• The KIPS Transactions:PartB
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• v.17B no.4
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• pp.327-332
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• 2010

Word mismatch is the most significant problem that causes low performance in question classification, whose questions consist of only two or three words that expressed in many different ways. So, it is necessary to apply word association in question classification. In this paper, we propose question classification method using translation-based language model, which use word translation probabilities for question-question pair that is learned in the same category. In the experiment, we prove that translation probabilities of question-question pairs in the same category is more effective than question-answer pairs in total collection.

• IMMUNE NETWORK
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• v.3 no.3
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• pp.219-226
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• 2003

Background: Phage display is the most widely used technique among display methods to produce monoclonal antibody fragment with a specific binding activity. Having a large library for efficient antibody display/selection is quite laborious process to have more than $10^9$ members of transformants. To overcome these limitations, several in vitro selection approaches have been reported. Ribosome display that links phenotypes, proteins, directly to genotype, mRNA, is one of the in vitro display methods. Ribosome display can reach the size of scFv library up to $10^{14}$ molecules and it can be further diversified during PCR steps. To select the high affinity scFv from one pot library, we established ribosome display technique by modifying the previously reported eukaryotic translation system. Methods: To establish the antibody selection system by ribosome display, we used 3D8, anti-DNA antibody. A 3D8 scFv was synthesized in vitro by an in vitro transcription-translation system. The translated 3D8 scFv and the encoding 3D8 mRNA are connected to the ribosome. These scFv-ribosome-mRNA complexes were selected by binding to their specific antigens. The eluted mRNAs from the complexes are reverse transcribed and re-amplified by PCR. To apply this system, antibody library from immunized mouse with terminal protein (TP)-peptide of hepatitis B virus DNA polymerase TP domain was also used. This TP-peptide encompasses the 57~80 amino acid residues of TP. These mRNA/ribosome/scFv complexes by our system were panned three times against TP-peptide. The enrichment of antibody from library was determined by radioimmunoassay. Results: We specifically selected 3D8, anti-DNA antibody, against ssDNA as a model system. The selected 3D8 RNAs sequences from translation complexes were recovered by RT-PCR. By applying this model system, we enriched TP-peptide-specific scFv pools through three cycles of panning from immunized library. Conclusion: We show that our translating ribosome complexes are well maintained and we can enrich the TP-specific scFv pools. This system can be applied to select specific antibody from an antibody library.

• Korean Journal of Health Education and Promotion
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• v.2 no.1
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• pp.1-19
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• 2000

With rapid economic development, the emphasis of the public health movement in Korea has shifted towards addressing the burden of chronic disease. With this shift in direction comes a greater focus on health behaviour and the need for planning models to assist in lifestyle modification programs. The Health Belief Model (HBM), which originated in the US, has generated more research than any other theoretical approach to describe and predict the health behaviour of individuals. In recent years it has been applied in many different cultures and modifications have been suggested to accommodate different cultures. Given the centrality of language and culture, any attempts to use models of health behaviour developed in a different culture, must be studied and tested for local applicability. The paper reviews the applicability and suitability of the HBM in Korea, in the context of the Korean language and culture. The HBM has been used in Korea for almost three decades. The predictability of the HBM has varied in Korean studies as in other cultures. Overall, this literature review indicates that the HBM has been found applicable in predicting health and illness behaviours by Korean people. However if the HBM is used in a Korean context, the acquisition of health knowledge is an important consideration. Most new knowledge in the health sciences is originally published in English and less frequently in another foreign language. Most health knowledge in Korea is acquired through the media or from health professionals and its acquisition often involves translation from the original. The selection of articles for translation and the accuracy of translation into language acceptable in the Korean culture become important determinants of health knowledge. As such translation becomes an important part of the context of the HBM. In this paper modifications to the HBM are suggested to accommodate the issues of language and knowledge in Korea.

• Proceedings of the Korea Inteligent Information System Society Conference
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• 2001.01a
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• pp.421-427
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• 2001

In this paper, a method for selection of the optimal feature vectors is proposed for the classification of closed 2D shapes using the bispectrum of a contour sequence. The bispectrum based on third order cumulants is applied to the contour sequences of the images to extract feature vectors for each planar image. These bispectral feature vectors, which are invariant to shape translation, rotation and scale transformation, can be used to represent two-dimensional planar images, but there is no certain criterion on the selection of the feature vectors for optimal classification of closed 2D images. In this paper, a new method for selecting the optimal bispectral feature vectors based on the variances of the feature vectors. The experimental results are presented using eight different shapes of aircraft images, the feature vectors of the bispectrum from five to fifteen and an weighted mean fuzzy classifier.

• Journal of Korean Foot and Ankle Society
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• v.14 no.1
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• pp.41-46
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• 2010

Purpose: Anterior drawer and varus stress test are commonly used for radiologic evaluation of chronic lateral ankle instability. However, there are controversies regarding the method of measurement and the normal value. This study was performed to investigate radiologic normal values in normal Korean adults and to analyze differences by age and gender. Materials and Methods: Sixty Korean adults were recruited and divided in three groups (20 in their twenties, 20 in their thirties, 20 in their forties). There were 10 males and 10 females in each group. The selection criteria were no history of ankle injury and no evidence of instability on physical examination. Radiologic measurement of varus talar tilt and anterior talar translation were performed through anterior and varus stress radiographs using Telos device (150N force). The measurement was repeated twice by three researchers, and intraobserver reproducibility and interobserver reliability were analyzed. The average talar tilt and anterior talar translation were obtained. Results: Talar tilt and anterior talar translation on ankle stress radiographs had good intraobserver reproducibility and interobserver reliability. Talar tilt was average $3.7^{\circ}$ and $5.1^{\circ}$ in male and female of twenties of age, $3.9^{\circ}$ and $4.8^{\circ}$ in their thirties, $3.4^{\circ}$ and $4.5^{\circ}$ in their forties. Anterior talar translation was average 3.5 mm and 4.2 mm in their twenties, 4.1 mm and 3.8 mm in their thirties, 3.6 mm and 4.1 mm in their forties. There was no significant difference in talar tilt and anterior talar translation by age. However, there was significant difference in talar tilt by gender. Conclusion: Normal range of talar tilt angle in Korean adults was below $8.3^{\circ}$, and normal range of anterior talar translation was below 7.6 mm. It seems to be able to serve as a good reference for radiologic evaluation and for treatment of chronic lateral ankle instability.

• The KIPS Transactions:PartB
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• v.11B no.6
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• pp.749-758
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• 2004

In this paper, we propose a new method utilizing only raw corpus without additional human effort for disambiguation of target word selection in English-Korean machine translation. We use two data-driven techniques; one is the Latent Semantic Analysis(LSA) and the other the Probabilistic Latent Semantic Analysis(PLSA). These two techniques can represent complex semantic structures in given contexts like text passages. We construct linguistic semantic knowledge by using the two techniques and use the knowledge for target word selection in English-Korean machine translation. For target word selection, we utilize a grammatical relationship stored in a dictionary. We use k- nearest neighbor learning algorithm for the resolution of data sparseness Problem in target word selection and estimate the distance between instances based on these models. In experiments, we use TREC data of AP news for construction of latent semantic space and Wail Street Journal corpus for evaluation of target word selection. Through the Latent Semantic Analysis methods, the accuracy of target word selection has improved over 10% and PLSA has showed better accuracy than LSA method. finally we have showed the relatedness between the accuracy and two important factors ; one is dimensionality of latent space and k value of k-NT learning by using correlation calculation.

• Genomics & Informatics
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• v.14 no.4
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• pp.234-240
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• 2016

Different mechanisms, including transcriptional and post transcriptional processes, regulate tissue specific expression of genes. In this study, we report differences in gene/protein compositional features between apoptosis involved genes selectively expressed in human tissues. We found some correlations between codon/amino acid usage and tissue specific expression level of genes. The findings can be significant for understanding the translational selection on these features. The selection may play an important role in the differentiation of human tissues and can be considered for future studies in diagnosis of some diseases such as cancer.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.1
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• pp.245-251
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• 2015

Objectives: Intrahepatic recurrence is the major cause of death among patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) after curative surgical resection. Several approaches have been reported to decrease the recurrence rate. The objective of our study was to compare the clinical effects of transcatheter arterial chemoembolization (TACE) combined with interferon-alpha (IFN-${\alpha}$) therapy on recurrence after hepatic resection in patients with HBV-related HCC with that of TACE chemotherapy alone. Methods: We retrospectively analyzed the data from 228 patients who were diagnosed with HBV-related HCC and underwent curative resection between January 2001 to December 2008. The patients were divided into TACE (n = 126) and TACE-IFN-${\alpha}$ (n = 102) groups for postoperative chemotherapy. The TACE regimen consisted of 5-fluorouracil (5-FU), cisplatin (DDP), and the emulsion mixed with mitomycin C (MMC) and lipiodol. The recurrence rates, disease-free survival (DFS), overall survival (OS), and risk of recurrence were evaluated. Results: The clinicopathological parameters and adverse effects were similar between the 2 groups (P > 0.05). The median OS for the TACE-IFN-${\alpha}$ group (36.3 months) was significantly longer than that of the TACE group (24.5 months, P < 0.05). The 3-and 5-year OS for the TACE-IFN-${\alpha}$ group were significantly longer than those of the TACE group (P < 0.05) and the recurrence rate was significantly lower (P < 0.05). The TACE and IFN-${\alpha}$ combination therapy, active hepatitis HBV infection, the number of tumor nodules, microvascular invasion, liver cirrhosis, and the BCLC stage were independent predictors of OS and DFS. Conclusions: The use of the TACE and IFN-${\alpha}$ combination chemotherapy after curative hepatic resection safely and effectively improves OS and decreases recurrence in patients with HBV-related HCC who are at high risk. Our findings can serve as a guide for the selection of postoperative adjuvant chemotherapy for patients with HBV-related HCC who are at high risk of recurrence.

• The Transactions of the Korea Information Processing Society
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• v.3 no.7
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• pp.1792-1802
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• 1996

The analysis of prepositional phrases in English-to Korean machine translation has problem on the PP-attachment resolution, semantic analysis, and acquisition of information. This paper presents an analysis system for prepositional phrases, which solves the problem. The analysis system consists of the PP-attachment resolution hybrid system, semantic analysis system, and semantic feature generator that automatically generates input information. It provides objectiveness in analyzing prepositional phrases with the automatic generation of semantic features. The semantic analysis system enables to generate natural Korean expressions through selection semantic roles of prepositional phrases. The PP-attachment resolution hybrid system has the merit of the rule-based and neural network-based method.

• Journal of Arbitration Studies
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• v.15 no.1
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• pp.207-228
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• 2005

When closing an international contract, both contract parties endeavor to convey their intentions from the stage of negotiation to the moment of signing the contract. Of the many problems presently related to contract language, the first one to consider is which contract party will run the risk of the language deficiencies occurring as a result of the misunderstanding and misinterpretation between different languages. The second problem to consider is whether the interpretation and translation of the contract language is needed and, if so, which party is going to bear the expenses and assume responsibility of the misinterpretation in the translation of, the contract language. The third problem is related to the obligation of explaining to both contract parties the contents and details of the international contract written in different languages. The fourth issue is which language of both contract parties becomes the standard contract language in the procedure of arbitration. The fifth, but not the last problem, is how to solve the language defects in interpreting and translating the contract languages. These five problems can be easily solved by the approval of the contract parties in scrutinizing and selecting the contract languages. However, this research mainly focuses on which effects of the contract language and as how to define and select the contract language.