• Journal of the Korean Data and Information Science Society
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• 제21권4호
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• pp.651-667
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• 2010

항-고지혈 효과에 대한 연관 측도로 효과 인자를 고려한 헤지의 표준화된 평균차를 이용하였다. 고정효과모형을 적용하여 메타분석을 시행하였다. 그 결과 변의 콜레스테롤 농도와 총 콜레스테롤 농도 그리고 트리글리세리드 농도에서 통계적으로 유의한 감소를 보였으며, 고농도지단백 콜레스테롤 농도에서 통계적으로 유의한 증가를 보였다. 다음으로 연구 간 분산을 고려하지 않고 고정효과모형을 가정하여 분석한 모든 변수들에 대해 동질성 검정을 실행하여 연구 간의 이질성의 존재를 확인하였다. 그 결과 신장의 무게, 간의 무게, 고농도지단백 콜레스테롤, 저농도지단백 콜레스테롤, 총 콜레스테롤, 트리글리세리드 농도에서 동질성을 만족하지 않았다.

• 한국환경과학회지
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• 제20권8호
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• pp.1031-1039
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• 2011

This study was conducted to examine the influences of chitosan, sericin and collagen extract complexes (1:1:1, w/w/w, CSC-F-005) in blood glucose and lipid concentrations in the sera of streptozotocin (STZ, 55 mg/kg BW, IP injection)-induced diabetic rats (SD strain) fed on experimental diets for 5 weeks. The concentrations of blood glucose, total cholesterol, HDL-cholesterol, ratio of HDL-cholesterol concentration to total cholesterol, atherosclerotic index, LDL-cholesterol, free cholesterol, cholesteryl ester, triglyceride (TG) and phospholipid (PL) in serum were effective on the metabolic regulation in diabetic rats. The activities of alkaline phosphatase (ALP) and aminotransferase (AST, ALT) in serum were lower in the extract complexes (CSC-F-005) than in the diabetic rats. The results shown above suggested that CSC-F-005 extract complexes supplementation effectively improvement of blood glucose and lipid components in the serum of STZ-induced diabetic rats.

• 한국환경과학회지
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• 제20권8호
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• pp.1021-1030
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• 2011

The objective of this study was to assess improvements caused by chitosan, sericin and collagen peptide extract complexes (1:1:1, w/w/w, CSC-F-005) in lipid concentrations in the sera of dyslipidemic rats (SD strain) fed on experimental diets for 5 weeks. Serum concentrations of total cholesterol, HDL-cholesterol, ratio of HDL-cholesterol concentration to total cholesterol, atherosclerotic index, LDL-cholesterol, free cholesterol, cholesteryl ester, triglyceride, phospholipid and blood glucose were effective on the metabolic regulation of dyslipidemic rats. The activities of alkaline phosphatase, aspartate aminotransferase and alanine aminotransferase in serum were remarkably lower in the extract complexes (CSC-F-005) than in the dyslipidemic model. From the above results shows that CSC-F-005 extract complexes were effective on the improvement of the lipid metabolism in sera of dyslipidemic rats.

• 대한한의학방제학회지
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• 제13권1호
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• pp.85-101
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• 2005

Kamiondamtang(KODT) has been used in oriental medicine as stress by many medical practitioner for the study of KODT, we had fed mice divided to three groups(basal diet, hyperlipidemic diet, hyperlipidemic diet + KODT), and observed the change of weight, total cholesterol, triglyceride, SGOT, SGPT, HDL-cholesterol, LDL-cholesterol on the serum per every 7days for 6weeks. To help comparison with the results above, we had tested endothelial cells and liver. The results of this Study were obtained as fallows ; 1. Total cholesterol, triglyceride and LDL-cholesterol were decreased significantly by KODT. 2. HDL-cholesterol was increasd significantly by KODT. 3. SGOT was intended to decrease by KODT, 4. %W was decreased significantly by KODT. 5. In case of supplying KODT, WBC attatched on endothelial cells and vacuoles in muscular layer were not observed. 6. In case of supplying KODT, fatty degeneration was not observed in liver portal area.

• 한국식품영양과학회지
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• 제28권1호
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• pp.205-211
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• 1999

Effects of Houttuynia cordata ethanol extracts on lipid metabolism and antioxidant enzymes in Sprague Dawley male rats were investigated. High fat used in the diet mixture included 10% of lard, 1% of cholesterol and 0.25% of sodium cholate. Total serum cholesterol contents of the rats fed Houttuynia cordata extracts were decreased compared to the control. On the other hand, HDL cholesterol contents were increased along with the decrease of athrogenic index. When high fat diet was fed, total serum cholesterol contents were significantly increased(p<0.01) with the athrogenic index increase of four times of the control. With the administration of Houttuynia cordata extract HDL cholesterol was increased by 53% in the high fat diet group. Antioxidant enzymes including GST and catalase activities were increased comparing the control. On the otherhand, the extracts lowered phospholipid(p<0.01), GOT, GPT, Cu,Zn SOD and alkaline phosphatase enzyme activities in the serum which are related to the liver functions. Therefore, the above results suggest that Houttuynia cordata ethanol extracts can help to maintain normal liver functions and help to protect from peroxidative damages caused by excess dietary fat intake.

• 사상체질의학회지
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• 제12권2호
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• pp.184-194
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• 2000

1.Purpose This study was researched in order to investigate the effect of Hyungbangdojucksan-Gami and Kamsuchunilhwan on the obesity in rats. 2. Methods The rats were divided into 10 groups - The normal group fed with normal diet. One of the sample groups fed with high fat diet, and since fifth week had fed with Hyungbangdojucksan-Gami. The other sample groups fed with high fat diet, and since fifth week had fed with Kamsuchunilhwan. The control group fed with high fat diet, and since fifth week had fed sodium chloride. 3. Results 1. The rate of increasing weight was significantly decreased after oral administration of Hyungbangdojucksan-Gami and Kamsuchunilhwan. 2. The rate of feeding effect was not significantly decreased after oral administration of Hyungbangdojucksan-Gami and Kamsuchunilhwan. 3. After oral administration of Hyungbangdojucksan-Gami, the quantities of total cholesterol, HDL cholesterol, LDL cholesterol and triglyceride on the serum were significantly decreased but that of lipid peroxide on the serum was significantly increased. 4. After oral administration of Kamsuchunilhwan., the quantities of glucose, total cholesterol, LDL cholesterol and triglyceride on the serum were significantly decreased but those of HDL cholesterol, lipid peroxide on the serum were significantly increased. 4.Conclusion Hyungbangdojucksan-Gami and Kamsuchunilhwan have significant effects on the obesity in the rats.

• 대한예방한의학회지
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• 제8권1호
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• pp.33-45
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• 2004

In order to study the effects of Typha angustata on hyperlipidemia, we divided the rats into three groups(normal group, control group & sample group) and perfomed the experimental research. Hyperlipidemia rats were induced by Triton WR-1339 for 3days. The sample group was administerd the extract of Typha angustata 2ml／200g for 3 days and control group was administerd equal dose of saline. And then we measured the amount of serum Total cholesterol, Triglyceride, LDL-cholesterol, HDL-cholesterol, and Phospholipid. The results were as follows: 1. Typha angustata showed decreasing effects on Total cholesterol, Triglyceride, LDL-cholesterol, and Phospholipid levels in serum significantly(p<0.01) 2. Typha angustata showed and showed increasing effects on HDL-cholesterol level in serum significantly(p<0.05). According to the above results, Typha angustata showed significant decreasing effects on hyperlipidemia, and it is considered that it is appropriate to apply for hyperlipidemia.

• Physical Therapy Rehabilitation Science
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• 제10권3호
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• pp.320-327
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• 2021

Objective: The community has implemented a variety of exercise programs for the elderly population. However, studies comparing changes in the cardiovascular system through body composition and blood analysis after applying aqua aerobic exercise are insufficient. The purpose of this study was to investigate the effect of a 12 weeks aqua exercise on body composition and cardiovascular index in elderly women. Design: Non-equivalence pre-post design. Methods: Thirty elderly women were assigned to aquarobic group(n=15) and control group(n=15). The aquarobic exercise was 60 minutes per every session, 2times per week, for 12weeks. Weight, skeletal muscle mass, body fat percentage, total cholesterol, triglyceride, HDL cholesterol, and LDL cholesterol were measured before and after the exercise program. Paired and independent t-tests were performed using SPSS program. Results: The result showed was weight(p<0.05), body fat percentage(p<0.05), total cholesterol(p<0.05), triglyceride(p<0.05), HDL cholesterol(p<0.05), and LDL cholesterol(p<0.05) were significantly decreased and skeletal muscle mass(p>0.05) was not significantly increased after aquatic exercise program. Conclusions: According to the study result, aqua exercise program made a positive effect in the improvement of obesity and cardiovascular function in elderly women. Therefore, we suggest that you actively consider implementing the Aquarobic exercise program when operating the community health promotion program in the future. In addition, in future studies, comparative studies according to various ages and genders and studies on the effects of aqua aerobic exercise as a community exercise program for chronically illness patients are needed.

• Journal of Animal Science and Technology
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• 제44권3호
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• pp.369-376
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• 2002

타우린 첨가가 복강지방 및 간과 혈청 중 콜레스테롤 농도에 미치는 영향을 육계 수컷병아리에서 조사하였다. 1일령 병아리를 사료에 타우린을 첨가하지 않은 대조구와 1% 그리고 2%를 첨가한 3가지 시험구에 균일하게 분포시켰다. 2% 타우린 첨가 시 육계의 증체량은 6% 감소하였으나, 사료효율은 처리구간 차이가 없었다. 간 중량과 체중대비 간 중량도 처리구간 차이가 없었으나, 복강지방은 1%와 2% 타우린 첨가구가 대조구에 비하여 각각 14%와 20% 낮았다. 혈청 중 중성지방, glucose, GOT, 및 GPT 농도는 처리구간 차이가 없었으나, 혈청 중 총 콜레스테롤 농도는 1%와 2% 타우린 첨가구가 대조구에 비하여 각각 10%와 12% 증가하였다. HDL-콜레스테롤 역시 1%와 2% 첨가구가 대조구에 비하여 각각 20%와 34% 높았다. 간의 총 콜레스테롤 농도는 1%와 2% 첨가구가 대조구에 비하여 각각 9%와 13% 낮았으며, 간의 HDL-콜레스테롤 농도 역시 1%와 2% 첨가구가 대조구에 비하여 각각 20%와 38% 낮았다. 본 연구의 결과는 타우린 첨가가 육계의 복강지방의 축적을 억제시키며 콜레스테롤 대사에 영향을 미친다는 것을 보여준다.

• Preventive Nutrition and Food Science
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• 제2권4호
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• pp.338-347
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• 1997

Apo E polymorphism(e2, e3, e4) was among the first reported genetic polymorphism that explained part of the normal vairation in plasma cholesterol concentrations. Both alleles E2 and E4 are significantly more frequent in patients with mixed forms of hyperlipidemia and contribute on the observed differences in CHD risk among different populations. Effects of apo E polymorphism on the distribution of plasma lipid profiles were studied in 89 normolipidemic healthy females, aged 19 up to 22 years. The relative frequencies of E3/3 was 0.787, E3/2 was 0.101, E3/4 allele was 0.112 and no E2/2, E2/4 and E4/4 were found. Weight, height and %LBM were elevated in E2 than those in E3&E4. No differences in the blood pressure among apo E isomers were found, otherwise the pulsation was higher in E4 than that in the others. There were no differences in plasma total-, total DL-, HDL$_3$-, HDL$_2$ cholesterol, apo B-100 and apo A-I, However, phenotype means rank E3/2>E3/3>E3/4 in average TG levels(p<0.0001) significantly, and rank E3/4>E3/3>E3/2 in LDL cholesterol levels. These results were related to the correlation between atherogenic indiced (AI) such as LDL/HDL, (TC-HDL)/HDL, HDL$_3$/HDL$_2$. The ratio of HDL$_3$& HDL$_2$was significantly increased in E2 & E4 than that in E3(P=0.043). LCAT activity was not different between E2 and E3 but was highly increased in E4 (p<0.0001 among apo E isomers), but CETP was not different. Since the negative correlation between LCAT and CETP in apo E2(r=-0.491) was stronger than that in apo E3, E2 allele impacts the clearance of plasma apo E mediated lipoproteins. In conclusion firstly, E4 mediated alteration through LDL or E receptors results in lower TG or higher $\beta$-lipoprotein levels and E2 shows reciprocal effects of E4, respectively. Second, E4 allele was more atherogenic than E2 allele because the higher levels of AI such as HDL$_3$/HDL$_2$ were criticized.