• Proceedings of the Plant Resources Society of Korea Conference
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• 2003.10a
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• pp.1-8
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• 2003

Poisonous mushrooms have attracted much attention of scientists because of the unique chemical structures and the remarkable biological properties of their toxic components. A wide range of compounds has been characterized as toxic principles, and some of them have widened the horizons of chemical and biological research. Therefore, poisonous mushrooms can serve for a resource of biomedical application. We will describe the recent progress of such aspect of poisonous mushrooms.

• Journal of the Korean Institute of Gas
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• v.18 no.4
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• pp.76-85
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• 2014

To establish the necessary safety technology in high-pressure toxic gas facilities, especially for the corrosion, which is the main causes of toxic gas accident, this study adopts and investigates the API-581 procedures developed by the American Petroleum Institute (API). And the applicability of the 8-step analytical procedures of consequence analysis in API-581 is discussed, and a method for consequence analysis in high-pressure toxic gas facilities is suggested. Based on the discussion and results, the analytical procedure is simplified as the 6 steps in total for the effective application to high-pressure toxic gas facilities: Step 1 (determination of representative material), Step 5 (determination of release type), Step 6 (determination of phase of fluid), and Step 8 (estimation of damage range) are not applied: Step 3 (estimation of total amount of release) is applied only for the inventory group concept; Step 4 (estimation of release rate) only for the gas release rate; and all of Step 2 (selection of release hole size) and Step 7 (evaluation of post-release response) are applied. In the proposed method, the generally applicable method of CCPS is adopted as alternative method for Steps 5 and 8.

• Molecular & Cellular Toxicology
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• v.1 no.4
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• pp.268-274
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• 2005

Bromobenzene (BB) is well known hepatotoxicant. Also, BB is an industrial solvent that arouses toxicity predominantly in the liver where it causes centrilobular necrosis. BB is subjected to Cytochrome P450 mediated epoxidation followed by either conjugation with glutathione, enzymatic hydrolysis or further oxidation. In this study, we focused on BB-induced gene expression at non-hepatotoxic dose. Mice were exposed to two levels of BB, sampled at 24 h, and hepatic gene expression levels were determined to evaluate dose dependent changes. When examining the toxic dose of BB treated group in other previous studies, genes related to heat shock protein, oxidative stress, and drug metabolism are expressed. Compared to these results, our study, in which non-toxic dose of BB was administrated, showed similar patterns as the toxic conditions above. The purpose of the study was to select genes that showed changes in relation to the differing dose through confirmation of the difference within transcriptomic boundaries, but those that are not detected by the existing classic toxicology tools in non-hepatotoxic dose.

• Journal of Environmental Science International
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• v.7 no.4
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• pp.565-572
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• 1998

This study estimate the degree of contamination in the streamwater around the Sudokwon landfill site. It was sampled at 10 sites in Jan., Apr., Jul. and Oct., 1996. There were analyzed five kinds of toxic chemical material-CN, AES, PCB, As, Org-p, and four kinds of heavy metal-Pb, Hg, Cd, $C^{+6}$ The result are 1)The COD was generally increased to compare before landfall, 2) The Org-P and PCB were not detected at all points, 3) The concentrations of Pb, $C^{+6}$ and As were lower than the environmental criteria values, 4) The CN, Hg and Cd were over envirommental criteria values. and so emergent regulation is needed, 5) The effects of the streamwater contamination were not only the leachate of the landfall, but also the small factories and agricultural land around the landfill.

• BMB Reports
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• v.34 no.5
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• pp.440-445
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• 2001

Pesticide waste and chemical stockpiles are posing a potential threat to both Vie environment and human health. There is currently a great effort toward developing effective and economical methods for the detoxification of these toxic organophosphates. In terms of safety and economy, enzymatic biodegradation has been recommended as the most promising tool to detoxify these toxic materials. To develop an enzymatic degradation method to detoxify such toxic organophosphorus compounds, a gene encoding organophosphorus acid anhydrolase (OPAA) from genomic DNA of Alteromonas haloplanktis C was subcloned and expressed. The enzyme consists of a single polypeptide chain with a molecular weight of 48 kDa. It demonstrates strong hydrolyzing activity on sarin, an acetylcholinesterase inhibitor. Moreover, its high activity is sustained for a considerable length of time. It is projected that the recombinant OPAA can be applied as an enzymatic tool that can be used not only for the detoxification of pesticide wastes, but also for the demilitarization of chemical stockpiles.

• Environmental Engineering Research
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• v.25 no.4
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• pp.614-621
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• 2020

Antibiotic pollution is one of the factors contributing to the spread of antibiotic-resistant bacteria in the environment. Advanced oxidation and irradiation processes have been introduced to eliminate antibiotics from water and wastewater. However, few studies have reported the toxic effects of residual antibiotics and their byproducts induced by a treatment system. In this study, we compared the efficacies of chemical (high-performance liquid chromatography (HPLC)) and biological (antimicrobial susceptibility test) assays for measuring the concentrations of residual antibiotics after gamma irradiation for degrading amoxicillin, cephradine, lincomycin, and tetracycline. The concentrations of residual antibiotics estimated using the two assay methods were almost identical, except cephradine. In the case of cephradine, inhibited bacterial growth was observed that was equivalent to twice the concentration measured by HPLC in the samples subjected to gamma irradiation. The observed inhibition of bacterial growth suggested the generation of potentially toxic intermediates following antibiotic degradation. These results indicate that biological and chemical assays should be used in concert for monitoring antibiotic contamination and the toxic derivatives of antibiotic degradation. The results demonstrate that these four antibiotics can be decomposed by 2.0 kGy gamma-irradiation without toxic effects of their byproducts.

• Korean Journal of Veterinary Research
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• v.36 no.1
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• pp.221-233
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• 1996

This experiment was carried out to study the toxic effect of solublized methylcellulose (MC). Sprague-Dawley rats were dosed with 1%(w/v) MC in 0.9% saline by gavage at a dose of 10ml/kg b.w/day or by intravenous injection at a dose of 5ml/kg b.w/day for 28 days. Clinical signs were observed once a day. Body weights, water and food consumptions were measured and urinalysis was performed several times during the experiment. Rats were sacrificed on days 3, 7, 15 and 28 for hematology, blood chemistry, organ weights and histopathology. The relative weight of the spleen and foamy cells of the spleen were increased in the gavage group. Body weight gain, food consumptions, the values of RBC, Hb, MCH, Hct, serum proteins, glucose, bilirubin, AST, and ALP were decreased in I.V. treatment group. On the other hand, water consumptions, the values of serum cholesterol, creatinine, and BUN were increased. Microscopic findings were granulomas, distended sinusoids, and hypertrophy of Kupffer cells with vacuoles in the liver. Spleen exhibited granuloma, increased extramedullary hematopoiesis, and congestion. Kidney exhibited foamy cells in the glomeruli, distension of the tubules. The findings appeared more severe when the treatment was extended. In conclusion, MC solution is not a safe vehicle for intravenous administration because of the toxic effects on the liver, kidney and spleen. In addition, a long-term and large dosage of oral administration of MC appears to be unsafe also and needs to be investigated further.

• Journal of Environmental Health Sciences
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• v.48 no.3
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• pp.183-194
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• 2022

Background: No study has examined the regulatory factors associated with fatal health problems due to the use of humidified disinfectants (HD) in South Korea. Objectives: This study aimed to identify and discuss the deficiencies and limitations found in the Toxic Chemical Control Acts (TCCA) that failed to prevent the health risk of chemicals in HD products. Methods: The South Korean TCCA was reviewed focusing on acts in operation from 1994 through the end of 2011, the period when HD was allowed in manufacturing and marketing. Results: The TCCA was the act intended to regulate the toxicity of chemicals in HD products. We found the TCCA to lack three key legal clauses which would have been essential to controlling the health risk of HD. First, there was the exemption of toxic and hazard testing for existing chemicals, including chloromethylisothiazolinone (CMIT), methylisothiazolinone (MIT), and benzalkonium chloride (BKC). Secondly, there were no articles requiring industry to provide animal inhalation test result for polymers such as polyhexamethylene guanidine (PHMG) and Oligo(2-)ethoxyethoxyethyl guanidine chloride (PGH). Finally, there was a lack of articles on examining the risk of products as well as on addressing changes in the usage of products. These articles were found to be generally provided in the US Toxic Substance Chemical Act (TSCA) and the EU Registration, Evaluation and Authorization of Chemicals (REACH). Conclusions: In conclusion, the Ministry of Environment of South Korea had not updated key articles for regulating hazardous chemicals, causing large-scale health problems due to HD which had been fundamentally addressed in chemical-related acts in other countries.

• Journal of the Korean Chemical Society
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• v.63 no.6
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• pp.411-414
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• 2019

• Korean Chemical Engineering Research
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• v.54 no.6
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• pp.781-785
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• 2016

Chloric acid is a toxic chemical and the risk of facility handling chloric acid was assessed from the list of accident scenario to provide countermeasure to keep the vicinity safe. Accident scenarios were listed by using MSDS and process safety information. The scenarios having effect to the off-site were selected and assessed further according to guideline provided by Korea government. Worst case and alternative scenarios including other interested scenarios were evaluated using ALOHA. Each evaluated scenario was assessed further considering countermeasures. The results showed that the facility handling chloric acid is safe enough and needed no further protections at the moment.