• Biomolecules & Therapeutics
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• 제16권3호
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• pp.293-298
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• 2008

Cirsium japonicum water extracts has been used to treat vascular related diseases. We have previously reported that Cirsium japonicum extracts activated estrogen receptors. It is widely known that estrogen increases the high density lipoprotein cholesterol and decrease the low density lipoprotein cholesterol on the lipid profile. But effects of Cirsium japonicum on lipid profile are not reported yet. Therefore, we have studied the effects of Cirsium japonicum on the lipid content in ovariectomized rats. Thirty Sprague-Dawley (SD) rats of $210{\pm}20\;g$ were studied for 10 weeks. The rats were divided into five groups; (I) sham, no ovariectomized rats plus olive oil, (II) ovariectomized rats plus olive oil, (III) ovariectomized rats plus 0.5 mg/kg $17{\beta}$-estradiol (E2) in olive oil, (IV) ovariectomized rats plus 0.5 mg/kg Cirsium japonicum in olive oil, and (V) ovariectomized rats plus 5 mg/kg Cirsium japonicum in olive oil. Treatment with Cirsium japonicum or E2 induced significant reduction in total cholesterol, low density lipoprotein cholesterol/total cholesterol, total cholesterol/high density lipoprotein cholesterol and low density lipoprotein cholesterol/high density lipoprotein cholesterol compared to control group as well as increase in uterine weight. However, changes in triglycerides levels were different. Our results suggest that Cirsium japonicum is functionally similar to E2 in vivo as well as in vitro.

• Journal of Nutrition and Health
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• 제27권6호
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• pp.563-573
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• 1994

This study was conducted to compare the lipid content and fatty acid composition of the Korean breast milk produced at 1, 2 and 3 months postpartum with the infant formula produced in Korea. The content of total lipids of the breast milk was low compared with the other data of Korean as well as foreign breast milk, and the content tended to reduce during the progress of lactation. The composition of fatty acids of the breast milk was characterized by low saturated fatty acids(SFA) and high $\omega$3 series of polyunsaturated fatty acids (PUFA), especially 20:5 and 22:6, so the P/S and $\omega$6/$\omega$3 rations were high. The formulas had more total lipids, triglycerides(TG) and phospholipids and less cholesterol(CHOL) and free fatty acids than the breast milk. The cholesterol content of the formulas was around 50% of that of the breast milk, so the CHOL/TG ratio was low. Although the formulas varied in fatty acid composition, the formulas had more SFA and $\omega$6 series of PUFA, but less monounsaturated fatty acids and $\omega$3 series of PUFA than the breast milk. This study shows that there are some differences in lipid content and fatty acid composition between breast milk and infant formula. Therefore, further studies needed to investigate the physiological effect of this difference on lipid metabolism of infants.

• 생약학회지
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• 제35권4호통권139호
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• pp.300-308
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• 2004

This study was done to investigate the antidiabetic effect of Glechoma hederacea LINNAEUS in Streptozotocin (STZ)-induced diabetic rats. Diabetes was induced by intravenous injection of STZ at a dose of 45 mg/kg dissolved in citrate buffer. The methanol extract of Glechoma hederacea was orally administrated once a day for 6 days. The contents of serum glucose, triglyceride (TG), total cholesterol and Atherogenic Index (Al) were significantly decreased, but high density lipoprotein (HDL)-cholesterol and HDL-cholesterol/total cholesterol ratio (HTR) were significantly increased in Glechoma hederacea treated STZ-sample group compared to the those of STZ-control group. The content of hepatic lipid peroxide and activity of catalase were decreased, but content of glutathione as well as activities of glutathione-S-transferase and superoxide dismutase were increased in Glechoma hederacea treated STZ-sample group compared to the those of STZ-control group. The content of hepatic glycogen and activities of glucose-6-phosphate dehydrogenase, glucokinase were significantly increased, but activity of glucose-6-phosphatase was decreased in Glechoma hederacea treated STZ-sample group compared to the those of STZ-control group. These results indicated that methanol extract of Glechoma hederacea would have antidiabetic effect in STZ-induced diabetic rats.

• 한국가금학회지
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• 제34권3호
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• pp.223-229
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• 2007

본 연구는 잣 부산물의 급여가 산란계의 산란율, 계란 품질, 혈청 콜레스테롤 및 난황 내 총 콜레스테롤과 지방산 함량에 미치는 영향에 대하여 알아보기 위하여 시험을 실시하였다. 사양 시험은 51주령 Hy-line Brown 252수를 공시하였으며 5주간 실시하였다. 1) T1(기초 사료 + 미루나무톱밥 1%), 2) T2(기초 사료 + 잣 부산물 0.5% + 미루나무톱밥 0.5%) 및 3) T3(기초 사료 + 잣 부산물 1%)로 3개 처리를 하여 처리당 7반복, 반복당 12수씩 완전 임의 배치하였다. 전체 사양 시험 기간 동안 산란율, 난중 및 계란 품질은 처리구간에 유의적인 차이가 없었다. 혈청 내 총 콜레스테롤, HDL, LDL 콜레스테롤 및 triglyceride의 함량 및 변화량은 처리구간에 유의적인 차이가 없었으며, 난황 내 콜레스테롤 함량은 처리구간에 유의적인 차이가 없었다. 난황 내 지방산 함량에 있어서 ${\alpha}$-linoleic acid은 T1처리구가 T3처리구와 비교하여 유의적으로 높게 나타났으나(P<0.05), Total SFA, total PUFA, total MUFA 및 total UFA/SFA는 처리구간에 유의적인 차이가 없었다. 결론적으로, 산란계 사료 내 잣 부산물의 첨가 급여는 ${\alpha}$-linoleic acid 함량에 영향을 미치는 것으로 사료된다.

• Food Science and Biotechnology
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• 제18권4호
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• pp.884-888
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• 2009

Effect of citrus pectin oligosaccharides produced by irradiation was studied on the ability to improve lipid metabolism and hypercholesterolemia in mice fed high cholesterol diets. A total of 35 mice were divided into 5 groups and fed the following diets for 6 weeks: normal diet (C), 0.5% cholesterol (CH), 0.5% cholesterol+5% non-irradiated pectin (P), 0.5% cholesterol+5% irradiated pectin at 20 kGy (PIR), and 0.5% cholesterol+5% irradiated at 20 kGy and dialyzed (PIR-F). CH group had significantly higher serum triglycerides, total cholesterol, and low density lipoprotein (LDL)-cholesterol contents than pectin oligosaccharide-treated groups (p<0.05). Triglycerides and total cholesterol contents was the lowest in C and PIR-F and followed by PIR and P group, and CH group had significantly higher LDL-cholesterol. Serum high density lipoprotein (HDL)-cholesterol content in C group was not different from that in CH and P groups, but lower than that of PIR and PIR-F groups. These results suggest that pectin oligosaccharides produced by irradiation can reduce the levels of serum triglyceride, total cholesterol, and LDL-cholesterol in the blood of mice fed high-cholesterol diets and therefore, irradiation can be used as a tool to produce functional oligosaccharides from citrus pectin.

• Journal of Community Nutrition
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• 제3권1호
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• pp.14-20
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• 2001

A cross-sectional study to determine dietary intake and plasma triglyceride total cholesterol LDL-cholesterol and HDL-cholesterol of 185K Korean men was conducted across three different age groups The younger group (age 21 to 34) was significantly (p<0.001) taller but showed lower (p<0.05) percent body fat than the older group (age 45 to 60) Weight and body mass index was not different among age groups. Older men showed significantly(p<0.01) lower energy and total fat intake than younger men Besides macronutrients, most participants consumed an adequate amount of micronutrients but calcium consumption of the middle age group (age 35 to 44) was less than 75% of RDA In older men plasma triglyceride(207.8$\pm$155.5 mg/dl) total cholesterol (201.4$\pm$40.0 mg/dl) and LDL-cholesterol(106.0$\pm$32.7 mg/dl) concentrations were significantly hight(p<0.001) than in younger men wereas no significant difference was observed in HDL-cholesterol concentration Subjects with a higher BMI(bMI$\geq$25.0) showed significantly higher (p<0.001) triglyceride(200.2$\pm$107.6 mg/dl) total cholesterol(211.0$\pm$40.1 mg/dl) LDC-cholesterol(118.16$\pm$35.5 mg/dl) concentrations and lower(p=0.001) HCL-cholesterol concentration (52.8$\pm$15.9 mg/dl) than subjects with lower BMI(BMI<23.0) Dietary intake of fat cholesterol did not show significant associations with any of the plasma lipid profiles. However, anima fat intake was significantly (p<0.05) correlated with plasma total cholesterol and triglyceride concentrations in the older age group. On the hand percent body fat was correlated (p<0.05) with all of the plasma lipid and lipoprotin concentrations examined for all age groups Results indicate both dietary intake and percent body fat are important determinants of the plasma lipid concentrations is the elderly but only percent body fat or body mass could be valid predictors for the plasma lipid concentrations of the younger age group.

• Journal of Nutrition and Health
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• 제29권2호
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• pp.199-205
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• 1996

The effects of several carbohydrate sources on plasma, liver and fecal lipid contents of rats fed diet containing sucrose, corn starch, brown rice, milled rice or wheat flour with 0.3% cholesterol for four weeks were investigated. Plasma triglyceride and total cholestrol increased significntly in sucrose group, and decreased significantly in milled rice group compared to other three groups. There were no significant differences in plasma lipid contents among corn starch, brown rice and wheat flour groups. The contents of liver triglyceride and cholesterol in brown rice group decreased significantly compared to there four groups. Fecal excretion of total cholesterol in rice and wheat flour groups was significantly higher than in sucrose and corn starch groups. The contents of fecal bile acid increased significantly in milled rice and brown rice groups compared to other three groups. Fecal bile acid content of wheat flour group was similar to those of sucrose and corn starch group. From these results, it is suggested that rice has a possibility of hypolipidemic effect in cholesterol fed rat.

• 한국식생활문화학회지
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• 제23권4호
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• pp.521-528
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• 2008

This study examined the effects of 2% Lycii fructus powder (LFP) supplementation on lipid metabolism in rats. Male Sprague-Dawley rats were administered 1% cholesterol and 0.25% sodium cholate to induce hypercholesterolemia. Then, 40 rats were divided into four diet groups: a normal diet group (NC), high cholesterol diet group (HC), normal diet plus 2% Lycii fructus powder (NC-LFP) group, and high cholesterol diet plus 2% Lycii fructus powder (HC-LFP) group. The HC group presented higher growth rates and liver weights than NC and NC-LFP however, growth rates and liver weights in the 2% LFP administered groups gradually decreased. HC also showed increased serum triglyceride, total cholesterol, free cholesterol, and LDL-cholesterol levels and decreased atherogenic index values, HDL-cholesterol, and phospholipid levels, whereas LFP group showed decreased serum triglyceride, total cholesterol, free cholesterol, and LDL-cholesterol levels as compared to HC. There were no differences in serum triglyceride, phospholipid, LDL-cholesterol, HDL-cholesterol, and free cholesterol concentrations between the normal diet groups (NC and NC-LFP). The high cholesterol diet groups (HC and HC-LFP) had significant increases in serum alanine aminotransferase (ALT), asparate aminotransferase (AST), alkaline phosphatase (ALP), and lactate dehydrogenase (LDHase) activities. And the 2% LFP administered groups had lower hepatic concentrations of total cholesterol and triglycerides than the HC groups. Overall, the results suggest that Lycii fructus powder has hypochloesterolemic effects by reducing serum and liver cholesterol contents.

• 대한가정학회지
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• 제18권4호
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• pp.103-107
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• 1980

This study was conducted to compare the effect of dietary sucrose and starch on the lipid metabolism of Rat fed by low protein diet for 3 and 6 weeks periods. Forty male weanling Spargue-Dawley rats weighing 52.7 grams each, after being adopted for 2 days with standard diet, were blocked into 8 groups and fed experimental diet as designed. Experimental diet were composed of two different levels of proteins, 6% designed as low protein diet and 15% designed as standard protein diet. In each group, the content of serum lipid, serum cholesterol and liver lipid were measured. The results of this experiment were summerized as follows. 1. liver lipid content was tended to be high in the sucrose group of low protein fed animal. 2. the content of total serum lipid was tended to be high in the sucrose group, and this tendency was showed statistical significance in the animals fed by low and standard protein after 6 weeks of experimental period. 3. The difference in the total serum cholesterol content between the sucrose and starch group was not significant

• 한국식품영양과학회지
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• 제23권4호
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• pp.568-571
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• 1994

This study was conducted to investigate the effect of Platycodi radix Saponin(PRS) on the reduction of lipid status in rats fed on high fat diet for 6 weeks after which lipid contents were measured in serum , liver and feces. The results obtained from this study are as follows : That the levels of total lipid, total cholesterol and triglyceride in serum and liver were significantly lower in the PRS group as compared with the control group. The contents of total lipid and total cholesterol excreted in the feces were tended to be slightly increase in PRS group compared to the control group, which were not significant.