• 대한수학회논문집
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• 제25권4호
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• pp.497-510
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• 2010

Let R be a ring and n a fixed non-negative integer. $\cal{TI}_n$ (resp. $\cal{TF}_n$) denotes the class of all right R-modules of FGT-injective dimensions at most n (resp. all left R-modules of FGT-flat dimensions at most n). We prove that, if R is a right $\prod$-coherent ring, then every right R-module has a $\cal{TI}_n$-cover and every left R-module has a $\cal{TF}_n$-preenvelope. A right R-module M is called n-TI-injective in case $Ext^1$(N,M) = 0 for any $N\;{\in}\;\cal{TI}_n$. A left R-module F is said to be n-TI-flat if $Tor_1$(N, F) = 0 for any $N\;{\in}\;\cal{TI}_n$. Some properties of n-TI-injective and n-TI-flat modules and their relations with $\cal{TI}_n$-(pre)covers and $\cal{TF}_n$-preenvelopes are also studied.

• 복식
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• 제27권
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• pp.87-101
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• 1996

The purpose of this study is to grasp the re-lationship between Sasang constitution of the disposition side and clothing value in grown-up women in order to apply Sasang consti-tution theory to the marketing strategy in clothing industry. The study is based on a questionnaie about Sasang constitution and clothing value. The questionnarie was answered by 519 women. The data ere collected from September 12 to September 30, 1994 and analyzed by cluster analysis correlation analysis ANOVA and fac-tor analysis using SAS. The Findings of this study are as follows: 1. The women were classfied in to 3 clusters by cluster analysis :Sp-Yaung-In type (30.8%) Tae-Em-In type (40.7%) So-em-in(28.5%). 2. Correlations between SO-Yaug In type and each of clothing values showed all signifi-cant and specially social value showed high corelation(0.57163) 3. In Tae-Em-In type all correlations showed significant and esocial value showed the highest correlation of all correlations. 4. In So-Em-In type there was no corre-lation inpolitical value and the order of cloth-ing values showing high correlation was theor-etical social economic and religious value. 5. The aesthetic valu among and consti-tution types showed the lowest correlation of all correlation. By means of the about study results we may know that all women belong to three types think social value of the more important value than any other in clothing value. This is because grown-up women in korea prefer yet clothing of the harmonic and similar type to this of individual type.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2001년도 춘계학술대회논문집A
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• pp.151-156
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• 2001

Experimental frictional and wear characteristics of silicon graphite materials is studied in this paper. Those specimens are lubricated with high temperature and highly pressurized water to simulate the same operating condition for the journal bearing and the thrust bearing on the main coolant pump bearing in the newly developing nuclear reactor named SMART(System-integrated Modular Advanced ReacTor). Operating condition of the bearings is realized by the tribometer and the autoclave. Friction coefficient and wear loss are analyzed to choose the best silicon graphite material. Pin on plate test specimens are used and coned disk springs are used to control the applied force on the specimens. Wear loss ana wear width are measured by a precision balance and a micrometer. The friction force is measured by the strain gauge which can be used under high temperature and high pressure. Three kinds of silicon graphite materials are examined and compared with each other, and each material shows similar but different results on frictional and wear characteristics.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2003년도 추계학술대회
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• pp.568-573
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• 2003

When a safety valve equipped in a nuclear power plant opens in an instant by an accident, a moving shock wave propagates downstream the valve, inducing a complicated unsteady flow field. The moving shock wave may exert severe load to the structure. So, to reduce the load acting on the wall of POSRV, a gradual opening of POSRV is adopted in general. In theses connections, a numerical work is performed to investigate the effect of valve opening time on the unsteady flow fields downstream of the valve. Compressible, two-dimensional Navier-Stokes equations are used with the finite volume method. The obtained results show that sharp pressure rise through moving shock tor the case of instant opening is attenuated by employing the gradual opening of valve. It is turned that the flows for the two cases of gradual valve opening time show the similar to that of highly under-expanded one in jet structure having expansion and compression waves and Mach stem. Also, comparing with the results for the two cases of opening time, the shorter the valve opening is, the pressure gradient at the downstream of the valve becomes softly.

• 한국품질경영학회:학술대회논문집
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• 한국품질경영학회 2004년도 품질경영모델을 통한 가치 창출
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• pp.114-119
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• 2004

Software verification and validation(V&V) is a means to develop high-quality software and assure safety and reliability for software. Also, we can achieve the desired software quality through systematic V&V activities. The software to be applied safety critical system like nuclear power plants is required to setup the V&V methodology that comply with licensing requirements for nuclear power plants and should be performed V&V activities according to it. In this paper, we classified safety-critical, safety-related and non-safety for software according to safety function to be peformed and define V&V activities to be applied software grade. Also, we defined V&V activities, procedures and documentation for each phase of software development life cycle and showed techniques and management to perform V&V. Finally, we propose the V&V framework to be applied software development of SMART(System-integrated Modular Advanced ReacTor) MMIS (Man-Machine Interface System) and to comply with domestic licensing requirements.

• Biomolecules & Therapeutics
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• 제19권1호
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• pp.21-26
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• 2011

Ceramide is an important lipid mediator of extracellular signals that control various cellular functions, including apoptosis. In this study, we showed that ceramide induced apoptosis in U373MG human glioblastoma cells associated with G1 cell cycle arrest. Treatment of cells with ceramide increased proapoptotic Bax expression and inhibited the expression of antiapoptotic Bcl-2 and Bcl-xL Ceramide also downregulated cyclin E, cyclin D1, cdk 2, and cdk4 which are involved in regulating cell cycle. In addition, ceramide suppressed phosphorylation of Akt, Bad, p70 S6 kinase, and 4E-BP1, suggesting the involvement of Akt/mTOR signaling pathway. Additionally, okadaic acid, an inhibitor of protein phosphatase 2A, partially blocked the ceramide mediated inhibition of phosphorylation of Akt and 4E-BP1. These results suggest that ceramide induces apoptosis in U373MG glioblastoma cells by regulating multiple signaling pathways that involve cell cycle arrest associated with Akt signaling pathway.

• Molecules and Cells
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• 제41권10호
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• pp.881-888
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• 2018

During the cortical development, cells in the brain acquire somatic mutations that can be implicated in various neurodevelopmental disorders. There is increasing evidence that brain somatic mutations lead to sporadic form of epileptic disorders with previously unknown etiology. In particular, malformation of cortical developments (MCD), ganglioglioma (GG) associated with intractable epilepsy and non-lesional focal epilepsy (NLFE) are known to be attributable to brain somatic mutations in mTOR pathway genes and others. In order to identify such somatic mutations presenting as low-level in epileptic brain tissues, the mutated cells should be enriched and sequenced with high-depth coverage. Nevertheless, there are a lot of technical limitations to accurately detect low-level of somatic mutations. Also, it is important to validate whether identified somatic mutations are truly causative for epileptic seizures or not. Furthermore, it will be necessary to understand the molecular mechanism of how brain somatic mutations disturb neuronal circuitry since epilepsy is a typical example of neural network disorder. In this review, we overview current genetic techniques and experimental tools in neuroscience that can address the existence and significance of brain somatic mutations in epileptic disorders as well as their effect on neuronal circuitry.

• Biomolecules & Therapeutics
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• 제24권1호
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• pp.1-8
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• 2016

Alpha-ketoglutarate (AKG) is a key molecule in the Krebs cycle determining the overall rate of the citric acid cycle of the organism. It is a nitrogen scavenger and a source of glutamate and glutamine that stimulates protein synthesis and inhibits protein degradation in muscles. AKG as a precursor of glutamate and glutamine is a central metabolic fuel for cells of the gastrointestinal tract as well. AKG can decrease protein catabolism and increase protein synthesis to enhance bone tissue formation in the skeletal muscles and can be used in clinical applications. In addition to these health benefits, a recent study has shown that AKG can extend the lifespan of adult Caenorhabditis elegans by inhibiting ATP synthase and TOR. AKG not only extends lifespan, but also delays age-related disease. In this review, we will summarize the advances in AKG research field, in the content of its physiological functions and applications.

• Journal of Plant Biotechnology
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• 제37권1호
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• pp.57-66
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• 2010

Programmed cell death systems are important for an active type of cell deaths. Among them, a type of programmed cell death, autophagy is activated in cancer cells in response to multiple stresses and has been demonstrated to promote tumor cell survival and drug resistance. Thus, in the area of cancer, over the time frame form around the 1940s to date, of the 155 small molecules, 73% are other than "synthetic", with 47% actually being either "natural products" or "directly derived therefrom". Autophagy has multiple physiological functions in multicellular organisms, including protein degradation and organelle turnover. Genes and proteins that constitute the basic machinery of the autophagic process were first identified in the yeast system and some of their mammalian orthologues have been characterized as well. Numerous oncogenes, including Akt1, Bcl-2, NF1, PDPK1, class I PI3K, PTEN, and Ras and oncosuppressors, inculuding Bec-1, Bif-1, DAPK-1, p53 and UVRAG suppress or promote the autophagy pathway. Regulation of autophagy in tumors is governed by similar principles of the normal cells, only in a much more complicated manner, given the frequently observed abnormal PI3K activation in cancer and the multitude of interactions between the PI3K/AKT/mTOR pathway and other cell signaling cascades, often also deregulated in tumor cells. Autophagy induction by some anticancer agents underlines the potential utility of its induction as a new cancer treatment modality of development for natural medicines.

• Molecules and Cells
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• 제27권3호
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• pp.299-305
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• 2009

Over-expression of phospholipase D (PLD) 1 or PLD2 down-regulated CKII activity in NIH3T3 cells. The same results were found with catalytically inactive mutants of PLD isozymes, indicating that the catalytic activity of PLD is not required for PLD-mediated CKII inhibition. Consistent with this, 1-butanol did not alter CKII activity. The reduction in CKII activity in PLD-over-expressing NIH3T3 cells was due to reduced protein level, but not mRNA level, of the $CKII{\beta}$ subunit. This PLD-induced $CKII{\beta}$ degradation was mediated by ubiquitin-proteasome machinery, but MAP kinase and mTOR were not involved in $CKII{\beta}$ degradation. PLD isozymes interacted with the $CKII{\beta}$ subunit. Immunocytochemical staining revealed that PLD and $CKII{\beta}$ colocalize in the cytoplasm of NIH3T3 cells, especially in the perinuclear region. PLD binding to $CKII{\beta}$ inhibited $CKII{\beta}$ autophosphorylation, which is known to be important for $CKII{\beta}$ stability. In summary, the current data indicate that PLD isozymes can down-regulate CKII activity through the acceleration of $CKII{\beta}$ degradation by ubiquitin-proteasome machinery.