• Journal of Pharmaceutical Investigation
• /
• v.32 no.3
• /
• pp.223-229
• /
• 2002

Metformin is an oral antihyperglycemic agent used in the therapy of noninsulin-dependent diabetes mellitus and does not cause hypoglycemia at the therapeutic dose. Its mechanism of action may involve an increased binding of insulin to its receptors and glucose uptake at the post-receptor level. The purpose of the present study was to evaluate the bioequivalence of two metformin tablets, Glucophage (Daewoong Pharmaceutical Co., Ltd.) and Glycomin (Ilsung Pharmaceuticals Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). The metformin release from the two metformin tablets in vitro was tested using KP VII Apparatus II method with various dissolution media (pH 1.2, 4.0, 6.8 buffer solution and water). Twenty four normal male volunteers, $23.75{\pm}1.96$ years in age and $68.77{\pm}10.41\;kg$ in body weight, were divided into two groups with a randomized $2{\times}2$ cross-over study. After one tablet containing 500 mg as metformin was orally administered, blood was taken at predetermined time intervals and the concentrations of metformin in serum were determined using HPLC with UV detector. Besides, the dissolution profiles of two metformin tablets were very similar at 떠1 dissolution media. The pharmacokinetic parameters such as $AVC_t,\;C_{max}\;and\;T_{max}$ were calculated. The ANOVA test was performed for the statistical analysis of the logarithmically transformed $AVC_t\;and\;C_{max}$, untransformed $T_{max}$. The results showed that the differences in $AVC_t,\;C_{max}\;and\;T_{max}$ between two tablets based on the Glucophage were 0.09%, 6.09% and -8.22%, respectively. There were no sequence effects between two tablets in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.25) $(e.g.,\;log(0.94){\sim}log(1.09)\;and \;log(1.01){\sim}log(1.15)$\;for\;AVC_t\;and\;C_{max},\;respectively)$, indicating that Glycomin tablet is bioequivalent to Glucophage tablet.

• Magazine of the Korean Society of Agricultural Engineers
• /
• v.32 no.3
• /
• pp.87-101
• /
• 1990

The purpose of this study is to estimate the flood discharge and runoff volume at a stream by using geomorphologic parameters obtained from the topographic maps following the law of stream classification and ordering by Horton and Strahier. The present model is modified from Cheng' s model which derives the geomorphologic instantaneous unit hydrograph. The present model uses the results of Laplace transformation and convolution intergral of probability density function of the travel time at each state. The stream flow velocity parameters are determined as a function of the rainfall intensity, and the effective rainfall is calculated by the SCS method. The total direct runoff volume until the time to peak is estimated by assuming a triangular hydrograph. The model is used to estimate the time to peak, the flood discharge, and the direct runoff at Andong, Imha. Geomchon, and Sunsan basin in the Nakdong River system. The results of the model application are as follows : 1.For each basin, as the rainfall intensity doubles form 1 mm/h to 2 mm/h with the same rainfall duration of 1 hour, the hydrographs show that the runoff volume doubles while the duration of the base flow and the time to peak are the same. This aggrees with the theory of the unit hydrograph. 2.Comparisions of the model predicted and observed values show that small relative errors of 0.44-7.4% of the flood discharge, and 1 hour difference in time to peak except the Geomchon basin which shows 10.32% and 2 hours respectively. 3.When the rainfall intensity is small, the error of flood discharge estimated by using this model is relatively large. The reason of this might be because of introducing the flood velocity concept in the stream flow velocity. 4.Total direct runoff volume until the time to peak estimated by using this model has small relative error comparing with the observed data. 5.The sensitivity analysis of velocity parameters to flood discharge shows that the flood discharge is sensitive to the velocity coefficient while it is insensitive to the ratio of arrival time of moving portion to that of storage portion of a stream and to the ratio of arrival time of stream to that of overland flow.

• Journal of Pharmaceutical Investigation
• /
• v.32 no.2
• /
• pp.135-140
• /
• 2002

Cefadroxil is a semi-synthetic cephalosporin active against many Gram-positive and Gram-negative bacteria. The drug has been used for the treatment of the urinary and respiratory tract infections when caused by susceptible strains of the designated microorganism. The purpose of the present study was to evaluate the bioequivalence of two cefadroxil capsules, Duricef (Bo Ryung Pharmaceutical Co. Ltd.) and Hanacef (Korean Pharmaceutical Co. Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). The cefadroxil release from the two cefadroxil capsules in vitro was tested using KP VII Apparatus II method with various different kinds of dissolution media (pH 1.2, 4.0, 6.8 buffer solution and water). Twenty four normal male volunteers, $21.58{\pm}2.43$ years in age and $70.74{\pm}10.29$ kg in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After one capsule containing 500 mg as cefadroxil was orally administered, blood was taken at predetermined time intervals and the concentrations of cefadroxil in serum were determined using HPLC with UV detector. The dissolution profiles of two cefadroxil capsules were very similar at all dissolution media. The pharmacokinetic parameters such as $AUC_t,\;C_{max}\;and\;T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_t\;and\;C_{max}$ and untransformed $T_{max}$. The results showed that the differences in $AUC_t,\;C_{max}\;and\;T_{max}$ between two capsules based on the Duricef were 0.05%, -5.29% and 4.53%. There were no sequence effects between two capsules in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.25) $(e.g.,\;log(0.95){\sim}log(1.05)\;and\;log(0.87){\sim}log(1.02)$ for $AUC_t\;and\;C_{max}$, respectively). The 90% confidence interval using untransformed data was within ${pm}20%$ $(e.g.,\;-6.75{\sim}15.74\;for\;T_{max})$. All parameters met the criteria of KFDA guideline for bioequivalence, indicating that Hanacef capsule is bioequivalent to Duricef capsule.

• Journal of KIISE:Software and Applications
• /
• v.37 no.4
• /
• pp.323-339
• /
• 2010

The complexity of embedded systems and the effort to develop them has been rising in proportion with their importance. Also, the heterogeneity of the hardware and software parts in embedded systems makes it more challenging to develop. Errors caused by hardware/software interfaces, especially, account for up to 13 percent of failures with an increasing trend. Therefore, verifying the interface between hardware and software in embedded system is one of the most important research areas. However, current approaches such as co-simulation method and model checking have explicit limitations. In this paper, we propose the synthesizable interface co-verification framework for hardware/software co-design. Firstly, we introduce the separate interface specifications for the heterogeneous components to describe hardware design and software design. Our specifications are expressive enough to describe both. We also provide the transformation rules from the software specification to the hardware specification so that the whole system can be described from the software view. Secondly, we address the solution of verifying the interface of the software and hardware design by adopting and extending existing verification-techniques and extending them. In hardware interface verification, we exploit the model checking technique and provide more efficient verification by closing the hardware design from the assumption of the software behavior which is ensured by software verification step. Lastly, we generate the interface codes such as device APIs, device driver, and device controller from the specification so that verified hardware and software codes can be synthesized without extra efforts.

• Journal of the Korean Institute of Traditional Landscape Architecture
• /
• v.31 no.1
• /
• pp.71-86
• /
• 2013

This study was carried out to find the changed contents and details of the ponds at Jondeokjeong area in the Changdeok Palace, where was modified during the reign of King Gojong(高宗, 1863~1907), and considered the internal context through the diachronic views about royal garden building in the Joseon Dynasty. The results were as belows. First, this study found that the transformed time of the ponds at Jondeokjeong area was the 21th year of King Gojong(1884) based on the pictures taken in the last half of the 19th century and the records of "Gojongsilrok(高宗實錄: Annals of the King Gojong)". Second, this study also found that the remodeled ponds at Jondeokjeong area by King Gojong were followed the landscape of Geoncheong Palace(乾淸宮) and Hiangwon-pond(香遠池) in Gyeongbok Palace because the remodeled ponds of Jondeokjeong area had the spatial organization similar to Hiangwon-pond. Third, the bridge of remodeled ponds at Jondeokjeong area was utilized as the expedient to expand the function of rear garden, which combines the areas of Yungyungdang(演慶堂) and Jondeokjeong. This was the same method that Konchunggung(乾淸宮) in Gyeongbok Palace had occupied the whole area through the Chui-hiang bridge(醉香橋) which connects to the Hiangwonjeong(香遠亭). Fourth, ponds at Jondeokjeong area and Hiangwonjeong that were created during the year of King Gojong promised the use of Yungyungdang and Konchung Palace, and reflected the statuses of the two building-blocks. Lastly, this study concluded the remodeled Jondeokjeong ponds were not only to create the necessary spaces of the landscape for King Gojong, but also to build the space on the context of Huwonjeongdang(後苑政堂: political structure in rear garden), which has been passed down from their ancestors.

• Journal of Microbiology and Biotechnology
• /
• v.19 no.7
• /
• pp.718-726
• /
• 2009

The objective of this study was to develop and validate secondary models that can predict growth parameters of L. monocytogenes Scott A as a function of concentrations (0-3%) of a commercial potassium lactate (PL) and sodium diacetate (SDA) mixture, pH (5.5-7.0), and temperature (4-37DC). A total of 120 growth curves were fitted to the Baranyi primary model that directly estimates lag time (LT) and specific growth rate (SGR). The effects of the variables on L. monocytogenes Scott A growth kinetics were modeled by response surface analysis using quadratic and cubic polynomial models of the natural logarithm transformation of both LT and SGR. Model performance was evaluated with dependent data and independent data using the prediction bias ($B_f$) and accuracy factors ($A_f$) as well as the acceptable prediction zone method [percentage of relative errors (%RE)]. Comparison of predicted versus observed values of SGR indicated that the cubic model fits better than the quadratic model, particularly at 4 and $10^{\circ}C$. The $B_f$and $A_f$for independent SGR were 1.00 and 1.08 for the cubic model and 1.08 and 1.16 for the quadratic model, respectively. For cubic and quadratic models, the %REs for the independent SGR data were 92.6 and 85.7, respectively. Both quadratic and cubic polynomial models for SGR and LT provided acceptable predictions of L. monocytogenes Scott A growth in the matrix of conditions described in the present study. Model performance can be more accurately evaluated with $B_f$and $A_f$and % RE together.

• Journal of Astronomy and Space Sciences
• /
• v.24 no.3
• /
• pp.209-218
• /
• 2007

In this paper, we have presented the observational result for the photometric quality of main telescopes in Gimhae Astronomical Observatory. Also we performed the observation of searching new minor planets as competitive work in public observatories. The observation was carried out using 60cm telescope of Gimhae Astronomical Observatory on 2007 January 13. And, $Sch\ddot{u}ler$ BVI filters and 1K CCD camera (AP8p) were used. To define the quality of CCD photometry, we observed the region of well-known standard stars in the open cluster M67. From observed data, The transformation coefficients and airmass coefficients were obtained, and the accuracy of CCD photometry was investigated. From PSF photometry, we obtained the color-magnitude diagram of M67, and considered the useful magnitude limit and the physical properties of M67. This method can be successfully used to confirm the photometric quality of main telescope in public observatories. To investigate the detection possibility of unknown object as astroid, we observed the near area of the opposition in the ecliptic plane. And we discussed the result. Our result show that it can be possible to detect minor planets in solar system brighter than $V{\sim}18.3mag$. and it can carry out photometric study brighter than V 16mag. in Gimhae Astronomical Observatory. These results imply that the public observatories can make the research work.

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.31 no.1C
• /
• pp.26-35
• /
• 2006

In this paper, an automatic mobile robot system for a intelligent path planning using the detection scheme of the spatial coordinates based on stereo camera is proposed. In the proposed system, face area of a moving person is detected from a left image among the stereo image pairs by using the YCbCr color model and its center coordinates are computed by using the centroid method and then using these data, the stereo camera embedded on the mobile robot can be controlled for tracking the moving target in real-time. Moreover, using the disparity map obtained from the left and right images captured by the tracking-controlled stereo camera system and the perspective transformation between a 3-D scene and an image plane, depth information can be detected. Finally, based-on the analysis of these calculated coordinates, a mobile robot system is derived as a intelligent path planning and a estimation. From some experiments on robot driving with 240 frames of the stereo images, it is analyzed that error ratio between the calculated and measured values of the distance between the mobile robot and the objects, and relative distance between the other objects is found to be very low value of $2.19\%$ and $1.52\%$ on average, respectably.

• Korean Chemical Engineering Research
• /
• v.48 no.1
• /
• pp.20-26
• /
• 2010

Water soluble organic and inorganic species are important components in atmospheric aerosol particles and may act as cloud condensation nuclei to indirectly affect the climate. To characterize organic and elemental carbon(OC and EC), water-soluble organic carbon(WSOC) and inorganic ionic species contents, daily $PM_{2.5}$ measurements were made during the wintertime at an urban site of Gwangju. Average concentrations of WSOC, $NO_3^-$, $SO_4^{2-}$ and $NH_4^+$, which are major components in the water-soluble fraction in PM2.5, are 2.11, 5.73, 3.51 and $3.31{\mu}g/m^3$, respectively, representing 12.0(2.9~23.9%), 21.0(12.9~37.6%), 11.6(2.5~25.9%) and 11.7%(3.8~18.6%) of the $PM_{2.5}$, respectively. Abundance of water soluble organic compounds ranged from 5.4 to 35.9% of total water soluble organic and inorganic components with a mean of 17.6%. Even though the sampling was performed during the winter, the average contributions of secondary OC and WSOC, as deduced from primary OC/EC(or WSOC/EC) ratio, were relatively high, accounting for 17.9%(0~44.4%) of the total OC and 11.2%(0.0~51.4%) of the total WSOC, respectively. During the sampling period, low $SO_4^{2-}/(SO_4^{2-}+SO_2$) ratio of 0.14(0.03~0.32) and relative humidity condition in the winter time suggest an possibility of impact of long-range transport and/or aqueous transformation processes such as metal catalyzed oxidation of sulfur, in-cloud processes, etc.

• The Journal of the Korea Contents Association
• /
• v.14 no.3
• /
• pp.103-112
• /
• 2014

Oh, hein-kuhn is a representative portrait photographer in Korea. His works, , , , which treated portraits of women are a bit different from those of the past that described the appearance of characters. The artist expressed the figure of inner side that conflicts and feels uneasy between 'family and society' and 'child and woman' along with the look of character. That is, he included specific aura which the whole of aunts and girls' group radiates by showing similar photos repeatedly, that we can be aware of 'aunt' and 'girl' by seeing them. The important technique of Oh, hein-kuhn's Portrait Photograph is 'repetition' of image. The artist delivers the meaning of the photo by looking at the character upright in the front and showing photos with similar frame repeatedly. Such form and content of the work as this might feel a bit boring, since it's very simple just like identification picture. However, the photos in the frames which do not move in the fixed position can deliver the meaning of work more clearly rather than the image which expresses flowing time and moving space, we can grasp the message that the artist intends to deliver rather quickly. In the environment of photograph production mainly with image transformation, Oh, hein-kuhn's works of authentic original work method definitely stand forth. Through the portraits of aunts and girls, the artist tells an aspect of our society and we reconfirm the reality through the portraits made by him.