• Journal of Sasang Constitutional Medicine
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• v.12 no.1
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• pp.136-143
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• 2000

1. Purpose of study : In Oriental Traditional medicine, especially in Sasang Constitutional Medicine the mind and the body are not separated. Psychological characteristics are very important as well as physical characteristics in Sasang Constitutional Medicine. This study was performed to investigate the psychological characteristics of Sasang Constitution. 2. Subjects and Methode of Study : Subjects were 63 persons. There were male 54 and female 9 who were healthy. There were Taeumin 35, Soumin 17, and Soyangin 11. We judged Sasang Constitution in QSCC II and the diagnosis by a medical specialist. The degree of depression and anxiety was determined by Beck's Depression Inventory(BDI) and State-Trait Axiety Inventroy(STAI, State Anxiety : S-A, Trait Anxiety : T-A). We studied the psychological characteristics - Depression and Anxiety - in the Sasang Constitution by analyzing BDI and STAI scores. 3. Result of study : 1) The score of STAI(S-A) in Soeumin(少陰人) group was significantly higher than that in Taeumin(太陰人) group. 2) The score of STAI(T-A) in Soeumin(少陰人) group was significantly higher than that in Taeumin(太陰人) group and Soyangin(少陽人) group. 3) The score of BDI in Soeumin(少陰人) group was higher than that in Taeumin(太陰人) group and Soyangin(少陽人) group, but it was not significant statistically. 4. Conclusion of study These result suggest that Soeumin(少陰人) is more anxious than Soyangin(少陽人) and Taeumin(太陰人).

• Journal of the Korea Academia-Industrial cooperation Society
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• v.9 no.5
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• pp.1210-1217
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• 2008

Sasang medicine is our country's unique traditional medicine based on the classification of individual physical constitution. In the Sasang medicine, what is considered the most important task is to categorize Sasang constitution exactly. Therefore, security of objective elements and diagnosis index is a problem awaiting solution in Sasang constitution classification. To this the paper abstracted result value from objectification, visualization, a fixed quantity of Sasang constitution to analyze face image signals and voice signals. And, comparing the differences constitution would like to develop system classification of Sasang constitution. Specially, image and voice signals are different because of gender, age, region so it composed Sasang constitution group to 40-50 years women in Seoul. To extract of these image and voice signals wanted to perform comparison, analysis in constitution. Finally, it would like to prove a significance of research result through experiment.

• Advances in Traditional Medicine
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• v.6 no.1
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• pp.27-33
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• 2006

The Sasang constitutional medicine classifies the mankind into four constitutional types according to the individual psychological and physical traits. Differences in the Sasang constitutional medicine may be explained by the genetic factors. In order to determine the association of Sasang constitutional classification and interleukin-1 receptor antagonist (IL-1Ra) in genetic susceptibility to ischemic stroke, we classified the four constitutional types in ischemic stroke patients (n = 125) and the healthy control subjects (n = 107), and genotyped for IL-1Ra polymorphism by polymerase chain reaction (PCR) methods. The distribution of the $IL1RN^*1/IL1RN^*2$ genotype in the ischemic stroke patients was significantly different from the healthy controls (OR = 6.09; P =0.0134). And the prevalence of $IL1RN^*1/IL1RN^*2$ genotype was increased in Taeum-in ischemic stroke patients, as compared to Taeum-in healthy controls (OR = 14.71; P = 0.0144). These results suggest that $IL1RN^*1/IL1RN^*2$ genotype in Taeum-in might be associated with the increasing risk for ischemic stroke. Furthermore, this relationship could provide the basis for a new approach in the investigation of the etiology of ischemic stroke.

• Journal of Physiology & Pathology in Korean Medicine
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• v.23 no.6
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• pp.1234-1240
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• 2009

This study was to compare the effectiveness and validity of various data-mining algorithm for Sasang type diagnostic test. We compared the sensitivity and specificity index of nine attribute selection and eleven class classification algorithms with 31 data-set characterizing Sasang typology and 10-fold validation methods installed in Waikato Environment Knowledge Analysis (WEKA). The highest classification validity score can be acquired as follows; 69.9 as Percentage Correctly Predicted index with Naive Bayes Classifier, 80 as sensitivity index with LWL/Tae-Eum type, 93.5 as specificity index with Naive Bayes Classifier/So-Eum type. The classification algorithm with highest PCP index of 69.62 after attribute selection was Naive Bayes Classifier. In this study we can find that the best-fit algorithm for traditional medicine is case sensitive and that characteristics of clinical circumstances, and data-mining algorithms and study purpose should be considered to get the highest validity even with the well defined data sets. It is also confirmed that we can't find one-fits-all algorithm and there should be many studies with trials and errors. This study will serve as a pivotal foundation for the development of medical instruments for Pattern Identification and Sasang type diagnosis on the basis of traditional Korean Medicine.

• Journal of Sasang Constitutional Medicine
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• v.25 no.3
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• pp.208-217
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• 2013

Objectives Modified Yeolda-Hanso tang (MYH) is a traditional herbal formula in Korea for various diseases. MYH is containing the 10 herbs : Pueraria lobata (Willd.) Ohwi, Angelica tenuissima Nakai, Scutellaria baicalensis Georgi, Platycodon grandiflorum (Jacq), Angelicae Dahurica, Cimicifuga heracleifolia Kom, Raphanus sativa L., Polygala tenuifolia (Willd), Acorus gramineus Soland and Dimocarpus longan Lour. The 10 herbs is constituted as a ratio of the 6:4:2:1:2:2:2:4:6:6. We investigated neuroprotective effects of MYH on human neuroblastoma SH-SY5Y cells and evaluated the ability of MYH to prevent and treat for neurodegenerative diseases such as Parkinson's disease via basal autophagy enhancement. Methods Pharmacological induction of Autophagy by MYH in SH-SY5Y cells: Induction of autophagy by MYH in human neuroblastoma SH-SY5Y cells was carreid out by immunoblot analysis with several autophagy markers. SH-SY5Y cells were treated with MYH at the concentration of 400 and $800{\mu}g/ml$ for 24 hr. Specifically, the autophagosome proteins LC3 II and Atg5 levels were increased and autophagy pathway related proteins such as beclin-1, PI3 Kinase class III protein, ULK1, mTOR and AMPK were activated. Conclusions MYH can enhance the induction of autophagy through key regulator AMPK, mTOR, and Beclin-1 and it should be considered as a possible candidate of neuroprotective agents for such as Parkinson's disease.

• Journal of Sasang Constitutional Medicine
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• v.34 no.3
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• pp.31-40
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• 2022

Objectives Sasang constitutional medicine is a traditional Korean medicine that classifies humans into four constitutions in consideration of individual differences in physical, psychological, and physiological characteristics. In this paper, we proposed a method to classify Taeeum person (TE) and Non-Taeeum person (NTE), Soeum person (SE) and Non-Soeum person (NSE), and Soyang person (ST) and Non-Soyang person (NSY) using a convolutional neural network with only facial images. Methods Based on the convolutional neural network VGG16 architecture, transfer learning is carried out on the facial images of 3738 subjects to classify TE and NTE, SE and NSE, and SY and NSY. Data augmentation techniques are used to increase classification performance. Results The classification performance of TE and NTE, SE and NSE, and SY and NSY was 77.24%, 85.17%, and 80.18% by F1 score and 80.02%, 85.96%, and 72.76% by Precision-Recall AUC (Area Under the receiver operating characteristic Curve) respectively. Conclusions It was found that Soeum person had the most heterogeneous facial features as it had the best classification performance compared to the rest of the constitution, followed by Taeeum person and Soyang person. The experimental results showed that there is a possibility to classify constitutions only with facial images. The performance is expected to increase with additional data such as BMI or personality questionnaire.

• Journal of Oriental Neuropsychiatry
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• v.16 no.1
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• pp.193-200
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• 2005

Objective : This study was carried out to investigate the differences of mental illness between Korea and China in oriental medicine Method : Several main texts in oriental medicine and articles related with topic were collected and inquired. Result : There are some differences of mental illness between Korea and China in oriental medicine. Brain is more important than heart in psychophysiology of chinese medicine, and blood stasis is a main pathologic factor of mental illness. They use not only Ohaeng(five elements) theory, but also Yin-yang theory in oriental psychotherapy. Conclusion : It seems that materialism and western medicine had some influences on modern chinese medicine. On the other hand, There are respect for traditional theory and creativity in Korean medicine represented by Dongeuibogam(東醫寶鑑) and Sasang constitutional medicine.

• Journal of Physiology & Pathology in Korean Medicine
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• v.26 no.2
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• pp.141-146
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• 2012

Researches of Sasang Consitutional Medicine(SCM) have been conducted in many ways, especially for objective diagnosis methods of SCM. Despite of these efforts, relationship between SCM and abdominal examination is rarely known. Therefore 7 books related to abdominal examination and arranged specific abdominal examination descriptions in each books based on Experienced prescriptions(經驗方) of Donguisusebowon(東醫壽世保元) or Longevity and Life Preservation in Eastern Medicine were collected. In result, So-eumin and So-yangin show opposite descriptions to each others in abdominal examination. So-eumin has stuffiness and rigidity below heart, lower abdominal fullness and cramp. In contrast, So-yangin has fullness in the chest and hypochondrium, chest bind, lower abdominal numbness and lower tension. Strong abdominal surface tension could be palpated in Taeum-in's abdominal examination. Advantages of Abdominal Examination are notified recently, thanks to easiness of performing, objectiveness and well-adaptation to Theory of Traditional Eastern Medicine. These advantages could contribute to researching diagnosis of SCM with theory consensus of SCM specialists and practical trials.

• Journal of Sasang Constitutional Medicine
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• v.35 no.1
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• pp.14-24
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• 2023

Objectives This study was conducted to observe physiological changes when the function of spleen was extremely deteriorated, and to make an animal model with spleen deficiency. Methods The Normal group (Nr group) was not administered with Senna Folium extract. The SFE group(Senna Folium extract group) was administered with Senna Folium extract every day for the first 2 weeks and then every other day for another week. And the SFE_G group(Senna Folium extract_Ginseng group) was also administered with Senna Folium for 3weeks like the SFE group and fed with ginseng in the third week. Results The score of spleen deficiency was significantly higher in SFE group than in the Nr group and significantly lower in the SFE_G group than in the SFE group. The total weight gain was significantly lower in the SFE group than in the Nr group, and the average daily weight gain was significantly lower in the SFE group than in the Nr group. The difference in stool weight before and after the process of drying was significantly higher in the SFE group than in the Nr group, and significantly lower in the SFE-G group than the SFE group. There was no significant difference in the outcomes related to cold and heat among the three groups. Conclusions Through this study, the animal model with spleen deficiency was developed to prepare a stepping stone for animal tests to verify the efficacy and safety of constitutional prescriptions.

• Journal of Sasang Constitutional Medicine
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• v.26 no.2
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• pp.165-179
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• 2014

Objectives To evaluate the neuroprotective effects of Hyangsayangwi-tang (HY), a Korean traditional medicinal prescription in a Parkinson's disease mouse model. Methods Four groups(each of 10 mouse per group) were used in this study. The neuroprotective effect of HY was examined in a Parkinson's disease mouse model. C57BL/6 mouse treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP, 30mg/kg/day), intraperitoneal (i.p.) for 5 days. Slow behavioral responses and memory disorder is the major clinical symptoms of PD. In order to investigate the effect of HY on recovery of behavioral deficits and memory, we examined the motor function and memory by using Morris water maze and Forced swimming test. Ischemic mouse brain stained with TTC(2,3,5 triphenyl tetrazolium chloride) in the MPTP-induced Parkinson's disease to find out ischemia and tissue damage in mouse. The convenient, simple, and accurate high-performance liquid chromatography (HPLC) method was established for simultaneous determination of neurotransmitters in MPTP-HY group. To measure the amount of dopamine in mice brain, striatum-substantia nigra, was examined by Bradford assay. Immunohistochemistry was examined in the MPTP-induced Parkinson's disease (PD) mouse to evaluate the neuroprotective effects of Hyangsayangwi-tang on hippocampal lesion, ST and SNpc. Results and Conclusions Hyangsayangwi-tang (HY) prevents MPTP-induced loss of serotonin, hippocampus and TH-ir cell.