• Title/Summary/Keyword: total synthesis

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A Total Synthesis of Aliskiren Starting from D-Tartrate Diester

  • Kim, Ji Hei;Ko, Soo Y.
    • Bulletin of the Korean Chemical Society
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    • v.34 no.12
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    • pp.3777-3781
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    • 2013

  • A formal total synthesis of aliskiren was accomplished. A key in our synthesis was to use the symmetric ciscisoid-cis-bis-lactone 3' as a precursor, which was prepared from D-tartrate diester. Appending the end groups and functional group transformations completed the synthesis.

  • https://doi.org/10.5012/bkcs.2013.34.12.3777 인용 PDF KSCI KPUBS HTML

Total Synthesis of Isopimarol Diterpene (Isopimarol Diterpene의 전합성)

  • 서영거;전라옥
    • YAKHAK HOEJI
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    • v.43 no.6
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    • pp.696-702
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    • 1999

  • The first and versatile total synthesis of isopimarol diterpene has been achieved via stereoselective construction of C-13 quaternary carbon unit as a key step. Isopimarol diterpene was synthesized from the known decalone in 17% overall yield of 16 steps.

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THE EFFECT OF NATURAL EXTRACTS ON CELL GROWTH AND CYTOKINE PRODUCTION (생약 추출물이 세포성장 및 cytokine 생산에 미치는 영향)

  • Ryu, In-Cheol;Son, Seong-Heui;Chung, Chong-Pyoung;Bae, Ki-Hwan
    • Journal of Periodontal and Implant Science
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    • v.23 no.1
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    • pp.37-47
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    • 1993

  • The native connective tissue attachment of the periodontium is known to be a complex consisting of gingival fibroblasts, periodontal ligament cells, gingival epithelial cells, cementum, alveolar bone and extensive extracellular matrix (collagen, glycoprotein and proteoglycans). The purpose of this study was to evaluate the effects of natural extracts on DNA, collagen and protein synthesis and inhibition of cytokine production in the gingival and periodontal ligament fibroblasts and gingival epithelial cells. Healthy gingival tissue was obtained from orthodontic treatment patients, and gingival epithelial cells, gingival fibroblasts and periodontal ligament cells were isolated and cultured from the samples. After treated with Ginseng protein, Pluronic F-68, Scutellariae Radix, centella asiatica, PDGF, IGF, DNA synthesis, total protein and collagen synthesis, and cytokine production of gingival epithelial cell, gingival fibroblast and periodontal ligamentcells were measured. MTT method for DNA synthesis, Peterkofsky and Dingerman method for total protein and collagen synthesis, and IL-1 ELISA kit for cytokine production were used. The proliferation of epithelial cells was enhanced in Centella asiatica, Ginseng protein, Pluronic F-68 and Scutellariae Radix. The activities of PDL cells were increased in PDGF, IGF, and Pluronic F-68. Higher collagen synthesis was observed in Scutellariae Radix and total protein synthesis was increased in Scutellariae Radix and PDGF. The inhibitory effects on IL-1, IL-6, $TNF-{\alpha}$ were observed in all exrracts.

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Enantioselective Total Synthesis of (-)-Clavosolide A and B

  • Son, Jung-Beom;Kim, Si-Nae;Kim, Na-Yeong;Hwang, Min-Ho;Lee, Won-Sun;Lee, Duck-Hyung
    • Bulletin of the Korean Chemical Society
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    • v.31 no.3
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    • pp.653-663
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    • 2010

  • Enantioselective total synthesis of (-)-clavosolide A and B was reported in full including the synthesis of proposed structure of (-)-clavosoldie A (1), revised structure of (-)-clavosoldie A (5), and revised structure of (-)-clavosoldie B (6). The relative and absolute stereochemistries of the natural products were confirmed unambiguously by comparing the optical rotation values and $^1H$ and $^{13}C$ NMR spectra of them.

  • https://doi.org/10.5012/bkcs.2010.31.03.653 인용 PDF KSCI