• 한국자기공명학회논문지
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• 제26권1호
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• pp.1-9
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• 2022

There are two distinct approaches to improving the quality of protein NMR structures during refinement: all-atom force fields and accumulated knowledge-assisted methods that include Rosetta. Mao et al. reported that, for 40 proteins, Rosetta increased the accuracies of their NMR-determined structures with respect to the X-ray crystal structures (Mao et al., J. Am. Chem. Soc. 136, 1893 (2014)). In this study, we calculated 32 structures of those studied by Mao et al. using all-atom force field and implicit solvent model, and we compared the results with those obtained from Rosetta. For a single protein, using only the experimental NOE-derived distances and backbone torsion angle restraints, 20 of the lowest energy structures were extracted as an ensemble from 100 generated structures. Restrained simulated annealing by molecular dynamics simulation searched conformational spaces with a total time step of 1-ns. The use of GPU-accelerated AMBER code allowed the calculations to be completed in hours using a single GPU computer-even for proteins larger than 20 kDa. Remarkably, statistical analyses indicated that the structures determined in this way showed overall higher accuracies to their X-ray structures compared to those refined by Rosetta (p-value < 0.01). Our data demonstrate the capability of sophisticated atomistic force fields in refining NMR structures, particularly when they are coupled with the latest GPU-based calculations. The straightforwardness of the protocol allows its use to be extended to all NMR structures.

• 한국자기학회지
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• 제10권5호
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• pp.250-255
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• 2000

본 연구에서는 double rectangular spiral형 공심 인덕터를 유사 LIGA공정으로, F $e_{86.7}$Z $r_{3.3}$ $B_{4}$A $g_{6}$ 자성막을 dc magnetron sputtering법으로 각각 제조한 후 인덕터의 구조를 변화시켜, 인덕터의 임피던스 특성에 미치는 자성막의 특성 인자에 대해 연구하였다. 공심 인덕터의 전류 방향과 자성 박막의 자화 용이축이 수직일 경우 인덕터의 인덕턴스가 향상되었고, 공심 인덕터와 F $e_{86.7}$Z $r_{3.3}$ $B_{4}$A $g_{6}$ 자성막 사이 절연막이 없는 경우 자성막의 자속 집속효과가 증가하여 절연막이 있는 경우보다 인덕턴스는 높고, 저항의 증가율이 높았으며, F $e_{86.7}$Z $r_{3.3}$ $B_{4}$A $g_{6}$ 자성막의 투자율이 높을수록 인덕터의 인덕턴스에 기여하는 부분이 증가하므로 인턱턴스는 향상되었다. 또한 인덕터의 주파수 특성은 공심 인덕터의 특성에 지배적인 영향을 받으므로 인덕터의 주파수 특성을 향상시키기 위해서는 자성막의 특성보다 공심 인덕터의 특성을 향상시키는 것이 바람직하다.키는 것이 바람직하다.

• Journal of Astronomy and Space Sciences
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• 제29권4호
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• pp.329-336
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• 2012

Korea Astronomy and Space Science Institute researchers have installed and operated magnetometers at Bohyunsan Observatory to measure the Earth's magnetic field variations in South Korea. In 2007, we installed a fluxgate magnetometer (RFP-523C) to measure H, D, and Z components of the geomagnetic field. In addition, in 2009, we installed a Overhauser proton sensor to measure the absolute total magnetic field F and a three-axis magneto-impedance sensor for spectrum analysis. Currently three types of magnetometer data have been accumulated. In this paper, we use the H, D, Z components of fluxgate magnetometer data to investigate the characteristics of mid-latitude geomagnetic field variation. To remove the temporary changes in Earth's geomagnetic filed by space weather, we use the international quiet days' data only. In other words, we performed a superposed epoch analysis using five days per each month during 2008-2011. We find that daily variations of H, D, and Z shows similar tendency compared to previous results using all days. That is, H, D, Z all three components' quiet intervals terminate near the sunrise and shows maximum 2-3 hours after the culmination and the quiet interval start from near the sunset. Seasonal variations show similar dependences to the Sun. As it becomes hot season, the geomagnetic field variation's amplitude becomes large and the quiet interval becomes shortened. It is well-known that these variations are effects of Sq current system in the Earth's atmosphere. We confirm that the typical mid-latitude geomagnetic field variations due to the Sq current system by excluding all possible association with the space weather.

• 대한전자공학회논문지SD
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• 제44권2호
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• pp.1-6
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• 2007

본 연구에서는 모양으로 유도된 자기 이방성을 가진 $Ni_{80}Fe_{20}/SiO_2$ laminates 다층막의 자기적 성질을 조사 하였다. 다층막은 rf 다이오드 스퍼터링 시스템을 이용하여 개개의 $Ni_{80}Fe_{20} 와 $SiO_2$ (at%) 합금 타겟들로부터 Si 또는 upilex 기판에 적층하였다. 여러 가지 개수(N)의 이중층으로 구성된 $Ni_{80}Fe_{20}/SiO_2$ laminates 가 적층되었다. 사진식각기술을 사용하여 타원형 어레이 패턴을 가진 $Ni_{80}Fe_{20}/SiO_2$ laminates 가 제작 되었다. 자기적 성질은 B-H 히스테리시스 그래프와 고주파 permeameter를 사용하여 상온에서 측정 되었다. 다층막에서 도메인 reversal 시 발견된 몇 개의 스텝들은 자성체 박막 사이에 존재하는 coupling 때문으로 사료된다. 내재하는 intrinsic 일축 자기 이방성 field는 N이 증가하면 증가한다. 전체 자기 이방성 field의 실험값은 계산된 값과 잘 일치 하였다. 본 연구에서는 소형의 타원형 어레이를 가진 다층막의 laminate 구조체를 이용하여 더 큰 일축 자기 이방성을 유도하고 그 결과 laminate의 동작 주파수를 극대화시키고자 하였다.

• Journal of Magnetics
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• 제21권4호
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• pp.593-598
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• 2016

In order to reduce the amount of noise component in X-ray imaging system, various reduction techniques were frequently used in the field of diagnostic imaging. Although the previous techniques -such as median, Wiener filters and Anscombe noise reduction technique - were able to reduce the noise, the edge information was still damaged. In order to cope with this problem, total variation (TV) noise reduction technique has been developed and researched. The purpose of this study was to evaluate and compare the image quality using normalized noise power spectrum (NNPS) and contrast-to-noise ratio (CNR) through simulations and experiments with respect to the above-mentioned noise reduction techniques. As a result, not only lowest NNPS value but also highest CNR values were acquired using a TV noise reduction technique. In conclusion, the results demonstrated that TV noise reduction technique is proved as the most practical method to ensure accurate denoising in X-ray imaging system.

• 대한물리의학회지
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• 제15권4호
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• pp.101-109
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• 2020

PURPOSE: This study investigates the therapeutic effect of a prototype of a hand rehabilitation device based on magnetic forces. METHODS: Using an electromagnet and permanent magnets, we developed an end effector type device that induces various movements of the finger in accordance with the magnetic field direction. A total of 26 subacute stroke patients were enrolled and assigned to two groups in this randomized controlled trial. The intervention group received 30 minutes hand rehabilitation therapy per day for 4 weeks, using the device developed by us. Conventional physical therapies were conducted equally twice a day, 30 minutes per session, during the same period in both groups. RESULTS: After 4 weeks, rate of the Wolf Motor Function Test as a primary outcome measure showed significant improvement in the intervention group as compared to control group(p = .036). Scores of the Manual Function Test and Fugl-Meyer Assessment of upper limb were also significantly increased in the intervention group as compared to control group(p = .038 and p = .042, respectively). Moreover, the Korean version of Modified Barthel Index tended to improve after subjecting to physical therapy in both groups. CONCLUSION: Our results indicate that the novel hand rehabilitation device developed using a magnetic force, improves the hand motor functions and activities of daily life in subacute stroke patients.

• Journal of Astronomy and Space Sciences
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• 제28권3호
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• pp.173-181
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• 2011

Korea Astronomy and Space Science Institute researchers have installed and operated magnetometers at Mt. Bohyun Observatory to measure the Earth's magnetic field variations in South Korea. We, in 2007, installed a fluxgate magnetometer (RFP-523C) to measure H, D, and Z components of the geomagnetic field. In addition, in 2009, we installed a Overhauser proton sensor to measure the absolute total magnetic field F and a three-axis magneto-impedance sensor for spectrum analysis. Currently three types of magnetometer data have been accumulated. In this paper, we provide the preliminary and the first statistical analysis using the BOH magnetometer installed at Mt. Bohyun Observatory. By superposed analysis, we find that daily variations of H, D, and Z shows similar tendency, that is, about 30 minutes before the meridian (11:28) a minimum appears and the time after about 3 hours and 30 minutes (15:28) a maximum appears. Also, a quiet interval start time (19:06) is near the sunset time, and a quiet interval end time (06:40) is near the sunrise time. From the sunset to the sunrise, the value of H has a nearly constant interval, that is, the sun affects the changes in H values. Seasonal variations show similar dependences to the sun. Local time variations show that noon region has the biggest variations and midnight region has the smallest variations. We compare the correlations between geomagnetic variations and activity indices as we expect the geomagnetic variation would contain the effects of geomagnetic activity variations. As a result, the correlation coefficient between H and Dst is the highest (r = 0.947), and other AL, AE, AU index and showed a high correlation. Therefore, the effects of geomagnetic storms and geomagnetic substorms might contribute to the geomagnetic changes significantly.

• 한국초전도ㆍ저온공학회논문지
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• 제8권4호
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• pp.30-33
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• 2006

Several crucial issues are discussed in the design of cryogenic cooling system for high field magnets. This study is mainly motivated by our ongoing program to develop a 21 T Fourier Transform Ion Cyclotron Resonance Mass Spectrometer (FT-ICR MS). The magnets of this system will be built horizontally to accomplish the requirement of user friendliness and reliability, and the replenishment of cryogen will not be necessary by a closed-loop cooling concept. The initial cool-down and safety are basically considered in this paper. The effects of the helium II volume and the gap distance of the weight load relief valve (or safety valve) on the cool-down time and temperature rising during an off-normal state are discussed. The total amount of cryogenic cooling loads and the required helium flow rate during cool-down are also estimated by a relevant heat transfer analysis. The temperatures of cryogen-free radiation shield are finally determined from the refrigeration power of a cryocooler and the total cryogenic loads.

• Journal of Astronomy and Space Sciences
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• 제34권4호
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• pp.237-244
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• 2017

Magnetic flux ropes, often observed during intervals of interplanetary coronal mass ejections, have long been recognized to be critical in space weather. In this work, we focus on magnetic flux rope structure but on a much smaller scale, and not necessarily related to interplanetary coronal mass ejections. Using near-Earth solar wind advanced composition explorer (ACE) observations from 1998 to 2016, we identified a total of 309 small-scale magnetic flux ropes (SMFRs). We compared the characteristics of identified SMFR events with those of normal magnetic cloud (MC) events available from the existing literature. First, most of the MCs and SMFRs have similar values of accompanying solar wind speed and proton densities. However, the average magnetic field intensity of SMFRs is weaker (~7.4 nT) than that of MCs (~10.6 nT). Also, the average duration time and expansion speed of SMFRs are ~2.5 hr and 2.6 km/s, respectively, both of which are smaller by a factor of ~10 than those of MCs. In addition, we examined the geoeffectiveness of SMFR events by checking their correlation with magnetic storms and substorms. Based on the criteria Sym-H < -50 nT (for identification of storm occurrence) and AL < -200 nT (for identification of substorm occurrence), we found that for 88 SMFR events (corresponding to 28.5 % of the total SMFR events), substorms occurred after the impact of SMFRs, implying a possible triggering of substorms by SMFRs. In contrast, we found only two SMFRs that triggered storms. We emphasize that, based on a much larger database than used in previous studies, all these previously known features are now firmly confirmed by the current work. Accordingly, the results emphasize the significance of SMFRs from the viewpoint of possible triggering of substorms.

• 천문학회보
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• 제36권2호
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• pp.56.2-56.2
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• 2011

Building a relativistic magnetohydrodynamic (RMHD) codes based on upwind schemes is a challenging project, because the characteristic wave structures for RMHDs has not yet been analytically given. We obtained an analytic expression of eigenvalues and eigenvectors of the flux Jacobian matrix of RMHDs for one-dimensional, isothermal flows with two velocity and magnetic field components (that is, x and y components only), which can be used to build numerical codes. The degeneracies were taken into account. Here, we present preliminary test results with an RMHD code based on the total variation diminishing (TVD) scheme.