• Genomics & Informatics
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• v.4 no.4
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• pp.161-166
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• 2006

The establishment of DNA microarray technology has enabled high-throughput analysis and molecular profiling of various types of cancers. By using the gene expression data from microarray analysis we are able to investigate diagnostic applications at the molecular level. The most important step in the application of microarray technology to cancer diagnostics is the selection of specific markers from gene expression profiles. In order to select markers of Immortalization and transformation we used c-myc and $H-ras^{V12}$ oncogene-transfected NIH3T3 cells as our model system. We have identified 8751 differentially expressed genes in the immortalization/transformation model by multivariate permutation F-test (95% confidence, FDR<0.01). Using the support vector machine algorithm, we selected 13 discriminative genes which could be used to predict immortalization and transformation with perfect accuracy. We assayed $H-ras^{V12}$-transfected 'transformed' cells to validate our immortalization/transformation dassification system. The selected molecular markers generated valuable additional information for tumor diagnosis, prognosis and therapy development.

• Proceedings of the Korean Society of Plant Biotechnology Conference
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• 2005.11a
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• pp.258-258
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• 2005

• Journal of the Korea Institute of Information and Communication Engineering
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• v.26 no.12
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• pp.1826-1831
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• 2022

Rapid Aging Society demands the transformation of medical paradigm of diagnosis and treatment towards prevention and management. This paper explores the norm and development of digital health care, focusing on Busan Metropolitan City. Digital health care which combines new ICT technology and medical technology is predictive, preventive, personalized and participatory; and suggests alternative to solve the problem of demographic changes and increasing social cost of medical welfare. Community Health Center in Busan is unique one based in the minimum community of collecting data from self-leading health management. Digital transformation using basic health data and social information can build preventive care system in the community. Easy access leads community center to test bed of developing new technology, as a living lab. In order to use the newly developed goods and service effectively, user-participatory test is nicessary. Finally community nurse and activists can specify health-welfare converged service through digital transformation empowerment training.

• The Journal of Asian Finance, Economics and Business
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• v.9 no.3
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• pp.11-22
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• 2022

The iron and steel sector is caught between two worlds: "carbon reduction" and "development." The goal of this study is to show that optimizing asset structure to boost intangible assets, particularly brand assets, is a viable strategy to achieve low-carbon development. This study uses panel data from 38 A-share companies in China's iron and steel industry from 2010 to 2020, as well as World Brand Lab data, to create a comprehensive impact index of enterprise value from the standpoint of an asset structure optimization, and to test the impact of intangible assets and brand equity on enterprise value. The findings show that: the asset structure of iron and steel enterprises is closely related to enterprise value, implying that iron and steel industry development necessitates a transformation of quantity control and quality improvement; the proportion of intangible assets in the asset structure of iron and steel enterprises plays a positive and critical role in enterprise value under surplus conditions. The iron and steel industry begins to shift from tangible to intangible assets; there is heterogeneity in the iron and steel industry transformation. Given certain technological levels, the share of brand assets contributes significantly to the increase in enterprise value.

• Journal of Ocean Engineering and Technology
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• v.9 no.1
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• pp.101-110
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• 1995

In SMA(Shape Memory Alloy), the degradation by fatigue is one of the most important problems to be overcome, when SMA is used for robot-actuator materials. The actuator is operated repetitively for long time and its repeating operation develops the fatigue degradation of SMA. The fatigue degradation changes the transformation temperature and deformation behavior and results in inaccurate operation and deformation which results form repeating operation is to be investigated in advance and the scheme to resolve those problems have to be made for the design of actuator. In this paper, for the improvement of the fatigue degradation by repetive movement and better control of the correct movement by the stability of martensite transformation in the development of Robots actuator, Pre-strain(0, 1.5, 5, 8%) are loaded in the specimens and fatigue testing were carried out by the method of heating and cooling in direct condition. From the results of these experiments, the effect on pre-strain which affect the transformation characteristic and fatigue degradation phenomena were correctly investigated.

• Journal of the Korean Institute of Landscape Architecture
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• v.23 no.1
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• pp.157-173
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• 1995

Seowons were first established during the Koryo Dynasty and contain primate shrines for the service of ancestors and ancient sages. Seowons were located in a scenic or rural place some distance from a residential area. The direct motive for building the Seowon came from the need for transcendental concealment and evasive retirement which developed as a result of oppression of scholars The indirect motivations were the development of loaming in an idyllic natural settings and the creation of a beautiful natural environment. he purpose of tai study is to investigate the characteristics and transformation process of the location of Seowon in the Chosen dynasty. The results of this research are summarized as fellows : 1. Seowons were in hilly areas with good geographical features including a nice view of the mountains and waters. Beowons were also built on the relation place of an ancient sage and of destroyed Buddist temples. 2. The location patterns of seowon in the Choson dynasty underwent three stages with the change of time Political and social phenomena influenced the transformation of the location patterns Research in this area is at an early stage. The present study was confined to an examination of 7he characteristics and transformation process of the location of seowons. However, it is hoped that this study will offer meaningful guide for further research.

• Journal of Korean Society on Water Environment
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• v.27 no.1
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• pp.98-103
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• 2011

Photocatalysis using UV light and catalysts is an attractive low temperature and non-energy- intensive method for remediation of a wide range of chemical contaminants like chloroform (CF). Recently development of environmental friendly and sustainable catalytic systems is needed before such catalysts can be routinely applied to large-scale remediation or drinking water treatment. Titanium dioxide is a candidate material, since it is stable, highly reactive, and inexpensive. Diatoms are photosynthetic, single-celled algae that make a microscale silica shell with nano scale features. These diatoms have an ability to biologically fabricate $TiO_2$ nanoparticles into this shell in a process that parallels nanoscale silica mineralization. We cultivated diatoms, metabolically deposited titanium into the shell by using a two-stage photobioreactor and used this biogenic $TiO_2$ to this study. In this study we evaluated how effectively biogenic $TiO_2$ nanoparticles transform CF compared with chemically-synthesized $TiO_2$ nanoparticlesthe and effect of pretreatment of diatom-produced $TiO_2$ nanoparticles on photocatalytic transformation of CF. The rate of CF transformation by diatom-$TiO_2$ particles is a factor of 3 slower than chemically-synthesized one and chloride ion production was also co-related with CF transformation, and 79~91% of CF mineralization was observed in two $TiO_2$ particles. And the period of sonication and mass transfer due to particle size, evaluated by difference of oxygen tention does not affect on the CF transformation. Based on the XRD analysis we conclude that slower CF transformation by diatom-$TiO_2$ might be due to incomplete annealing to the anatase form.

• Proceedings of the Korea Committee for Ocean Resources and Engineering Conference
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• 2004.05a
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• pp.241-248
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• 2004

In general, the salient features if the floating breakwater have excellent regulation of sea-water keeping the marine a1ways clean, up and dorm free movement with the incoming and outgoing tides, capable of being installed without considering the geological condition of sea-bed at any water depth, This study discusses the three dimensional wave transformation of the floating breakwater moored by catenary. Numerical method is based at the Green function method and eigenfunction expansion method. The validity of the present is confirmed by comparing it with the result of Ijima et a1.(1975) fer tensile maxed floating breakwater. According to the numerical results, drift and width of the floating breakwater affect at the wave transformation greatly, and incident wave of long period is well transmitted to the rear of the floating breakwater.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.28 no.2
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• pp.144-147
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• 2017

Laryngeal neoplasm is the second most common malignancy of the upper aerodigestive tract. About 85% to 95% of laryngeal malignancies are squamous cell carcinoma that arises from the epithelial lining of the larynx. The exact cause of laryngeal neoplasm is unknown, but certain risk factors can affect the chances of developing it. Chronic inflammation is a mutagen factor confirmed in the carcinogenesis of various tumor. Inhalation injuries cause histopathologic damage to laryngeal mucosa and inflammation change. This long term inflammation may leads to the development of dysplasia and malignant transformation. Recently, we experienced a case of malignant transformation of laryngeal mucosa after inhalation injury patient 25 years ago. Herein, we reported this rare case and review the relevant literature.

• Journal of Plant Biotechnology
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• v.37 no.4
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• pp.379-387
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• 2010

Oilseed rape (Brassica napus L.) is an important crop due to its high oil content in the seed. Recently, the demand for the improvement of crop for biodisel energy source is increased as oil prices in the world has increased dramatically. Until now, oilseed rape breeding was carried out by cross-hybridization between different varieties and related germplasms. However, like as many other crops, the application of tissue culture and gene transformation systems has been introduced into oilseed rape breeding program including the development of transgenic canola plants. In this study, we reviewed a history of tissue culture and genetic transformation research in oilseed rape plants and indicated some important aspects for the production of transgenic oilseed rape plants.