• 대한한의학원전학회지
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• 제23권1호
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• pp.133-142
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• 2010

Preconditions for the separation of prescribing and dispensing medicinal herbs in Traditional Korean Medicine are classification of medicinal herbs for general public and special medical uses, establishment of national medicinal herb distribution company of governmental base, restriction in purchase of medicinal herbs for special medical use, partnership between doctors and pharmacists of Traditional Korean Medicine, and coverage of herbal medicine-based medication in national health insurance, etc. The number of Traditional Korean Medicine Pharmacists which was born during 'the herbal medicine conflict' initiated in 1993, goes over 1,000 and will increase by 120 annually. The number of Traditional Korean Medical Doctors is over 17,000 and increases by 850 annually. So in order to engage partnership between two groups, the government have to arrange the number of outputs of each group. Standardization and classification of diagnosis and diseases in Traditional Korean Medicine is a matter of course in the separation of prescribing and dispensing medicinal herbs. Related societies and academies need to do researches with governmental fund first. After these works, we can launch a task force team for implementation of process for the separation of prescribing and dispensing medicinal herbs in Traditional Korean Medicine properly. Entering the national health insurance system for full coverage of Korean Medicine care service will be essential for the patients. Implementation the separation of prescribing and dispensing medicinal herbs in Traditional Korean Medicine would be the core of health insurance coverage for medication.

• 한국식품저장유통학회지
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• 제18권6호
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• pp.923-929
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• 2011

본 연구는 당뇨처방을 근거로 구성된 생약재 복합물의 항당뇨 효능을 조사하기 위하여 복합물의 인슐린성 물질을 탐색하고 ${\alpha}$-amylase 및 ${\alpha}$-glucosidase 저해활성을 평가하였다. 3T3-L1 세포에 복합 생약재 추출물을 $10{\mu}g/mL$의 농도로 처리하였을 때 지방세포로의 분화능은 151.7%로 인슐린의 작용을 향상시키는 것으로 확인되었다. 혈당저하제로서 생약재 복합 추출물의 ${\alpha}$-amylase에 대한 저해활성은 생약재 복합 추출물 10.0, 1.0 및 0.1 mg/mL의 농도에서 각각 38.4, 31.5 및 16.6%이었으며, ${\alpha}$-glucosidase에 대한 생약재 복합 추출물의 저해활성은 같은 농도에서 각각 81.3, 35.8 및 26.7%였다. 열수 추출물과 80% ethanol 추출물의 각종 용매 분획물에 대한 ${\alpha}$-glucosidase 저해활성은 다양한 용매 분획물 가운데 ethyl acetate층에서 66.9%와 55.1%로 가장 높은 활성을 나타내었다.

• 대한약침학회지
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• 제18권1호
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• pp.7-18
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• 2015

Objectives: Loranthus ferrugineus (L. ferrugineus) from Loranthaceae, a mistletoe, is a medicinal herb used for a variety of human ailments. Traditionally, decoctions of this parasitic shrub have been mainly used to treat high blood pressure (BP) and gastrointestinal complaints; usage which is supported by experimental based pharmacological investigations. Nonetheless, there is still limited data available evaluating this plant's traditions, and few studies have been scientifically translated toward evidence based phytomedicine. We therefore provide a concise review of the currently available L. ferrugineus literature and discuss potential directions for future areas of investigation. Methods: We surveyed available literature covering ethnopharmacological usage of L. ferrugineus and discussed relevant findings, including important future directions and shortcomings for the medicinal values of this parasitic shrub. Results: Evidence based pharmacological approaches significantly covered the medicinal application of L. ferrugineus for hypertension and gastrointestinal complaint management, with a particular focus on the active hydrophilic extract of this herb. Conclusion: Understanding the sites of action of this plant and its beneficial effects will provide justification for its use in old traditional treatments, and potentially lead to the development of therapies. Other medicinal applicative areas of this parasitic shrub, such as wound healing, gerontological effects, and antiviral and anticancer activities, are yet to be researched.

• Natural Product Sciences
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• 제26권2호
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• pp.136-143
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• 2020

Psoriasis is one of the most common inflammatory skin disorders, with a global prevalence of 2% - 3%. It is an autoimmune skin disorder characterized by excessive generation of plaques on the skin with typical long-lasting red, itchy, and scaly lesions. In this study, we aimed to elucidate the anti-psoriatic effect of the methanolic extract of Persicaria senticosa (PS), a bioactive edible plant extract used in traditional medicine, using a mouse model of imiquimod (IMQ)-induced psoriasis. The daily topical application of IMQ could induce human psoriasis-like lesion. The extract ameliorated IMQ-induced psoriasis. Furthermore, hematoxylin and eosin staining and the Psoriasis Area and Severity Index (PASI) scores indicated that topical application of PS led to an improvement in erythema, scaling, and thickness scores of the mouse dorsal skin and a considerable decrease in the epidermal thickness of the ear and dorsal skin in the IMQ-induced psoriatic mouse model. We also studied the effect of PS on the proliferation of keratinocytes using HaCaT cells. The extract inhibited cell proliferation and IL-6 and pSTAT3 expression induced by M5 cocktail (comprising interleukin [IL]-1α, IL-17A, IL-22, oncostatin M, and tumor necrosis factor-α) in HaCaT cells. Thus, PS might serve as a potential therapeutic agent for the treatment of psoriasis.

• 한국한의학연구원논문집
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• 제14권1호
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• pp.123-128
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• 2008

Glehnia littoralis (Umbelliferae), a perennial herb distributed along the coastline of northern Pacific countries, is the medicinal plant used traditionally for treatment of various diseases. This review focuses on the various pharmacological activities of Glehnia littoralis for understanding about its traditional medicinal applications, medicinal uses in the modern society, and potentials for drug development Glehnia littoralis was reported to have anti-oxidant, anti-tumor, anti-amnesic, blood circulation-promoting, immunomodulatory, anti-microbial, and allelopathic activities. However, their mechanisms remain to be clarified. Because Glehnia littoralis has been prescribed in traditional Oriental medicine as a tonic herb, Glehnia littoralis can be better than other chemical drugs and medicines which exert the equal pharmacological activities. Although the activities of Glehnia littoralis are not specifically high-potent with unique mode of action, it may turn out that it can be beneficial to exert multiple pharmacological activities. In view of low toxicity, relative cheapness, presence in the diet, and occurrence in various herbal remedies of Glehnia littoralis, it needs to be prudent to evaluate its properties and applications further.

• 한국약용작물학회:학술대회논문집
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• 한국약용작물학회 2011년도 춘계학술발표회
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• pp.376-377
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• 2011

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2019년도 춘계학술대회
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• pp.122-122
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• 2019

Protaetia brevitarsis (PB) extracts has been traditionally used as medicinal stuff to treat blood stasis, occlusion of menstruation, tetanus and liver cancer in Asian countries (Korea, Japan, China, Taiwan, India and Myanmar). Especially, Donguibogam, which is traditional korean medicinal book, described the PB extracts as traditional medicine to treat hepatic diseases and vascular disorders. The PB extracts has been considered as highly nutritional food. The major constituents of PB extracts are rich in protein, healthy fats, iron, calcium. Recent studies announced that PB extracts has hepatoprotective effect and anti-microbacterial effect. However, the effect of PB on ulcerative colitis has not been uncovered yet. The aim of this study was to examine the anti-inflammatory effect of PB extracts in dextran sulfate sodium (DSS)-induced colitis mice model. Cytotoxicity of PB was determined by MTT assay and the antiinflammatory effect of PB extract was investigated by measuring nitric oxide (NO) production. PB extracts did not show any cytotoxicity. AIso, PB extracts supressed NO production in LPS-stimulated mice peritoneal macrophages. To determine whether PB could be an effective treatment on ulcerative colitis, DSS was administered in BALB/c mice for 10 days. PB extract significantly improved the clinical signs of DSS-induced UC, including body weight loss, colon length shortening, and disease activity index increase, with histological markers of colon injury. These findings indicated the possibility of PB as a therapeutic agent on ulcerative colitis.

• 농촌지도와개발
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• 제7권1호
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• pp.193-208
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• 2000

이 연구는 우리 나라에 자생하고 있거나 도입재배되고 있는 식물 중 향료 및 약료적 이용성을 함께 지닌 자원식물종을 조사하여 이들 식물종에 대한 체계적 ${\cdot}$ 종합적인 연구를 위한 자료를 확보하기 위한 목적으로 수행되었다. 이 연구에서는 선행연구(변과 박$^{1)}$, 1999)에서 조사 ${\cdot}$ 분류하였던 우리 나라에 분포하고 있거나 또는 재배되고 있는 식물 중 향료자원화의 가능성이 있다고 조사된 방향성식물 초 69과(科), 1039종(種)을 중심으로 동의보감 등의 고문헌에 약재로 제시된 자원식물과 한방 상용약에 가용할 수 있는 약재로 이용되고 있는 방향성식물종을 비교 ${\cdot}$ 검토하는 한편 이들 방향성식물의 생활요품 및 식향, 조리용, 약료로서의 이용성도 함께 검토하였다. 연구결과 다음과 같은 사항을 확인할 수 있었다. 즉, 우리 나라에 서식 또는 재배되고 있는 향료식물 중 전통의약물의 원료로 이용되고 있는 식물이 매우 높을 뿐만 아니라, 주요한 한방 상용약의 재료로 대부분 가용할 수 있는 것으로 나타났다. 연구 결과 식물이 함유하고 있는 방향성물질과 인체에 미치는 약리적 효과는 상관관계가 매우 깊은 것으로 보여지며, 그와 관련된 보다 심도 있는 후속연구의 필요성이 제기되고 있다.

• 한국식품영양과학회지
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• 제34권1호
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• pp.113-119
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• 2005

한국의 전통적인 식육가공품인 양념 불고기에 한약재 물 추출물을 첨가함으로서 얻어지는 저장성 및 품질 증진효과를 살펴본 결과, pH는 4$^{\circ}C$에서 저장 9일 이후에도 변화가 거의 없이 안정하게 유지되었다. 수분함량은 전반적으로 감소하는 경향을 보였지만 한약재 물 추출물을 2% 첨가한 구에서는 가장 안정하게 유지되었다. 양념 우육의 전단력은 저장기간 동안 점점 낮아졌는데, 한약재 물 추출물 처리구가 무 처리구보다 전단력이 낮게 나타나 식육의 연화효과가 있음을 보여 주고 있다. 양념우육의 색은 적색도에 있어 한약재 2% 처리구에서 저장 기간 중 큰 변화가 없이 가장 안정하게 유지되었다. TBA값은 저장 9일 이후에 한약재 물 추출물을 첨가한 구에서 매우 낮게 나타났고 증가 비율도 낮았다. 양념 우육의 생균수 변화는 무 처리구에서 가장 빠르게 증가해, 한약재 물 추출물을 첨가한 경우 저장 6일까지 $10^{5}$ CFU/g으로 안정하게 유지되어 가식기간을 연장시켜 주었다. 관능평가에서 양념우육의 색, 외관, 연도, 탄성, 다즙성, 향, 맛은 전반적으로 한약재 물 추출물 처리구에서 무 처리구보다 더 높은 값을 얻었으며, 양념우육의 저장성과 연도에 있어서 한약재 물 추출을 0.5%에서 1% 첨가했을 때 관능적 특성과 색 등에 관하여 가장 바람직한 결과를 기대할 수 있음을 알 수 있었다. 이상의 결과를 종합해 보면, 양념우육에 한약재 물 추출물을 0.5%에서 1% 정도 첨가하는 것이 저장성의 증진 및 연도의 개선, 관능적 특징의 개선 등으로 양념우육의 품질을 향상시키는데 적합한 방법이라 사료된다.

• 동의생리병리학회지
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• 제32권3호
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• pp.149-156
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• 2018

Traditional medicines (TM) in Korea, China, and Japan share most of the theories and therapeutic tools, but there are also differences due to their unique histories and cultures. Here, we aim to identify the differences in the utilization of TM theory between three countries by analyzing herb usage data in terms of the related traditional theories. Herb usage data of each country was collected from "Investigation of Korean medicine use and herbal medicine consumption survey" (Korea), "Analytical report on circulation of key Chinese medicinal materials" (China), and "Survey report on raw material crude drug usage" (Japan). Fifty five herbs with sixty features belonging to five theoretical categories (four properties, five tastes, targeting meridians, treatment strategies, and herbal parts) were selected and analyzed. Weight Sum Model (WSM) and Network-Based Group Features (NBGF) were used to compare the theoretical characteristics of TM between three countries. For the statistical evaluation, we developed and applied Herb Set Enrichment Analysis (HSEA) for WSM and NBGF results. HSEA for WSM results revealed the kidney meridian were targeted more in Korea than Japan, while the spleen meridian were targeted more in Japan than Korea. Herbs with sour taste were used more in Japan than China. HSEA for NBGF results found that NBGF including warm, neutral, sweet, and tonifying features were more dominant in Korea and than Japan, while NBGF including cold, bitter, heat-clearing features were more dominant in Japan than the others. These results suggest that TM in Korea, China, and Japan have unique aspects of practice patterns and theoretical utilization.