• 한국IT서비스학회지
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• 제5권1호
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• pp.17-34
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• 2006

As insurers have undergone changing customer expectations, increased cross-industry competition and restructured distribution channels, they need to enhance customer relationships, cut costs, increase agility and streamline operations while differentiating the core competency. As such, the importance of e-business transformation has increased where organizational core processes are restructured around customers and interned-based technology is adopted for flexible and adaptive information systems. This paper presents a case study of process innovation for e-business transformation in a Korea-based leading property & casualty insurance company. The company initiated three years-long e-business transformation program to remain competitive and to keep sustainable growth under risky and down economy. The program, which covered enterprise-wide business processes such as product, marketing & sales, customer, claim, investment & loan, accountings, etc., included redesigning processes from customers' viewpoint and then implementing process-aligned information systems. Leadership, sponsorship, change management, performance measurement, business and IT alignment, empowerment, and customized methodology, were emphasized throughout the program. As a result, the company could expect not only improvements in customer-centricity, sales productivity, and operational excellence but also increased revenues and profits in the next three years. The presented case addresses a feasible approach for enterprise-wide e-business transformation. Although the strategies, actions, and business and IT models are not described in detail due to confidentiality, the methodology and the success factors would be applicable to other insurers and possibly organizations in different industries.

• 한국육종학회지
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• 제40권2호
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• pp.128-135
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• 2008

Herbicide resistance is the most common trait being tested and thus herbicide?resistant genetically modified plants are now the most widely cultivated worldwide. Here we developed herbicide?resistant transgenic Agrostis mongolica Roshev. by employing an efficient Agrobacterium?mediated transformation procedure with 25.2% of transformation efficiency. The identification and employment of regenerable and reproducible type of callus was one of the most critical factors to ensure success in this study. PCR analysis confirmed that the bar transgene was integrated into the genome of transgenic plants. The expression of 35S?bar gene was confirmed by Northern blot analysis. The transgenic plants showed complete resistance to herbicide, indicating that the bar gene is functional in transgenic plants.

• 식물조직배양학회지
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• 제28권4호
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• pp.221-225
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• 2001

사과 갈라 품종의 고효율 형질전환 기술체계를 확립하기 위하여 Agobacterium을 이용한 형질전환에 관여하는 상처유도 방법, 배지 고형물, 엽절편체 기원, acetosyringone의 농도와 MES첨가 등 몇 가지 요인이 재분화 및 형질전환에 미치는 영향에 대하여 연구하였다. 엽절편체의 상처유도는 수술용 핀셋 (non-traumatic forcep)의 사용보다는 단순한 절단 후 균접종과 3일 공동배양을 할 경우 재분화와 형질전환율이 더 증가하는 경향을 나타냈다. Agar (A)와 Gelrit $e^{ }$(G)의 조성에 따른 배지 고형물의 처리에서는 Gelrite의 농도가 높을수록 재분화율이 증가하였으나, 형질전환율에 있어서는 2.5 G, 3.5 A+l.2 G 및 7.0 A의 처리 간에 차이가 없었다. 엽신장배지 또는 증식배지 유래가 재분화 및 형질전환율에 유의한 차이를 보이지는 않았으나, 증식배지 유래가 형질전환율을 더 높이는 경향을 나타냈다. Acetosyringone은 0.1 mM 이상의 농도가 첨가할 경우 높은 재분화 및 형질전환을 나타냈고, 0.15 mM의 농도에서 가장 높은 형질전환율을 나타냈다. MES의 재분화와 형질전환에 미치는 영향은 나타나지 않았다.다.

• Journal of Ginseng Research
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• 제47권2호
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• pp.237-245
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• 2023

Background: Ginsenoside Rg2 (Rg2) has a variety of pharmacological activities and provides benefits during inflammation, cancer, and other diseases. However, there are no reports about the relationship between Rg2 and atherosclerosis. Methods: We used 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) to detect the cell viability of Rg2 in vascular smooth muscle cells (VSMCs) and human umbilical vein endothelial cells (HUVECs). The expression of inflammatory factors in HUVECs and the expression of phenotypic transformation-related marker in VSMCs were detected at mRNA levels. Western blot method was used to detect the expression of inflammation pathways and the expression of phenotypic transformation at the protein levels. The rat carotid balloon injury model was performed to explore the effect of Rg2 on inflammation and phenotypic transformation in vivo. Results: Rg2 decreased the expression of inflammatory factors induced by lipopolysaccharide in HUVECs-without affecting cell viability. These events depend on the blocking regulation of NF-κB and p-ERK signaling pathway. In VSMCs, Rg2 can inhibit the proliferation, migration, and phenotypic transformation of VSMCs induced by platelet derived growth factor-BB (PDGF-BB)-which may contribute to its anti-atherosclerotic role. In rats with carotid balloon injury, Rg2 can reduce intimal proliferation after injury, regulate the inflammatory pathway to reduce inflammatory response, and also suppress the phenotypic transformation of VSMCs. Conclusion: These results suggest that Rg2 can exert its anti-atherosclerotic effect at the cellular level and animal level, which provides a more sufficient basis for ginseng as a functional dietary regulator.

• 복식
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• 제52권4호
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• pp.111-123
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• 2002

The purpose of this study is to correctly understand the shaping process of Mongolian women's costumes, which had close connection with Korean costumes. 'Nomadic' factors of Mongol costumes are trousers and jacket, with deel(袍) pleated in the waistline for horse riding, and knee-covering narrow-sleeved long dress for men and women alike for protection against the cold. However, Married women wore bogthag(gogo: ) containing symbols derived from nomadic way of life. 'Foreign' factors are divided into two kinds; foreign culture applied to Mongolian costumes(woven stuff, Koryo style), and transformation in costumes to adjust to the environmental alteration owing to extended territory(pigap(比甲), Jacket and skirt), the last of which served as the chief distinction between nomadic and Y an fashions. 'Religious' factors are unique patterns and colors while retaining their symbolism. Some aspects(mongke tengri or eternal sky) of Shamanism is reflected in avoidance of washing, while positive effect of Lamanism is evidenced in yellow cosmetic applied on the forehead and 16 sky devil dance clothes.dance clothes.

• The Journal of Asian Finance, Economics and Business
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• 제7권11호
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• pp.479-489
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• 2020

The purpose of this paper is to uncover whether and how contextual factors (information exchange, participation, trust in management, and training), relate to resistance to change. It also explores the mediating effect of perceived impact of change on the relations between contextual factors and resistance to change. This study is conducted in several manufacturing plants in food processing industry in Vietnam, which is implementing a top-down large-scale change - Lean transformation, adopting Total Productive Maintenance (TPM) program, to be specific. The findings suggest that all four contextual factors are negatively associated with resistance to change, in which training had the strongest impact. Also, the perceived change impact partially mediates the relationships between the four contextual factors and resistance to change. The practical implications of this paper are that employees who receive adequate, timely and useful information relating to change are less likely to show opposing behaviors towards change. Fostering trust in management among employees, and employee involvement in decision-making, also have a significant influence when addressing employee resistance to change. Employees who are well-trained, well-equipped with tools and knowledge about the change, are less likely to resist as they view the benefits of changes more significant than the risks.

• Asian Pacific Journal of Cancer Prevention
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• 제16권6호
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• pp.2441-2445
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• 2015

Background: Several risk factors leading to malignant transformation of hydatidiform moles have been described previously. Many studies showed that prophylactic chemotherapy for high risk hydatidiform moles could significantly decrease the incidence of malignancy. Thus, it is essential to discover a breakthrough to determine patients with high risk malignancy so that prophylactic chemotherapy can be started as soon as possible. Objectives: Development of a scoring system of risk factors as a predictor of hydatidiform mole malignant transformation. Materials and Methods: This research is a case control study with hydatidiform mole and choriocarcinoma patients as subjects. Multiple logistic regression was used to analyze the data. Odds ratios (OR), attributable at risk (AR : OR-1) and risk index ($ARx{\beta}$) were calculated for develoipment of a scoring system of malignancy risk. The optimal cut-off point was determined using receiver operating characteristic (ROC) curve. Results: This study analyzed 34 choriocarcinoma cases and 68 benign hydatidiform mole cases. Four factors significantly increased the risk of malignancy, namely age ${\geq}35$ years old (OR:4.41, 95%CI:1.07-16.09, risk index 5); gestational age ${\geq}$ 12weeks (OR:11.7, 95%CI:1.8-72.4, risk index 26); uterine size greater than the gestational age (OR:10.2, 95%CI:2.8-36.6, risk index 21); and histopathological grade II-III (OR:3.4, 95%CI:1.1-10.6, risk index 3). The lowest and the highest scores for the risk factors were zero and 55, respectively. The best cut-off point to decide high risk malignancy patients was ${\geq}31$. Conclusions: Malignant transformation of hydatidiform moles can be predicted using the risk scoring by analyzing the above four parameters. Score ${\geq}31$ implies high risk patients so that prophylactic chemotherapy can be promptly administered for prevention.

• Asian Pacific Journal of Cancer Prevention
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• 제14권10호
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• pp.5589-5597
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• 2013

The aim of this review article was to evaluate the relationship and the possible etiological mechanisms between endometriosis, leiomyoma (LM) and adenomyosis and gynecological cancers, such as ovarian and endometrial cancer and leiomyosarcoma (LMS). MEDLINE was searched for all articles written in the English literature from July 1966 to May 2013. Reports were collected systematically and all the references were also reviewed. Malignant transformation of gynecologic benign diseases such as endometriosis, adenomyosis and LM to ovarian and endometrial cancer remains unclear. Hormonal factors, inflammation, familial predisposition, genetic alterations, growth factors, diet, altered immune system, environmental factors and oxidative stress may be causative factors in carcinogenesis. Early menarche, low parity, late menopause and infertility have also been implicated in the pathogenesis of these cancers. Ovarian cancers and endometriosis have been shown to have common genetic alterations such as loss of heterozygosity (LOH), PTEN, p53, ARID1A mutations. MicroRNAs have also been implicated in malignant transformation. Inflammation releases proinflammatory cytokines, and activates tumor associated macrophages (TAMS) and nuclear factor kappa b (NF-KB) signaling pathways that promote genetic mutations and carcinogenesis. MED12 mutations in LM and smooth muscle tumors of undetermined malignant potential (STUMP) may contribute to malignant transformation to LMS. A hyperestrogenic state may be shared in common with pathogenesis of adenomyosis, LM and endometrial cancer. However, the effect of these benign gynecologic diseases on endometrial cancer should be studied in detail. This review study indicates that endometriosis, LM, adenomyosis may be associated with increased risk of gynecological cancers such as endometrial and ovarian cancers. The patients who have these gynecological benign diseases should be counseled about the future risks of developing cancer. Further studies are needed to investigate the relationship between STUMPs, LMS and LM and characteristics and outcome endometrial carcinoma in adenomyotic patients.

• 한국실내디자인학회논문집
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• 제18권5호
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• pp.164-174
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• 2009

Since the end of 19th century, The form and inner space for the religious ceremony; liturgical space of Catholic churches in Busan diocese have been changed as various styles by several outer and inner factors. The changing of historical, social, and religious environment, such as Opening Harbor, Japanese Occupation, Korean War & Rehabilitation Period, and Vatican II are generally regarded as main outer factors, and the locality that lay behind the flux of those events is considered as the main inner factor. The former has usually operated as a momentum for showing general trend of Catholic church, while the latter has made local singularity expressed as unusual style and somewhat modified liturgical space compared with Its contemporary churches. In the context, this paper attempt to analyze the transformation process of style and liturgical space of Catholic churches in Busan diocese focused on revealing local singularity with main five churches, Bumil Church, Samrangjin Church, Milyang Church, Jungang Church, and Dongrae Church, constructed between the end of 19th century and 1962.

• 한국재료학회지
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• 제25권8호
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• pp.417-422
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• 2015

In this study, low-carbon hypoeutectoid steels with different ferrite-pearlite microstructures were fabricated by varying transformation temperature. The microstructural factors such as pearlite fraction and interlamellar spacing, and cementite thickness were quantitatively measured and then Charpy impact tests conducted on the specimens in order to investigate the correlation of the microstructural factors with impact toughness and ductile-brittle transition temperature. The microstructural analysis results showed that the pearlite interlamellar spacing and cementite thickness decreases while the pearlite fraction increases as the transformation temperature decreases. Although the specimens with higher pearlite fractions have low absorbed energy, on the other hand, the absorbed energy is higher in room temperature than in low temperature. The upper-shelf energy slightly increases with decreasing the pearlite interlamellar spacing. However, the ductile-brittle transition temperature is hardly affected by the pearlite interlamellar spacing because there is an optimum interlamellar spacing dependent on lamellar ferrite and cementite thickness and because the increase in pearlite fraction and the decrease in interlamellar spacing with decreasing transformation temperature have a contradictory role on absorbed energy.