• Communications of the Korean Mathematical Society
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• v.38 no.1
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• pp.21-38
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• 2023

Let R be a commutative ring with identity. Let R be an integral domain and M a torsion-free R-module. We investigate the relation between the notion of e-exactness, recently introduced by Akray and Zebari [1], and generalized the concept of homology, and establish a relation between e-exact sequences and homology of modules. We modify some applications of e-exact sequences in homology and reprove some results of homology with e-exact sequences such as horseshoe lemma, long exact sequences, connecting homomorphisms and etc. Next, we generalize two special drived functor T or and Ext, and study some properties of them.

• Journal of the Korean Society for Precision Engineering
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• v.14 no.2
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• pp.48-57
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• 1997

A computer aided analysis and design system is developed for analyzing the driveline torsional vibration of a vehicle. Torsional vibration characteristics of driveline component are investigated and 10 types of module are developed. They can be connected together to represent any driveline configuration. During assembly process simulation program is generated. It is implemented using C++language. A driveline tor- sional vibration system at full load driving condition and idle rattle system are modeled and simulated with this system. Their responses for engine torque excitation are evaluated on time and frequency domain, and the results are compared with test results favorably. This system makes it simpler and easier for design and analysis engineer to model and analyse the driveline system.

• Journal of Microbiology and Biotechnology
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• v.33 no.5
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• pp.680-686
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• 2023

Aging is a complex series of multi-organ processes that occur in various organisms. As such, an in vivo study using an animal model of aging is necessary to define its exact mechanisms and identify anti-aging substances. Using Drosophila as an in vivo model system, we identified Crataegus pinnatifida extract (CPE) as a novel anti-aging substance. Regardless of sex, Drosophila treated with CPE showed a significantly increased lifespan compared to those without CPE. In this study, we also evaluated the involvement of CPE in aging-related biochemical pathways, including TOR, stem cell generation, and antioxidative effects, and found that the representative genes of each pathway were induced by CPE administration. CPE administration did not result in significant differences in fecundity, locomotion, feeding amount, or TAG level. These conclusions suggest that CPE is a good candidate as an anti-aging food substance capable of promoting a healthy lifespan.

• Proceedings of the Korean Society of Computer Information Conference
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• 2023.07a
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• pp.207-208
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• 2023

다크웹을 통한 마약, 금융거래, 해킹 등 사이버 범죄가 증가하면서 다크웹 상의 범죄 추적을 위한 사이버 수사 필요성이 증대되고 있다. Tor와 같은 다크웹 접속 브라우저는 강력한 익명성을 제공하기 때문에 주로 다크웹 운영상의 취약점 분석, 악성코드를 활용한 함정수사 기법이 실효성 높은 다크웹 수사 기술로 간주된다. 그러나 사이트 개설 및 폐쇄가 빈번하게 발생하는 다크웹의 특성상 최신 범죄 정보를 수집하기 위해서는 방대한 다크웹 정보를 실시간 수집하고, 능동적으로 검색 키워드를 확장할 수 있는 고도화된 크롤러 기술 개발이 필요하다. 본 논문은 다양한 다크웹 사이트 중, 아동 음란물 사이트를 크롤링을 통해 수집하고, 수집된 텍스트의 연관 분석을 통해 검색 키워드를 확장하는 수집 체계를 제안한다.

• Kyungpook Mathematical Journal
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• v.63 no.3
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• pp.333-344
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• 2023

In this paper, we generalize the notions uniformly S-flat, briefly u-S-flat, modules and dimensions. We introduce and study the notions of weak u-S-flat modules. An R-module M is said to be weak u-S-flat if Tor^R₁ (R/I, M) is u-S-torsion for any ideal I of R. This new class of modules will be used to characterize u-S-von Neumann regular rings. Hence, we introduce the weak u-S-flat dimensions of modules and rings. The relations between the introduced dimensions and other (classical) homological dimensions are discussed.

• Bulletin of the Korean Mathematical Society
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• v.61 no.1
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• pp.273-280
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• 2024

Let I be an ideal of a commutative Noetherian semi-local ring R and M be an R-module. It is shown that if dim M ≤ 2 and Supp_R M ⊆ V (I), then M is I-weakly cofinite if (and only if) the R-modules Hom_R(R/I, M) and Ext¹_R(R/I, M) are weakly Laskerian. As a consequence of this result, it is shown that the category of all I-weakly cofinite modules X with dim X ≤ 2, forms an Abelian subcategory of the category of all R-modules. Finally, it is shown that if dim R/I ≤ 2, then for each pair of finitely generated R-modules M and N and each pair of the integers i, j ≥ 0, the R-modules Tor^R_i(N, H^j_I(M)) and Extⁱ_R(N, H^j_I(M)) are I-weakly cofinite.

• Biomolecules & Therapeutics
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• v.32 no.3
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• pp.291-300
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• 2024

Autosomal dominant polycystic kidney disease (ADPKD), a congenital genetic disorder, is a notable contributor to the prevalence of chronic kidney disease worldwide. Despite the absence of a complete cure, ongoing research aims for early diagnosis and treatment. Although agents such as tolvaptan and mTOR inhibitors have been utilized, their effectiveness in managing the disease during its initial phase has certain limitations. This review aimed to explore new targets for the early diagnosis and treatment of ADPKD, considering ongoing developments. We particularly focus on cell polarity, which is a key factor that influences the process and pace of cyst formation. In addition, we aimed to identify agents or treatments that can prevent or impede the progression of renal fibrosis, ultimately slowing its trajectory toward end-stage renal disease. Recent advances in slowing ADPKD progression have been examined, and potential therapeutic approaches targeting multiple pathways have been introduced. This comprehensive review discusses innovative strategies to address the challenges of ADPKD and provides valuable insights into potential avenues for its prevention and treatment.

• International Journal of Oral Biology
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• v.49 no.2
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• pp.42-47
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• 2024

Ophiopogonin D (OPD) is a steroidal glycoside derived from Ophiopogon japonicus, a traditional Chinese medicine with diverse biological activities, including antithrombosis, anti-inflammation, and antitussive effects. To investigate the cellular effects and mechanisms of OPD on oral squamous cell carcinoma, cell viability was explored, and the effects of OPD on cell cycle regulators, apoptotic marker proteins, and key proteins involved in metastasis and signaling pathways were examined by MTT assay and Western blotting in YD38 cells. OPD strongly inhibited cell proliferation and induced caspase-dependent apoptosis of YD38 cells by suppressing the cell cycle and activating caspase-3 and poly ADP ribose polymerase. Additionally, OPD suppressed the expression of vital proteins regulating metastasis and proliferation within the integrin/matrix metalloproteinases/FAK and AKT/PI3K/mTor pathways. Thus, OPD can be a potential treatment candidate for gingival cancer.

• The Korean Journal of Medicine
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• v.99 no.1
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• pp.25-31
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• 2024

Lymphangioleiomyomatosis (LAM) is a rare condition that exclusively affects women and is characterized by lung parenchymal destruction and the formation of cysts due to infiltration by LAM cells. It can also impact the lymphatic system, leading to the development of fluid-filled cystic structures and abdominal involvement, including renal angiomyolipomas (AML) or lymphangioleiomyoma. LAM can occur sporadically or be associated with tuberous sclerosis complex. Common symptoms include respiratory issues such as dyspnea, pneumothorax, chylothorax, along with other manifestations like renal AML and lymphatic involvement. The diagnosis of LAM relies on a combination of clinical, radiological, and laboratory findings, and treatment options vary depending on symptoms and patient status, with mTOR inhibitors being considered as a treatment option. This case outlines the diagnostic journey and clinical course of a 32-year-old female patient with LAM.

• Journal of Ginseng Research
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• v.44 no.3
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• pp.435-441
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• 2020

Background: As a process of aging, skeletal muscle mass and function gradually decrease. It is reported that ginsenoside Rb1 and Rb2 play a role as AMP-activated protein kinase activator, resulting in regulating glucose homeostasis, and Rb1 reduces oxidative stress in aged skeletal muscles through activating the phosphatidylinositol 3-kinase/Akt/Nrf2 pathway. We examined the effects of Rb1 and Rb2 on differentiation of the muscle stem cells and myotube formation. Methods: C2C12 myoblasts treated with Rb1 and/or Rb2 were differentiated and induced to myotube formation, followed by immunoblotting for myogenic marker proteins, such as myosin heavy chain, MyoD, and myogenin, or immunostaining for myosin heavy chain or immunoprecipitation analysis for heterodimerization of MyoD/E-proteins. Results: Rb1 and Rb2 enhanced myoblast differentiation through accelerating MyoD/E-protein heterodimerization and increased myotube hypertrophy, accompanied by activation of Akt/mammalian target of rapamycin signaling. In addition, Rb1 and Rb2 induced the MyoD-mediated transdifferentiation of the rhabdomyosarcoma cells into myoblasts. Furthermore, co-treatment with Rb1 and Rb2 had synergistically enhanced myoblast differentiation through Akt activation. Conclusion: Rb1 and Rb2 upregulate myotube growth and myogenic differentiation through activating Akt/mammalian target of rapamycin signaling and inducing myogenic conversion of fibroblasts. Thus, our first finding indicates that Rb1 and Rb2 have strong potential as a helpful remedy to prevent and treat muscle atrophy, such as age-related muscular dystrophy.