• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.5
• /
• pp.3363-3368
• /
• 2013

Background: The burden due to cancers is an emerging public health concern especially in resource-limited countries like Nigeria. The WHO estimates that cancer kills more people than tuberculosis, HIV/AIDS and malaria combined. As people in Nigeria and other developing countries are beginning to survive infectious diseases, there is an observed epidemiologic transition to chronic diseases, such as cancers. In 2008, 75 out of 1,000 Nigerians died of cancer. Despite the rising incidence and public health importance, Nigeria lacks an organized and comprehensive strategy to deal with cancers. Materials and Methods: This article reviewed 30 peer-reviewed manuscripts on cancer care in four countries. It highlights the limitations to cancer care in Nigeria; due to lack of awareness, low health literacy, absence of organized screening programs, inadequate manpower (in terms of quality and quantity) as well as limited treatment options. Results: This review led to the formulation of a proposal for Nigerian National Cancer Policy, mainly drawn from effective strategies used in Canada, Brazil and Kenya. This is a vertical cancer program that is patient-centered with an emphasis on tobacco control and cancer disease screening (similar to Canada and Brazil). Additionally, it emphasizes primary cancer prevention (similar to Kenya). Its horizontal integration with other disease programs like HIV/AIDS will improve affordability in a poor resourced country like Nigeria. Capacity building for health professionals, hub-and-spoke implementation of screening services, as well as investment in effective treatment options and increased research in cancer care are essential. International 'twinning collaborations' between institutions in richer countries and Nigeria will enhance effective knowledge translation and improve the quality of patient care. Conclusions: A national cancer policy must be developed and implemented in Nigeria in order to overcome the present limitations which help contribute to the observed increases in cancer morbidity and mortality rates. Cancer control is feasible in Nigeria if the nation was to consider and employ some of the cost-effective strategies proposed here.

• The Journal of Korean Society of Virology
• /
• v.29 no.4
• /
• pp.221-233
• /
• 1999

Prospect Hill Virus (PHV) is the well known serotype of hantavirus, a newly established genus in family Bunyaviridae. Extensive studies have upheld the original view of PHV genetics with three genes such as nucleocapsid (N) protein, envelope proteins (G1, G2) and RNA dependent RNA polymerase. In this study, we report the existence of additional gene that is encoded in an overlapping reading frame of the N protein gene within S genome segment of PHV. This gene is expected to encode a nonstructural small (NSs) protein and it seems to be only found in PHV infected cell. The presence and synthesis of NSs protein could be demonstrated in the cell infected with PHV using anti-peptide sera specific to the predicted amino acid sequence deduced from the second open reading frame. Ribosomal synthesis of this protein appears to occur at AUG codon at the 83rd base of S genome segment, downstream of N protein initiation codon. This protein is small in size (10.4 KDa) and highly basic in nature. The expression strategy of NSs protein appears that a signal mRNA is used to translate both N and NSs protein in PHV infected cell. 10 KDa protein in virus infected cell lysates can bind to mimic dsRNA. This fact strongly suggests that NSs protein may be involved in virus replication on late phase of viral life cycle.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
• /
• 2006.05a
• /
• pp.764-769
• /
• 2006

Vibration test on MAST(multi axial simulation table) system has several advantage over one-axial vibration test that could simulate 6-DOF, 3-axial translation and 3-axial moment, at the same time. Since field vibration motion can be fully represented with 6-DOF, multi-axial vibration test on vehicle component is widely conducted in technical leading companies to make sure its fatigue performance in vibration environment. On the way to fulfill the process, editing technique of obtained field data is key issue to success a reliable vibration testing with MAST system. Since the original signals are not only too large to fulfill it directly, but all of the measured data is not guarantee its convergency on generating its driving files, editing technique of the original signals are highly required to make some events that should meet the equal fatigue damage on the target component In this paper, key technique on editing a field data feasible for MAST system is described based on energy method in vibration fatigue. To explain its technique explicitly, author first introduced a process on field data acquisition of two vehicle component and then, representing events are produced to keep up with the editing strategy about a energy method. In the final chapter, a time information regarding a vibration test on MAST system is derived from the energy data which is critical information to perform a vibration test.

• The Transactions of the Korea Information Processing Society
• /
• v.4 no.3
• /
• pp.775-791
• /
• 1997

This paper describes Real-Time Trasport Protocol(RTTP) that procisdes for a ; user cmnnection-oriented sercices with performance fuarantee.Assuming that eral-time network services will be provided,RTTP solves provlems at end-hosts.RTTP has defined a new set of primitives for real-time communication servies based on the analysis of uwer requirements on various applications.Introducing the notion of Abstract Network Layer independent of real networks.RTTP's implementation scheme can be applied to various netwoeks.The study also intriduces an inplemenation strategy, provide prdeictability of protocol processing time,wich should be known a priori for performance guarantee.Intermally,RTTP has a set of QoS translation rules that change a user'w performance requirements to the equivalent network QoS paramenters.RTTP also introuduces a new apportunistic error control mehtod that can trade-off between overhead and error corredtion according to a uwer's requirement on reliability.

• BMB Reports
• /
• v.54 no.9
• /
• pp.470-475
• /
• 2021

Low-dose metronomic chemotherapy has been introduced as a less toxic and effective strategy to inhibit tumor angiogenesis, but its anti-angiogenic mechanism on endothelial progenitor cells (EPCs) has not been fully elucidated. Here, we investigated the functional role of regulated in development and DNA damage response 1 (REDD1), an endogenous inhibitor of mTORC1, in low-dose doxorubicin (DOX)-mediated dysregulation of EPC functions. DOX treatment induced REDD1 expression in bone marrow mononuclear cells (BMMNCs) and subsequently reduced mTORC1-dependent translation of endothelial growth factor (VEGF) receptor (Vegfr)-2 mRNA, but not that of the mRNA transcripts for Vegfr-1, epidermal growth factor receptor, and insulin-like growth factor-1 receptor. This selective event was a risk factor for the inhibition of BMMNC differentiation into EPCs and their angiogenic responses to VEGF-A, but was not observed in Redd1-deficient BMMNCs. Low-dose metronomic DOX treatment reduced the mobilization of circulating EPCs in B16 melanoma-bearing wild-type but not Redd1-deficient mice. However, REDD1 overexpression inhibited the differentiation and mobilization of EPCs in both wild-type and Redd1-deficient mice. These data suggest that REDD1 is crucial for metronomic DOX-mediated EPC dysfunction through the translational repression of Vegfr-2 transcript, providing REDD1 as a potential therapeutic target for the inhibition of tumor angiogenesis and tumor progression.

• The Korean Journal of Pain
• /
• v.35 no.1
• /
• pp.43-58
• /
• 2022

Background: Current therapies are quite unsuccessful in the management of neuropathic pain. Therefore, considering the inhibitory characteristics of GABA mediators, the present systematic review and meta-analysis aimed to determine the efficacy of GABAergic neural precursor cells on neuropathic pain management. Methods: Search was conducted on Medline, Embase, Scopus, and Web of Science databases. A search strategy was designed based on the keywords related to GABAergic cells combined with neuropathic pain. The outcomes were allodynia and hyperalgesia. The results were reported as a pooled standardized mean difference (SMD) with a 95% confidence interval (95% CI). Results: Data of 13 studies were analyzed in the present meta-analysis. The results showed that administration of GABAergic cells improved allodynia (SMD = 1.79; 95% CI: 0.87, 271; P < 0.001) and hyperalgesia (SMD = 1.29; 95% CI: 0.26, 2.32; P = 0.019). Moreover, the analyses demonstrated that the efficacy of GABAergic cells in the management of allodynia and hyperalgesia is only observed in rats. Also, only genetically modified cells are effective in improving both of allodynia, and hyperalgesia. Conclusions: A moderate level of pre-clinical evidence showed that transplantation of genetically-modified GABAergic cells is effective in the management of neuropathic pain. However, it seems that the transplantation efficacy of these cells is only statistically significant in improving pain symptoms in rats. Hence, caution should be exercised regarding the generalizability and the translation of the findings from rats and mice studies to large animal studies and clinical trials.

• KIPS Transactions on Computer and Communication Systems
• /
• v.12 no.1
• /
• pp.1-8
• /
• 2023

It is impossible to overwrite on an already allocated page in SSDs, so whenever a write operation occurs a page replacement with a clean page is required. To resolve this problem, SSDs have an internal flash translation layer called FTL that maps logical pages managed by a file system of operating system to currently allocated physical pages. SSD pages discarded due to write operations must be recycled through initialization, but since the number of initialization times is limited the FTL provides a caching function to reduce the number of writes in addition to the page mapping function, which is a core function. In this study, we focus on the FTL cache methodologies reducing the number of page writes and analyze the related algorithms, and propose a write-only cache strategy. As a result of experimenting with the write-only cache using a simulator, it showed an improvement of up to 29%.

• Journal of the International Relations & Interdisciplinary Education
• /
• v.3 no.1
• /
• pp.77-86
• /
• 2023

At present, under the background of "One Belt and One Road", great achievements have been made in cultural confidence, overseas communication, education, and modernization of Chinese medicine. However, the overseas dissemination of Chinese medicine culture has not yet fulfilled the requirements of the Cultural Power Strategy and the historical mission of Chinese medicine. Challenges are still faced in the cultural theory of traditional Chinese medicine, overseas communication mechanisms, and translation of Chinese medicine terms. Therefore, Chinese medicine practitioners must firm their faith in culture and traditional Chinese medicine, disseminate the cultural theory of traditional Chinese medicine, exert the advantages of the media and improve its mechanism, and speed up cross-cultural language exchange and research. These efforts will innovate Chinese medicine culture, strengthen overseas exchange and cooperation as well as flourish traditional Chinese medicine overseas.

• International Journal of Computer Science & Network Security
• /
• v.23 no.4
• /
• pp.1-6
• /
• 2023

Morphological analysis is a branch of natural language processing, is now a rapidly growing field. The fundamental tenet of morphological analysis is that it can establish the roots or stems of words and enable comparison to the original term. Arabic is a highly inflected and derivational language and it has a strong structure. Each root or stem can have a large number of affixes attached to it due to the non-concatenative nature of Arabic morphology, increasing the number of possible inflected words that can be created. Accurate verb recognition and extraction are necessary nearly all issues in well-known study topics include Web Search, Information Retrieval, Machine Translation, Question Answering and so forth. in this work we have designed and implemented an algorithm to detect and recognize Arbic Verbs from Arabic text.The suggested technique was created with "Python" and the "pyqt5" visual package, allowing for quick modification and easy addition of new patterns. We employed 17 alternative patterns to represent all verbs in terms of singular, plural, masculine, and feminine pronouns as well as past, present, and imperative verb tenses. All of the verbs that matched these patterns were used when a verb has a root, and the outcomes were reliable. The approach is able to recognize all verbs with the same structure without requiring any alterations to the code or design. The verbs that are not recognized by our method have no antecedents in the Arabic roots. According to our work, the strategy can rapidly and precisely identify verbs with roots, but it cannot be used to identify verbs that are not in the Arabic language. We advise employing a hybrid approach that combines many principles as a result.

• Genomics & Informatics
• /
• v.21 no.1
• /
• pp.12.1-12.8
• /
• 2023

A wave of new technologies has created opportunities for the cost-effective generation of high-throughput profiles of biological systems, foreshadowing a "data-driven science" era. The large variety of data available from biological research is also a rich resource that can be used for innovative endeavors. However, we are facing considerable challenges in big data deposition, integration, and translation due to the complexity of biological data and its production at unprecedented exponential rates. To address these problems, in 2020, the Korean government officially announced a national strategy to collect and manage the biological data produced through national R&D fund allocations and provide the collected data to researchers. To this end, the Korea Bioinformation Center (KOBIC) developed a new biological data repository, the Korea BioData Station (K-BDS), for sharing data from individual researchers and research programs to create a data-driven biological study environment. The K-BDS is dedicated to providing free open access to a suite of featured data resources in support of worldwide activities in both academia and industry.