• The Journal of the Acoustical Society of Korea
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• v.17 no.2E
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• pp.53-58
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• 1998

In this paper, we study the response of several anisotropic systems to buried transient line loads. The problem is mathematically formulated based on the equations of motion in the constitutive relations. The load is in form of a normal stress acting with arbitrary axis on the plane of monoclinic symmetry. Plane wave equation is coupled with vertical shear wave, longitudinal wave and horizontal shear wave. We first considered the equation of motion in reference coordinate system, where the line load is coincident with symmetry axis of the orthotrioic material. Then the equation of motion is transformed with respect to general coordiante system with azimuthal angle by using transformation tensor. The load is first described as a body force in the equations of the motion for the infinite media and then it is mathematically characterized. Subsequently the results for semi-infinite spaces is also obtained by using superposition of the infinite medium solution together with a scattered solution from the free surface. Consequently explicit solutions for the displacements are obtained by using Cargniard-DeHoop contour. Numerical results which are drawn from concrete examples of orthotropic material belonging to monoclinic symmetry are demonstrated.

• 한국생물공학회:학술대회논문집
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• 2003.10a
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• pp.186-189
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• 2003

Helicobacter pylori is the etiologic agent of human gastritis and peptic ulceration and produces urease as the major protein component on its surface. H. pylori urease is known to serve as a potent immunogen as well as major virulence factor. In order to express the recombinant urease in tobacco plants, a DNA fragment containing the minimal H. pylori urease gene cluster was subcloned into a plant expression vector. The recombinant vector was transformed to tobacco plants. The integration of the recombinant plasmids into tobacco chromosomal genome was verified by genomic PCR. Expression to mRNA was confirmed by Northern blot analysis, and expression to recombinant urease protein was observed by Western blot analysis. These results showed that the recombinant urease can be produced in tobacco plants and will be tested for immune response to use as an edible vaccine.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.35 no.4
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• pp.435-447
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• 1999

It is main objective of this approach to present a method to analyse stochastic design sensitivity for problems of structural dynamics with randomness in design parameters. A combination of the adjoint variable approach and the second order perturbation method is used in the finite element approach. An alternative form of the constant functional that holds for all times is introduced to consider the time response of dynamic sensitivity. The terminal problem of the adjoint system is solved using equivalent homogeneous equations excited by initial velocities. The numerical procedures are shown to be much more efficient when based on the fold superposition method: the generalized co-ordinates are normalized and the correlated random variables are transformed to uncorrelated variables, whereas the secularities are eliminated by the fast Fourier transform of complex valued sequences. Numerical algorithms have been worked out and proved to be accurate and efficient : they can be readily adapted to fit into the existing finite element codes whose element derivative matrices can be explicitly generated. The numerical results of two cases -2 dimensional portal frame for the comparison with reference and 3-dimensional frame structure - for the deterministic sensitivity analysis are presented.

• Journal of computational fluids engineering
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• v.13 no.1
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• pp.41-48
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• 2008

The fluid-structure interaction analysis such as a static aeroelastic analysis requires the result of each analysis as an input to the other analysis. Usually the grids for the fluid analysis and the structural analysis are different, so the results should be transformed properly for each other. The Infinite Plate Spline(IPS) and the Thin Plate Spline(TPS) are used in interpolating the displacement and the pressure. In this study, such interpolation methods are compared with kriging which provides a precise response surface. The static aeroelastic analysis is performed for the supersonic flow field with shock waves and the pressure field is interpolated by the TPS and kriging. The TPS shows tendency to weaken the shock strength, whereas kriging preserves the shock strength.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2005.05a
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• pp.978-981
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• 2005

The vibration analysis of damped sandwich beam is conducted using finite element method. The equation of motion presented by Mead and Markus is used to formulate FEM. Also as the thickness of the core in the damped sandwich beam goes to zero, conventional beam theory based on the transformed-section method and the equation of Mead and Markus are compared. According to the change of thickness and loss factor of the core, the forced frequency response of beam is calculated and discussed. And then using the half-power band width method, the damping ratio of each mode is calculated and discussed about each case.

• International Journal of Quality Innovation
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• v.5 no.2
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• pp.70-78
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• 2004

Client-supplier collaboration in new product development (NPD) has been a strategy in response to fierce global competition. Traditionally, Hong Kong suppliers collaborate with worldwide clients through original equipment manufacturing (OEM) arrangement in which suppliers manufacture products according to clients' design. In recent years, a growing number of Hong Kong suppliers have transformed to original design manufacturing (ODM) in which they are assigned a design responsibility other than manufacturing products. The ODM arrangement necessitates a close interaction between clients and suppliers, which brings about intense conflict. Conflict has been recognized as an important factor affecting NPD performance including product quality. This paper studies the conflict handling practices of Hong Kong ODM suppliers based on 87 survey data. The results show that the suppliers frequently adopt effective conflict handling practices by which they can develop products of good quality through better design decisions. The results also suggest that the use of ineffective conflict handling behaviors, particularly avoiding, should be reduced for better product quality.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2006.11a
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• pp.809-814
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• 2006

In this paper, the modified direct method employing beam transformation technique is proposed in order to efficiently calculate hydroelastic responses of floating structure. Since the proposed method expresses the displacements of three-dimensional structure with those of transformed beam which leads to small number of equations of motion, the method is numerically efficient compared to the conventional direct method. To verify the efficiency of the proposed method a 500 m-long floating structure under wave loads is considered in numerical example. Displacements, bending moments, torsion moments and shear forces are calculated and computing tine is examined. The results are also compared with those of the conventional direct method.

• Journal of Korean Association for Spatial Structures
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• v.2 no.1 s.3
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• pp.67-73
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• 2002

Measurement of fluctuating pressure by tube system is carefully designed due to the organ-pipe resonance. It is necessary to correct the pressure before analysis. The three method for correction the distortion fluctuation pressure short tube length and the frequency response functions and insert a restrictor in the tube to increase the damping. The first method is useful when the tube length is short. In second method, the distorted signal through the tubing transformed into the frequency domain, dividing by transfer function and inverse fourier transforming back into the time domain gives the required pressure signal. In this paper three types of tubing which have different length of 100cm, 150cm, 200cm were experimented the distorted signal and correct the distortion signal

• 한국전산유체공학회:학술대회논문집
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• 2005.10a
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• pp.141-144
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• 2005

The fluid-structure interaction analysis such as a static aeroelastic analysis requires the result of each analysis as an input to other analysis. Usually the grids for the fluid analysis and the structural analysis are different, so the results should be transformed properly for each other. The Infinite Plate Spline(IPS) and the Thin Plate Spline(TPS) are used in interpolating the displacement and the pressure. In this study, such interpolation methods are compared with kriging which provides a precise response surface. The static aeroelastic analysis is performed for the supersonic flow field with shock waves and the pressure field is interpolated by the TPS and kriging. The TPS shows tendency to weaken the shock stength, whereas kriging preserves the shock strength.

• Toxicological Research
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• v.17
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• pp.89-96
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• 2001

Recently, considerable attention has been focused on the role of cyclooxygenase-2 (COX-2) in the carcinogenesis as well as in inflammation. Improperly overexpressed COX-2 has been observed in many types of human cancers and transformed cells in culture. Thus, it is conceivable that targeted inhibition of abnormally or improperly up-regulated COX-2 provides one of the most effective and promising strategies for cancer prevention. A ubiquitous eukaryotic transcription factor, NF-kB is considered to be involved in regulation of COX-2 expression. Furthermore, extracellular-regulated protein kinase and p38 mitogen-activated protein (MAP) kinase appear to be key elements of the intracellular signaling cascades involved in NF-kB activation in response to a wide array of external stimuli. Certain chemopreventive phytochemicals suppress activation of NF-kB by blocking one or more of the MAP kinases, which may contribute to their inhibitory effects on COX-2 induction. One of the plausible mechanisms by which chemopreventive phytochemicals inhibit NF-kB activation involves suppression of degradation of the inhibitory unit I kB, which hampers subsequent translocation of p65, the functionally active subunit of NF-kB.