• 한국환경농학회지
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• 제29권2호
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• pp.115-119
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• 2010

Zinc (Zn) is an essential element required for growth and development of plants. However, Zn can be toxic to plants when it presents excessive amount. Phytoextraction is an economic and environment-friendly technique using plants to clean-up metal-contaminated soils. However, the technique cannot be applied in highly metal-contaminated areas because plants will not normally grow in such conditions. Therefore, this research focuses on identifying chelating agents which are biodegradable and applicable to highly metalcontaminated areas. Zn as a target metal and cysteine (Cys), histidine (His), malate, citrate oxalate, succinate, and ethylenediamine (EDA) as biodegradable chelating agents were selected. Plants were grown on agar media containing various chelating agents with Zn to analyze the effect on plant growth. Malate and His slightly increased the inhibitory effect of Zn on root growth of plants, whereas Cys, citrate, oxalate, and succinate did not show significant effects. However, EDA strongly diminished the inhibitory effect of Zn on root growth. The effect of EDA is correlated with decreased Zn uptake into the plants. In conclusion, as biodegradable chelating agents, EDA is a good candidate for growth of plants in highly Zn-contaminated areas.

• 환경영향평가
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• 제16권1호
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• pp.27-33
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• 2007

Hexavalent chromium-contaminated soils are encounted at many unregulated discharge and improper handling of wastes from electroplating, leather tanning, steelmaking, corrosion control, and wood preservation industries. Contamination of hexavalent chromium in the soil is a major concern because of its toxicity and threat to human life and environment. Current technologies for hexavalent chromium-contaminated soil remediation are usually costly and/or cannot permanently prohibit the toxic element from entering into the biosphere. Thus, as an alternative technique, immobilization is seen as a cost-effective and promising remediation technology that may reduce the leachable potential of hexavalent chromium. The purpose of this paper is to develope an immobilization technique for the formation of the geochemically stabilized hexavalent chromium-contaminated soil from the reactions of labile soil hexavalent chromium forms with the added soluble phosphate and chromium reducing agent. From the liquid phase experiment, reaction order of chromium reducing agent, soluble phosphate, alkali solution shows the best removal efficiency of 95%. In addition, actual soil phase experiment demonstrates up to 97.9% removal efficiency with 1:1 molar ratio of chromium reducing agent and soluble phosphate. These results provide evidence for the potential use of soluble phosphate and chromium reducing agent for the hexavalent chromium-contaminated soil remediation.

• Asian Pacific Journal of Cancer Prevention
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• 제15권6호
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• pp.2625-2629
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• 2014

Background: Trace elements are major components of biological structures; however, excessive levels of these elements can be toxic. Materials and Methods: In the present study, serum levels of trace elements were measured in 30 patients with newly diagnosed as prostate cancer and 32 healthy volunteer by using furnace atomic absorption spectrophotometry. Results: It was found that there was an increase in serum levels of Co, Cu, Mg and Pb (p<0.05), whereas a decrease in serum levels of Fe, Mn, and Zn levels in patients with prostate cancer (p<0.05). Conclusions: These changes may be important in the pathogenesis of prostate cancers; however, further prospective studies are needed to identify relationships between prostate cancer and trace elements.

• Asian Pacific Journal of Cancer Prevention
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• 제14권1호
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• pp.499-502
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• 2013

Trace elements which are essential components of biological structures may also be toxic when present at levels above the amounts required for biological function. In our study, trace element levels were measured with furnace atomic absorption spectrophotometry in 33 newly diagnosed renal cell carcinoma cases (preoperative) and 32 healthy controls. When compared with the control group, it was found that the levels of cadmium (Cd), lead (Pb) were higher and the levels of zinc (Zn), iron (Fe) and manganese (Mn) were lower in the patient group. These changes may be important in the formation of renal cell carcinoma, a question which should be explored with postoperative comparative studies.

• Applied Biological Chemistry
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• 제42권2호
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• pp.123-127
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• 1999

철은 사람에게 필수적인 영양소일 뿐 아니라 해로운 요소로도 작용한다. 이러한 철에 의해 진핵생물체에서 발현이 조절되는 유전자들을 밝히기 위해 철이 첨가되거나, 제거된 조건에서 배양된 HeLa세포로부터 RNA differential display 방법을 이용하여 발현 또는 억제되는 유전자들을 선별하였다. 모두 24개의 유전자가 선별되었으며, 염기배열 확인과 northern blot의 발현 확인과정을 거쳐 4개의 유전자들이 철에 의해 영향을 받는 것으로 확인되었다.

• 분석과학
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• 제8권3호
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• pp.371-374
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• 1995

유기게르마늄 화합물인 Ge-132의 분석법을 확립하였다. 이온교환수지 컬럼을 사용하고 $Na_2B_4O_7$ buffer를 이동상으로 하여 Ge-132를 분리한 다음, 전기전도도 검출기를 사용하여 검출하는 방법을 이용한 결과 50pmol의 농도까지 분석할 수 있었다. 이 방법은 Ge-132의 원료와 제품의 품질 관리에 응용이 가능하였다.

• The Korean Journal of Physiology and Pharmacology
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• 제18권4호
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• pp.307-311
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• 2014

In this study, we isolated scopoletin from Cirsium setidens Nakai (Compositae) and tested its effects on melanogenesis. Scopoletin was not toxic to cells at concentrations less than $50{\mu}M$ and increased melanin synthesis in a dose-dependent manner. As melanin synthesis increased, scopoletin stimulated the total tyrosinase activity, the rate-limiting enzyme of melanogenesis. In a cell-free system, however, scopoletin did not increase tyrosinase activity, indicating that scopoletin is not a direct activator of tyrosinase. Furthermore, Western blot analysis showed that scopoletin stimulated the production of microphthalmia-associated transcription factor (MITF) and tyrosinase expression via cAMP response element-binding protein (CREB) phosphorylation in a dose-dependent manner. Based on these results, preclinical and clinical studies are needed to assess the use of scopoletin for the treatment of vitiligo.

• 대한의생명과학회지
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• 제18권1호
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• pp.1-9
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• 2012

Differentially expressed genes by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) were identified in order to evaluate them as dioxin-sensitive markers and crucial signaling molecules to understand dioxin-induced toxic mechanisms in human bronchial cells. Gene expression profiling was analyzed by cDNA microarray and ten genes were selected for further study. They were cytochrome P450, family 1, subfamily B, polypeptide 1 (CYP1B1), S100 calcium binding protein A8 (calgranulin A), S100 calcium binding protein A9 (calgranulin B), aldehyde dehydrogenase 1 family, member A3 (ALDH6) and peroxiredoxin 5 (PRDX5) in up-regulated group. Among them, CYP1B1 was used as a hallmark for dioxin and sharply increased by TCDD exposure. Down-regulated genes were IK cytokine, interferon-induced protein with tetratricopeptide repeats 1 (IFIT1), nuclease sensitive element binding protein 1 (NSEP1), protein tyrosine phosphatase type VI A, member 1 (PTP4A1), ras oncogene family 32 (RAB32). Although up-regulated 4 genes in microarray were coincided with northern hybridization, down-regulated 5 genes showed U-shaped expression pattern which is sharply decreased at lower doses and gradually increased at higher doses. These results introduce some of TCDD-responsive genes can be sensitive markers against TCDD exposure and used as signaling cues to understand toxicity initiated by TCDD inhalation in pulmonary tissues.

• 세라미스트
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• 제21권4호
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• pp.312-330
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• 2018

Energy storage/conversion has become crucial not only to meet the present energy demand but also more importantly to sustain the modern society. Particularly, electrical energy storage is critical not only to support electronic, vehicular and load-levelling applications but also to efficiently commercialize renewable energy resources such as solar and wind. While Li-ion batteries are being intensely researched for electric vehicle applications, there is a pressing need to seek for new battery chemistries aimed at stationary storage systems. In this aspect, Zn-ion batteries offer a viable option to be utilized for high energy and power density applications since every intercalated Zn-ion yields a concurrent charge transfer of two electrons and thereby high theoretical capacities can be realized. Furthermore, the simplicity of fabrication under open-air conditions combined with the abundant and less toxic zinc element makes aqueous Zn-ion batteries one of the most economical, safe and green energy storage technologies with prospective use for stationary grid storage applications. Also, Zn-ion batteries are very safe for next-generation technologies based on flexible, roll-up, wearable implantable devices the portable electronics market. Following this advantages, a wide range of approaches and materials, namely, cathodes, anodes and electrolytes have been investigated for Zn-ion batteries applications to date. Herein, we review the progresses and major advancements related to aqueous. Zn-ion batteries, facilitating energy storage/conversion via $Zn^{2+}$ (de)intercalation mechanism.

• Journal of Ginseng Research
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• 제47권2호
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• pp.193-198
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• 2023

Several chemicals have been developed owing to the progression of industrialization, among which endocrine-disrupting chemicals (EDCs; essential for plastic production) are used as plasticizers and flame retardants. Plastics have become an essential element in modern life because they provide convenience, thus increasing EDCs exposure to humans. EDCs cause adverse effects such as deterioration of reproductive function, cancer, and neurological abnormalities by disrupting the endocrine system and hence are classified as "dangerous substances." Additionally, they are toxic to various organs but continue to be used. Therefore, it is necessary to review the contamination status of EDCs, select potentially hazardous substances for management, and monitor the safety standards. In addition, it is necessary to discover substances that can protect against EDC toxicity and conduct active research on the protective effects of these substances. According to recent research, Korean Red Ginseng (KRG) exhibits protective effects against several toxicities caused by EDCs to humans. In this review, the effects of EDCs on the human body and the role of KRG in protection against EDC toxicity are discussed.