• 대한한의학방제학회지
• /
• 제31권4호
• /
• pp.373-388
• /
• 2023

Objectives : This study aimed to provide basic data for research by investigating non-clinical experimental studies on herbal medicines and its compounds for precocious puberty. Methods : A search was conducted for all literature until October 2023 using combinations of keywords such as precocious puberty, puberty, and chinese medicine in three databases (Pubmed, OASIS, and ScienceON). Results : 1. In animal experiments, studies were mainly conducted using a model that induced precocious puberty by subcutaneously administering danazol to SD rats on the 5th day after birth, and in cell experiments, precocious puberty was induced by treating GT1-7 cells with kisspeptin 10 or estradiol. 2. Anemarrhenae Rhizoma, Phellodendri Cortex, and Prunellae Spica were mainly used as herbal medicine to evaluate their efficacy on precocious puberty in non-clinical experiments. 3. Macroscopic observation, hematological analysis, histological analysis, and genetic analysis were performed as methods to analyze the experimental results. Conclusions : In this study, the effects of herbal medicine on precocious puberty and non-clinical research methods were confirmed. Based on the results of this study, it is expected that non-clinical effectiveness and mechanism research on materials that are clinically effective in Traditional Korean Medicine will be revitalized.

• 대한한의학방제학회지
• /
• 제31권4호
• /
• pp.245-252
• /
• 2023

Objectives : The purpose of this study was to explore the compounds, targets and related diseases of garlic by the approaches of network pharmacology and bioinformatics in traditional chinese medicine. Methods : We investigated components and their target molecules of garlic using SymMap and TCMSP and they were compared with analysis platform. Results : 56 potential compounds were identified in garlic, 26 of which contained target information, and it was found that these 26 compounds and 154 targets interact with each other through a combination of 243 compounds. In addition, Apigenin was linked to the most targeted gene (78) in 26 compounds, followed by Kaempferol (61 genes), Nicotic Acid (14 genes), Geraniol (11 genes), Eee (10 genes), and Sobrol A (9 genes). Among 56 potential compounds, three compounds (Kaempferol, Dipterocarpol, and N-Methyl cytisine) corresponded to the active compound by screening criterion Absorption, Distribution, Metabolism, Excretion (ADME). In addition, 12 compounds in 56 potential compounds were associated with gastrointestinal (GI) motility disorder. Among them, Kaempferol was a compound that met the ADME parameters and the rest were potential compounds that did not meet. Also, Kaempferol was closely related to GI motility disorder, indicating that this Kaempferol could be a candidate for potential medical efficacy. Conclusions : It shows the relationship between the compound of garlic, an herbal supplement, and the biological process associated with GI motility disorder. These results are thought to help develop strategies for treating GI motility disorders.

• 대한한의학방제학회지
• /
• 제32권1호
• /
• pp.39-49
• /
• 2024

Objectives : The purpose of this study was to investigate the molecular targets and pathways of anti-inflammatory effects of Jakyakgamchotang with corydalis tuber (JC) using network pharmacology. Methods : The compounds in constituent herbal medicines of JC were searched in TCM systems pharmacology (TCMSP). Target gene informations of the components were collected using chemical-target interactions database provided by Pubchem. Afterwards, network analysis between compounds and inflammation-related target genes was performed using cytoscape. Go enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were performed on inflammation-related targets using DAVID database. Results : 70 active compounds related to inflammation were identified, and 295 target genes related to the anti-inflammatory activity of the compound of JC were identified. In the Go biological process DB and KEGG pathway DB, "inflammatory response", "cellular response to lipopolysaccharide", "positive regulation of interleukin-6 production", and "positive regulation of protein kinase B. signaling", "positive regulation of ERK1 and ERK2 cascade", "positive regulation of I-kappaB kinase/NF-kappaB signaling", "negative regulation of apoptotic process", and "PI3K-Akt signaling pathway" were found to be mechanisms related to the anti-inflammatory effects related to the target genes of JC. The main compounds predicted to be involved in the anti-inflammatory effect of JC were quercetin, licochalcone B, (+)-catechin, kaempferol, and emodin. Conclusions : This study provides the molecular targets and potential pathways of JC on inflammation. It can be used as a basic data for using JC for various inflammatory disease in traditional korean medicine clinic.

• 한국멀티미디어학회논문지
• /
• 제17권3호
• /
• pp.393-404
• /
• 2014

본 연구는 전통건축 방식의 지붕곡을 전산학적으로 재해석하고 지붕가구부를 구성하는 부재들간의 기하학적 상관관계를 3D 데이터로 설계하기 위한 방안을 제시한다. 지붕곡을 형성하는 여러 개의 구성 요소, 즉 지붕가구부 부재들간의 상관관계를 전통건축 축조 방식에 근거하여 함수식으로 정의하고 분석된 데이터를 토대로 사용자가 원하는 지붕면을 구성하기 위한 각 부재들의 3차원 데이터 자동 생성 기법을 구현한다. 제안하는 방식은 부재간의 상관관계를 고려하여 지붕곡의 속성이 변경되면 지붕곡에 영향을 미치는 여러 개의 부재들이 자동으로 재설계되는 방식으로써 전통건축 설계의 효율을 높일 수 있다. 또한, 한옥의 다양한 지붕곡 설계를 보장하면서도 체계적인 설계와 규격화된 생산 및 가공을 가능하게 하여 한옥의 보급에 크게 기여할 수 있을 것으로 기대된다.

• Archives of Pharmacal Research
• /
• 제25권6호
• /
• pp.917-922
• /
• 2002

We investigated the long term effects of Sopungsungi-won (SP), a Korean traditional formula used for senile constipation and diabetes mellitus, on the development of diabetic nephropathy (DN) in Zucker diabetic fatty (ZDF) rats. ZDF rats were fed regular laboratory chow mixed with SP or rosiglitazone (RSG) for an 8-week period. Kidney hypertrophy was developed with increasing plasma glucose level, and glomerular hypertrophy was improved by 22% and 45% in SP- and RSG-treated rats, respectively. Urinary glucose and albumin excretions were also significantly lower in SP-treated rats than in ZDF control rats. Activation of the mitogen-activated protein kinase (MAPK)-transforming growth factor ${\beta}1$ (TGF ${\beta}1$)-fibronectin pathway in kidney, responsible for glomerular dysfunction, was markedly blunted by SP treatment in a dose dependent manner. Our findings, for the first time, provide strong evidence that long-term administration of SP formula prevents the development and progression of DN in ZDF rats. Human trials are needed to confirm these experimental results.

• 대한한의학방제학회지
• /
• 제26권1호
• /
• pp.27-41
• /
• 2018

Objective : This study's purpose was to review the Daeseunggi-tang as the typical purgative. Method : We searched papers about Daeseunggi-tang about the gastrointestinal dysfunction caused by constipation, surgery and MODS. In total, 31 papers were analyzed in this study. Results : In matter of subject, researches on the gastrointestinal dysfunction caused by constipation were 16 cases, researches on the gastrointestinal dysfunction caused by surgery were 8 cases, researches on gastrointestinal dysfunction caused by MODS were 7 cases. Conclusion : In conclusion, the traditional use of Daeseunggi-tang on constipation, frequent flatus, and stomachache has proven to have sufficient evidences through the experimental and clinical evidences.

• 대한한의학방제학회지
• /
• 제21권2호
• /
• pp.181-186
• /
• 2013

Objectives : The purpose of this study is to report the clinical effect of herbal medicine on the patient considering chronic renal failure. The patient complained of hemiparesis, general weakness, anorexia, nausea and dizziness. Methods : According to the traditional Korean medicine syndrome differentiation, the patient was classified as Deficiency of Spleen Qi and prescribed Bojungikki-tang and Bojungikki-tang gamibang as well as acupuncture and moxibustion treatment. Changes of BUN, creatinine, VAS for genaral weakness, nausea, dizziness were compared before and after treatment for 2 weeks. Results : After treatment, the level of BUN and creatinine was decreased and main symptoms were improved. Conclusions : Herbal medicine Bojungikki-tang and Bojungikki-tang gamibang with acupuncture and moxibustion treatment would be efficient to the patient of chronic renal failure.

• 대한한방내과학회지
• /
• 제31권3호
• /
• pp.688-692
• /
• 2010

The aim of this study was to report eight patients with dizziness, diagnosed as Qi-dizziness. The cause of Qi-dizziness is seven emotions(七情), and seven emotions induce liver qi depression(肝氣鬱結), spleen deficiency(肝脾不和) and dual deficiency of the heart-spleen(心脾兩虛). Guibisoyo-san($Gu\={i}p\'{\i}xi\={a}oy\'{a}o-s\`{a}n$) modified formula, which can treat the above diagnosis, was given to patients three times a day. To evaluate the therapeutic effect, visual analog scale(VAS) and inconvenience degree (ICD) were examined. After treatment, the VAS score decreased 7.37 points on average and ICD score decreased 1.62 points on average in patients with both peripheral vestibular dizziness and nonvestibular dizziness. This study shows that herbal therapy by traditional Korean medicine has considerable effects on dizziness, regardless of the etiological cause.

• 대한한의학방제학회지
• /
• 제8권1호
• /
• pp.241-255
• /
• 2000

Sihosamultang(SST) has been used for the treatment of puerperal fever, liver disease in traditional medicine. The present study was carried out to evaluate the antioxidant effects of SST extract in vitro. The inhibitory effect of SST extract on lipid peroxidant was examined in the linoleic acid autoxidation system. In this test, SST extract significantly inhibited the time course of the lipid peroxidation. And SST extract showed about 73% scavenging effect on DPPH radical. And this extract inhibited not only the lipid peroxide formation induced by hydroxyl radical derived from $ H_{2}O_{2}-Fe^{2+}$ in the rat liver homogenate, but also the superoxide generation from xanthine-xanthine oxidase system in a dose-dependent manner. In addition, SST extract protected the hepatic cell death induced by tert-butyl hydroperoxide. These data indicated that SST might play a protective role against oxidative injury by free radicals.

• 대한한의학방제학회지
• /
• 제21권1호
• /
• pp.111-118
• /
• 2013

Objectives : Traditional medicine Oryeong-san (ORS) has been prescribed for a long time to treat light fever, thirst, dysuria, and accompanying edema. However, the acute toxicity and safety were not reported. In this study, we evaluated the potent acute toxicity and safety of ORS. Methods : ICR mice were used to evaluate acute toxicity and safety by oral administration of 0, 500, 1,000, 2,000mg/kg of ORS. Mortality, body weight, and clinical symptoms were observed, and organ weight and blood biochemical parameters were analyzed after necropsy. Results : We found no mortality and no toxic or abnormal clinical symptoms by administration of ORS. Comparing with control group, no significant alterations in organ weight and blood biochemical parameters were observed. Conclusions : ORS recognized as safe and non-toxic medicinal material, and median lethal dose considered to be over 2,000 mg/kg in both male and female ICR mice.