• 대한수의학회지
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• 제47권2호
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• pp.209-212
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• 2007

A 3-year-old female Cocker Spaniel dog acutely developed hepatopathy following ingestion of root of Cycad (Cycas revoluta). Seven hours after the ingestion, she showed acute continuous nausea, vomiting, and marked depression and was presented to the local veterinary clinic. At physical evaluation, the dog showed moderate weakness, pale mucous membrane, jaundice, and dehydration. Serum biochemical analysis revealed elevated alanine aminotransferase and aspartate aminotransferase, and mild azotemia. The dog was treated with intravenous fluid, antibiotics, and hepatic protectants for 10 days and recovered without any sequela. Although the ingestion of Cycad in dogs is rare, it can be treated successfully with appropriate supportive therapy.

• 약학회지
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• 제35권5호
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• pp.438-443
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• 1991

This study was designed to examine the effects of diphenhydramine and papaverine on the toxic manifestations of cholinesterase inhibitors. It was found that papaverine increase acetylcholinesterase activity in cerebral cortex of mice. Papaverine pretreatment tended to increase acetylcholinesterase activity against the actions of neostigmine and physostigmine. When diphenhydramine (20~30 mg/kg, s.c.) was treated 20 min before the administration of cholinesterase inhibitor, it significantly extended the onset latency in the signs of toxicosis which were characteristically produced by physostigmine (0.25~1.5 mg/kg, s.c.) or neostigmine (0.125~0.5 mg/kg, s.c.), and it also prevented lethality in all of the animals.

• 한국임상수의학회지
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• 제25권6호
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• pp.510-513
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• 2008

Two dogs were referred due to vomiting, depression and anorexia after ingestion of xylitol gum. Both dogs were presented with hepatic failure and one dog had concurrent renal failure. Aggressive supportive treatment was performed, but these dogs died. Necropsy of one dog revealed acute hepatic necrosis, severe renal damages, and hemoperitoneum. This case report demonstrates potential hazard of xylitol toxicity for dogs with clinicopathological and pathological findings.

• 동의생리병리학회지
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• 제16권5호
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• pp.831-839
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• 2002

Allergy has a born predominant cause of atopy in body and react oversenstively several meterial. The cause of allergy are tick, house dust, egg, milk, bean, cosmetics, virus, bacteria, flesh and meat in Western medicine. While, Oriental medicine did not have an application on the allergy, but recognized that allergy is connected with fetal toxicosis, heat-syndrome in new born, syndrome characterized by dyspnea, sneezing, stuffy nose, nasal discharge and phlegm. Therefor, We knowed method of medical treatment following cause of disease and pathogenesis against allergy. Allergic disease(atopic dermatitis, bronchial asthma, rhinitis) were related with lung, spleen, kidney. To prevent allergic disease in born, Oriental medicine taked a serious view of fetal education. In Western medicine, The cause of allergy applied to exopathogen of Oriental medicine. In Oriental medicine, Treatment of allergy used generally strengthening the body resistance to eliminate pathogenic factors.

• 한국임상수의학회지
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• 제23권4권
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• pp.427-431
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• 2006

Pulse Doppler ultrasonographic evaluation was performed to investigate the resistive index (RI) of the Interlobar renal artery in 17 dogs (32 kidneys) which were diagnosed with an acute renal failure caused by ochratoxin-A and citrinin contaminated commercial diet. RI was investigated in 7 normal beagle dogs and recovered patients. The mean of RI was resulted as $0.69{\pm}0.04$ in normal dog, however, significantly (p<0.001) increased as $0.76{\pm}0.05$ in renal failure dog. But RI had no relationship with the results of blood chemistry, urine analysis, and excretory urographic image quality. From these results, even though the results of the renal function test were within a normal reference range, it was considered that RI index is more reliable to represent a damaged renal parenchyma, and may have the potential to be a useful clinical tool in monitoring of the renal function.

• 한국임상수의학회지
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• 제16권2호
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• pp.257-264
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• 1999

The objective of this study was to estimate the possibility of use as a crude feed about Korean pine foliage. Foliage was fermented aerobic and anaerobic state. And then, it was fed Korean native bull 5 to 6 month old. Bulls were fed control (n=4), aerobic fermented (n=4) and anaerobic fermented (n=4) feed 30 percent of total ration. Bulls were examined with blood sample and body weight on day 0, 60, 120 and 180. There were no differences on complete blood cell count serum chemistry and incidence of disease among groups for experiment period. Also, electrolytes (Ca, Mg, P) balance were good condition. Experimental feed did not induced toxicosis in kidney and liver, Fermented foliage and leaves of Korean softwood were efficient crude feed in carbohydrate, fat and protein metabolism. Experimental feed induced growth of Korean native bull body weight in growing stage without retard. In addition to anaerobic fermented feed has a more higher growth rate than control feed. Our conclusion is that fermented softwood substitute some part of ration, minimum 30 percent, in growing stage of a Korean native bull.

• 대한수의학회지
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• 제48권2호
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• pp.215-218
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• 2008

A 2-year-old, female, Maltese dog (3.2 kg of body weight) was referred to the Veterinary Medical Teaching Hospital, Chungnam National University with vomiting, anorexia and depression. Twelve hours prior to the onset of clinical signs, the dog ingested some grape skins (about 60 g). Physical examination at the time of presentation showed peripheral edema and mucous pallor. Blood and blood chemical analysis revealed anemia and moderate azotemia with elevated blood urea nitrogen (107.2 mg/dl), creatinine (6.3 mg/dl) and hyperphosphatemia (11.3 mg/dl). Echogenicity of renal cortex were observred by ultrasonography. The dog was diagnosed as acute renal failure occurred by grape skin toxicosis. The dog was treated with supportive care such as fluid therapy, diuretics (furosemide) and phosphorus binder (almagate). A normal condition of blood and blood chemical findings and clinical signs was observed at five days after treatment, and prognosis is good to date.

• 한국식품위생안전성학회지
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• 제8권2호
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• pp.23-32
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• 1993

Species of the genus Fusarium are worldwide in their distribution. They are saprophytes as soil inhabitants and parasites of cultivated plants. Some isolates of certain species car capable of producing mycotoxins. Mycotoxicoses, including moldy corn toxicosis, alimentary toxic aleukia, fusariotoxicosis, and rel mold disease are known to be associated with trichothecene-producing fungi. Historically severe epidemic of cereal scab occred in the southern part of Korea in 1963. The epidemic caused a social problem because of not only heavy economic losses but also mycotoxicoses to humans and farm animals. However the toxic principles were remained unknown until some publications in 1980's indicated that trichothecenes and zearalenone were major mycotoxins in Korea cereals contaminated with Fusarium moniliforme have been found to be associated with human and animal disease such as leukoencephalomalacia in horses, pulmonary edema in swine and esophageal cancer in humans. High concentrations of fumonisins have been detected in corn samples from high espohoageal cancer risk areas of South Africa and China. Thus fumonisins have been implicated in the etiolgy of human esophageal cancer in those high incidence countries. Recently increase of imported cereals from foreign countries demands to assess the safety of mycotoxins in Korea. The informations on the natural occurrence of mycotoxins are needed to solve the toxicological problems in humans and farm animals associated with the consumption of moldy cereals.

• 한국임상수의학회지
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• 제24권2호
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• pp.264-268
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• 2007

Three German Shepherd dogs (5 years old, 30 kg, male; 4 years old, 23 kg, female; 4 years old, 24 kg, female) with history of acute vomiting, hemorrhagic diarrhea, anorexia and dullness were admitted to veterinary clinic in the military working dogs training corp (MWDTC). All of them showed same symptoms after ingestion the $'PREVNTIC^{(R)}'$ collar to control ecto-parasites infection in field. One dog was operated by gastrotomy and the $5{\sim}6$ pieces of the $'PREVNTIC^{(R)}'$ collar were removed. The dog was completely cured by intensive care within 2 hours after $'PREVNTIC^{(R)}'$ collar ingestion. However, two dogs were operated by gastrotomy and intensive care over 24 hours after $'PREVNTIC^{(R)}'$ collar ingestion but died. In autopsy, the $5{\sim}6$ pieces of hard materials were found in the stomach, and severe thickness, congestion hemorrhage and swelling of the stomach walls and mucous membrane were observed. In these cases, it was suggested that the first aid of treatment such as gastrotomy within two hours after $'PREVNTIC^{(R)}'$ collar ingestion as soon as possible was helpful for attenuating of toxicosis.

• 한국식품위생안전성학회지
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• 제1권2호
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• pp.143-149
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• 1986

Paraquat의 만성독성에 대한 vitamin E 급여의 효과를 조사하기 위하여 랫드에 paraquat를 50 ppm의 농도로 희석한 물을 음수 대신 투여하면서 vitamin E 함유 사료를 급여하여 paraquat에 대한 vitamin E의 방어 효과를 측정하였는 바 다음과 같은 결과를 얻었다. 1.혈장 vitamin E 농도는 사료 kg 당 10 mg까지의 vitamin E 함유 사료의 급여로 약 150$\mu\textrm{g}$/100ml까지 급격히 상승하였으며 그 후 급여량의 증가에도 비교적 안정된 혈중 농도를 유지하였고, 또한 paraquat 투여는 vitamin E 급여량에 관계없이 혈중 vitamin E 농도의 감소를 가져왔다. 2. 간저장 vitamin E 농도는 혈장 vitamin E 농도와 달리 급여량의 증가에 따라 비례하여 증가하는 경향을 보였으며 paraquat 투여에 의한 영향이 적었다. 3. Paraquat 투여는 적혈구 용혈율을 크게 증가시켰음 (95%), 100$\mu\textrm{g}$/100ml 이상의 vitamin E 혈장 농도에서는 안정된 적혈구 용혈율 (10% 이하)을 나타내었다. 4. Paraquat 투여는 혈장 trypsin inhibitor capacity를 크게 증가시켰으며, vitamin E 급여에 의하여 다소 회복되는 경향을 보였으나 정상에 이르지 못하였다. 5. 혈장 및 적혈구 glutathione peroxidase 활성은 paraquat 투여에 의하여 영향을 받지 않았다. 6. paraquat 투여 후의 lipid peroxide는 vitamin E의 급여로 감소되었다.