• 정보처리학회논문지B
• /
• 제17B권4호
• /
• pp.327-332
• /
• 2010

보통 두 세 개의 어휘로 구성된 질문 분류에서 어휘의 다양한 표현으로 인한 어휘 불일치문제는 성능 저하의 주요 원인이다. 따라서 질문 분류에서 어휘 사이의 연관성을 반영하는 것이 필수적이다. 본 논문에서는 같은 범주의 질문-질문 쌍들에 대해 계산한 어휘 번역확률을 번역기반 언어모델에 반영하여 질문을 분류하는 방법을 제안한다. 실험에서 야후!앤써 질문대답 아카이브를 이용해서 전체 질문-대답 쌍들에 대해서 번역확률을 계산하는 것보다 같은 범주에 속하는 질문-질문 쌍들에 대해서 번역확률을 계산하는 것이 질문 분류에서 더 좋은 번역확률인 것을 증명한다.

• IMMUNE NETWORK
• /
• 제3권3호
• /
• pp.219-226
• /
• 2003

Background: Phage display is the most widely used technique among display methods to produce monoclonal antibody fragment with a specific binding activity. Having a large library for efficient antibody display/selection is quite laborious process to have more than $10^9$ members of transformants. To overcome these limitations, several in vitro selection approaches have been reported. Ribosome display that links phenotypes, proteins, directly to genotype, mRNA, is one of the in vitro display methods. Ribosome display can reach the size of scFv library up to $10^{14}$ molecules and it can be further diversified during PCR steps. To select the high affinity scFv from one pot library, we established ribosome display technique by modifying the previously reported eukaryotic translation system. Methods: To establish the antibody selection system by ribosome display, we used 3D8, anti-DNA antibody. A 3D8 scFv was synthesized in vitro by an in vitro transcription-translation system. The translated 3D8 scFv and the encoding 3D8 mRNA are connected to the ribosome. These scFv-ribosome-mRNA complexes were selected by binding to their specific antigens. The eluted mRNAs from the complexes are reverse transcribed and re-amplified by PCR. To apply this system, antibody library from immunized mouse with terminal protein (TP)-peptide of hepatitis B virus DNA polymerase TP domain was also used. This TP-peptide encompasses the 57~80 amino acid residues of TP. These mRNA/ribosome/scFv complexes by our system were panned three times against TP-peptide. The enrichment of antibody from library was determined by radioimmunoassay. Results: We specifically selected 3D8, anti-DNA antibody, against ssDNA as a model system. The selected 3D8 RNAs sequences from translation complexes were recovered by RT-PCR. By applying this model system, we enriched TP-peptide-specific scFv pools through three cycles of panning from immunized library. Conclusion: We show that our translating ribosome complexes are well maintained and we can enrich the TP-specific scFv pools. This system can be applied to select specific antibody from an antibody library.

• Korean Journal of Health Education and Promotion
• /
• 제2권1호
• /
• pp.1-19
• /
• 2000

With rapid economic development, the emphasis of the public health movement in Korea has shifted towards addressing the burden of chronic disease. With this shift in direction comes a greater focus on health behaviour and the need for planning models to assist in lifestyle modification programs. The Health Belief Model (HBM), which originated in the US, has generated more research than any other theoretical approach to describe and predict the health behaviour of individuals. In recent years it has been applied in many different cultures and modifications have been suggested to accommodate different cultures. Given the centrality of language and culture, any attempts to use models of health behaviour developed in a different culture, must be studied and tested for local applicability. The paper reviews the applicability and suitability of the HBM in Korea, in the context of the Korean language and culture. The HBM has been used in Korea for almost three decades. The predictability of the HBM has varied in Korean studies as in other cultures. Overall, this literature review indicates that the HBM has been found applicable in predicting health and illness behaviours by Korean people. However if the HBM is used in a Korean context, the acquisition of health knowledge is an important consideration. Most new knowledge in the health sciences is originally published in English and less frequently in another foreign language. Most health knowledge in Korea is acquired through the media or from health professionals and its acquisition often involves translation from the original. The selection of articles for translation and the accuracy of translation into language acceptable in the Korean culture become important determinants of health knowledge. As such translation becomes an important part of the context of the HBM. In this paper modifications to the HBM are suggested to accommodate the issues of language and knowledge in Korea.

• 한국지능정보시스템학회:학술대회논문집
• /
• 한국지능정보시스템학회 2001년도 The Pacific Aisan Confrence On Intelligent Systems 2001
• /
• pp.421-427
• /
• 2001

In this paper, a method for selection of the optimal feature vectors is proposed for the classification of closed 2D shapes using the bispectrum of a contour sequence. The bispectrum based on third order cumulants is applied to the contour sequences of the images to extract feature vectors for each planar image. These bispectral feature vectors, which are invariant to shape translation, rotation and scale transformation, can be used to represent two-dimensional planar images, but there is no certain criterion on the selection of the feature vectors for optimal classification of closed 2D images. In this paper, a new method for selecting the optimal bispectral feature vectors based on the variances of the feature vectors. The experimental results are presented using eight different shapes of aircraft images, the feature vectors of the bispectrum from five to fifteen and an weighted mean fuzzy classifier.

• 대한족부족관절학회지
• /
• 제14권1호
• /
• pp.41-46
• /
• 2010

Purpose: Anterior drawer and varus stress test are commonly used for radiologic evaluation of chronic lateral ankle instability. However, there are controversies regarding the method of measurement and the normal value. This study was performed to investigate radiologic normal values in normal Korean adults and to analyze differences by age and gender. Materials and Methods: Sixty Korean adults were recruited and divided in three groups (20 in their twenties, 20 in their thirties, 20 in their forties). There were 10 males and 10 females in each group. The selection criteria were no history of ankle injury and no evidence of instability on physical examination. Radiologic measurement of varus talar tilt and anterior talar translation were performed through anterior and varus stress radiographs using Telos device (150N force). The measurement was repeated twice by three researchers, and intraobserver reproducibility and interobserver reliability were analyzed. The average talar tilt and anterior talar translation were obtained. Results: Talar tilt and anterior talar translation on ankle stress radiographs had good intraobserver reproducibility and interobserver reliability. Talar tilt was average $3.7^{\circ}$ and $5.1^{\circ}$ in male and female of twenties of age, $3.9^{\circ}$ and $4.8^{\circ}$ in their thirties, $3.4^{\circ}$ and $4.5^{\circ}$ in their forties. Anterior talar translation was average 3.5 mm and 4.2 mm in their twenties, 4.1 mm and 3.8 mm in their thirties, 3.6 mm and 4.1 mm in their forties. There was no significant difference in talar tilt and anterior talar translation by age. However, there was significant difference in talar tilt by gender. Conclusion: Normal range of talar tilt angle in Korean adults was below $8.3^{\circ}$, and normal range of anterior talar translation was below 7.6 mm. It seems to be able to serve as a good reference for radiologic evaluation and for treatment of chronic lateral ankle instability.

• 정보처리학회논문지B
• /
• 제11B권6호
• /
• pp.749-758
• /
• 2004

본 논문에서는 미가공 말뭉치 데이터를 활용하여 영한 기계번역 시스템의 대역어 선택 시 발생하는 중의성을 해소하는 방법을 제안한다. 이를 위하여 은닉 의미 분석(Latent Semantic Analysis : LSA)과 확률적 은닉 의미 분석(Probabilistic LSA : PLSA)을 적용한다. 이 두 기법은 텍스트 문단과 같은 문맥 정보가 주어졌을 때, 이 문맥이 내포하고 있는 복잡한 의미 구조를 표현할 수 있다 본 논문에서는 이들을 사용하여 언어적인 의미 지식(Semantic Knowledge)을 구축하였으며 이 지식은 결국 영한 기계번역에서의 대역어 선택 시 발생하는 중의성을 해소하기 위하여 단어간 의미 유사도를 추정하는데 사용된다. 또한 대역어 선택을 위해서는 미리 사전에 저장된 문법 관계를 활용하여야 한다. 본 논문에서는 이러한 대역어 선택 시 발생하는 데이터 희소성 문제를 해소하기 위하여 k-최근점 학습 알고리즘을 사용한다. 그리고 위의 두 모델을 활용하여 k-최근점 학습에서 필요한 예제 간 거리를 추정하였다. 실험에서는, 두 기법에서의 은닉 의미 공간을 구성하기 위하여 TREC 데이터(AP news)론 활용하였고, 대역어 선택의 정확도를 평가하기 위하여 Wall Street Journal 말뭉치를 사용하였다. 그리고 은닉 의미 분석을 통하여 대역어 선택의 정확성이 디폴트 의미 선택과 비교하여 약 10% 향상되었으며 PLSA가 LSA보다 근소하게 더 좋은 성능을 보였다. 또한 은닉 공간에서의 축소된 벡터의 차원수와 k-최근점 학습에서의 k값이 대역어 선택의 정확도에 미치는 영향을 대역어 선택 정확도와의 상관관계를 계산함으로써 검증하였다.젝트의 성격에 맞도록 필요한 조정만을 통하여 품질보증 프로세스를 확립할 수 있다. 개발 된 패키지의 효율적인 활용이 내조직의 소프트웨어 품질보증 구축에 투입되는 공수 및 어려움을 줄일 것으로 기대된다.도가 증가할 때 구기자 열수 추출 농축액은 $1.6182{\sim}2.0543$, 혼합구기자 열수 추출 농축액은 $1.7057{\sim}2.1462{\times}10^7\;J/kg{\cdot}mol$로 증가하였다. 이와 같이 구기자 열수 추출 농축액과 혼합구기자 열수 추출 농축액의 리올리지적 특성에 큰 차이를 나타내지는 않았다. security simultaneously.% 첨가시 pH 5.0, 7.0 및 8.0에서 각각 대조구의 57, 413 및 315% 증진되었다. 거품의 열안정성은 15분 whipping시, pH 4.0(대조구, 30.2%) 및 5.0(대조구, 23.7%)에서 각각 $0{\sim}38.0$ 및 $0{\sim}57.0%$이었고 pH 7.0(대조구, 39.6%) 및 8.0(대조구, 43.6%)에서 각각 $0{\sim}59.4$ 및 $36.6{\sim}58.4%$이었으며 sodium alginate 첨가시가 가장 양호하였다. 전체적으로 보아 거품안정성이 높은 것은 열안정성도 높은 경향이며, 표면장력이 낮으면 거품형성능이 높아지고, 비점도가 높으면 거품안정성 및 열안정성이 높아지는 경향이 있었다.protocol.eractions between application agents that are developed using different

• Genomics & Informatics
• /
• 제14권4호
• /
• pp.234-240
• /
• 2016

Different mechanisms, including transcriptional and post transcriptional processes, regulate tissue specific expression of genes. In this study, we report differences in gene/protein compositional features between apoptosis involved genes selectively expressed in human tissues. We found some correlations between codon/amino acid usage and tissue specific expression level of genes. The findings can be significant for understanding the translational selection on these features. The selection may play an important role in the differentiation of human tissues and can be considered for future studies in diagnosis of some diseases such as cancer.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권1호
• /
• pp.245-251
• /
• 2015

Objectives: Intrahepatic recurrence is the major cause of death among patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) after curative surgical resection. Several approaches have been reported to decrease the recurrence rate. The objective of our study was to compare the clinical effects of transcatheter arterial chemoembolization (TACE) combined with interferon-alpha (IFN-${\alpha}$) therapy on recurrence after hepatic resection in patients with HBV-related HCC with that of TACE chemotherapy alone. Methods: We retrospectively analyzed the data from 228 patients who were diagnosed with HBV-related HCC and underwent curative resection between January 2001 to December 2008. The patients were divided into TACE (n = 126) and TACE-IFN-${\alpha}$ (n = 102) groups for postoperative chemotherapy. The TACE regimen consisted of 5-fluorouracil (5-FU), cisplatin (DDP), and the emulsion mixed with mitomycin C (MMC) and lipiodol. The recurrence rates, disease-free survival (DFS), overall survival (OS), and risk of recurrence were evaluated. Results: The clinicopathological parameters and adverse effects were similar between the 2 groups (P > 0.05). The median OS for the TACE-IFN-${\alpha}$ group (36.3 months) was significantly longer than that of the TACE group (24.5 months, P < 0.05). The 3-and 5-year OS for the TACE-IFN-${\alpha}$ group were significantly longer than those of the TACE group (P < 0.05) and the recurrence rate was significantly lower (P < 0.05). The TACE and IFN-${\alpha}$ combination therapy, active hepatitis HBV infection, the number of tumor nodules, microvascular invasion, liver cirrhosis, and the BCLC stage were independent predictors of OS and DFS. Conclusions: The use of the TACE and IFN-${\alpha}$ combination chemotherapy after curative hepatic resection safely and effectively improves OS and decreases recurrence in patients with HBV-related HCC who are at high risk. Our findings can serve as a guide for the selection of postoperative adjuvant chemotherapy for patients with HBV-related HCC who are at high risk of recurrence.

• 한국정보처리학회논문지
• /
• 제3권7호
• /
• pp.1792-1802
• /
• 1996

영한 기계번역에서 전치사구의 해석 부착의 문제(Attachment Problem)와 의미 해석의 문제, 그리고 해석에 필요한 정보 획득의 문제가 있다. 이 세 가지 문제를 해결하기 위하여 본 논문은 전치사구 해석 시스템을 제시한다. 이 시스템은 규칙 제어기와 신경망의 하이브리드 구문해석 시스템, 격의미 해석 시스템, 그리고 신경망 의 입력 정보를 자동으로 생성하는 의미속성 생성기로 구성한다. 의미속성 생성기는 시스템의 입력이 되는 의미속성을 자동으로 생성하는 방법으로 인위적인 방법의 단점 을보완하여 객관성 있는 전치사구 해석을 하게 한다. 격의미 해석 시스템은 영한 기계 번역에 맞는 격의미를 찾아내어 자연스런 한국어 생성을 하게 하고 구문해석 시스템은 규칙 방법의 장점과 신경망 방법의 장점을 취한 하이브리드 방식의 시스템으로 전치사 구 부착의 문제를 해결한다.

• 한국중재학회지:중재연구
• /
• 제15권1호
• /
• pp.207-228
• /
• 2005

When closing an international contract, both contract parties endeavor to convey their intentions from the stage of negotiation to the moment of signing the contract. Of the many problems presently related to contract language, the first one to consider is which contract party will run the risk of the language deficiencies occurring as a result of the misunderstanding and misinterpretation between different languages. The second problem to consider is whether the interpretation and translation of the contract language is needed and, if so, which party is going to bear the expenses and assume responsibility of the misinterpretation in the translation of, the contract language. The third problem is related to the obligation of explaining to both contract parties the contents and details of the international contract written in different languages. The fourth issue is which language of both contract parties becomes the standard contract language in the procedure of arbitration. The fifth, but not the last problem, is how to solve the language defects in interpreting and translating the contract languages. These five problems can be easily solved by the approval of the contract parties in scrutinizing and selecting the contract languages. However, this research mainly focuses on which effects of the contract language and as how to define and select the contract language.