Roots Extract of Adenophora triphylla var. japonica Inhibits Adipogenesis in 3T3-L1 Cells through the Downregulation of IRS1 |
Kim, Hae Lim
(NutraPharm Tech Co., Ltd.)
Lee, Hae Jin (NutraPharm Tech Co., Ltd.) Choi, Bong-Keun (NutraPharm Tech Co., Ltd.) Park, Sung-Bum (DONG IL Pharmtec Co., Ltd.) Woo, Sung Min (SM-WOOIL Co., Ltd.) Lee, Dong-Ryung (NutraPharm Tech Co., Ltd.) |
1 | Lee IS, Yang EJ, Kim HS, Chung SK, Furukawa F, Nishikawa A. Suppressive effects of Adenophora triphylla extracts on in vitro tumor growth and in vivo gastric epithelial proliferation. Anticancer Res. 2000;20(5A):3227-31. |
2 | Kim JH, Hong JY, Shin SR, Yoon KY. Comparison of antioxidant activity in wild plant (Adenophora triphylla) leaves and roots as a potential source of functional foods. Int J Food Sci Nutr. 2009;60(Suppl 2):150-61. DOI |
3 | Kim AJ, Han MR, Kim MH, Lee MS, Yoon TJ, Ha SD. The antioxidant and chemopreventive potentialities of Mosidae (Adenophora remotiflora) leaves. Nutr Res Pract. 2010;4(1):30-5. DOI |
4 | Choi HJ, Chung MJ, Ham SS. Anti-obese and hypocholesterolaemic effects of an Adenophora triphylla extract in HepG2 cells and high fat diet-induced obese mice. Food Chem. 2010;119(2):437-44. DOI |
5 | Xing Y, Yan F, Liu Y, Liu Y, Zhao Y. Matrine inhibits 3T3-L1 preadipocyte differentiation associated with suppression of ERK1/2 phosphorylation. Biochemical and biophysical research communications. 2010;396(3):691-5. DOI |
6 |
Quan X, Wang Y, Ma X, Liang Y, Tian W, Ma Q, Jiang H, Zhao Y. |
7 | Rosen ED, Walkey CJ, Puigserver P, Spiegelman BM. Transcriptional regulation of adipogenesis. Genes & development. 2000;14(11):1293-307. |
8 | Wong RH, Sul HS. Insulin signaling in fatty acid and fat synthesis: a transcriptional perspective. Curr Opin Pharmacol. 2010;10(6):684-91. DOI |
9 | Huang KC. The Pharmacology of Chinese Herbs. CRC Press: Boca Raton. 1993. |
10 | Giri S, Rattan R, Haq E, Khan M, Yasmin R, Won JS, Key L, Singh AK, Singh I. AICAR inhibit adipocyte differentiation in 3T3L1 and restores metabolic alteractions in diet-induced obesity mice model. Nutr Metab. 2006;3(1):31-50. DOI |
11 | Kim SK, Kong CS. Anti-adipogenic effect of dioxinodehydoeckol via AMPK activation in 3T3-L1 adipocytes. Chem Biol. 2010;186(1):24-9. |
12 | Sesti G, Federici M, Hribal ML, Lauro D, Sbraccia P, Lauro R. Defects of the insulin recptor substrate (IRS) system in human metabolic disorders. J FASEB. 2001;15(12):2099-111. DOI |
13 | Kopelman PG. Obesity as a medical problem. Nature. 2000;404(6778):635-43. DOI |
14 | Kang SI, Shin HS, Kim SJ. Sinensetin enhances adipogenesis and lipolysis by increasing cyclic adenosine monophosphate levels in 3T3-L1 adipocytes. Biol Pharm Bull. 2015;38(4):552-8. DOI |
15 | Park JY, Kim Y, Im J, You S, Lee H. Inhibition of adipogenesis by oligonol through Akt-mTOR inhibition in 3T3-L1 adipocytes. Evidence-Based Complementary and Alternative Medicine. 2014;2014. |
16 | Khan A, Pessin J. Insulin regulation of glucose uptake: a complex interplay of intracellular signaling pathways. Diabetologia. 2002;45(11):1475-83. DOI |
17 | Magun R, Burgering BM, Coffer PJ, Pardasani D, Lin Y, Chabot J, Sorisky A. Expression of a constitutively activated form of protein kinase B (c-Akt) in 3T3-L1 preadipose cells causes spontaneous differentiation. Endocrinology. 1996;137(8):3590-3. DOI |
18 | Xu J, Liao K. Protein kinase B/AKT1 plays a pivotal role in insulin-like growth factor-1 receptor signaling induced 3T3-L1 adipocyte differentiation. J Biol Chem. 2004;279(34):35914-22. DOI |
19 |
Adochio R, Leitner JW, Hedlund R, Draznin B. Rescuing 3T3-L1 adipocytes from insulin resistance induced by stimulation of Akt-mammalian target of rapamycin/p70 S6 Kinase (S6K1). Pathway and serine phosphorylation of insulin receptor substrate-1: effect of reduced expression of |
20 |
Prusty D, Park BH, Davis KE, Farmer SR. Activation of MEK/ERK signaling promotes adipogenesis by enhancing peroxisome proliferator-activated receptor |
21 | Lee DR, Lee YS, Choi BK, Lee HJ, Park SB, Kim TM, Oh HJ, Yang SH, Suh JW. Roots extracts of Adenophora triphylla var. japonica improve obesity in 3T3-L1 adipocytes and high-fat diet-induced obese mice. Asian Pacific journal of tropical medicine. 2015;8(11):898-906. DOI |
22 | Gan L, Liu Z, Jin W, Zhou Z, Sun C. Foxc2 enhances proliferation and inhibits apoptosis through activating Akt/mTORC1 signaling pathway in mouse preadipocytes. Journal of lipid research. 2015;56(8):1471-80. DOI |
23 |
Kim JE, Chen J. Regulation of peroxisome proliferator-activated receptor- |
24 | Konno C, Saito T, Oshima Y, Hikino H, Kabuto C. Structure of methyl adenophorate and triphyllol, triterpenoids of Adenophora triphylla var. japonica roots. Planta Med. 1981;42(7):268-74. DOI |
25 | Araki E, Lipes MA, Patti ME, Bruning JC, Haag III B, Johnson RS, Kahn CR. Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature. 1994;372(6502):186. DOI |
26 | Aubert J, Dessolin S, Belmonte N, Li M, McKenzie FR, Staccini L, Villageois P, Barhanin B, Vernallis A, Smith A G, Ailhaud G, Dani C. Leukemia inhibitory factor and its receptor promote adipocyte differentiation via the mitogen-activated protein kinase cascade. Journal of Biological Chemistry. 1999;274(35):24965-72. DOI |
27 | White MF. IRS proteins and the common path to diabetes. American Journal of Physiology-Endocrinology And Metabolism. 2002;283(3):E413-E422. DOI |
28 | SESTI G, FEDERICI M, HRIBAL ML, LAURO D, SBRACCIA P, LAURO R. Defects of the insulin receptor substrate (IRS) system in human metabolic disorders. The FASEB Journal. 2001;15(12):2099-111. DOI |
29 | Tamemoto H, Kadowaki T, Tobe K, Yagi T, Sakura H, Hayakawa T, Terauchi Y, Ueki K, Kaburagi Y, Satoh S, Sekihara H, Yoshioka S, Horikoshi H, Furuta Y, Ikawa Y, Kasuga M, Yazaki Y, Sekihara, H. Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. Nature.1994;372(6502):182. DOI |
30 | Bruning JC, Winnay J, Cheatham B, Kahn CR. Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1-deficient cells. Molecular and cellular biology. 1997;17(3):1513-21. DOI |
![]() |