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http://dx.doi.org/10.5808/GI.2016.14.4.234

Tissue Specific Expression Levels of Apoptosis Involved Genes Have Correlations with Codon and Amino Acid Usage  

Hajjari, Mohammadreza (Department of Genetics, Faculty of Sciences, Shahid Chamran University of Ahvaz)
Sadeghi, Iman (Department of Molecular Genetics, Faculty of Biosciences, Tarbiat Modares University of Tehran)
Salavaty, Abbas (Department of Genetics, Faculty of Sciences, Shahid Chamran University of Ahvaz)
Nasiri, Habib (Department of Medical Genetics, Nika Center of Preventive Medicine and Health Promotion)
Birgani, Maryam Tahmasebi (Department of Medical Genetics, School of Medicine, Ahvaz Jundishapur University of Medical Sciences)
Publication Information
Genomics & Informatics / v.14, no.4, 2016 , pp. 234-240 More about this Journal
Abstract
Different mechanisms, including transcriptional and post transcriptional processes, regulate tissue specific expression of genes. In this study, we report differences in gene/protein compositional features between apoptosis involved genes selectively expressed in human tissues. We found some correlations between codon/amino acid usage and tissue specific expression level of genes. The findings can be significant for understanding the translational selection on these features. The selection may play an important role in the differentiation of human tissues and can be considered for future studies in diagnosis of some diseases such as cancer.
Keywords
apoptosis; codon; gene expression regulation; translation;
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