• Journal of Arbitration Studies
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• v.13 no.2
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• pp.353-376
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• 2004

In the inner turn key constructions the problems of uniform types are repeatedly occurred, and, especially, many problems happen up to the stage of pre-construction(from a bid to a contract) owing to the specialties of the turn key constructions. So the claim factors of the Korean turn key constructions were abstracted through the literature searches, the site document examinations, the case studies and the interviews with the experts. When the technicians meeting the interior turn key constructions for the first time and working here now are well acquainted with only these factors, many claims will be prevented. By analysing the degree of claims by claims factors through the questionnaires to the experts about the abstracted factors and surveying the amount of the claims through the case studies, what factors exerted how much of influence on the claims was tested and analyzed. Proposing the response devices to the factors affecting the claims much led the technicians in charge of internal turn key constructions to the prevention and the proper solution of the site claims.

• BMB Reports
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• v.47 no.12
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• pp.697-702
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• 2014

Recently, the interest in natural products for the treatment of cancer is increasing because they are the pre-screened candidates. In the present study, we demonstrate the therapeutic effect of celastrol, a triterpene extracted from the root bark of Chinese medicine on gastric cancer. The proliferation of AGS and YCC-2 cells were most sensitively decreased in six kinds of gastric cancer cell lines after the treatment with celastrol. Celastrol inhibited the cell migration and increased G1 arrest in cell-cycle populations in both cell lines. The treatment with celastrol significantly induced autophagy and apoptosis and increased the expression of autophagy and apoptosis-related proteins. We also found an increase in phosphorylated AMPK following a decrease in all phosphorylated forms of AKT, mTOR and S6K after the treatment with celastrol. Moreover, gastric tumor burdens were reduced in a dose-dependent manner by celastrol administration in a xenografted mice model. Taken together, celastrol distinctly inhibits the gastric cancer cell proliferation and induces autophagy and apoptosis.

• BMB Reports
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• v.51 no.1
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• pp.45-53
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• 2018

Mammalian target of rapamycin complex 1 (mTORC1) plays a major role in cell growth, proliferation, polarity, differentiation, development, and controls transitioning between anabolic and catabolic states of the cell. It collects almost all extracellular and intracellular signals from growth factors, nutrients, and maintains cellular homeostasis, and is involved in several pathological conditions including, neurodegeneration, Type 2 diabetes (T2D), obesity, and cancer. In this review, we summarize current knowledge of upstream signaling of mTORC1 to explain etiology of T2D and hypertriglyceridemia, in which state, the role of telomere attrition is explained. We discuss if chronic inhibition of mTORC1 can reverse adverse effects resulting from hyperactivation. In conclusion, we suggest the regulatory roles of telomerase (TERT) and hexokinase II (HKII) on mTORC1 as possible remedies to treat hyperactivation. The former inhibits mTORC1 under nutrient-rich while the latter under starved condition. We provide an idea of TOS (TOR signaling) motifs that can be used for regulation of mTORC1.

• Wind and Structures
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• v.20 no.1
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• pp.75-93
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• 2015

This work is focused on a parametric numerical study of the barrier's bar inclination shelter effect in crosswind scenario. The parametric study combines mesh morphing and design of experiments in automated manner. Radial Basis Functions (RBF) method is used for mesh morphing and Ansys Workbench is used as an automation platform. Wind barrier consists of five bars where each bar angle is parameterized. Design points are defined using the design of experiments (DOE) technique to accurately represent the entire design space. Three-dimensional RANS numerical simulation was utilized with commercial software Ansys Fluent 14.5. In addition to the numerical study, experimental measurement of the aerodynamic forces acting on a vehicle is performed in order to define the critical wind disturbance scenario. The wind barrier optimization method combines morphing, an advanced CFD solver, high performance computing, and process automaters. The goal is to present a parametric aerodynamic simulation methodology for the wind barrier shelter that integrates accuracy and an extended design space in an automated manner. In addition, goal driven optimization is conducted for the most influential parameters for the wind barrier shelter.

• Proceedings of the KSME Conference
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• 2004.04a
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• pp.2053-2058
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• 2004

The pressurized light water cooled, medium power (330 MWt) SMART (System-integrated Modular Advanced ReacTor) has been under development at KAERI for a dual purpose : seawater desalination and electricity generation. The SMART design verification phase was followed to conduct various separate effects tests and comprehensive integral effect tests. The high temperature / high pressure thermal-hydraulic test facility, VISTA(Experimental Verification by Integral Simulation of Transient and Accidents) has been constructed to simulate the SMART-P (the one fifth scaled pilot plant) by KAERI. Experimental tests have been performed to investigate the thermal-hydraulic dynamic characteristics of the primary and the secondary systems. Heat transfer characteristics and natural circulation performance of the PRHRS (Passive Residual Heat Removal System) of SMART-P were also investigated using the VISTA facility. The coolant flows steadily in the natural circulation loop which is composed of the steam generator (SG) primary side, the secondary system, and the PRHRS. The heat transfers through the PRHRS heat exchanger and ECT are sufficient enough to enable the natural circulation of the coolant.

• The Journal of Engineering Geology
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• v.6 no.3
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• pp.111-118
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• 1996

In general, a three dimensional ground behaviour during tunneling is simulated by using two dimensional analysis programs in consideration of a certain ratio of stress or strain distribution to take into account the effect of construction stage by a tunnel face advance. A series of trree dimensional analyses was conducted to deduce a normalized displacement (surface or crown settlement) curve in longitudinal direction, of which curve is reflecting an effect of a tunnel advance under a various condition. And, by using try and error technique, two dimensional analyses were carried out to determine an optimum stress distribution ratio for a settiement curve coincided with the curve obtained by three dimensional analyses. Finally, monitored results from a subway tunnel were compared with two dimensional analysis results for varification of the deduced stress distribution ratio as well as the two dimensional analysis program employed in this study.

• The Transactions of the Korean Institute of Power Electronics
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• v.4 no.6
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• pp.561-569
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• 1999

In this paper, the diode bridge-type ZVT(Zero- Voltage Transition) inverter is proposed. It consists of one a auxiliaI${\gamma}$ switch, three resonant inductors and six blockin당 diodes. So, the main advantage of the proposed t torXJ!ogy is the reduction of the auxiliar${\gamma}$ switch compare to the conventional ZVT inverter. The topology of t the propostxl lVT inverter is analyztxl with a description of the control conditions based on the load current. A And the resonant period control for operating the proposed inverter optimally is discussed by using resonant i inductor current ftxxlback. To verify the proposed topology, the detailed simulation and exJX끼mental results i indicate that zero volta당e operation during transition can be achieved.

• Resources Recycling
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• v.8 no.5
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• pp.28-33
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• 1999

Trus paper presenls a hydrometallurgical process Tor recovcnng ~uckcals mckcl sulfate fiom the spent nickel-cadrnlum bauery in whch c:,dmi~lm war re~novcdb y vapowing m e h d in vacuum. F ~ s ts,e lcct~vcc rushing and classification mell~odw ere performed to separate iron physically and the nickel-rich sample (over 80% nickel) was obtained. Ths sarnple was dissolved in sulf~ uiuica cid to obtain a luckcl sulfatc soluho~d~o se to its seluradon painl. TIE Cree acid in the unpurificd nickcl solut~onw as neutl-dized and iron war ve~novedk om the solulmn Thc mckel sulhte solution was c~yst~llizeadt around 45'C to obtain ruckel sulfate henahyril-ate.

• Journal of Physiology & Pathology in Korean Medicine
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• v.34 no.3
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• pp.136-141
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• 2020

The purpose of this study was to investigate the action mechanism of the roots of Adenophora triphylla var. japonica extract (ATE) in 3T3-L1 adipocytes. Cell toxicity test by MTT assay and lipid accumulation was performed to evaluate the inhibitory effect on the differentiation of adipocyte from preadipocytes induced by MDI differentiation medium, while adipogenesis related proteins expression level were evaluated by western blotting. As a result, ATE inhibited MDI-induced adipocyte differentiation in 3T3-L1 cells dose-dependently without cytotoxicity. Our results showed that ATE inhibited the phosphorylation of IRS1, thereby decreasing the expression of PI3K110α and reducing the phosphorylation of AKT and mTOR, resulting in attenuated protein expression of C/EBPα, PPARγ, ap2 and FAS in 3T3-L1 cells. These results suggest anti-adipogenic functions for ATE, and identified IRS1 as a novel target for ATE in adipogenesis.

• Transactions of the Korean Society of Mechanical Engineers
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• v.11 no.2
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• pp.331-344
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• 1987

A numerical analysis has been conducted on the interaction of the thermal radiation and natural convection in a rectangular enclosure filled with a gray fluid. P-1 approximation is adopted for the radiative transfer and its application limit is examined. Considered are the Stark number effect, the optical thickness effect and the wall emissivity effect on the flow and heat transfer characteristics. As the Stark number increase or the optical thickness decreases, the boundary layer thickness and the flow velocity increase. Transition to turbulence is retarded with the increase of the radiation effect. When the optical thickness is one, the radiation effect is negligible for the Stark numbers larger than 10.