Browse > Article

Acute Hepatic Failure Induced by Xylitol Toxicosis in Two Dogs  

Lim, Chae-Young (Departments of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University)
Yoo, Jong-Hyun (BK21 program of Integrative network systems for veterinarians in basic science, industrial animals and preventive medicines, Konkuk University)
Kim, Chun-Geun (Departments of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University)
Park, Chul (Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California)
Park, Hee-Myung (Departments of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University)
Publication Information
Journal of Veterinary Clinics / v.25, no.6, 2008 , pp. 510-513 More about this Journal
Abstract
Two dogs were referred due to vomiting, depression and anorexia after ingestion of xylitol gum. Both dogs were presented with hepatic failure and one dog had concurrent renal failure. Aggressive supportive treatment was performed, but these dogs died. Necropsy of one dog revealed acute hepatic necrosis, severe renal damages, and hemoperitoneum. This case report demonstrates potential hazard of xylitol toxicity for dogs with clinicopathological and pathological findings.
Keywords
dog; hepatic failure; renal failure; xylitol;
Citations & Related Records

Times Cited By SCOPUS : 0
연도 인용수 순위
  • Reference
1 Dunayer EK. Hypoglycemia following canine ingestion of xylitol-containing gum. Vet Hum Toxicol 2004; 46: 87-88
2 Wilson RB, Martin JM. Plasma insulin concentrations in dogs and monkeys after xylitol, glucose or tolbutamide infusion. Diabetes 1970; 19: 17-22   DOI
3 Cope RB. A screening study of xylitol binding in vitro to activated charcoal. Vet Hum Toxicol 2004; 46: 336-337
4 Kuzuya T, Kanazawa Y, Kosaka K. Plasma insulin response to intravenously administered xylitol in dogs. Metabolism 1966; 15: 1149-1152   DOI   ScienceOn
5 Dunayer EK, Gwaltney-Brant SM. Acute hepatic failure and coagulopathy associated with xylitol ingestion in eight dogs. J Am Vet Med Assoc 2006; 229: 1113-1117   DOI   ScienceOn
6 Asano T, Greenberg BZ, Wittmers RV, Goetz FC. Xylitol, a partial homologue ot alpha-D-glucopyranose: potent stimulator of insulin release in dogs. Endocrinology 1977; 100: 339- 345   DOI   ScienceOn
7 Kuzuya T, Kajinuma H, Sando H, Hayashi M, Ide T, Kosaka K. Comparison of the early time courses of the release of insulin that follow injections of tetragastrin, tolbutamide, xylitol, and glucose into the pancreatic artery of dogs. Diabetes 1978; 27: 1189-1195   DOI   ScienceOn