• 한국식품영양과학회지
• /
• 제23권1호
• /
• pp.38-43
• /
• 1994

크릴 및 카드뮴이 콜레스테롤 식이 흰주의 혈장 지질 성분에 미치는 영향을 조사하기 위하여, Spragu-Dawley계의 숫쥐를 8식이군으로 나누어 4주간 사육하였다. 혈장중 콜레스테롤, 인지질 및 중성지질 농도에서 5%이하의 크릴식이첨가군은 대조군과 유의적인 차이가 없었다. 카드뮴투여군은 대조군에 비하여 혈장중 중성지질(1.6배), 유리콜레스테롤(1.6배), 지단백(1.4배) 및 총콜레스테롤(1.3배)의 농도가 증가되었으며, HDL-콜레스테롤 농도는 약 1.6배 정도 낮았다. 카드뮴식이군에서 크릴첨가는 혈장의 총콜레스테롤, 유리 콜레스테롤, 지단백 및 중성지질의 농도를 오히려 증가시키는 결과를 초래하였다.

• 대한한방내과학회지
• /
• 제18권2호
• /
• pp.195-206
• /
• 1997

In order to study the effects of Ohwangsahwatang on Hyperchole-sterolemia, experimental study were performed on Hypercholesterolemia Rats induced by 2% cholesterol diet. Also the level of total cholesterol. triglyceride, LDL-cholesterol. HDL-cholesterol, phospholipid, transami-nase(GOT, GPT) were measured. The results were summerized as follows : In the model of Hypercholesterolemia induced by 2% cholesterol diet in rats, Ohwangsahwatang showed decreasing effects on total cholesterol, triglyceride, LDL-cholesterol, phospholipid level, and transaminase (GOT, GPT) activity in serum significantly, depending on the concentration, and showed increasing effects on HDL-cholesterol level in serum significantly depending on the concentration. According to the above results, Ohwangsahwatang showed significant decreasing effects on Hypercholesterolemia, and it is considered that it is appropriate to apply for Hypercholesterolemia.

• Journal of Chest Surgery
• /
• 제26권1호
• /
• pp.12-17
• /
• 1993

Among the many deleterious effects of cardiopulmonary bypass[CPB], deterioration of plasma lipoprotein is a significant problem. Break-down of lipoprotein releases free fatty acids into the systemic circulation which, in turn, can cause microembolism. This study conducted on 30 patients undergoing CPB, was designed to elucidate the changes of plasma lipoproteins during and after CPB. Blood samples were taken at pre-CPB, on-CPB 30 minutes and 60 minutes, postoperative 1st, 3rd, 7th days. The levels of total cholesterol and triglyceride were measured and lipoprotein was subdivided into three kinds on electrophoresis. During CPB, the amounts of plasma total cholesterol and triglyceride decreased significantly and were recovered to pre-CPB levels after postoperative third day. There was no significant correlation between the duration and the severity of decrease in plasma total cholesterol and triglyceride levels. During CPB, the fraction of VLDL decreased and that of LDL increased. After cessation of CPB, the fraction of LDL decreased and that of HDL increased. After postoperative 1st day, the fraction of HDL decreased and that of LDL increased.

• 한국식품영양과학회지
• /
• 제31권2호
• /
• pp.284-289
• /
• 2002

동의보감에서 소갈증에 응용되는 옥천산 분말이 당뇨 암쥐의 혈당, 혈청과 간의 지질 및 단백질 농도에 미치는 영향을 조사하고자, 평균체중 313.6$\pm$18.5 g되는 Spraque-Dawley계 암쥐를 정상군, 당뇨 대조군 및 당뇨 옥천산군 등 3군으로 나누어 각 실험식 이로 5주간 사육한 결과는 다음과 같다. 5주간 체중변화는 정상군은 3.5 g 증가하였으나, 당뇨 대조군과 당뇨 옥천산군은 당뇨로 인한 대사장애로 각각 97.8 g과 99.1 g씩 체중이 감소되었다. 췌장의 무게는 정상군에 비하여 당뇨 대조군은 유의하게 증가되었으나 당뇨 옥천산 군은 정상군과 비슷하였다. 비장의 무게는 정상군에 비하여 당뇨 대조군과 당뇨 옥천산군이 유의하게 감소하였다. 혈청의 중성지질, 총 콜레스테롤, LDL-콜레스테를 및 간의 콜레스테를 농도는 당뇨 옥천산군이 당뇨 대조군보다 유의하게 감소되어 정상군과 비슷한 수준을 보였다. HDL-콜레스테를 농도와 HDL-콜레스테롤/총 콜레스테롤의 비율은 정상군과 당뇨 실험군들이 비슷한 수준을 보였다. 동맥경화지수 및 혈당량은 정상군에 비하여 당뇨 실험군들이 증가하였다. 간의 총 지질 및 중성지질 농도는 정상군에 비하여 당뇨 대조군과 당뇨 옥천산군이 유의하게 감소되었다. 혈청의 단백질과 알부민 농도는 정상군에 비하여 당뇨 대조군과 당뇨 옥천산군이 유의하게 감소되었다. 이상의 결과로 보아 당뇨 쥐에 옥천산 분말이 혈당 및 동맥경화지수를 낮추는 효과는 없었으나, 혈청의 중성지질, 총 콜레스테롤, LDL-콜레스테를 및 간의 콜레스테를 농도를 낮추는 효과가 나타났다.

• 한국식품영양과학회지
• /
• 제34권7호
• /
• pp.980-986
• /
• 2005

녹차와 오미자추출분말을 양념닭고기제품과 패티 (patty)에 각각 $1\%$의 농도로 첨가했을 때, 녹차를 첨가한 닭고기 제품은 대조구보다 관능적 특성 이 약간 높게 나타났으며, 오미자를 첨가한 패티는 대조구와 차이를 나타내지 않았다. 양념닭고기 제품과 패티를 사료에 1:1로 배합하여 45일간 실험 동물에게 식이 급여 후 식이섭취량에 대한 체중증가량은 일반 고형사료를 섭취한 대조구의 경우 $23.1\%$의 체중증가량을 나타낸 반면 양념 닭고기제품 급여구와 패티 급여구의 경우 각각 $27.5\%,\;26.0\%$로 대조구보다 유의 적으로 높은 증가량을 나타내었다. 그러나 녹차를 첨가한 양념 닭고기제품과 오미자를 첨가한 패티 급여구의 경우 대조구와 같은 $23.5\%,\;23.3\%$의 체중증가량을 나타내어 고지방 육제품 섭취시 녹차와 오미자는 체중증가량에 영향을 미치는 것으로 나타났다. 고지방식이 섭취로 인한 실험동물의 장기중량의 변화는 치킨과 패티 급여구 모두 차이가 나타나지 않았다 육제품 첨가식 이를 섭취한 실험 동물의 혈장 콜레스테롤, HDL 콜레스테롤, 중성지질 및 총지질 함량은 대조군에 비하여 양념 닭고기 제품과 패티 섭취군은 증가하는 반면 녹차를 첨가한 양념 닭고기 제품과 오미자를 첨가한 패티 섭취군은 혈장 콜레스테롤, 중성지질 및 총지질 함량을 저하시키는 것으로 나타났다. 간조직에서의 지방산화도는 대조군과 유의적인 차이는 나타나지 않았다. 따라서, 동물실험 결과 육제품에 녹차와 오미자추출분말을 첨가함으로써 체중감소 및 혈중 중성지질 및 콜레스테롤 함량이 미미하게 감소되는 것으로 사료된다.

• 한국임상수의학회지
• /
• 제26권5호
• /
• pp.413-418
• /
• 2009

This study was performed to investigate the changes of the serological parameters of the rats fed a high fat and high cholesterol diets with or without quercetin supplement for five weeks. Thirty Sprague-Dawley male rats ($152.1{\pm}17.0\;g$ of body weight) were randomly divided into three groups with 10 rats in each group. Rats in the control(C) group were fed the high fat and high cholesterol diet containing 15% lard, 2% cholesterol and 0.5% sodium cholate (w/w). Rats in two treatment groups were fed the same diet supplemented with 0.25% quercetin (Q-0.25) or 0.5% quercetin (Q-0.5) on the weight to weight basis, respectively. The final body weight, gain of body weight, the amount of feed intake and the feed efficiency of rats in between control and treatment groups were not significantly different. Serum glucose, total protein, albumin, globulin and albumin/globulin (A/G) ratio of rats showed no significant differences between control and treatment groups. Serum total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C) and atherogenic index(AI) of rats in both Q-0.25 and Q-0.5 groups were significantly lower than in C group (p < 0.05). However serum high density lipoprotein-cholesterol (HDL-C) was significantly higher in both Q-0.25 and Q-0.5 groups than in C group (p < 0.05). The levels of triglyceride in sera of rats showed no significant differences between control and treatment groups. The values of AST and ALT in sera of rats showed no significant differences between control and treatment groups. Therefore the supplementation of quercetin to high fat and high cholesterol diet in rats was effective in reducing the levels of serum lipids to cause cardiovascular diseases and in elevating the level of HDL-C to protect cardiovascular diseases.

• 동아시아식생활학회지
• /
• 제22권3호
• /
• pp.341-349
• /
• 2012

This study was aimed to investigate whether or not black soybean supplements affect levels of lipid profiles and female hormone (estradiol; E2, estrogen; Es) in 57 middle-aged women (in their 40s and 50s). All subjects were randomly assigned to the control or black soybean supplement group (BSS group). The BSS group was allocated to use dietary black soybean supplements (100 g/day) for 8 weeks. The BSS subjects were divided into two subgroups; 14 women were in the premenopausal group and 15 were in the postmenopausal group. We measured lipid profiles, female hormones and nutrient intakes at 0 weesk and 8 weeks. After 8 weeks, high-density lipoprotein (HDL) cholesterol was significantly decreased (P<0.01) and the athrogenic index (AI) was significantly increased (P<0.01) in control group. In BSS group, triglyceride (TG) (P<0.05), low-density lipoprotein (LDL) cholesterol (P<0.01) and LDL-HDL ratio (LHR) (P<0.01) were significantly decreased. However, E2 and Es were significantly increased (P<0.01). Compared to the control group, the BSS group revealed statistically significant improvements in the levels of TG, HDL-cholesterol, AI, LHR, E2 and Es (P<0.05). In the premenopausal group, HDL-cholesterol (P<0.05), E2 (P<0.01) and Es (P<0.05) were significantly increased and AI (P<0.01) and LHR (P<0.01) were significantly decreased after 8 weeks. In the postmenopausal group, E2 (P<0.05), and Es (P<0.05) were significantly decreased. However, total cholesterol (TC) was increased (P<0.01). Compared to the postmenopausal group, the premenopausal group was significantly improved on HDL-cholesterol, LDL-cholesterol and LHR (P<0.05). In conclusion, black soybean supplements may have beneficial effects on improving lipid profiles and female hormones.

• 대한의생명과학회지
• /
• 제23권2호
• /
• pp.80-88
• /
• 2017

Ginkgo biloba extract (EGb 761) is a standardized extract of Ginkgo biloba leaves and has anti- atherosclerosis properties. Many patients with atherosclerosis disorders take Ginkgo biloba extracts to supplement current therapy. In addition, normal healthy individuals also take Ginkgo biloba extracts for prophylactic purposes. However, it is unknown whether supplementation of Gingko biloba extracts in healthy individuals offer a benefit. In this study, we assessed whether EGb 761 could provide beneficial effects on serum cholesterol levels in normal mice. Wild-type C56Bl/6 mice were orally administered EGb 761 at 25 mg/kg (Group 3) or 50 mg/kg (Group 4) every other day for 40 days. We found that the serum levels of HDL-cholesterol (HDL-C) were significantly increased in EGb 761 and lovastatin treated groups. Treatment with EGb 761 and lovastatin resulted in reduced serum total cholesterol and LDL-cholesterol (LDL-C) compared to control group. Serum lecithin cholesterol acyltransferase (LCAT) levels were higher in EGb 761 and lovastatin treated group compared to the control group. However, no difference was observed in serum APO A-I levels between the control group and treatment group. These results suggest that EGb 761 can increase HDL-C resulting in increased serum LCAT levels.

• 동아시아식생활학회지
• /
• 제8권2호
• /
• pp.93-106
• /
• 1998

This study was designed to find out the effects on the lipid metabolism of two herbs used in folk treatment in Korea The two herbs were A: Equisetum arvense L. (Seddugi), B: Eunymus alatus Siebold (Hwasalnamoo). The experiment was performed with the male rats of Sprague-Dawley which fed on high calorie and animal fat supplemented diets from which 30% of the total calories can from lard. Experimental groups were divided into standard (ST) and two other(A, B) groups for the each herb. Each of the two experimental groups consisted of three subgroups (I, II, III) according to the three different doses of the folk remedy used, which were five times and ten times the dose commonly used in a folk remedy. During the experimental period, total food intake and body weight gains were measured, and FER, CER, PER were calculated at the same times. Serum levels of triglyceride, total lipid, ttal cholesterol, HDL-cholesterol, and total lipid as well as cholesterol contents of the liver were measured at the time of sacrifice. Epididymal fat pads were weighted and an indes was calculated. The results of the effects on the lipid metabolism were as follows : 1.Total food intake and body weight gains increased in group A & B. 2. The serum levels of the total lipid and triglyceride decreased in AIII, BI and BIII.3. The serum level of cholesterol decreased in group B, while level of HDL-Cholesterol were increased in all groups and most effectively in group B. 4. The contents of total liver lipid increased in groups A&B. cholesterol decreased in groups A&B. In conclusion, effects on the lipid metabolism associated with the kinds of herbs a diet were the increase of body weighta and the decrease of total lipid and cholesterol levels in serum and liver.

• Journal of Preventive Medicine and Public Health
• /
• 제30권4호
• /
• pp.686-696
• /
• 1997

본 연구는 부산지역 소아의 연령별 혈청지질치의 분포와 이에 영향을 미치는 요인에 대한 단면조사연구로서 1996년 4월에 2세부터 12세의 941명을 대상으로 혈청 지질을 조사한 결과는 다음과 같다. 1. 평균 혈청지질치 혈청지질치는 여아의 경우 총콜레스테롤 $171.4{\pm}26.2mg/dl$, 중성지방 $104.7{\pm}50.6mg/dl,\;LDL-C\;95.4{\pm}32.9mg/dl$로 남아의 $167.9{\pm}25.2mg/dl,\;90.6{\pm}45.5mg/dl,\;94.4{\pm}23.6mg/dl$보다 높았다. 총콜레스테롤 (p<0.05)과 중성지방(p<0.01)에서는 여아에서 통계적으로 유의하게 높았다. HDL-C은 남아가 $55.4{\pm}11.7mg/dl$로 여아의 $54.4{\pm}14.8mg/dl$보다 높았다. 2. 혈청지질치의 백분위수 소아의 혈청지질치의 백분위수는 총콜레스테롤의 경우 95퍼센타일이 남아에서 210mg/dl, 여아의 경우 214mg/d1로 미국에서 보고된 남아의 191mg/dl과 여아의 209mg/dl보다 오히려 높았다. 3. 혈청 지질과 비만도 경도 비만군과 중등도 비만군이 정상군보다 총콜레스테롤, 중성지방, LDL-C 등에서 의미있게 높았고, HDL-C에서 의미있게 낮았다(p<0.05). 4. 혈청 지질과 부모의 학력 총콜레스테롤, 중성지방, LDL-C은 아버지의 최종학력이 높을수록 의미 있게 감소하였고(p<0.05), 총콜레스테롤, 중성지방, LDL-C은 어머니의 최종학력이 높을수록 의미 있게 감소하였고(p<0.01), HDL-C은 어머니의 최종학력이 높을수록 통계학적으로 의미있게 증가하였다(p<0.05).