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http://dx.doi.org/10.5012/bkcs.2013.34.12.3777

A Total Synthesis of Aliskiren Starting from D-Tartrate Diester  

Kim, Ji Hei (Department of Chemistry, Ewha Womans University)
Ko, Soo Y. (Department of Chemistry, Ewha Womans University)
Publication Information
Bulletin of the Korean Chemical Society / v.34, no.12, 2013 , pp. 3777-3781 More about this Journal
Abstract
A formal total synthesis of aliskiren was accomplished. A key in our synthesis was to use the symmetric ciscisoid-cis-bis-lactone 3' as a precursor, which was prepared from D-tartrate diester. Appending the end groups and functional group transformations completed the synthesis.
Keywords
Aliskiren; Total synthesis; D-tartrate diester; Symmetric precursor;
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