synthesis of Some new heterocyclic compounds containing benzimidazole of expected biological activity. Thesis, Faculty of Science, Cairo University, (2001)
27 Abdou, O. A., Bahia, Y. R., and Suzan, I. A., Reaction with 2-aminobenzimidazole: Synthesis of several new pyrimido[1,2-a]benzimidazole derivatives. Arch. Pharm. (weinheim) , 320, 642-646 (1987)   DOI
28 Vogel, A. I., 'Text book of practical organic chemistry' $4^{th}$ edition, Longman Group UK Ltd, 735 (1978)