[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.5483/BMBRep.2014.47.12.069

Celastrol inhibits gastric cancer growth by induction of apoptosis and autophagy

Lee, Hyun-Woo (Department of Biochemistry and Molecular Biology, Yonsei University College of Medicine)
Jang, Kenny Seung Bin (Department of Biochemistry and Molecular Biology, Yonsei University College of Medicine)
Choi, Hye Ji (Department of Surgery, Yonsei University College of Medicine)
Jo, Ara (Department of Surgery, Yonsei University College of Medicine)
Cheong, Jae-Ho (Department of Surgery, Yonsei University College of Medicine)
Chun, Kyung-Hee (Department of Biochemistry and Molecular Biology, Yonsei University College of Medicine)

Publication Information

BMB Reports / v.47, no.12, 2014 , pp. 697-702 More about this Journal

Abstract

Recently, the interest in natural products for the treatment of cancer is increasing because they are the pre-screened candidates. In the present study, we demonstrate the therapeutic effect of celastrol, a triterpene extracted from the root bark of Chinese medicine on gastric cancer. The proliferation of AGS and YCC-2 cells were most sensitively decreased in six kinds of gastric cancer cell lines after the treatment with celastrol. Celastrol inhibited the cell migration and increased G1 arrest in cell-cycle populations in both cell lines. The treatment with celastrol significantly induced autophagy and apoptosis and increased the expression of autophagy and apoptosis-related proteins. We also found an increase in phosphorylated AMPK following a decrease in all phosphorylated forms of AKT, mTOR and S6K after the treatment with celastrol. Moreover, gastric tumor burdens were reduced in a dose-dependent manner by celastrol administration in a xenografted mice model. Taken together, celastrol distinctly inhibits the gastric cancer cell proliferation and induces autophagy and apoptosis.

Keywords

Apoptosis; Autophagy; Celastrol; Chemo therapy; Gastric cancer;

Citations & Related Records

Times Cited By KSCI : 1 (Citation Analysis)

Reference
Cited By KSCI

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