Journal of Chest Surgery

The Korean Society for Thoracic and Cardiovascular Surgery (대한심장혈관흉부외과학회)
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Changes of plasma lopoproteins during and after cardiopulmonary bypass

체외순환에 따른 혈청 지단백의 변화에 관한 연구

  • Published : 1993.01.01
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Abstract

Among the many deleterious effects of cardiopulmonary bypass[CPB], deterioration of plasma lipoprotein is a significant problem. Break-down of lipoprotein releases free fatty acids into the systemic circulation which, in turn, can cause microembolism. This study conducted on 30 patients undergoing CPB, was designed to elucidate the changes of plasma lipoproteins during and after CPB. Blood samples were taken at pre-CPB, on-CPB 30 minutes and 60 minutes, postoperative 1st, 3rd, 7th days. The levels of total cholesterol and triglyceride were measured and lipoprotein was subdivided into three kinds on electrophoresis. During CPB, the amounts of plasma total cholesterol and triglyceride decreased significantly and were recovered to pre-CPB levels after postoperative third day. There was no significant correlation between the duration and the severity of decrease in plasma total cholesterol and triglyceride levels. During CPB, the fraction of VLDL decreased and that of LDL increased. After cessation of CPB, the fraction of LDL decreased and that of HDL increased. After postoperative 1st day, the fraction of HDL decreased and that of LDL increased.

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References

  1. Pathophsiology and Techniques of Cardiopulmonary Bypass(1st ed.) Joe,R.Utley;E.Alexandra Ashleigh
  2. Seoul J Med v.17 Metabolic effects of cardiopulmonary bypass. kim,C.W.
  3. J Thorac Cardiovasc Surg v.89 Deleterious effectss of cardiopulmonary bypass. Oeveren,W.V.;Kazatchkine,M.D.;Descampas-Latscha,B.(et al.)
  4. Surgery v.50 Denaturation of plasma proteins as a cause of morbidity and death after intracardiac operation. Lee,W.H.;Krumhaar,D.;Fonkalsrud,E.(et al.)
  5. Lancet v.1 A metabolic cause for arrhythmia during acute myocardial hypoxia. Kurien,V.A.;Olive,M.E.
  6. Surgery v.63 Fat globulinemia in extracorporeal circulation. Wright,R.E.;Sarkozy,E.;Dobell,A.R.C.(et al.)
  7. Surgery v.77 Fat and solid filtration in clinical perfusions. Clark,R.E.;Margaf,R.W.;Beauchamp,R.A.
  8. Ann Throac Surg v.7 Neruopathological manifestation of cardiac surgery. Hill,J.D.;Aguilar,M.J.;Baranco,A.(et al.)
  9. Curr Top Surg Res v.1 In vitro denaturation of palsma alpha lipoproteins by bubble oxygenator in the dog. Zapol,W.M.;Levy,R.I.;Kolobow,T(et al.)
  10. J Thorac Cardiovasc Surg v.86 Complement and the damaging effects of cardiopulmonary bypass. Kirkin,J.K.;Westaby,S.;Blackstone,E.H.(et al.)
  11. The plarmacological Basis of The-rapeutics(7th ed.) Goodmann,L.;Gilman,A.
  12. J Thorac Cardiovasc Surg v.59 Myocardial metabolism in open-heart surgery. Correlation with insulin response. Moffitt,E.A.;Rosevear,J.W.;Molnar,G.D.(et al.)
  13. Ann Throac Surg v.15 Effects of extracorporeal circulation upon blood lipids. Arrants,J.R.;Gabsden,R.H.;Huggins,M.B.(et al.)
  14. Ann Chir Gynaecol v.66 The effect of cardiopulmonary bypasstime on plasma. Nuitnen,L.;Mononen,P.;Karaluoma,M.(et al.)
  15. J Appl Physiol v.14 Experimental alterations of certain colloidal properties of blood during cardiopulmary bypass. Owens,G.;Adams,J.E.;McAlhannon,F.M.(et al.)
  16. Scand J Thorac Cardiovasc Surg v.2 Human lung fat microembolism associated with cardiopulmonary bypass; Electronmicroscopic evidence. De Gasperis,C.
  17. J Lipid Res v.25 Plasma lipoproteins:apolipoprotein structure and funrion. Mahley,R.W.;Innerarity,T.L;Rall,S.C.(et al.)
  18. Principles of internal medicine.(10th ed.) Petersdorf,R.G.;Adams,R.D.;Braunwald,E.;Isselbacher,K.J.;Martin,J.B.;Wilson,R.D.
  19. N Engl J Med v.276 Fat transport in lipoproteins. Fredrickson,D.S.;Levy,R.I.;Lees,R.S.
  20. J Thorac Cardiovasc Surg v.91 Arterial line filtration during cardiopulmonary bypass. Atis,A.;Solanes,H.;Camara,M.L.(et al.)